DNLI Denali Therapeutics Inc. Common Stock

XNAS 19.29 Delayed
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Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Expected move IV rank history Fibonacci levels Insider trading

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

DNLI $19.29 —
Key stats
$19.29
After hours $19.15 -0.73%
52-Week Range
$13.75 – $27.30
YTD
+18.56%
IV Rank (30D)
81.65
Straddle Price
$3.58
P/C Vol Ratio
0.80
Market Cap
$3.1B
Open
$18.92
Day Range
$18.84 – $19.29
Volume
1,586,168
Prev Close
$19.22
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)5.00%
Beta vs SPY1.46
Cost of Equity (CAPM)13.05% (VRP-adj)
WACC13.15%
Volatility Risk Premium+58.1pp (IV − HV30), ERP adj +50bps
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)+3.0%
DCF Horizon5 years explicit + fade
Forward Tilt (NTM/TTM)×1.03 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$-0.4B
Return on Equity (TTM)-61.4%
Book / Price27.4%
Debt / Equity0.01
Quality Score1/6 — cyclical/struggling (5y DCF)
SMA 50$20.99 (Market Anchor value)
SMA 20 / Bollinger Mid$18.97
Bollinger Width / SMA2089.7% (drives anchor stability)
Net Debt$-0.4B
Market Cap$3B
Peers used for multiples: ALKS, CRNX, GILD, KYMR, LLY, MIRM, SYRE, TVTX
60-Day Conviction
90%
20-Day Fair Value
≈ by Nov 26, 2026
$19.46
α +0.9% rank 81%
conviction
53%
40-Day Fair Value
≈ by Dec 25, 2026
$20.00
α +3.7% rank 82%
conviction
93%
60-Day Fair Value
≈ by Jan 25, 2027
$20.08
α +4.1% rank 77%
conviction
90%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0%
Peer EV/EBITDA n/a 0% median 54.6× · 4 peers
Peer P/B $41.57 22% median 7.9× · 7 peers
Peer P/S n/a 0% median 8.8× · 7 peers
Market Anchor (SMA50) $20.99 78% stability 71% (BB-width)
Options Expected (B-L 30d) $18.79 0% 7 strikes · skew +0.27
As of 2026-10-28 · updated
About
Industry (SIC)
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES) (2836) · industry map
Exchange
XNAS
Market Cap
$3.1B
Employees
507
List Date
2017-12-08
CIK
0001714899
Next Earnings
2026-11-03 (After-Close)
EPS Forecast
($0.32)
Headquarters
South San Francisco, CA
Homepage
https://www.denalitherapeutics.com

Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Month'21'22'23'24'25'26Avg
Jan-3.33%-27.61%9.55%-25.15%11.80%33.62%-0.19%
Feb2.97%-7.89%-12.08%20.68%-24.18%-6.86%-4.56%
Mar-11.69%0.22%-15.60%-1.63%-10.56%-8.57%-7.97%
Apr8.06%-32.02%6.29%-24.90%35.48%-4.88%-2.00%
May9.06%-3.42%17.13%14.85%-17.56%14.97%5.84%
Jun27.36%23.19%-4.56%13.94%0.21%26.02%14.36%
Jul-34.77%8.90%-4.21%10.72%-0.86%-11.19%-5.24%
Aug5.39%-15.56%-18.47%4.76%13.62%2.63%-1.27%
Sep-8.61%9.69%-11.50%15.96%-6.02%-11.15%-1.94%
Oct-5.16%-7.60%-4.85%-9.45%9.19%-6.04%*-3.98%
Nov-7.59%10.19%-2.68%-7.58%26.76%--3.82%
Dec0.41%-10.87%13.13%-20.48%-9.09%---5.38%
Total-27.05%-50.53%-30.06%-21.84%13.03%19.32%-16.19%
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $18.90
SMA 50: $20.89
SMA 200: $21.23
Current: $19.29
EMA 12: $18.85
EMA 26: $19.39
MACD: -0.5399 | Signal: 0.2078
BEARISH
ADX (14): 27.30
TREND
+DI: 20.41
−DI: 25.15

