Vertex Pharmaceuticals Inc(VRTX)

Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership.

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

VRTX $489.79
Snapshot
$489.79
52-Week Range
$362.50 – $533.67
YTD
+8.33%
IV Rank (30D)
54.52
Straddle Price
$40.70
P/C Vol Ratio
2.23
Market Cap
$126.5B
Fair Value
MODEL: SHORT

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)4.48%
Beta vs SPY1.00
Cost of Equity (CAPM)9.98% (VRP-adj)
WACC9.72%
Volatility Risk Premium+22.1pp (IV − HV30), ERP adj +50bps
Effective Tax Rate16.0%
Rev. Growth (YoY, DCF input)+0.7%
DCF Horizon12 years explicit + fade
Forward Tilt (NTM/TTM)×1.01 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$3.7B
Return on Equity (TTM)22.4%
Book / Price15.1%
Gross Margin (TTM)86.2%
FCF Margin (TTM)30.4%
Debt / Equity0.00
Quality Score5/6 — high quality (12y DCF)
Market-Implied Growth+16.0% (reverse-DCF on current price)
SMA 50$451.86 (Market Anchor value)
SMA 20 / Bollinger Mid$477.02
Bollinger Width / SMA205.1% (drives anchor stability)
Net Debt$-5.5B
Market Cap$128B
Peers used for multiples: ALNY, AMGN, BIIB, GILD, LLY, MRNA, NTRA, REGN
Model Conviction
64%
20-Day Fair Value
≈ by Aug 7, 2026
$488.44
α +0.1% rank 19%
40-Day Fair Value
≈ by Sep 7, 2026
$485.01
α -0.6% rank 19%
60-Day Fair Value
≈ by Oct 6, 2026
$446.32
α -8.5% rank 19%
MethodImplied PriceWeightDetail
DCF $204.37 19%
DDM (Gordon) n/a 0%
Peer P/E $404.12 9% median 23.8× · 6 peers
Peer EV/EBITDA $342.31 9% median 16.4× · 6 peers
Peer P/B $1082.67 2% median 14.4× · 8 peers
Peer P/S $375.21 6% median 7.9× · 8 peers
Market Anchor (SMA50) $451.86 38% stability 100% (BB-width)
Options Expected (B-L 30d) $446.30 19% 72 strikes · skew -0.74
As of 2026-07-09 · updated
Info
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834)
Exchange
XNAS
Market Cap
$126.5B

Vertex Pharmaceuticals is a global biotechnology company that discovers and develops small-molecule drugs for the treatment of serious diseases. Its key drugs are Kalydeco, Orkambi, Symdeko, and Trikafta/Kaftrio, and Alyftrek for cystic fibrosis, where Vertex therapies remain the standard of care globally. Vertex has diversified its portfolio through Casgevy, a gene-editing therapy for beta thalassemia and sickle-cell disease, and Journavx, a non-opioid pain medication approved for the treatment of moderate-to-severe acute pain in adults. Additionally, Vertex is evaluating small-molecule inhib…

Summary
composite
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
MonthAvg ReturnYears of Data
Jan +3.43% 23
Feb +1.48% 23
Mar +0.64% 23
Apr +3.54% 23
May +5.78% 23
Jun +5.84% 23
Jul +0.15% 23
Aug +1.42% 22
Sep +0.38% 23
Oct -1.26% 23
Nov -2.33% 23
Dec +2.87% 23
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators
SMA 20: $479.18
SMA 50: $453.12
SMA 200: $446.33
Current: $488.95
EMA 12: $495.95
EMA 26: $478.68
MACD: 17.2754 | Signal: 1.2628
BULLISH
ADX (14): 36.87
TREND
+DI: 27.60
−DI: 17.92
Momentum Oscillators
RSI (14): 55.12
NEUTRAL
Stoch %K: 64.21
Stoch %D: 80.45
Williams %R: -53.70
Volume & Volatility
BB Upper: $535.14
BB Lower: $423.21
NEUTRAL
OBV: 16,280,121
Vol SMA 20: 1,962,026
Vol ROC: -37.40%
ATR: $15.56
True Range: $18.66
HV 20: 35.7%
HV 30: 33.4%
HV 60: 27.1%

Data Summary
Data Points: 500
Last Updated:
Date Range: 2024-07-10T00:00:00 – 2026-07-08T00:00:00
AI Analysis

Choose Frenzy-Fast™ for quick analysis or Frenzy-Pro™ for comprehensive analysis.

