ALNY Alnylam Pharmaceuticals, Inc.

XNAS 231.83 Delayed
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ALNY $231.83 —
Key stats
$231.83
52-Week Range
$197.81 – $495.55
YTD
-42.07%
IV Rank (30D)
95.4
Straddle Price
$33.35
P/C Vol Ratio
0.22
Market Cap
$31.3B
Open
$235.18
Day Range
$231.29 – $237.98
Volume
1,404,862
Prev Close
$234.03
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)5.21%
Beta vs SPY0.93
Cost of Equity (CAPM)9.84% (VRP-adj)
WACC9.70%
Volatility Risk Premium+22.4pp (IV − HV30)
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)+3.4%
DCF Horizon12 years explicit + fade
Forward Tilt (NTM/TTM)×1.03 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$0.8B
Return on Equity (TTM)59.7%
Book / Price4.2%
Gross Margin (TTM)79.8%
FCF Margin (TTM)16.5%
Debt / Equity0.75
Quality Score4/6 — high quality (12y DCF)
Market-Implied Growth+18.7% (reverse-DCF on current price)
SMA 50$238.10 (Market Anchor value)
SMA 20 / Bollinger Mid$236.47
Bollinger Width / SMA209.0% (drives anchor stability)
Net Debt$-0.7B
Market Cap$32B
Peers used for multiples: ABBV, AMGN, GILD, JNJ, LLY, NTRA, REGN, VRTX
60-Day Conviction
37%
20-Day Fair Value
≈ by Nov 16, 2026
$234.38
α +1.1% rank 27%
conviction
64%
40-Day Fair Value
≈ by Dec 15, 2026
$237.21
α +2.3% rank 31%
conviction
68%
60-Day Fair Value
≈ by Jan 13, 2027
$233.94
α +0.9% rank 28%
conviction
37%
MethodImplied PriceWeightDetail
DCF $92.11 19%
DDM (Gordon) n/a 0%
Peer P/E $177.34 9% median 28.9× · 6 peers
Peer EV/EBITDA $157.37 9% median 19.2× · 7 peers
Peer P/B $158.98 2% median 16.1× · 7 peers
Peer P/S $254.00 6% median 7.0× · 8 peers
Market Anchor (SMA50) $238.10 38% stability 100% (BB-width)
Options Expected (B-L 30d) $234.32 19% 28 strikes · skew +0.05
As of 2026-10-16 · updated
About
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834) · industry map
Exchange
XNAS
Market Cap
$31.3B
Employees
2,500
List Date
2004-05-28
CIK
0001178670
Next Earnings
2026-10-29 (Pre-Market)
EPS Forecast
$1.68 (9 est.)
Headquarters
Cambridge, MA
Homepage
https://www.alnylam.com

Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam's commercial RNAi therapeutic products include Onpattro and Amvuttra (for hATTR amyloidosis), Givlaari (for acute hepatic porphyria), and Oxlumo (for primary hyperoxaluria type 1), all developed and commercialized by Alnylam. Plus, Leqvio (for hypercholesterolemia) and Qfitlia (for hemophilia A or B), which are being commercialized by Alnylam's partners, Novartis and San…

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Month'21'22'23'24'25'26Avg
Jan17.47%-20.88%-3.08%-11.30%16.13%-15.52%-2.86%
Feb-0.77%8.91%-14.88%-13.62%-10.13%-1.83%-5.39%
Mar-5.08%0.48%2.52%-2.07%10.88%1.78%1.42%
Apr-0.83%-21.18%-0.75%-6.12%2.92%-5.85%-5.30%
May4.91%-9.53%-8.35%-1.02%19.37%1.98%1.23%
Jun17.49%18.53%0.67%61.52%6.53%1.83%17.76%
Jul5.41%-4.19%3.01%-2.41%21.79%-32.69%-1.51%
Aug13.19%47.67%4.64%-2.20%11.13%9.24%13.95%
Sep-4.18%-5.25%-11.97%8.37%2.01%0.26%-1.79%
Oct-17.19%5.32%-15.18%-3.43%-1.00%0.28%*-5.20%
Nov10.48%3.51%7.17%-7.61%3.95%--3.50%
Dec-5.75%7.90%11.67%-7.00%-12.52%---1.14%
Total33.33%15.40%-25.40%-3.35%88.25%-38.99%11.54%
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $236.09
SMA 50: $238.41
SMA 200: $294.32
Current: $231.83
EMA 12: $230.77
EMA 26: $235.52
MACD: -4.7496 | Signal: 0.0660
BEARISH
ADX (14): 14.68
RANGE
+DI: 22.58
−DI: 22.88