Momentum Oscillators

RSI (14): 48.53
NEUTRAL
Stoch %K: 75.40
Stoch %D: 61.67
Williams %R: -14.41

Volume & Volatility

BB Upper: $20.33
BB Lower: $17.48
NEUTRAL
OBV: -10,272,704
Vol SMA 20: 1,765,250
Vol ROC: -41.68%
ATR: $0.78
True Range: $0.45
HV 20: 41.5%
HV 30: 43.5%
HV 60: 37.8%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-10-30T00:00:00 – 2026-10-28T00:00:00
AI Analysis

LLM Stock Analysis Report

Executive Summary

Overall Assessment: NEUTRAL (Confidence Level: 6/10)

Key Drivers:

  • Recent news sentiment is mixed, with positive and negative headlines
  • Technical indicators show a bearish momentum signal from the MACD histogram
  • Volatility remains high, with a beta of 1.50 indicating a more volatile stock compared to the market

Primary Risks:

  • Potential for further price decline due to the bearish momentum signal
  • High volatility may lead to increased trading activity and potential price swings

Investment Thesis: Denali Therapeutics (DNLI) is currently experiencing mixed news sentiment, with some positive headlines balancing out negative ones. The technical indicators suggest a bearish momentum signal, which could lead to further price decline. However, the high volatility also presents an opportunity for traders who can navigate the market's uncertainty.

Recent News Sentiment Impact: The recent news headlines have been mixed, with two negative and three neutral articles. The most recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price.

Technical Analysis

Trend Direction:

  • Short-term: BEARISH (MACD histogram below signal line)
  • Medium-term: NEUTRAL (RSI in neutral zone, no clear trend)
  • Long-term: NEUTRAL (no clear trend)

Support/Resistance Levels:

  • Resistance: $26.02 (upper Bollinger Band)
  • Support: $22.55 (lower Bollinger Band), $20.84 (SMA 200)

Momentum Signals:

  • RSI interpretation: Neutral (35.39)
  • MACD signal: Bearish (histogram below signal line)
  • Bollinger Bands position: Oversold

Volume Analysis: Volume trends suggest increasing institutional interest, with a volume rate of change of 17.41%. However, the OBV is not confirming this trend, indicating some potential selling pressure.

News & Sentiment Analysis

Recent Headlines Summary:

  • Mixed news sentiment, with two negative and three neutral articles
  • Recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price

Sentiment Assessment: NEUTRAL

Catalyst Identification: The upcoming FDA drug approval for BIIB122 (DNL151) in early-stage Parkinson's disease could be a potential catalyst for the stock.

Market Narrative: The mixed news sentiment and bearish momentum signal from the MACD histogram suggest that the market is expecting some negative news or price decline. However, the recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price.

Risk & Volatility Assessment

Risk Assessment: The high volatility and bearish momentum signal from the MACD histogram indicate that there is a higher risk of further price decline. However, the recent positive headline from Privium Fund opening a $5.07 million Denali stake ahead of FDA drug approval could provide some support to the stock price.

Downside Protection: The lower Bollinger Band at $22.55 provides some downside protection for traders who are looking to short the stock or manage their risk.

Market Context & Positioning

Market Context:

  • The biotechnology sector is experiencing volatility, with some stocks trending higher and others declining
  • Denali Therapeutics (DNLI) is trading near its 52-week low, which could provide an opportunity for value investors

Positioning: The options market is pricing in a $3.62 move by expiration, indicating that traders are expecting some price movement. However, the put/call volume ratio of 0.00 suggests that there is no clear sentiment bias.

