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Foresite Capital Management VI LLC — 13F Holdings & Portfolio

CIK 2013341 · latest 13F-HR filed 2026-08-14

Backtest portfolio

Foresite Capital Management VI LLC manages $642.6M in 13F-reported U.S. long-equity assets across 23 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are CGON (26.20%), ALMS (18.60%), SPTX (6.02%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 8 new positions and exited 2; 10 existing positions rose in reported value and 2 fell.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

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AUM
$642.6M

Long-equity book

Holdings
23

Distinct positions

Period
2026-06-30

Filed 2026-08-14

Q/Q Activity
+8 / −2 / ↑10 / ↓2

vs 2026-03-31

Portfolio charts

Latest quarter's book, what changed, and how the portfolio has evolved across filings.

Portfolio map

Q2 26
CGON26.2% · +7%ALMS18.6% · 0%SPTX6.0% · newDNLI5.6% · +15%CLDX5.1% · +178%AGIO4.5% · +50%CRVS4.3% · 0%PBLS4.3% · newGHRS3.9% · +198%JBIO3.1% · +177%HNGE2.8% · 0%KYMR2.6% · 0%ATAI2.3% · 0%VSTM1.9% · 0%BEAM1.8% · newNERV1.7% · -0%AVBP1.6% · newAURA1.5% · newCRNX1.2% · 0%RACC0.5% · newZURA0.4% · 0%KLRA0.1% · newIRON0.0% · new

Box size = position value; colour = change in share count vs the prior quarter (green added, red trimmed, blue new). Rows split across managers or share classes are combined. Click a box for the stock.

Sector mix

% of 13F value

Sectors from each company's SIC code; funds and ETFs grouped separately.

Biggest buys and sells

Q1 26 → Q2 26

Estimated from the change in shares held × the quarter-end price, so price moves alone don't count as buying. New and exited positions are included.

13F assets and positions

4 quarters

Total reported 13F value (bars) and number of positions (line) each quarter. Value changes include market moves.

Top positions over time

reported value

The eight largest current positions, valued at each quarter end.

Concentration

top 10 = 81.5%

Cumulative share of the portfolio held in the largest N positions.

Firm Profile & Key People
Name Title / Status Ownership Type

Quarter-over-quarter changes

Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.

Foresite Capital Management VI LLC Holdings (2026-06-30)

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 CG Oncology, Inc. CGON 156944100 $168.4M 26.20% 2,369,574 SH
2 ALUMIS INC. ALMS 022307102 $119.5M 18.60% 4,247,670 SH
3 Seaport Therapeutics, Inc. SPTX 81221K108 $38.7M 6.02% 1,779,521 SH
4 Denali Therapeutics Inc. DNLI 24823R105 $35.9M 5.59% 1,396,771 SH
5 Celldex Therapeutics, Inc. CLDX 15117B202 $32.7M 5.09% 879,713 SH
6 AGIOS PHARMACEUTICALS, INC. AGIO 00847X104 $29.1M 4.53% 785,000 SH
7 Corvus Pharmaceuticals, Inc. CRVS 221015100 $27.4M 4.26% 1,831,233 SH
8 Parabilis Medicines, Inc. PBLS 698955101 $27.3M 4.26% 999,044 SH
9 GH Research PLC GHRS G3855L106 $25.3M 3.93% 940,493 SH
10 Jade Biosciences, Inc. JBIO 008064206 $19.7M 3.07% 886,667 SH
11 Hinge Health, Inc. HNGE 433313103 $18.3M 2.85% 220,400 SH
12 Kymera Therapeutics, Inc. KYMR 501575104 $16.8M 2.61% 146,332 SH
13 AtaiBeckley Inc. ATAI 04650F101 $14.5M 2.26% 2,750,000 SH
14 Verastem, Inc. VSTM 92337C203 $12.0M 1.87% 3,146,631 SH
15 Beam Therapeutics Inc. BEAM 07373V105 $11.3M 1.76% 330,000 SH
16 Minerva Neurosciences, Inc. NERV 603380205 $11.0M 1.71% 1,985,584 SH
17 ArriVent BioPharma, Inc. AVBP 04272N102 $10.5M 1.63% 301,341 SH
18 Aura Biosciences, Inc. AURA 05153U107 $9.5M 1.47% 1,333,334 SH
19 Crinetics Pharmaceuticals, Inc. CRNX 22663K107 $7.9M 1.23% 212,010 SH
20 Research Alliance Corp III RACC G75226103 $3.2M 0.50% 300,000 SH
21 Zura Bio Ltd ZURA G9TY5A101 $2.7M 0.41% 450,000 SH
22 Kailera Therapeutics, Inc. KLRA 482931102 $826.1K 0.13% 37,500 SH
23 Disc Medicine, Inc. IRON 254604101 $70.9K 0.01% 970 SH
Filing History
Period Filed AUM Holdings Accession
2026-06-30 2026-08-14 $642.6M 23 0001104659-26-097133
2026-03-31 2026-05-15 $460.3M 17 0001104659-26-062467
2025-12-31 2026-02-17 $330.8M 12 0001104659-26-015412
2025-09-30 2025-11-14 $258.9M 12 0001104659-25-112509
Filer Information
Address
9200 SUNSET BOULEVARD
SUITE PH1
WEST HOLLYWOOD, CA 90069
Phone
(415) 877-4887
Filing Manager
Foresite Capital Management VI LLC
WEST HOLLYWOOD, CA
Signatory
James B. Tananbaum
Managing Member