Analysis includes technical indicators, news sentiment, risk assessment, and specific price levels to watch.

News
Earnings History
6 of 8 under expected move
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2024-08-01 After-Close 4.21% 2.53% 0.60x Within
2024-11-04 After-Close 5.52% 4.24% 0.77x Within
2025-02-10 After-Close 5.07% 2.34% 0.46x Within
2025-05-05 After-Close 4.71% 10.27% 2.18x Exceeded
2025-08-04 After-Close 10.98% 12.42% 1.13x Exceeded
2025-11-03 After-Close 7.08% 1.10% 0.16x Within
2026-02-12 After-Close 7.19% 5.26% 0.73x Within
2026-05-04 After-Close 6.12% 1.09% 0.18x Within
Options Activity
IV Rank (30D)
54.52
IV Rank (7D)
60.7
Avg IV
56.7%
Straddle (30D)
$40.70
Straddle (7D)
$18.75
P/C Volume
2.23
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d
pts EXTREME
ATM — / Wing —
30 DTE / 10d
pts EXTREME
ATM — / Wing —

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)
Straddle Price (30 DTE)
Beta Analysis
Beta (1Y vs SPY)
0.60
Correlation (SPY)
21.5%
0.05
Ann. Volatility
35.1%
SPY Volatility
12.6%

Low volatility - stock moves less than market

Beta & Alpha Over Time
Institutional Ownership (13F)
Latest filings — 2026-06-30
Diluted shares outstanding: 257,700,000 (as of 2026-03-31)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