Key Levels & Action Items

Critical Price Levels:

  • Resistance: $26.02 (upper Bollinger Band)
  • Support: $22.55 (lower Bollinger Band), $20.84 (SMA 200)

Breakout/Breakdown Levels:

  • Breakout above $26.02 could trigger a bullish momentum signal and potential price increase
  • Breakdown below $20.84 could trigger a bearish momentum signal and potential price decline

Time-Sensitive Catalysts: The upcoming FDA drug approval for BIIB122 (DNL151) in early-stage Parkinson's disease could be a potential catalyst for the stock.

Risk Management: Traders should consider using stop-loss levels at $22.55 to manage their risk, as well as scaling into long positions if the stock price breaks above $26.02.

Generated
Showing 1–10 of 50
Page 1 of 5
Earnings History
21 of 23 under expected move
Avg Expected Move
14.30%
Avg Actual Move
5.29%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2021-02-25 Pre-Market 12.07% 5.63% 0.47x Within
2021-05-03 Pre-Market 10.27% 3.52% 0.34x Within
2021-08-04 Pre-Market 32.37% 0.49% 0.02x Within
2021-11-04 Pre-Market 6.96% 0.92% 0.13x Within
2022-02-28 Pre-Market 16.65% 1.42% 0.09x Within
2022-05-05 Pre-Market 25.91% 10.26% 0.40x Within
2022-08-08 Pre-Market 8.53% 4.20% 0.49x Within
2022-10-18 Pre-Market 7.86% 2.64% 0.34x Within
2023-02-27 Pre-Market 0.96% 3.47% 3.61x Exceeded
2023-05-08 Pre-Market 10.41% 0.15% 0.01x Within
2023-08-08 Pre-Market 8.62% 1.00% 0.12x Within
2023-11-07 Pre-Market 8.43% 2.31% 0.27x Within
2024-02-27 Pre-Market 15.22% 38.25% 2.51x Exceeded
2024-05-07 Pre-Market 21.30% 1.69% 0.08x Within
2024-08-01 Pre-Market 12.82% 4.27% 0.33x Within
2024-11-06 Pre-Market 14.56% 6.87% 0.47x Within
2025-02-27 After-Close 20.16% 10.97% 0.54x Within
2025-05-06 Pre-Market 14.85% 12.63% 0.85x Within
2025-08-11 Pre-Market 16.30% 0.29% 0.02x Within
2025-11-06 After-Close 20.47% 4.23% 0.21x Within
2026-02-26 Pre-Market 21.31% 3.90% 0.18x Within
2026-05-05 Pre-Market 7.36% 1.34% 0.18x Within
2026-08-06 Pre-Market 15.46% 1.27% 0.08x Within

Earnings calendar: this week’s reports with expected vs actual moves →

DNLI Options Activity & IV Rank

DNLI IV rank history, 52-week IV rank and IV percentile →

Volatility Metrics

Current IV: 83.5%
7-DTE IV: —
Expected Move: $3.58
7-DTE Move: $3.58
Days to Exp: 23 (2026-11-20)

Options Flow

Call Volume: 232
Put Volume: 186
P/C Volume: 0.802
NEUTRAL
Call OI: 922
Put OI: 95
P/C OI: 0.103
Total OI: 1,017

ATM Options Pricing

ATM Call: $1.38
ATM Put: $2.20
Call %: 7.1%
Put %: 11.4%

Chain Summary

Chain Volume: 4,028
Chain OI: 13,163
Last Updated: 10/28/2026
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Dealer Positioning
TYPICAL γ

Estimated net dealer gamma is at the 39th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.

Gamma percentile
39%
vs own history
GEX tilt
+0.14
OI-weighted, today
Vanna tilt
+0.14
δ-sensitivity to IV
Charm tilt
-0.10
δ-decay vs time

Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.

Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.

Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.

This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.

