DNLI Denali Therapeutics Inc. Common Stock
XNAS 19.29 DelayedStock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Expected move IV rank history Fibonacci levels Insider trading
Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.
- 52-Week Range
- $13.75 – $27.30
- YTD
- +18.56%
- IV Rank (30D)
- 81.65
- Straddle Price
- $3.58
- P/C Vol Ratio
- 0.80
- Market Cap
- $3.1B
- Open
- $18.92
- Day Range
- $18.84 – $19.29
- Volume
- 1,586,168
- Prev Close
- $19.22
A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.
- DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
- Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
- DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
- P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
- Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
- Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
- Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
- Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
| 10-yr Treasury (rf) | 5.00% |
| Beta vs SPY | 1.46 |
| Cost of Equity (CAPM) | 13.05% (VRP-adj) |
| WACC | 13.15% |
| Volatility Risk Premium | +58.1pp (IV − HV30), ERP adj +50bps |
| Effective Tax Rate | 21.0% |
| Rev. Growth (YoY, DCF input) | +3.0% |
| DCF Horizon | 5 years explicit + fade |
| Forward Tilt (NTM/TTM) | ×1.03 (applied to P/E, EV/EBITDA, P/S) |
| Free Cash Flow (TTM) | $-0.4B |
| Return on Equity (TTM) | -61.4% |
| Book / Price | 27.4% |
| Debt / Equity | 0.01 |
| Quality Score | 1/6 — cyclical/struggling (5y DCF) |
| SMA 50 | $20.99 (Market Anchor value) |
| SMA 20 / Bollinger Mid | $18.97 |
| Bollinger Width / SMA20 | 89.7% (drives anchor stability) |
| Net Debt | $-0.4B |
| Market Cap | $3B |
| Method | Implied Price | Weight | Detail |
|---|---|---|---|
| DCF | n/a | 0% | |
| DDM (Gordon) | n/a | 0% | |
| Peer P/E | n/a | 0% | |
| Peer EV/EBITDA | n/a | 0% | median 54.6× · 4 peers |
| Peer P/B | $41.57 | 22% | median 7.9× · 7 peers |
| Peer P/S | n/a | 0% | median 8.8× · 7 peers |
| Market Anchor (SMA50) | $20.99 | 78% | stability 71% (BB-width) |
| Options Expected (B-L 30d) | $18.79 | 0% | 7 strikes · skew +0.27 |
- Industry (SIC)
- BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES) (2836) · industry map
- Exchange
- XNAS
- Market Cap
- $3.1B
- Employees
- 507
- List Date
- 2017-12-08
- CIK
- 0001714899
- Next Earnings
- 2026-11-03 (After-Close)
- EPS Forecast
- ($0.32)
- Headquarters
- South San Francisco, CA
- Homepage
- https://www.denalitherapeutics.com
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.
| Month | '21 | '22 | '23 | '24 | '25 | '26 | Avg |
|---|---|---|---|---|---|---|---|
| Jan | -3.33% | -27.61% | 9.55% | -25.15% | 11.80% | 33.62% | -0.19% |
| Feb | 2.97% | -7.89% | -12.08% | 20.68% | -24.18% | -6.86% | -4.56% |
| Mar | -11.69% | 0.22% | -15.60% | -1.63% | -10.56% | -8.57% | -7.97% |
| Apr | 8.06% | -32.02% | 6.29% | -24.90% | 35.48% | -4.88% | -2.00% |
| May | 9.06% | -3.42% | 17.13% | 14.85% | -17.56% | 14.97% | 5.84% |
| Jun | 27.36% | 23.19% | -4.56% | 13.94% | 0.21% | 26.02% | 14.36% |
| Jul | -34.77% | 8.90% | -4.21% | 10.72% | -0.86% | -11.19% | -5.24% |
| Aug | 5.39% | -15.56% | -18.47% | 4.76% | 13.62% | 2.63% | -1.27% |
| Sep | -8.61% | 9.69% | -11.50% | 15.96% | -6.02% | -11.15% | -1.94% |
| Oct | -5.16% | -7.60% | -4.85% | -9.45% | 9.19% | -6.04%* | -3.98% |
| Nov | -7.59% | 10.19% | -2.68% | -7.58% | 26.76% | -- | 3.82% |
| Dec | 0.41% | -10.87% | 13.13% | -20.48% | -9.09% | -- | -5.38% |
| Total | -27.05% | -50.53% | -30.06% | -21.84% | 13.03% | 19.32% | -16.19% |
Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.
- SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
- EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
- MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
- ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
- +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
- RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
- Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
- Williams %R — inverted scale: <−80 oversold, >−20 overbought.
Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.
- Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
- OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
- Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
- ATR / True Range — average daily $ move; sizing and stop-loss reference.
- HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.
Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →
Trend Indicators
Momentum Oscillators
Volume & Volatility
Data Summary
LLM Stock Analysis Report
Executive Summary
Overall Assessment: NEUTRAL (Confidence Level: 6/10)
Key Drivers:
- Recent news sentiment is mixed, with positive and negative headlines
- Technical indicators show a bearish momentum signal from the MACD histogram
- Volatility remains high, with a beta of 1.50 indicating a more volatile stock compared to the market
Primary Risks:
- Potential for further price decline due to the bearish momentum signal
- High volatility may lead to increased trading activity and potential price swings
Investment Thesis: Denali Therapeutics (DNLI) is currently experiencing mixed news sentiment, with some positive headlines balancing out negative ones. The technical indicators suggest a bearish momentum signal, which could lead to further price decline. However, the high volatility also presents an opportunity for traders who can navigate the market's uncertainty.
Recent News Sentiment Impact: The recent news headlines have been mixed, with two negative and three neutral articles. The most recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price.
Technical Analysis
Trend Direction:
- Short-term: BEARISH (MACD histogram below signal line)
- Medium-term: NEUTRAL (RSI in neutral zone, no clear trend)
- Long-term: NEUTRAL (no clear trend)
Support/Resistance Levels:
- Resistance: $26.02 (upper Bollinger Band)
- Support: $22.55 (lower Bollinger Band), $20.84 (SMA 200)
Momentum Signals:
- RSI interpretation: Neutral (35.39)
- MACD signal: Bearish (histogram below signal line)
- Bollinger Bands position: Oversold
Volume Analysis: Volume trends suggest increasing institutional interest, with a volume rate of change of 17.41%. However, the OBV is not confirming this trend, indicating some potential selling pressure.
News & Sentiment Analysis
Recent Headlines Summary:
- Mixed news sentiment, with two negative and three neutral articles
- Recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price
Sentiment Assessment: NEUTRAL
Catalyst Identification: The upcoming FDA drug approval for BIIB122 (DNL151) in early-stage Parkinson's disease could be a potential catalyst for the stock.
Market Narrative: The mixed news sentiment and bearish momentum signal from the MACD histogram suggest that the market is expecting some negative news or price decline. However, the recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price.
Risk & Volatility Assessment
Risk Assessment: The high volatility and bearish momentum signal from the MACD histogram indicate that there is a higher risk of further price decline. However, the recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price.
Downside Protection: The lower Bollinger Band at $22.55 provides some downside protection for traders who are looking to short the stock or manage their risk.
Market Context & Positioning
Market Context:
- The biotechnology sector is experiencing volatility, with some stocks trending higher and others declining
- Denali Therapeutics (DNLI) is trading near its 52-week low, which could provide an opportunity for value investors
Positioning: The options market is pricing in a $3.62 move by expiration, indicating that traders are expecting some price movement. However, the put/call volume ratio of 0.00 suggests that there is no clear sentiment bias.
Key Levels & Action Items
Critical Price Levels:
- Resistance: $26.02 (upper Bollinger Band)
- Support: $22.55 (lower Bollinger Band), $20.84 (SMA 200)
Breakout/Breakdown Levels:
- Breakout above $26.02 could trigger a bullish momentum signal and potential price increase
- Breakdown below $20.84 could trigger a bearish momentum signal and potential price decline
Time-Sensitive Catalysts: The upcoming FDA drug approval for BIIB122 (DNL151) in early-stage Parkinson's disease could be a potential catalyst for the stock.