Momentum Oscillators

RSI (14): 46.87
NEUTRAL
Stoch %K: 35.04
Stoch %D: 28.92
Williams %R: -60.85

Volume & Volatility

BB Upper: $261.30
BB Lower: $210.88
NEUTRAL
OBV: 28,825,597
Vol SMA 20: 1,234,064
Vol ROC: -15.51%
ATR: $9.33
True Range: $6.69
HV 20: 43.7%
HV 30: 41.5%
HV 60: 82.7%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-10-18T00:00:00 – 2026-10-16T00:00:00
AI Analysis

Here is a comprehensive stock analysis report for ALNY (Alnylam Pharmaceuticals, Inc.) based on the provided data:

Executive Summary

BULLISH/BEARISH: BEARISH with confidence level 6/10

Key drivers and primary risks: The company faces potential headwinds from ongoing securities fraud investigations and negative sentiment surrounding recent news headlines. However, the stock's low volatility and positive sector performance could provide some support.

2-3 sentence investment thesis: ALNY's current price may be affected by the prevailing negative news environment, but its beta relative to the market suggests a relatively defensive posture. The company's low volatility also reduces the likelihood of sharp price movements. A potential catalyst for upside could come from improved investor sentiment or more positive industry developments.

Recent news sentiment impact: The recent headlines have been predominantly negative, with three out of five articles featuring securities fraud investigations. This has likely contributed to the stock's downward trend and bearish sentiment.

Technical Analysis

Trend Direction:

  • Short-term (1-4 weeks): NEUTRAL
  • Medium-term (1-3 months): BEARISH
  • Long-term (3-12 months): NEUTRAL

Support/Resistance Levels: The 20-day SMA at $229.59 and the Bollinger Bands' middle band at $229.59 could serve as short-term support levels.

Momentum Signals:

  • RSI interpretation: Neutral, with a reading of 49.57
  • MACD signal: Bearish crossover, with a value of -4.79 below the signal line
  • Bollinger Bands position: Squeeze, indicating reduced volatility

Volume Analysis: The volume rate of change is positive at 6.25%, suggesting increased buying pressure.

News & Sentiment Analysis

Recent Headlines Summary: The recent headlines have been predominantly negative, with three out of five articles featuring securities fraud investigations.

Sentiment Assessment: NEGATIVE sentiment due to the prevalence of negative news headlines.

Catalyst Identification: Upcoming earnings reports could provide a catalyst for price movement.

Market Narrative: The current market narrative is focused on the ongoing securities fraud investigations and their potential impact on ALNY's stock price.

Risk & Volatility Assessment

Risk Assessment: MEDIUM risk due to the company's relatively low volatility and defensive posture, but also considering the negative news environment.

Beta Interpretation: LOW risk relative to the market, with a beta of 0.35.

Volatility Regime: The current volatility regime is relatively calm, with an average true range (ATR) of $11.33.

Options Market Signals:

  • IV rank: HIGH at 92.9%
  • Put/call volume ratio: BEARISH at 4.01
  • Unusual activity: CALLS dominate PUTS

Downside Protection: Support levels include the 20-day SMA and the Bollinger Bands' middle band, both around $229.59.

Market Context & Positioning

Sector Performance: The sector is performing relatively well, with a correlation of 0.10 between ALNY's stock price and the broader market.

Institutional Activity: Moderate institutional interest is present, with an IV rank of 92.9%.