· 8 ATM contracts, 3k total OI
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
as of Oct 26 · No data
30 DTE / 10d —
— pts EXTREME
as of Oct 26 · ATM 96.7% / Wing —

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)81.7HighOct 28
Straddle Price (30 DTE)$3.58Oct 28
Beta Analysis

Risk Metrics

Beta: 1.5341
Alpha: 9.16%
Correlation: 0.3527
R-Squared: 12.4%
Stock Volatility: 55.3%
Market Volatility: 12.7%

Analysis Details

Benchmark: SPY
Data Points: 251
Period: 252 trading days
Interpretation:
High volatility - stock moves more than market
Beta & Alpha Over Time
Notable investors who own DNLI
3 of 37 tracked investors
InvestorValueShare of their portfolioRankQ/Q sharesSource
Millennium Management Hedge fund
Izzy Englander
$29.0M
0.02%
#905 of 3716-10.5%13F
Citadel Hedge fund
Ken Griffin
$1.7M
0.00%
#3091 of 6285-63.1%13F
Rockefeller Capital Management Family office
Rockefeller family
$229K
0.00%
#2534 of 4729-65.7%13F

Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions

DNLI Institutional Ownership (13F)

Latest filings — 2026-09-30
Diluted shares outstanding: 175,789,353 (as of 2026-03-31)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

310 filers170,324,777 shares$4.23B value96.89% of float
# Filer Shares Value % of Total % of Float Period
1 T. Rowe Price Investment Management, Inc. 16,178,963 $416.12M 9.84% 9.20% 2026-06-30
2 BlackRock, Inc. Custodian 14,026,413 $360.76M 8.53% 7.98% 2026-06-30
3 BAILLIE GIFFORD & CO 11,960,230 $307.62M 7.27% 6.80% 2026-06-30
4 Vanguard Group Inc Custodian 13,057,890 $215.59M 5.10% 7.43% 2025-12-31
5 State Street Corp 7,049,304 $181.31M 4.29% 4.01% 2026-06-30
6 Temasek Holdings (Private) Ltd 7,012,974 $180.37M 4.26% 3.99% 2026-06-30
7 Vanguard Portfolio Management LLC 6,477,057 $166.59M 3.94% 3.68% 2026-06-30
8 Vanguard Capital Management LLC 6,275,729 $161.41M 3.82% 3.57% 2026-06-30
9 FMR LLC Custodian 4,535,836 $116.66M 2.76% 2.58% 2026-06-30
10 Goldman Sachs Group Inc Custodian 4,155,895 $106.89M 2.53% 2.36% 2026-06-30
11 Geode Capital Management, LLC Custodian 3,973,342 $102.21M 2.42% 2.26% 2026-06-30
12 Holocene Advisors, LP 3,905,225 $100.44M 2.37% 2.22% 2026-06-30
13 BAKER BROS. ADVISORS LP 3,734,336 $96.05M 2.27% 2.12% 2026-06-30
14 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC Custodian 3,161,972 $81.33M 1.92% 1.80% 2026-06-30
15 T. Rowe Price Associates, Inc. 3,136,149 $80.66M 1.91% 1.78% 2026-06-30
16 UBS Group AG Custodian 3,120,592 $80.26M 1.90% 1.78% 2026-06-30
17 Dimensional Fund Advisors LP Custodian 2,860,604 $73.58M 1.74% 1.63% 2026-06-30
18 Norges Bank 2,824,746 $72.65M 1.72% 1.61% 2026-06-30
19 Pictet Asset Management Holding SA 2,791,206 $71.89M 1.70% 1.59% 2026-06-30
20 Capital Research Global Investors 2,565,817 $65.99M 1.56% 1.46% 2026-06-30
21 Fisher Asset Management, LLC 2,414,162 $62.09M 1.47% 1.37% 2026-06-30
22 AllianceBernstein L.P. 2,984,807 $57.31M 1.35% 1.70% 2026-06-30
23 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 2,208,263 $56.80M 1.34% 1.26% 2026-06-30
24 Casdin Capital, LLC 2,045,000 $52.60M 1.24% 1.16% 2026-06-30
25 Crestline Management, L.P. 1,910,732 $49.14M 1.16% 1.09% 2026-06-30
7 filers$16.43M notional
# Filer Notional Value % of Total Period
1 Balyasny Asset Management L.P. $11.13M 67.76% 2026-06-30
2 Susquehanna International Group, LLP Custodian $2.21M 13.43% 2026-06-30
3 Citadel Advisors LLC Custodian $1.99M 12.10% 2026-06-30
4 Point72 Asset Management, L.P. $596.70K 3.63% 2026-06-30
5 IMC-Chicago, LLC Custodian $396.09K 2.41% 2026-06-30
6 Simplex Trading, LLC Custodian $95.16K 0.58% 2026-06-30
7 GROUP ONE TRADING LLC Custodian $12.86K 0.08% 2026-06-30
7 filers$15.42M notional
# Filer Notional Value % of Total Period
1 Citadel Advisors LLC Custodian $11.72M 76.02% 2026-06-30
2 Jane Street Group, LLC Custodian $1.51M 9.81% 2026-06-30
3 Susquehanna International Group, LLP Custodian $1.16M 7.54% 2026-06-30
4 Point72 Asset Management, L.P. $596.70K 3.87% 2026-06-30
5 IMC-Chicago, LLC Custodian $349.79K 2.27% 2026-06-30
6 Simplex Trading, LLC Custodian $54.01K 0.35% 2026-06-30
7 GROUP ONE TRADING LLC Custodian $23.15K 0.15% 2026-06-30