Risk Management: Traders should consider using stop-loss levels at $22.55 to manage their risk, as well as scaling into long positions if the stock price breaks above $26.02.
| Earnings Date | Timing | Expected Move | Actual Move | Ratio | Outcome |
|---|---|---|---|---|---|
| 2021-02-25 | Pre-Market | 12.07% | 5.63% | 0.47x | Within |
| 2021-05-03 | Pre-Market | 10.27% | 3.52% | 0.34x | Within |
| 2021-08-04 | Pre-Market | 32.37% | 0.49% | 0.02x | Within |
| 2021-11-04 | Pre-Market | 6.96% | 0.92% | 0.13x | Within |
| 2022-02-28 | Pre-Market | 16.65% | 1.42% | 0.09x | Within |
| 2022-05-05 | Pre-Market | 25.91% | 10.26% | 0.40x | Within |
| 2022-08-08 | Pre-Market | 8.53% | 4.20% | 0.49x | Within |
| 2022-10-18 | Pre-Market | 7.86% | 2.64% | 0.34x | Within |
| 2023-02-27 | Pre-Market | 0.96% | 3.47% | 3.61x | Exceeded |
| 2023-05-08 | Pre-Market | 10.41% | 0.15% | 0.01x | Within |
| 2023-08-08 | Pre-Market | 8.62% | 1.00% | 0.12x | Within |
| 2023-11-07 | Pre-Market | 8.43% | 2.31% | 0.27x | Within |
| 2024-02-27 | Pre-Market | 15.22% | 38.25% | 2.51x | Exceeded |
| 2024-05-07 | Pre-Market | 21.30% | 1.69% | 0.08x | Within |
| 2024-08-01 | Pre-Market | 12.82% | 4.27% | 0.33x | Within |
| 2024-11-06 | Pre-Market | 14.56% | 6.87% | 0.47x | Within |
| 2025-02-27 | After-Close | 20.16% | 10.97% | 0.54x | Within |
| 2025-05-06 | Pre-Market | 14.85% | 12.63% | 0.85x | Within |
| 2025-08-11 | Pre-Market | 16.30% | 0.29% | 0.02x | Within |
| 2025-11-06 | After-Close | 20.47% | 4.23% | 0.21x | Within |
| 2026-02-26 | Pre-Market | 21.31% | 3.90% | 0.18x | Within |
| 2026-05-05 | Pre-Market | 7.36% | 1.34% | 0.18x | Within |
| 2026-08-06 | Pre-Market | 15.46% | 1.27% | 0.08x | Within |
Earnings calendar: this week’s reports with expected vs actual moves →
DNLI Options Activity & IV Rank
DNLI IV rank history, 52-week IV rank and IV percentile →
Volatility Metrics
Options Flow
ATM Options Pricing
Chain Summary
Each spread is ranked by a composite score built in three stages. Full documentation →
score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.
- RSI <40 bullish / >60 bearish
- MACD crossover + histogram trend
- Price vs SMA 50 & SMA 200
- Stochastic %K <20 / >80
- Williams %R <−80 / >−20
- Blended ATR + straddle expected-move penalty
- Bollinger Band signal (+ counter-trend penalty)
- BB width — vol contraction boost for ICs
- IV rank ≥ 75 → strong boost for credit spreads
- IV rank < 25 → penalty (selling cheap vol)
- Min open interest across all legs
- OI < 100 → −0.10 · OI < 500 → −0.05
score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →
Enter a ticker to scan for optimal spread opportunities.
Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.
Estimated net dealer gamma is at the 39th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.
Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.
Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.
Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.
This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.
IV(put wing) − IV(ATM), in vol pointsHow much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.
- Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
- Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
- Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
- Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
IV(call wing) − IV(put wing), equal delta on each sideWhich side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.
- Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
- Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
- Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
- Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:
- High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
- Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
- Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.
Enter a ticker to render the implied volatility surface.
Enter a ticker to render the implied volatility smile.