1,740 filers562,085,581 shares$102.19B value218.12% of float
# Filer Shares Value % of Total % of Float Period
1 Capital World Investors 25,368,124 $11.33B 11.09% 9.84% 2026-03-31
2 VANGUARD GROUP INC Custodian 24,105,823 $10.93B 10.69% 9.35% 2025-12-31
3 BlackRock, Inc. Custodian 29,269,517 $10.71B 10.48% 11.36% 2026-03-31
4 Capital Research Global Investors 21,125,964 $9.43B 9.23% 8.20% 2026-03-31
5 STATE STREET CORP 11,730,139 $5.24B 5.13% 4.55% 2026-03-31
6 JPMORGAN CHASE & CO Custodian 12,680,156 $3.12B 3.05% 4.92% 2026-03-31
7 GEODE CAPITAL MANAGEMENT, LLC Custodian 6,139,621 $2.73B 2.67% 2.38% 2026-03-31
8 Capital International Investors 5,126,077 $2.29B 2.24% 1.99% 2026-03-31
9 LOOMIS SAYLES & CO L P 4,003,821 $1.79B 1.75% 1.55% 2026-03-31
10 ALLIANCEBERNSTEIN L.P. 3,910,786 $1.77B 1.74% 1.52% 2026-03-31
11 WELLINGTON MANAGEMENT GROUP LLP Custodian 3,212,589 $1.43B 1.40% 1.25% 2026-03-31
12 MORGAN STANLEY Custodian 5,550,310 $1.42B 1.39% 2.15% 2025-12-31
13 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME Custodian 3,057,396 $1.37B 1.34% 1.19% 2026-03-31
14 BANK OF AMERICA CORP /DE/ Custodian 8,245,183 $1.29B 1.26% 3.20% 2026-03-31
15 JENNISON ASSOCIATES LLC 2,740,059 $1.22B 1.20% 1.06% 2026-03-31
16 Clearbridge Investments, LLC 2,700,975 $1.21B 1.18% 1.05% 2026-03-31
17 AMERIPRISE FINANCIAL INC Custodian 2,633,481 $1.18B 1.15% 1.02% 2026-03-31
18 NORTHERN TRUST CORP Custodian 2,564,264 $1.15B 1.12% 1.00% 2026-03-31
19 Invesco Ltd. Custodian 2,561,057 $1.14B 1.12% 0.99% 2026-03-31
20 GOLDMAN SACHS GROUP INC Custodian 2,417,875 $1.08B 1.06% 0.94% 2026-03-31
21 JANUS HENDERSON GROUP PLC 2,131,527 $951.79M 0.93% 0.83% 2026-03-31
22 FMR LLC Custodian 5,988,265 $905.56M 0.89% 2.32% 2026-03-31
23 Legal & General Group Plc Custodian 1,955,764 $873.33M 0.85% 0.76% 2026-03-31
24 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,920,871 $857.75M 0.84% 0.75% 2026-03-31
25 VICTORY CAPITAL MANAGEMENT INC 1,888,521 $843.33M 0.83% 0.73% 2026-03-31
44 filers$1.01B notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $313.65M 31.18% 2026-03-31
2 CITADEL ADVISORS LLC Custodian $100.07M 9.95% 2026-03-31
3 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt $98.89M 9.83% 2024-09-30
4 JANE STREET GROUP, LLC Custodian $68.10M 6.77% 2026-03-31
5 JPMORGAN CHASE & CO Custodian $49.41M 4.91% 2026-03-31
6 DIADEMA PARTNERS LP $41.57M 4.13% 2026-03-31
7 WOLVERINE TRADING, LLC Custodian $40.36M 4.01% 2025-09-30
8 Eversept Partners, LP $40.19M 4.00% 2026-03-31
9 IMC-Chicago, LLC Custodian $35.63M 3.54% 2026-03-31
10 MILLENNIUM MANAGEMENT LLC Custodian $24.38M 2.42% 2026-03-31
11 Walleye Trading LLC $22.95M 2.28% 2026-03-31
12 UBS Group AG Custodian $20.14M 2.00% 2026-03-31
13 GROUP ONE TRADING LLC Custodian $18.24M 1.81% 2026-03-31
14 SIMPLEX TRADING, LLC Custodian $17.87M 1.78% 2026-03-31
15 BALYASNY ASSET MANAGEMENT L.P. $10.58M 1.05% 2026-03-31
16 NOMURA HOLDINGS INC $9.91M 0.99% 2026-03-31
17 CITIGROUP INC Custodian $9.78M 0.97% 2026-03-31
18 Cubist Systematic Strategies, LLC $9.28M 0.92% 2025-09-30
19 GOLDMAN SACHS GROUP INC Custodian $7.99M 0.79% 2026-03-31
20 Point72 Asset Management, L.P. $7.41M 0.74% 2026-03-31
21 Alphadyne Asset Management LP $6.56M 0.65% 2026-03-31
22 Eisler Capital Management Ltd. $5.66M 0.56% 2025-09-30
23 Twin Tree Management, LP $5.36M 0.53% 2026-03-31
24 BNP PARIBAS FINANCIAL MARKETS Custodian $5.22M 0.52% 2026-03-31
25 Lighthouse Investment Partners, LLC $4.47M 0.44% 2026-03-31
38 filers$717.58M notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $250.55M 34.92% 2026-03-31
2 JANE STREET GROUP, LLC Custodian $64.88M 9.04% 2026-03-31
3 MILLENNIUM MANAGEMENT LLC Custodian $43.27M 6.03% 2026-03-31