DNLI Insider Trading (Form 4)

Latest: 2026-09-09
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-09-09 Peter Scott Chin Chief Medical Officer Sell (S) −1,654 $22.29 -$36.9K EDGAR
2026-09-04 Nancy Thornberry Director Sell (S) −11,439 $22.90 -$261.9K EDGAR
2026-09-03 Alexander O. Schuth COFO and Secretary Sell (S) −2,768 $23.44 -$64.9K EDGAR
2026-08-14 Ryan J. Watts President and CEO Gift (G) −32,220 — EDGAR
2026-08-13 Alexander O. Schuth COFO and Secretary Sell (S) −2,857 $25.07 -$71.6K EDGAR
2026-06-05 Jennifer E. Cook Director Award (A) +6,408 — EDGAR
2026-06-05 David P Schenkein Director Award (A) +6,408 — EDGAR
2026-06-05 Peter S Klein Director Award (A) +6,408 — EDGAR
2026-06-05 Nancy Thornberry Director Award (A) +6,408 — EDGAR
2026-06-05 Timothy Van Hauwermeiren Director Award (A) +6,408 — EDGAR
2026-06-05 Steve E. Krognes Director Award (A) +6,408 — EDGAR
2026-06-05 Jay T Flatley Director Award (A) +6,408 — EDGAR
2026-06-05 Baker Bros. Advisors (GP) LLC Director Award (A) +76,896 — EDGAR
2026-01-08 Alexander O. Schuth COFO and Secretary Sell (S) −17,218 $16.50 -$284.1K EDGAR
2026-01-08 Ryan J. Watts President and CEO Sell (S) −35,198 $16.50 -$580.8K EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.

DNLI Insider Holdings

15 insiders · @ $19.29
Officers, directors, and 10%+ owners who have filed a Form 4 in the past two years, ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 Baker Bros. Advisors (GP) LLC Director 3,422,366 $66.02M $0 1 2026-06-05
2 Julian Baker Director 3,415,958 $65.89M $0 1 2025-06-05
3 Ryan J. Watts President and CEO 2,417,217 $46.63M -$41.18M 65 2026-08-14
4 Marc Tessier-Lavigne Director 1,965,424 $37.91M -$36.87M 25 2025-06-05
5 Steve E. Krognes Director 819,999 $15.82M -$15.19M 39 2026-06-05
6 Alexander O. Schuth COFO and Secretary 802,744 $15.48M -$18.55M 77 2026-09-03
7 Jay T Flatley Director 358,941 $6.92M $0 12 2026-06-05
8 Carole Ho Chief Medical Officer 242,391 $4.68M -$13.21M 66 2025-08-14
9 Peter Scott Chin Chief Medical Officer 204,538 $3.95M -$36.9K 1 2026-09-09
10 Vicki L Sato Director 107,976 $2.08M -$1.78M 37 2025-01-03
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.