Risk Metrics
Analysis Details
Data Points: 251
Period: 252 trading days
High volatility - stock moves more than market
| Investor | Value | Share of their portfolio | Rank | Q/Q shares | Source |
|---|---|---|---|---|---|
| Millennium Management Hedge fund Izzy Englander | $29.0M | #905 of 3716 | -10.5% | 13F | |
| Citadel Hedge fund Ken Griffin | $1.7M | #3091 of 6285 | -63.1% | 13F | |
| Rockefeller Capital Management Family office Rockefeller family | $229K | #2534 of 4729 | -65.7% | 13F |
Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions
DNLI Institutional Ownership (13F)
Latest filings — 2026-09-30Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.
- Shares — long equity positions in this name, aggregated across share classes.
- Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
- % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
- Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.
Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Balyasny Asset Management L.P. | $11.13M | 67.76% | 2026-06-30 |
| 2 | Susquehanna International Group, LLP Custodian | $2.21M | 13.43% | 2026-06-30 |
| 3 | Citadel Advisors LLC Custodian | $1.99M | 12.10% | 2026-06-30 |
| 4 | Point72 Asset Management, L.P. | $596.70K | 3.63% | 2026-06-30 |
| 5 | IMC-Chicago, LLC Custodian | $396.09K | 2.41% | 2026-06-30 |
| 6 | Simplex Trading, LLC Custodian | $95.16K | 0.58% | 2026-06-30 |
| 7 | GROUP ONE TRADING LLC Custodian | $12.86K | 0.08% | 2026-06-30 |
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Citadel Advisors LLC Custodian | $11.72M | 76.02% | 2026-06-30 |
| 2 | Jane Street Group, LLC Custodian | $1.51M | 9.81% | 2026-06-30 |
| 3 | Susquehanna International Group, LLP Custodian | $1.16M | 7.54% | 2026-06-30 |
| 4 | Point72 Asset Management, L.P. | $596.70K | 3.87% | 2026-06-30 |
| 5 | IMC-Chicago, LLC Custodian | $349.79K | 2.27% | 2026-06-30 |
| 6 | Simplex Trading, LLC Custodian | $54.01K | 0.35% | 2026-06-30 |
| 7 | GROUP ONE TRADING LLC Custodian | $23.15K | 0.15% | 2026-06-30 |
DNLI Insider Trading (Form 4)
Latest: 2026-09-09| Filed | Reporter | Role | Action | Shares | Avg Price | Net $ | Link |
|---|---|---|---|---|---|---|---|
| 2026-09-09 | Peter Scott Chin | Chief Medical Officer | Sell (S) | −1,654 | $22.29 | -$36.9K | EDGAR |
| 2026-09-04 | Nancy Thornberry | Director | Sell (S) | −11,439 | $22.90 | -$261.9K | EDGAR |
| 2026-09-03 | Alexander O. Schuth | COFO and Secretary | Sell (S) | −2,768 | $23.44 | -$64.9K | EDGAR |
| 2026-08-14 | Ryan J. Watts | President and CEO | Gift (G) | −32,220 | — | EDGAR | |
| 2026-08-13 | Alexander O. Schuth | COFO and Secretary | Sell (S) | −2,857 | $25.07 | -$71.6K | EDGAR |
| 2026-06-05 | Jennifer E. Cook | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | David P Schenkein | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | Peter S Klein | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | Nancy Thornberry | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | Timothy Van Hauwermeiren | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | Steve E. Krognes | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | Jay T Flatley | Director | Award (A) | +6,408 | — | EDGAR | |
| 2026-06-05 | Baker Bros. Advisors (GP) LLC | Director | Award (A) | +76,896 | — | EDGAR | |
| 2026-01-08 | Alexander O. Schuth | COFO and Secretary | Sell (S) | −17,218 | $16.50 | -$284.1K | EDGAR |
| 2026-01-08 | Ryan J. Watts | President and CEO | Sell (S) | −35,198 | $16.50 | -$580.8K | EDGAR |
