Caligan Partners LP — 13F Holdings & Portfolio
CIK 1727492 · latest 13F-HR filed 2026-08-14
Caligan Partners LP manages $2.13B in 13F-reported U.S. long-equity assets across 28 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are LQDA (30.45%), RVMD (17.28%), ABVX (9.77%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 5 new positions, exited 4, added to 13, and trimmed 4.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
30TH FLOOR
NEW YORK, NY 10017
$2.13B
Long-equity book
28
Distinct positions
2026-06-30
Filed 2026-08-14
+5 / −4 / ↑13 / ↓4
vs 2026-03-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- LIQUIDIA CORPORATION$340.9M +111.3%
- REVOLUTION MEDICINES INC$206.7M +128.6%
- ABIVAX SA$44.8M +27.5%
- AVALO THERAPEUTICS INC$34.1M +139.5%
- AURA BIOSCIENCES INC$29.0M +1884.5%
Top Trims
- XENON PHARMACEUTICALS INC-$27.3M -33.7%
- TYRA BIOSCIENCES INC-$23.1M -47.3%
- MBX BIOSCIENCES INC-$14.3M -56.4%
- OPUS GENETICS INC-$2.7M -9.6%
New Positions
- IMMUNOCORE HLDGS PLC$43.9M
- VIRIDIAN THERAPEUTICS INC$40.3M
- SAGIMET BIOSCIENCES INC$19.3M
- ARTIVA BIOTHERAPEUTICS INC$16.8M
- CELLECTAR BIOSCIENCES INC$1.3M
Exited Positions
- MINERALYS THERAPEUTICS INC$75.1M
- SPYRE THERAPEUTICS INC$44.3M
- MAZE THERAPEUTICS INC$18.4M
- XILIO THERAPEUTICS INC$943.0K
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | LIQUIDIA CORPORATION | LQDA | 53635D202 | $647.3M | 30.45% | 8,118,892 | SH |
| 2 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $367.4M | 17.28% | 1,961,795 | SH |
| 3 | ABIVAX SA | ABVX | 00370M103 | $207.6M | 9.77% | 1,557,924 | SH |
| 4 | VAXCYTE INC | PCVX | 92243G108 | $127.2M | 5.99% | 2,188,636 | SH |
| 5 | EXELIXIS INC | EXEL | 30161Q104 | $84.5M | 3.98% | 1,553,262 | SH |
| 6 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $78.2M | 3.68% | 2,500,103 | SH |
| 7 | AVALO THERAPEUTICS INC | AVTX | 05338F306 | $58.5M | 2.75% | 3,163,866 | SH |
| 8 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $53.7M | 2.53% | 889,944 | SH |
| 9 | ADMA BIOLOGICS INC | ADMA | 000899104 | $47.9M | 2.25% | 5,725,007 | SH |
| 10 | REVOLUTION MEDICINES INC Call | RVMD | 76155X100 | $47.2M | 2.22% | 251,800 | SH |
| 11 | LB PHARMACEUTICALS INC | LBRX | 50180M108 | $46.7M | 2.20% | 1,438,070 | SH |
| 12 | IMMUNOCORE HLDGS PLC | IMCR | 45258D105 | $43.9M | 2.06% | 1,381,317 | SH |
| 13 | VIRIDIAN THERAPEUTICS INC | VRDN | 92790C104 | $40.3M | 1.90% | 2,193,981 | SH |
| 14 | VOR BIOPHARMA INC | VOR | 929033207 | $35.4M | 1.67% | 1,925,066 | SH |
| 15 | SAB BIOTHERAPEUTICS INC | SABS | 78397T202 | $31.1M | 1.46% | 7,967,207 | SH |
| 16 | INVENTIVA SA | IVA | 46124U107 | $30.9M | 1.45% | 8,163,191 | SH |
| 17 | AURA BIOSCIENCES INC | AURA | 05153U107 | $30.5M | 1.44% | 4,298,248 | SH |
| 18 | TYRA BIOSCIENCES INC | TYRA | 90240B106 | $25.8M | 1.21% | 806,986 | SH |
| 19 | OPUS GENETICS INC | IRD | 67577R102 | $25.0M | 1.17% | 6,077,084 | SH |
| 20 | ANIKA THERAPEUTICS INC | ANIK | 035255108 | $21.0M | 0.99% | 1,435,130 | SH |
| 21 | SAGIMET BIOSCIENCES INC | SGMT | 786700104 | $19.3M | 0.91% | 2,500,000 | SH |
| 22 | ARTIVA BIOTHERAPEUTICS INC | ARTV | 04317A107 | $16.8M | 0.79% | 1,736,111 | SH |
| 23 | FAETH THERAPEUTICS INC | FTH | 81728A207 | $15.7M | 0.74% | 629,467 | SH |
| 24 | MBX BIOSCIENCES INC | MBX | 55287L101 | $11.0M | 0.52% | 200,000 | SH |
| 25 | VERRICA PHARMACEUTICALS INC | VRCA | 92511W207 | $5.7M | 0.27% | 923,910 | SH |
| 26 | AGIOS PHARMACEUTICALS INC Call | AGIO | 00847X104 | $3.3M | 0.16% | 90,000 | SH |
| 27 | ADMA BIOLOGICS INC Call | ADMA | 000899104 | $2.5M | 0.12% | 300,000 | SH |
| 28 | CELLECTAR BIOSCIENCES INC | CLRB | 15117F880 | $1.3M | 0.06% | 469,998 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $2.13B | 28 | 0001420506-26-001809 |
| 2026-03-31 | 2026-05-15 | $1.50B | 28 | 0001420506-26-001039 |
| 2025-12-31 | 2026-02-17 | $1.21B | 24 | 0001420506-26-000584 |
| 2025-09-30 | 2025-11-14 | $763.5M | 18 | 0001420506-25-003441 |