Correlation Analysis: The stock moves less than the market, with a correlation coefficient of 0.10.

Relative Valuation: ALNY is trading within its historical range, but at a relatively high valuation compared to its peers.

Key Levels & Action Items

Critical Price Levels: Short-term support levels include the 20-day SMA and the Bollinger Bands' middle band, both around $229.59.

Breakout/Breakdown Levels: A potential breakdown below the 20-day SMA could trigger a more significant decline.

Time-Sensitive Catalysts: Upcoming earnings reports and regulatory updates could provide catalysts for price movement.

Risk Management: Consider setting stop-loss levels around the 20-day SMA to limit potential losses.

Generated
Earnings History
15 of 20 under expected move
Avg Expected Move
9.88%
Avg Actual Move
6.17%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2021-01-11 Pre-Market 6.03% 6.80% 1.13x Exceeded
2021-04-29 Pre-Market 10.00% 2.68% 0.27x Within
2021-08-03 Pre-Market 13.51% 0.48% 0.04x Within
2021-10-28 Pre-Market 8.32% 15.18% 1.82x Exceeded
2022-01-10 Pre-Market 8.84% 1.37% 0.15x Within
2022-04-28 Pre-Market 10.50% 7.59% 0.72x Within
2022-07-28 Pre-Market 32.43% 1.09% 0.03x Within
2022-10-27 Pre-Market 9.95% 3.49% 0.35x Within
2023-01-09 Pre-Market 6.22% 2.35% 0.38x Within
2023-02-23 Pre-Market 8.17% 2.42% 0.30x Within
2023-05-04 Pre-Market 8.43% 2.95% 0.35x Within
2023-08-03 Pre-Market 7.46% 1.65% 0.22x Within
2023-11-02 Pre-Market 7.58% 2.89% 0.38x Within
2024-01-08 Pre-Market 6.63% 3.93% 0.59x Within
2025-01-13 Pre-Market 4.62% 8.53% 1.85x Exceeded
2025-07-31 Pre-Market 7.98% 15.43% 1.93x Exceeded
2025-10-30 Pre-Market 10.96% 6.65% 0.61x Within
2026-01-12 Pre-Market 9.01% 6.87% 0.76x Within
2026-04-30 Pre-Market 9.26% 2.76% 0.30x Within
2026-07-30 Pre-Market 11.62% 28.31% 2.44x Exceeded

Earnings calendar: this week’s reports with expected vs actual moves →

ALNY Options Activity & IV Rank

ALNY IV rank history, 52-week IV rank and IV percentile →

Volatility Metrics

Current IV: 58.2%
7-DTE IV: —
Expected Move: $33.35
7-DTE Move: $4.03
Days to Exp: 35 (2026-11-20)

Options Flow

Call Volume: 652
Put Volume: 142
P/C Volume: 0.218
BULLISH
Call OI: 1,162
Put OI: 797
P/C OI: 0.686
Total OI: 1,959

ATM Options Pricing

ATM Call: $18.00
ATM Put: $15.35
Call %: 7.8%
Put %: 6.6%

Chain Summary

Chain Volume: 5,232
Chain OI: 40,962
Last Updated: 10/16/2026
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Dealer Positioning
TYPICAL γ

Estimated net dealer gamma is at the 25th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.

Gamma percentile
25%
vs own history
GEX tilt
-0.24
OI-weighted, today
Vanna tilt
+0.08
δ-sensitivity to IV
Charm tilt
-0.09
δ-decay vs time

Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.

Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.

Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.

This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.