DNLI Insider Holdings
15 insiders · @ $19.29| # | Insider | Role | Shares | Disclosed Exposure | Lifetime OM Net | Filings | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors (GP) LLC | Director | 3,422,366 | $66.02M | $0 | 1 | 2026-06-05 |
| 2 | Julian Baker | Director | 3,415,958 | $65.89M | $0 | 1 | 2025-06-05 |
| 3 | Ryan J. Watts | President and CEO | 2,417,217 | $46.63M | -$41.18M | 65 | 2026-08-14 |
| 4 | Marc Tessier-Lavigne | Director | 1,965,424 | $37.91M | -$36.87M | 25 | 2025-06-05 |
| 5 | Steve E. Krognes | Director | 819,999 | $15.82M | -$15.19M | 39 | 2026-06-05 |
| 6 | Alexander O. Schuth | COFO and Secretary | 802,744 | $15.48M | -$18.55M | 77 | 2026-09-03 |
| 7 | Jay T Flatley | Director | 358,941 | $6.92M | $0 | 12 | 2026-06-05 |
| 8 | Carole Ho | Chief Medical Officer | 242,391 | $4.68M | -$13.21M | 66 | 2025-08-14 |
| 9 | Peter Scott Chin | Chief Medical Officer | 204,538 | $3.95M | -$36.9K | 1 | 2026-09-09 |
| 10 | Vicki L Sato | Director | 107,976 | $2.08M | -$1.78M | 37 | 2025-01-03 |
DNLI Board & Officers
As of SEC filings through Sep 9, 2026Directors 15
- David P Schenkein · since Dec 7, 2017
- Jay T Flatley · since Dec 7, 2017
- Marc Tessier-Lavigne · since Dec 7, 2017
- Ryan J. Watts · since Dec 7, 2017
- Peter S Klein · since Mar 16, 2018
- Jennifer E. Cook · since Nov 6, 2018
- Nancy Thornberry · since Jan 8, 2021
- Steve E. Krognes · listed since Jul 2022
- 667, L.p. (entity) · since Jun 3, 2025
- Baker Bros. Advisors (GP) LLC (entity) · since Jun 3, 2025
- Baker Bros. Advisors LP (entity) · since Jun 3, 2025
- Baker Brothers Life Sciences LP (entity) · since Jun 3, 2025
- Felix Baker · since Jun 3, 2025
- Julian Baker · since Jun 3, 2025
- Timothy Van Hauwermeiren · since Nov 4, 2025
Officers 4
- Ryan J. Watts · President and CEO · since Dec 7, 2017
- Carole Ho · Chief Medical Officer · since Dec 7, 2017
- Peter Scott Chin · Chief Medical Officer · since Apr 10, 2026
- Alexander O. Schuth · COFO and Secretary · listed since Aug 2022
Changes in the last 10 years (54)
| Apr 10, 2026 | Peter Scott Chin became Chief Medical Officer |
| Nov 4, 2025 | Timothy Van Hauwermeiren became a director |
| Jun 3, 2025 | Julian Baker became a director |
| Jun 3, 2025 | Felix Baker became a director |
| Jun 3, 2025 | Baker Brothers Life Sciences LP became a director |
| Jun 3, 2025 | Baker Bros. Advisors LP became a director |
| Jun 3, 2025 | Baker Bros. Advisors (GP) LLC became a director |
| Jun 3, 2025 | 667, L.p. became a director |
| Aug 11, 2022 | Alexander O. Schuth listed as COFO and Secretary (previously COO and Secretary) in SEC filings |
| Jul 21, 2022 | Steve E. Krognes first listed as a director in an SEC filing |
| Mar 14, 2022 | The company announced the departure of Steve E. Krognes as CFO and Treasurer in an SEC filing |
| Feb 3, 2022 | Erik Harris became a director |
| Jun 3, 2021 | Robert Nelsen no longer listed as a 10% owner in SEC filings |
| Feb 17, 2021 | Douglas K Bratton reported in an SEC filing no longer being a 10% owner |
| Feb 17, 2021 | Crestline SI (GP), L.P. reported in an SEC filing no longer being a 10% owner |
| Feb 17, 2021 | Crestline Management, LP reported in an SEC filing no longer being a 10% owner |
| Feb 17, 2021 | Crestline Investors, Inc. reported in an SEC filing no longer being a 10% owner |
| Feb 17, 2021 | Akdl, L.p. reported in an SEC filing no longer being a 10% owner |
| Jan 8, 2021 | Nancy Thornberry became a director |