4 IMC-Chicago, LLC Custodian $34.43M 4.80% 2026-03-31
5 JPMORGAN CHASE & CO Custodian $33.37M 4.65% 2026-03-31
6 CITADEL ADVISORS LLC Custodian $30.41M 4.24% 2026-03-31
7 UBS Group AG Custodian $29.92M 4.17% 2026-03-31
8 Caption Management, LLC $26.79M 3.73% 2026-03-31
9 GROUP ONE TRADING LLC Custodian $22.38M 3.12% 2026-03-31
10 WOLVERINE TRADING, LLC Custodian $21.50M 3.00% 2025-09-30
11 GOLDMAN SACHS GROUP INC Custodian $13.75M 1.92% 2026-03-31
12 SIMPLEX TRADING, LLC Custodian $13.09M 1.82% 2026-03-31
13 CITIGROUP INC Custodian $12.68M 1.77% 2026-03-31
14 BNP PARIBAS FINANCIAL MARKETS Custodian $12.10M 1.69% 2026-03-31
15 Twin Tree Management, LP $11.97M 1.67% 2026-03-31
16 CAPSTONE INVESTMENT ADVISORS, LLC $10.67M 1.49% 2026-03-31
17 Alphadyne Asset Management LP $10.09M 1.41% 2026-03-31
18 NOMURA HOLDINGS INC $9.91M 1.38% 2026-03-31
19 BARCLAYS PLC Custodian $9.69M 1.35% 2026-03-31
20 LMR Partners LLP $9.60M 1.34% 2026-03-31
21 Eisler Capital Management Ltd. $7.42M 1.03% 2025-09-30
22 Allianz Asset Management GmbH $5.67M 0.79% 2026-03-31
23 Walleye Trading LLC $5.18M 0.72% 2026-03-31
24 Qube Research & Technologies Ltd $4.55M 0.63% 2026-03-31
25 Walleye Capital LLC $4.42M 0.62% 2026-03-31
Insider Activity
Latest: 2026-07-07
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-07-07 Duncan McKechnie EVP, Chief Commercial Officer Sell (S) −1,541 $519.00 -$799.8K EDGAR
2026-07-07 Ourania Tatsis EVP, Chief Reg. & Quality Off. Sell (S) −1,500 $524.99 -$787.5K EDGAR
2026-07-06 Joy Liu EVP and Chief Legal Officer Sell (S) −828 $502.71 -$416.2K EDGAR
2026-06-23 Carmen Bozic EVP and CMO Sell (S) −1,020 $462.17 -$471.4K EDGAR
2026-06-17 Carmen Bozic EVP and CMO Sell (S) −4,062 $450.00 -$1.83M EDGAR
2026-06-09 Carmen Bozic EVP and CMO Sell (S) −1,745 $450.00 -$785.2K EDGAR
2026-06-03 Joy Liu EVP and Chief Legal Officer Sell (S) −828 $439.91 -$364.2K EDGAR
2026-06-02 Carmen Bozic EVP and CMO Sell (S) −1,974 $450.00 -$888.3K EDGAR
2026-05-19 Carmen Bozic EVP and CMO Sell (S) −1,354 $453.45 -$614.0K EDGAR
2026-05-19 Mark E. Bunnage EVP, Chief Scientific Officer Sell (S) −33 $453.45 -$15.0K EDGAR
2026-05-14 Carmen Bozic EVP and CMO Sell (S) −6,988 $450.00 -$3.14M EDGAR
2026-05-05 Sangeeta N. Bhatia Director Mixed +625 $423.73 -$134.7K EDGAR
2026-05-05 LLOYD CARNEY Director Grant (A) +2,866 opt EDGAR
2026-05-05 Alan M Garber Director Award (A) +472 EDGAR
2026-05-05 Michel Lagarde Director Grant (A) +2,866 opt EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.
Insider Holdings
56 insiders · @ $487.75
Officers, directors, and 10%+ owners ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 KENNETH S BOGER SVP & Chief Legal Officer 309,166 $150.80M -$12.17M 30 2011-09-14
2 JOSHUA S BOGER Director 297,374 $145.04M -$172.35M 311 2017-06-09
3 Matthew Emmens Executive Chairman 200,873 $97.98M -$3.11M 12 2012-11-20
4 PETER MUELLER EVP, Global R&D, CSO 165,538 $80.74M -$29.56M 73 2014-03-19
5 JOHN J ALAM EVP, Med. Dev. Group & CMO 146,185 $71.30M -$3.25M 20 2008-10-02
6 Reshma Kewalramani CEO & President 127,596 $62.23M -$74.81M 59 2026-03-03
7 Victor A Hartmann EVP, Strategic & Corp. Devlp. 101,384 $49.45M -$592.3K 8 2007-06-05
8 IAN F SMITH EVP, COO 75,380 $36.77M -$162.37M 74 2018-07-03
9 Kenneth L Horton EVP & Chief Legal Officer 72,419 $35.32M -$7.37M 11 2014-11-19
10 Jeffrey Chodakewitz EVP GMDA, CMO 72,385 $35.31M -$30.85M 35 2018-02-14
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.
Notice of Proposed Sale (Form 144)
Latest: 2026-07-02
Last 30d: 6 filings · $4.6M notice value  ·  Last 90d: 15 filings · $13.2M notice value · 7 unique filers · 93% under 10b5-1 plans