· 39 ATM contracts, 7k total OI
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
No data
30 DTE / 10d 71%
+9.1 pts EXTREME
ATM 58.3% / Wing 67.4%

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)95.4HighOct 16
Straddle Price (30 DTE)$33.35Oct 16
Beta Analysis

Risk Metrics

Beta: 0.4694
Alpha: -67.80%
Correlation: 0.1238
R-Squared: 1.5%
Stock Volatility: 48.3%
Market Volatility: 12.7%

Analysis Details

Benchmark: SPY
Data Points: 251
Period: 252 trading days
Interpretation:
Low volatility - stock moves less than market
Beta & Alpha Over Time
Notable investors who own ALNY
4 of 37 tracked investors
InvestorValueShare of their portfolioRankQ/Q sharesSource
Millennium Management Hedge fund
Izzy Englander
$95.1M
0.06%
#353 of 3716-29.4%13F
Citadel Hedge fund
Ken Griffin
$57.5M
0.03%
#618 of 6285+715.8%13F
Bridgewater Associates Hedge fund
Ray Dalio
$30.0M
0.12%
#136 of 997-6.6%13F
Rockefeller Capital Management Family office
Rockefeller family
$1.9M
0.00%
#1414 of 4729-3.4%13F

Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions

ALNY Institutional Ownership (13F)

Latest filings — 2026-09-30
Diluted shares outstanding: 137,134,750 (as of 2026-06-30)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