| Sep 22, 2020 | Biogen MA Inc. became a 10% owner |
| Sep 22, 2020 | Biogen Inc. became a 10% owner |
| Nov 6, 2018 | Jennifer E. Cook became a director |
| Mar 16, 2018 | Peter S Klein became a director |
| Dec 12, 2017 | Noubar Afeyan reported in an SEC filing no longer being a 10% owner |
| Dec 12, 2017 | Flagship Ventures Fund V, L.P. reported in an SEC filing no longer being a 10% owner |
| Dec 12, 2017 | Flagship Ventures Fund V General Partner LLC reported in an SEC filing no longer being a 10% owner |
| Dec 7, 2017 | Vicki L Sato became a director |
| Dec 7, 2017 | Steve E. Krognes became CFO and Treasurer |
| Dec 7, 2017 | Ryan J. Watts became a director |
| Dec 7, 2017 | Ryan J. Watts became President and CEO |
| Dec 7, 2017 | Robert Nelsen became a director |
| Dec 7, 2017 | Robert Nelsen became a 10% owner |
| Dec 7, 2017 | Noubar Afeyan became a 10% owner |
| Dec 7, 2017 | Neuro Line Partners LP became a 10% owner |
| Dec 7, 2017 | Marc Tessier-Lavigne became a director |
| Dec 7, 2017 | Keith Crandell became a 10% owner |
| Dec 7, 2017 | Jay T Flatley became a director |
| Dec 7, 2017 | Flagship Ventures Fund V, L.P. became a 10% owner |
| Dec 7, 2017 | Flagship Ventures Fund V General Partner LLC became a 10% owner |
| Dec 7, 2017 | Douglas K Bratton became a 10% owner |
| Dec 7, 2017 | Douglas G. Cole became a director |
| Dec 7, 2017 | David P Schenkein became a director |
| Dec 7, 2017 | Crestline SI (GP), L.P. became a 10% owner |
| Dec 7, 2017 | Crestline Management, LP became a 10% owner |
| Dec 7, 2017 | Crestline Investors, Inc. became a 10% owner |
| Dec 7, 2017 | Clinton Bybee became a 10% owner |
| Dec 7, 2017 | Carole Ho became Chief Medical Officer |
| Dec 7, 2017 | Bratton Capital Management, L.P. became a 10% owner |
| Dec 7, 2017 | Bratton Capital Inc. became a 10% owner |
| Dec 7, 2017 | Alexander O. Schuth became COO and Secretary |
| Dec 7, 2017 | Akdl, L.p. became a 10% owner |
| Dec 7, 2017 | ARCH Venture Partners VIII, LLC became a 10% owner |
| Dec 7, 2017 | ARCH Venture Partners VIII, L.P. became a 10% owner |
| Dec 7, 2017 | ARCH Venture Fund VIII, L.P. became a 10% owner |
- Prev
- 1
Not reported recently (14)
- Vicki L Sato · Last reported as a director in an SEC filing dated Jan 3, 2025
- Erik Harris · Last reported as a director in an SEC filing dated Jun 4, 2024
- Douglas G. Cole · Last reported as a director in an SEC filing dated Jun 5, 2023
- Robert Nelsen · Last reported as a director in an SEC filing dated Jun 4, 2021
- Bratton Capital Inc. · Last reported as a 10% owner in an SEC filing dated Dec 23, 2020
- Neuro Line Partners LP · Last reported as a 10% owner in an SEC filing dated Dec 23, 2020
- Bratton Capital Management, L.P. · Last reported as a 10% owner in an SEC filing dated Dec 23, 2020
- Biogen Inc. · Last reported as a 10% owner in an SEC filing dated Sep 28, 2020
- Biogen MA Inc. · Last reported as a 10% owner in an SEC filing dated Sep 28, 2020
- ARCH Venture Fund VIII, L.P. · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
- Keith Crandell · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
- ARCH Venture Partners VIII, LLC · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
- Clinton Bybee · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
- ARCH Venture Partners VIII, L.P. · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
DNLI Proposed Insider Sales (Form 144)
Latest: 2026-09-04What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.