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. Amendments (Form 144/A) and post-cancellation refilings can inflate this if you sum naively; the rollup above excludes filings with zero stated value.

Source & freshness: Parsed directly from EDGAR primary-doc XML. Daily refresh; new filings typically appear here the morning after they hit EDGAR.

Top 90-day filers: Bozic Carmen (7, $8.0M) · Biller Jonathan (1, $2.2M) · Liu Joy (3, $1.2M) · McKechnie Duncan (1, $800K) · Tatsis Ourania (1, $787K)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-07-02 Tatsis Ourania Officer 1,500 $787.5K 2026-07-02 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-07-02 McKechnie Duncan Officer 1,541 $799.8K 2026-07-02 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-07-01 Liu Joy Officer 828 $416.2K 2026-07-01 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-06-26 Bozic Carmen Officer 596 $287.6K 2026-06-26 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-06-18 Bozic Carmen Officer 1,020 $471.4K 2026-06-18 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-06-15 Bozic Carmen Officer 4,062 $1.83M 2026-06-15 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-06-05 Bozic Carmen Officer 1,745 $785.2K 2026-06-05 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-06-01 Liu Joy Officer 828 $364.2K 2026-06-01 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-05-29 Bozic Carmen Officer 1,974 $888.3K 2026-05-29 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-05-15 Bozic Carmen Officer 1,354 $614.0K 2026-05-15 Fidelity Brokerage Services LLC 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed.
Recent SEC Filings
Latest: 2026-05-13
Current reports — material events the company must disclose within 4 business days (earnings releases, M&A, executive changes, etc.).
Filing Date Accession Link
2026-05-13 0000875320-26-000204 EDGAR
2026-05-04 0000875320-26-000171 EDGAR
2026-04-29 0000875320-26-000166 EDGAR
2026-03-31 0000875320-26-000147 EDGAR
2026-02-12 0000875320-26-000034 EDGAR
2025-11-03 0000875320-25-000230 EDGAR
2025-08-04 0000875320-25-000213 EDGAR
2025-05-19 0000875320-25-000199 EDGAR
2025-05-14 0000875320-25-000194 EDGAR
2025-05-05 0000875320-25-000171 EDGAR
Annual report — audited financial statements, MD&A, risk factors. Filed 60–90 days after fiscal year-end.
Filing Date Accession Link
2026-02-13 0000875320-26-000056 EDGAR
2025-02-13 0000875320-25-000053 EDGAR
2024-02-15 0000875320-24-000062 EDGAR
2023-02-10 0000875320-23-000007 EDGAR
2022-02-09 0000875320-22-000007 EDGAR
2021-02-11 0000875320-21-000006 EDGAR
Quarterly report — unaudited financials and MD&A. Filed 40–45 days after each of the first three fiscal quarters.
Filing Date Accession Link
2026-05-05 0000875320-26-000173 EDGAR
2025-11-04 0000875320-25-000232 EDGAR
2025-08-05 0000875320-25-000216 EDGAR
2025-05-06 0000875320-25-000192 EDGAR
2024-11-05 0000875320-24-000223 EDGAR
2024-08-02 0000875320-24-000198 EDGAR
2024-05-07 0000875320-24-000139 EDGAR
2023-11-07 0000875320-23-000031 EDGAR
2023-08-02 0000875320-23-000021 EDGAR
2023-05-02 0000875320-23-000012 EDGAR
ETF Holders
# ETF Provider Weight $ Exposure ETF AUM As Of
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

P/E Ratio29.1
P/B Ratio6.8
P/S Ratio10.8
EV/EBITDA25.4
TTM Revenue$12.2B
TTM Net Income$4.3B
TTM EPS$16.85
ROE22.4%