847 filers480,617,599 shares$46.11B value350.47% of float
# Filer Shares Value % of Total % of Float Period
1 Vanguard Group Inc Custodian 13,553,932 $5.39B 11.69% 9.88% 2025-12-31
2 FMR LLC Custodian 32,137,962 $4.54B 9.85% 23.44% 2026-06-30
3 Capital World Investors 12,627,846 $3.36B 7.28% 9.21% 2026-06-30
4 BlackRock, Inc. Custodian 18,907,675 $3.29B 7.14% 13.79% 2026-06-30
5 Capital Research Global Investors 9,750,699 $2.94B 6.37% 7.11% 2026-06-30
6 Vanguard Portfolio Management LLC 6,538,390 $1.97B 4.27% 4.77% 2026-06-30
7 Vanguard Capital Management LLC 6,029,478 $1.82B 3.94% 4.40% 2026-06-30
8 T. Rowe Price Investment Management, Inc. 5,642,173 $1.70B 3.68% 4.11% 2026-06-30
9 Invesco Ltd. Custodian 5,254,318 $1.13B 2.45% 3.83% 2026-06-30
10 State Street Corp 12,825,689 $1.08B 2.35% 9.35% 2026-06-30
11 Geode Capital Management, LLC Custodian 2,635,840 $791.35M 1.72% 1.92% 2026-06-30
12 JPMorgan Chase & Co Custodian 5,861,517 $789.11M 1.71% 4.27% 2026-06-30
13 BAILLIE GIFFORD & CO 2,439,889 $734.48M 1.59% 1.78% 2026-06-30
14 Norges Bank 2,271,813 $683.88M 1.48% 1.66% 2026-06-30
15 Wellington Management Group LLP Custodian 2,110,407 $635.30M 1.38% 1.54% 2026-06-30
16 Orbis Allan Gray Ltd 1,987,407 $598.27M 1.30% 1.45% 2026-06-30
17 Dodge & Cox 1,955,393 $588.63M 1.28% 1.43% 2026-06-30
18 Two Sigma Investments, LP Custodian 1,875,937 $564.71M 1.22% 1.37% 2026-06-30
19 American Century Companies, Inc. 1,853,956 $558.10M 1.21% 1.35% 2026-06-30
20 Clearbridge Investments, LLC 1,259,483 $379.14M 0.82% 0.92% 2026-06-30
21 T. Rowe Price Associates, Inc. 1,149,201 $345.94M 0.75% 0.84% 2026-06-30
22 D. E. Shaw & Co., Inc. Custodian 1,104,109 $332.37M 0.72% 0.81% 2026-06-30
23 Bank of America Corp Custodian 19,744,476 $321.91M 0.70% 14.40% 2026-06-30
24 Morgan Stanley Custodian 2,752,150 $312.78M 0.68% 2.01% 2026-06-30
25 The Manufacturers Life Insurance Company 14,693,795 $285.57M 0.62% 10.71% 2026-06-30
24 filers$466.66M notional
# Filer Notional Value % of Total Period
1 D. E. Shaw & Co., Inc. Custodian $129.53M 27.76% 2026-06-30
2 Wells Fargo & Company Custodian $111.38M 23.87% 2026-06-30
3 Susquehanna International Group, LLP Custodian $97.80M 20.96% 2026-06-30
4 Citadel Advisors LLC Custodian $24.56M 5.26% 2026-06-30
5 Wolverine Trading, LLC Custodian $13.11M 2.81% 2025-09-30
6 Millennium Management LLC Custodian $12.94M 2.77% 2026-06-30
7 Jane Street Group, LLC Custodian $12.67M 2.72% 2026-06-30
8 Caption Management, LLC $12.04M 2.58% 2026-06-30
9 IMC-Chicago, LLC Custodian $11.44M 2.45% 2026-06-30
10 Citigroup Inc. Custodian $7.19M 1.54% 2026-06-30
11 Squarepoint Ops LLC $7.19M 1.54% 2026-06-30
12 Alphadyne Asset Management LP $5.84M 1.25% 2026-06-30
13 J. Goldman & Co LP $5.75M 1.23% 2026-06-30
14 Barclays PLC Custodian $3.61M 0.77% 2026-06-30
15 Simplex Trading, LLC Custodian $3.49M 0.75% 2026-06-30
16 LMR Partners LLP $2.20M 0.47% 2026-06-30
17 Cubist Systematic Strategies, LLC $1.82M 0.39% 2025-09-30
18 Walleye Capital LLC $1.54M 0.33% 2026-06-30
19 GROUP ONE TRADING LLC Custodian $782.68K 0.17% 2026-06-30
20 Point72 Asset Management, L.P. $662.27K 0.14% 2026-06-30
21 Twin Tree Management, LP $451.55K 0.10% 2026-06-30
22 TUDOR INVESTMENT CORP ET AL $361.24K 0.08% 2026-06-30
23 PEAK6 LLC $240.82K 0.05% 2026-06-30
24 Walleye Trading LLC $30.10K <0.01% 2026-06-30
21 filers$220.19M notional
# Filer Notional Value % of Total Period
1 Susquehanna International Group, LLP Custodian $53.82M 24.44% 2026-06-30
2 HSBC Holdings plc Custodian $35.75M 16.24% 2026-06-30
3 683 Capital Management, LLC $32.36M 14.70% 2026-06-30
4 Portman Square Capital LLP $13.91M 6.32% 2026-06-30
5 Citadel Advisors LLC Custodian $12.79M 5.81% 2026-06-30
6 Citigroup Inc. Custodian $9.00M 4.09% 2026-06-30
7 IMC-Chicago, LLC Custodian $8.25M 3.75% 2026-06-30
8 Wolverine Trading, LLC Custodian $7.25M 3.29% 2025-09-30
9 Jane Street Group, LLC Custodian $6.53M 2.97% 2026-06-30
10 Alphadyne Asset Management LP $6.32M 2.87% 2026-06-30
11 Millennium Management LLC Custodian $6.08M 2.76% 2026-06-30
12 Simplex Trading, LLC Custodian $6.02M 2.73% 2026-06-30
13 NOMURA HOLDINGS INC $4.67M 2.12% 2026-06-30
14 Royal Bank of Canada Custodian $4.51M 2.05% 2026-06-30
15 Barclays PLC Custodian $3.61M 1.64% 2026-06-30
16 Deutsche Bank AG Custodian $3.13M 1.42% 2026-06-30
17 Walleye Capital LLC $2.08M 0.94% 2026-06-30
18 Walleye Trading LLC $1.99M 0.90% 2026-06-30
19 Balyasny Asset Management L.P. $1.05M 0.48% 2026-06-30
20 Advisory Services Network, LLC Custodian $602.06K 0.27% 2026-06-30
21 GROUP ONE TRADING LLC Custodian $451.55K 0.21% 2026-06-30

ALNY Insider Trading (Form 4)