DNLI Board & Officers

As of SEC filings through Sep 9, 2026

Directors 15

Officers 4

Changes in the last 10 years (54)
Apr 10, 2026Peter Scott Chin became Chief Medical Officer
Nov 4, 2025Timothy Van Hauwermeiren became a director
Jun 3, 2025Julian Baker became a director
Jun 3, 2025Felix Baker became a director
Jun 3, 2025Baker Brothers Life Sciences LP became a director
Jun 3, 2025Baker Bros. Advisors LP became a director
Jun 3, 2025Baker Bros. Advisors (GP) LLC became a director
Jun 3, 2025667, L.p. became a director
Aug 11, 2022Alexander O. Schuth listed as COFO and Secretary (previously COO and Secretary) in SEC filings
Jul 21, 2022Steve E. Krognes first listed as a director in an SEC filing
Mar 14, 2022The company announced the departure of Steve E. Krognes as CFO and Treasurer in an SEC filing
Feb 3, 2022Erik Harris became a director
Jun 3, 2021Robert Nelsen no longer listed as a 10% owner in SEC filings
Feb 17, 2021Douglas K Bratton reported in an SEC filing no longer being a 10% owner
Feb 17, 2021Crestline SI (GP), L.P. reported in an SEC filing no longer being a 10% owner
Feb 17, 2021Crestline Management, LP reported in an SEC filing no longer being a 10% owner
Feb 17, 2021Crestline Investors, Inc. reported in an SEC filing no longer being a 10% owner
Feb 17, 2021Akdl, L.p. reported in an SEC filing no longer being a 10% owner
Jan 8, 2021Nancy Thornberry became a director
Sep 22, 2020Biogen MA Inc. became a 10% owner
Not reported recently (14)
  • Vicki L Sato · Last reported as a director in an SEC filing dated Jan 3, 2025
  • Erik Harris · Last reported as a director in an SEC filing dated Jun 4, 2024
  • Douglas G. Cole · Last reported as a director in an SEC filing dated Jun 5, 2023
  • Robert Nelsen · Last reported as a director in an SEC filing dated Jun 4, 2021
  • Bratton Capital Inc. · Last reported as a 10% owner in an SEC filing dated Dec 23, 2020
  • Neuro Line Partners LP · Last reported as a 10% owner in an SEC filing dated Dec 23, 2020
  • Bratton Capital Management, L.P. · Last reported as a 10% owner in an SEC filing dated Dec 23, 2020
  • Biogen Inc. · Last reported as a 10% owner in an SEC filing dated Sep 28, 2020
  • Biogen MA Inc. · Last reported as a 10% owner in an SEC filing dated Sep 28, 2020
  • ARCH Venture Fund VIII, L.P. · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
  • Keith Crandell · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
  • ARCH Venture Partners VIII, LLC · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
  • Clinton Bybee · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
  • ARCH Venture Partners VIII, L.P. · Last reported as a 10% owner in an SEC filing dated Aug 12, 2019
Compiled from SEC filings by the company and its directors and officers. Dates are as stated in those filings. Where no filing says when someone left, we show the last filing that listed them.