How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.
10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.
"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.
Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.
| Filed | Filer | Role | Shares | Notice Value | Planned Sale | Broker | Plan | Link |
|---|---|---|---|---|---|---|---|---|
| 2026-09-04 | Chin Peter Scott | Officer | 1,654 | $36.9K | 2026-09-04 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-09-01 | ALEXANDER SCHUTH | Officer | 2,768 | $65.8K | 2026-09-01 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-08-11 | Schuth Alexander O. | Officer | 2,857 | $71.6K | 2026-08-11 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-02-05 | CAROLE HO | Former Affiliate | 39,490 | $801.4K | 2026-02-05 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-02-04 | CAROLE HO | Former Affiliate | 150,000 | $3.18M | 2026-02-04 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-02-03 | CAROLE HO | Former Affiliate | 150,000 | $3.32M | 2026-02-03 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-01-06 | Ho Carole | Consultant | 17,218 | $284.1K | 2026-01-06 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-01-06 | Schuth Alexander O. | Officer | 17,218 | $284.1K | 2026-01-06 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2026-01-06 | Watts Ryan J. | Director, Officer | 35,198 | $580.8K | 2026-01-06 | Morgan Stanley Smith Barney LLC … | — | EDGAR |
| 2025-12-04 | CAROLE HO | Officer | 1,882 | $35.8K | 2025-12-04 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| # | ETF | Provider | Weight | $ Exposure | ETF AUM | As Of |
|---|---|---|---|---|---|---|
| 1 | VTI Vanguard Morningstar Total Stock Market ETF | Vanguard | 0.00% | $96.7M | — | 2026-09-30 |
| 2 | IWM iShares Russell 2000 ETF | iShares (BlackRock) | 0.09% | $69.1M | $75.5B | 2026-10-26 |
| 3 | VB Vanguard Morningstar Small-Cap ETF | Vanguard | 0.04% | $67.0M | — | 2026-09-30 |
| 4 | XBI State Street® SPDR® S&P® Biotech ETF | SPDR (State Street) | 0.58% | $59.2M | $10.2B | 2026-10-26 |
| 5 | VXF Vanguard Extended Market ETF | Vanguard | 0.04% | $37.4M | — | 2026-09-30 |
| 6 | VBK Vanguard Morningstar Small-Cap Growth ETF | Vanguard | 0.08% | $37.3M | — | 2026-09-30 |
| 7 | IWN iShares Russell 2000 Value ETF | iShares (BlackRock) | 0.17% | $24.3M | $14.0B | 2026-10-26 |
| 8 | DFAS Dimensional US Small Cap ETF | Dimensional | 0.06% | $21.7M | — | 2026-10-26 |
| 9 | IBB iShares Biotechnology ETF | iShares (BlackRock) | 0.20% | $21.5M | $11.0B | 2026-10-26 |
| 10 | VTWO Vanguard Russell 2000 ETF | Vanguard | 0.10% | $17.6M | — | 2026-09-30 |
| 11 | SCHA Schwab U.S. Small-Cap ETF | Nport | 0.07% | $15.0M | — | 2026-05-31 |
| 12 | TCAF T. Rowe Price Capital Appreciation Equity ETF | Nport | 0.16% | $11.5M | — | 2026-06-30 |
| 13 | DFMC Dimensional US Micro Cap ETF | Dimensional | 0.13% | $9.5M | — | 2026-10-26 |
| 14 | VHT Vanguard Health Care ETF | Vanguard | 0.04% | $8.5M | — | 2026-09-30 |
| 15 | DFAC Dimensional US Core Equity 2 ETF | Dimensional | 0.01% | $7.6M | — | 2026-10-26 |
| 16 | TMSL T. Rowe Price Small-Mid Cap ETF | Nport | 0.18% | $5.0M | — | 2026-06-30 |
| 17 | SMLF iShares U.S. Small-Cap Equity Factor ETF | iShares (BlackRock) | 0.12% | $4.9M | $4.2B | 2026-10-26 |
| 18 | PRFZ Invesco RAFI US 1500 Small-Mid ETF | Nport | 0.17% | $4.6M | — | 2026-07-31 |
| 19 | ITOT iShares Core S&P Total U.S. Stock Market ETF | iShares (BlackRock) | 0.00% | $3.9M | $97.1B | 2026-10-26 |
| 20 | SBIO ALPS Medical Breakthroughs ETF | Nport | 2.13% | $3.4M | — | 2026-05-31 |
| 21 | VTWV Vanguard Russell 2000 Value ETF | Vanguard | 0.20% | $2.7M | — | 2026-09-30 |