Latest: 2026-10-06
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-10-06 Bryan Supran EVP, CLO and Secretary Sell (S) −1,758 $226.88 -$398.9K EDGAR
2026-09-22 Yvonne Greenstreet Chief Executive Officer Award (A) +107 — EDGAR
2026-06-03 Benjamin Cravatt Director Grant (A) +4,393 opt — EDGAR
2026-06-03 David E I Pyott Director Mixed — $299.18 -$1.15M EDGAR
2026-05-22 Stuart A Arbuckle Director Award (A) +671 — EDGAR
2026-05-22 Dennis A Ausiello Director Award (A) +671 — EDGAR
2026-05-22 Olivier Brandicourt Director Award (A) +671 — EDGAR
2026-05-22 Margaret A Hamburg Director Award (A) +671 — EDGAR
2026-05-22 Peter N Kellogg Director Award (A) +671 — EDGAR
2026-05-22 David E I Pyott Director Award (A) +671 — EDGAR
2026-05-22 Colleen F Reitan Director Award (A) +671 — EDGAR
2026-05-22 Amy W Schulman Director Award (A) +838 — EDGAR
2026-05-22 Charles Elliott Sigal Director Award (A) +671 — EDGAR
2026-05-14 Amy W Schulman Director Exer (M) +11,250 $70.20 $789.8K EDGAR
2026-04-07 Melissa McLaughlin Chief Human Resources Officer Sell (S) −3,910 $325.92 -$1.27M EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.

ALNY Insider Holdings

20 insiders · @ $231.83
Officers, directors, and 10%+ owners who have filed a Form 4 in the past two years, ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 Phillip A Sharp Director 266,899 $61.88M -$48.96M 40 2025-01-24
2 Yvonne Greenstreet Chief Executive Officer 96,209 $22.30M -$95.41M 57 2026-09-22
3 Jeffrey V. Poulton EVP, Chief Financial Officer 64,107 $14.86M -$8.59M 23 2026-03-06
4 Tolga Tanguler EVP, Chief Commercial Officer 36,398 $8.44M -$8.93M 22 2026-03-06
5 David E I Pyott Director 32,391 $7.51M -$9.50M 18 2026-06-03
6 Amy W Schulman Director 24,049 $5.58M -$5.26M 20 2026-05-22
7 Kevin Joseph Fitzgerald CSO & EVP, Head of Research 21,821 $5.06M -$19.69M 15 2026-03-06
8 Pushkal Garg EVP Chief R&D 20,874 $4.84M -$36.41M 25 2026-03-06
9 Michael W Bonney Director 20,804 $4.82M -$14.89M 18 2025-08-19
10 Bryan Supran EVP, CLO and Secretary 12,807 $2.97M -$398.9K 3 2026-10-06
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.

ALNY Proposed Insider Sales (Form 144)

Latest: 2026-10-02
Last 30d: 1 filing · $399K notice value  ·  Last 90d: 1 filing · $399K notice value · 1 unique filer