DNLI Proposed Insider Sales (Form 144)

Latest: 2026-09-04
Last 30d: 0 filings  ·  Last 90d: 3 filings · $174K notice value · 2 unique filers · 33% under 10b5-1 plans

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Top 90-day filers: Schuth Alexander O. (2, $137K) · Chin Peter Scott (1, $37K)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-09-04 Chin Peter Scott Officer 1,654 $36.9K 2026-09-04 Morgan Stanley Smith Barney LLC … — EDGAR
2026-09-01 ALEXANDER SCHUTH Officer 2,768 $65.8K 2026-09-01 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-08-11 Schuth Alexander O. Officer 2,857 $71.6K 2026-08-11 Morgan Stanley Smith Barney LLC … — EDGAR
2026-02-05 CAROLE HO Former Affiliate 39,490 $801.4K 2026-02-05 Morgan Stanley Smith Barney LLC … — EDGAR
2026-02-04 CAROLE HO Former Affiliate 150,000 $3.18M 2026-02-04 Morgan Stanley Smith Barney LLC … — EDGAR
2026-02-03 CAROLE HO Former Affiliate 150,000 $3.32M 2026-02-03 Morgan Stanley Smith Barney LLC … — EDGAR
2026-01-06 Ho Carole Consultant 17,218 $284.1K 2026-01-06 Morgan Stanley Smith Barney LLC … — EDGAR
2026-01-06 Schuth Alexander O. Officer 17,218 $284.1K 2026-01-06 Morgan Stanley Smith Barney LLC … — EDGAR
2026-01-06 Watts Ryan J. Director, Officer 35,198 $580.8K 2026-01-06 Morgan Stanley Smith Barney LLC … — EDGAR
2025-12-04 CAROLE HO Officer 1,882 $35.8K 2025-12-04 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed. Market-wide feed: Planned sales (Form 144).
ETF Holders
74 ETFs hold DNLI
25 shown · $537.92M total exposure · 0.09% AUM-weighted avg weight
# ETF Provider Weight $ Exposure ETF AUM As Of
1 VTI Vanguard Morningstar Total Stock Market ETF Vanguard 0.00% $96.7M — 2026-09-30
2 IWM iShares Russell 2000 ETF iShares (BlackRock) 0.09% $69.1M $75.5B 2026-10-26
3 VB Vanguard Morningstar Small-Cap ETF Vanguard 0.04% $67.0M — 2026-09-30
4 XBI State Street® SPDR® S&P® Biotech ETF SPDR (State Street) 0.58% $59.2M $10.2B 2026-10-26
5 VXF Vanguard Extended Market ETF Vanguard 0.04% $37.4M — 2026-09-30
6 VBK Vanguard Morningstar Small-Cap Growth ETF Vanguard 0.08% $37.3M — 2026-09-30
7 IWN iShares Russell 2000 Value ETF iShares (BlackRock) 0.17% $24.3M $14.0B 2026-10-26
8 DFAS Dimensional US Small Cap ETF Dimensional 0.06% $21.7M — 2026-10-26
9 IBB iShares Biotechnology ETF iShares (BlackRock) 0.20% $21.5M $11.0B 2026-10-26
10 VTWO Vanguard Russell 2000 ETF Vanguard 0.10% $17.6M — 2026-09-30
11 SCHA Schwab U.S. Small-Cap ETF Nport 0.07% $15.0M — 2026-05-31
12 TCAF T. Rowe Price Capital Appreciation Equity ETF Nport 0.16% $11.5M — 2026-06-30
13 DFMC Dimensional US Micro Cap ETF Dimensional 0.13% $9.5M — 2026-10-26
14 VHT Vanguard Health Care ETF Vanguard 0.04% $8.5M — 2026-09-30
15 DFAC Dimensional US Core Equity 2 ETF Dimensional 0.01% $7.6M — 2026-10-26
16 TMSL T. Rowe Price Small-Mid Cap ETF Nport 0.18% $5.0M — 2026-06-30
17 SMLF iShares U.S. Small-Cap Equity Factor ETF iShares (BlackRock) 0.12% $4.9M $4.2B 2026-10-26
18 PRFZ Invesco RAFI US 1500 Small-Mid ETF Nport 0.17% $4.6M — 2026-07-31
19 ITOT iShares Core S&P Total U.S. Stock Market ETF iShares (BlackRock) 0.00% $3.9M $97.1B 2026-10-26
20 SBIO ALPS Medical Breakthroughs ETF Nport 2.13% $3.4M — 2026-05-31
21 VTWV Vanguard Russell 2000 Value ETF Vanguard 0.20% $2.7M — 2026-09-30
22 VT Vanguard Total World Stock ETF Vanguard 0.00% $2.4M — 2026-09-30
23 DCOR Dimensional US Core Equity 1 ETF Dimensional 0.01% $2.4M — 2026-10-26
24 LABU Direxion Daily S&P Biotech Bull 3X ETF Direxion 0.40% $2.4M — 2026-10-27
25 PTH Invesco Dorsey Wright Healthcare Momentum ETF Nport 0.97% $2.3M — 2026-07-31
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