| 22 | VT Vanguard Total World Stock ETF | Vanguard | 0.00% | $2.4M | — | 2026-09-30 |
| 23 | DCOR Dimensional US Core Equity 1 ETF | Dimensional | 0.01% | $2.4M | — | 2026-10-26 |
| 24 | LABU Direxion Daily S&P Biotech Bull 3X ETF | Direxion | 0.40% | $2.4M | — | 2026-10-27 |
| 25 | PTH Invesco Dorsey Wright Healthcare Momentum ETF | Nport | 0.97% | $2.3M | — | 2026-07-31 |
Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.
- Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
- Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
- Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
- Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
- Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
- YoY growth — compare to the same quarter a year earlier to remove seasonality.
- Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
- Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.
TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.
Quarterly figures (12 quarters)
| Quarter | Period End | Revenue | Net Income | Diluted EPS | Op. Cash Flow |
|---|---|---|---|---|---|
| Q1 '26 | 2026-03-31 | — | $-129.81M | $-0.69 | $-131.20M |
| Q4 '25 | 2025-12-31 | — | $-128.55M | $-0.73 | $-98.54M |
| Q3 '25 | 2025-09-30 | — | $-126.90M | $-0.74 | $-107.30M |
| Q2 '25 | 2025-06-30 | — | $-124.12M | $-0.72 | $-75.30M |
| Q1 '25 | 2025-03-31 | — | $-132.95M | $-0.78 | $-131.47M |
| Q4 '24 | 2024-12-31 | — | $-114.75M | $-0.68 | $-83.72M |
| Q3 '24 | 2024-09-30 | — | $-107.19M | $-0.63 | $-59.14M |
| Q2 '24 | 2024-06-30 | — | $-99.03M | $-0.59 | $-91.22M |
| Q1 '24 | 2024-03-31 | — | $-101.80M | $-0.68 | $-113.62M |
| Q4 '23 | 2023-12-31 | $0.00 | $-119.47M | $-0.87 | $-98.66M |
| Q3 '23 | 2023-09-30 | $1.27M | $-99.35M | $-0.72 | $-87.36M |
| Q2 '23 | 2023-06-30 | $294.12M | $183.38M | $1.30 | $-113.17M |
Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.
- P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
- P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
- P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
- EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
- EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
- ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
- ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
- Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
- FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
- Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
- Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
- Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
- Multiples expanding while earnings are flat = sentiment-driven rally.
- Multiples compressing while earnings grow = value coming from fundamentals.
Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.
- Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
- SI % of Float — short interest / free float. The key crowding metric.
- Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
- Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
- Free Float — shares available for public trading (total shares minus insider / restricted).
- Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
- SI % of Float < 5% — typical, no particular signal.
- 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
- 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
- >30% — extreme; borrow is likely expensive and squeeze risk is material.
- Days to Cover > 5 combined with high SI% amplifies squeeze potential.
- Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
- A sudden drop in SI after a rally may indicate a squeeze in progress.
Short interest is reported mid-month and end-of-month; short volume is daily.