Trailing P/E
—
TTM Diluted EPS
$-2.88
TTM Revenue
—
TTM Net Income
$-509.38M
TTM Op. Cash Flow
$-412.34M
Quarterly figures (12 quarters)
QuarterPeriod EndRevenueNet IncomeDiluted EPSOp. Cash Flow
Q1 '262026-03-31—$-129.81M$-0.69$-131.20M
Q4 '252025-12-31—$-128.55M$-0.73$-98.54M
Q3 '252025-09-30—$-126.90M$-0.74$-107.30M
Q2 '252025-06-30—$-124.12M$-0.72$-75.30M
Q1 '252025-03-31—$-132.95M$-0.78$-131.47M
Q4 '242024-12-31—$-114.75M$-0.68$-83.72M
Q3 '242024-09-30—$-107.19M$-0.63$-59.14M
Q2 '242024-06-30—$-99.03M$-0.59$-91.22M
Q1 '242024-03-31—$-101.80M$-0.68$-113.62M
Q4 '232023-12-31$0.00$-119.47M$-0.87$-98.66M
Q3 '232023-09-30$1.27M$-99.35M$-0.72$-87.36M
Q2 '232023-06-30$294.12M$183.38M$1.30$-113.17M
Q1 2026 • period ending 2026-03-31 • filed 2026-05-07
Valuation

Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.

Price Multiples
  • P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
  • P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
  • P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
  • EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
  • EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
Profitability & Yields
  • ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
  • ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
  • Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
  • FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
Balance Sheet
  • Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
  • Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
Reading the history chart
  • Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
  • Multiples expanding while earnings are flat = sentiment-driven rally.
  • Multiples compressing while earnings grow = value coming from fundamentals.
P/E
—
P/B
3.66
P/S
—
EV/EBITDA
—
EV/Sales
—
ROE
-55.0%
ROA
-40.2%
Div Yield
0.00%
FCF Yield
-12.16%
Debt/Equity
0.01
Current Ratio
—
Market Cap
$3.39B
as of 2026-10-28
Short Interest & Float

Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.

Metric definitions
  • Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
  • SI % of Float — short interest / free float. The key crowding metric.
  • Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
  • Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
  • Free Float — shares available for public trading (total shares minus insider / restricted).
  • Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
How to read the signals
  • SI % of Float < 5% — typical, no particular signal.
  • 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
  • 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
  • >30% — extreme; borrow is likely expensive and squeeze risk is material.
  • Days to Cover > 5 combined with high SI% amplifies squeeze potential.
History chart
  • Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
  • A sudden drop in SI after a rally may indicate a squeeze in progress.

Short interest is reported mid-month and end-of-month; short volume is daily.

Short Interest
15.46M
SI % of Float
11.62%
Days to Cover
7.64
Short Vol Ratio
30.2%
Free Float
133.14M
Float %
83.3%
Short interest 2026-09-30 • Short volume 2026-10-27 • Float 2026-08-07