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Top 90-day filers: SUPRAN BRYAN (1, $399K)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-10-02 SUPRAN BRYAN Officer 1,758 $398.9K 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-06-01 PYOTT DAVID E I Director 3,830 $1.15M 2026-06-01 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-04-06 McLaughlin Melissa Officer 2,286 $731.7K 2026-04-06 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-03-05 Fitzgerald Kevin Joseph Officer 658 $213.0K 2026-03-05 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-03-05 Garg Pushkal Officer 2,404 $778.2K 2026-03-05 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-03-03 Fitzgerald Kevin Joseph Officer 1,652 $530.9K 2026-03-03 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-03-03 Garg Pushkal Officer 1,775 $570.4K 2026-03-03 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-02-27 Garg Pushkal Officer 4,627 $1.53M 2026-02-27 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-02-17 Fitzgerald Kevin Joseph Officer 2,041 $677.5K 2026-02-17 UBS Financial Services, Inc. 10b5-1 EDGAR
2026-01-13 Fitzgerald Kevin Joseph Officer 2,290 $845.2K 2026-01-13 UBS Financial Services, Inc. 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed. Market-wide feed: Planned sales (Form 144).
Recent SEC Filings
Latest: 2026-05-27
Current reports — material events the company must disclose within 4 business days (earnings releases, M&A, executive changes, etc.).
Filing Date Accession Link
2026-05-27 0001628280-26-038499 EDGAR
2026-04-30 0001628280-26-028601 EDGAR
2026-03-04 0001628280-26-014728 EDGAR
2026-02-12 0001628280-26-007491 EDGAR
2026-01-12 0001628280-26-001755 EDGAR
2025-12-11 0001193125-25-315047 EDGAR
2025-12-03 0001628280-25-055084 EDGAR
2025-10-30 0001628280-25-047342 EDGAR
2025-10-03 0001193125-25-230201 EDGAR
2025-09-12 0001193125-25-202366 EDGAR
Annual report — audited financial statements, MD&A, risk factors. Filed 60–90 days after fiscal year-end.
Filing Date Accession Link
2026-02-12 0001628280-26-007497 EDGAR
2025-02-13 0001178670-25-000026 EDGAR
2024-02-15 0001178670-24-000008 EDGAR
2023-02-23 0001178670-23-000005 EDGAR
2022-02-10 0001178670-22-000013 EDGAR
2021-02-11 0001178670-21-000010 EDGAR
2020-02-13 0001178670-20-000004 EDGAR
2019-02-14 0001564590-19-003022 EDGAR
2018-02-15 0001564590-18-002152 EDGAR
2017-02-15 0001564590-17-001649 EDGAR
Quarterly report — unaudited financials and MD&A. Filed 40–45 days after each of the first three fiscal quarters.
Filing Date Accession Link
2026-04-30 0001628280-26-028605 EDGAR
2025-10-30 0001628280-25-047345 EDGAR
2025-07-31 0001178670-25-000090 EDGAR
2025-05-01 0001178670-25-000052 EDGAR
2024-10-31 0001178670-24-000053 EDGAR
2024-08-01 0001178670-24-000041 EDGAR
2024-05-02 0001178670-24-000023 EDGAR
2023-11-02 0001178670-23-000023 EDGAR
2023-08-03 0001178670-23-000015 EDGAR
2023-05-04 0001178670-23-000011 EDGAR
ETF Holders
245 ETFs hold ALNY
25 shown · $5.31B total exposure · 0.31% AUM-weighted avg weight
# ETF Provider Weight $ Exposure ETF AUM As Of
1 VTI Vanguard Morningstar Total Stock Market ETF Vanguard 0.05% $1.0B — 2026-09-30
2 VO Vanguard Morningstar Mid-Cap ETF Vanguard 0.33% $707.0M — 2026-09-30
3 QQQ Invesco QQQ Trust, Series 1 Invesco 0.13% $627.5M — 2026-10-14
4 VUG Vanguard Morningstar Growth ETF Vanguard 0.11% $434.6M — 2026-09-30
5 VXF Vanguard Extended Market ETF Vanguard 0.40% $371.8M — 2026-09-30
6 VOT Vanguard Morningstar Mid-Cap Growth ETF Vanguard 0.78% $259.2M — 2026-09-30
7 IBB iShares Biotechnology ETF iShares (BlackRock) 2.18% $229.2M $10.7B 2026-10-14
8 CGGR Capital Group Growth ETF Capitalgroup 0.68% $177.6M $26.1B 2026-10-14
9 IWP iShares Russell Mid-Cap Growth ETF iShares (BlackRock) 0.88% $168.8M $19.4B 2026-10-14
10 QQQM Invesco NASDAQ 100 ETF Invesco 0.13% $139.8M — 2026-10-14
11 XBI State Street® SPDR® S&P® Biotech ETF SPDR (State Street) 1.34% $135.2M $10.1B 2026-10-14
12 IWR iShares Russell Mid-Cap ETF iShares (BlackRock) 0.22% $125.1M $56.8B 2026-10-14
13 USMV iShares MSCI USA Min Vol Factor ETF iShares (BlackRock) 0.51% $120.6M $23.9B 2026-10-14
14 IWF iShares Russell 1000 Growth ETF iShares (BlackRock) 0.09% $113.1M $127.6B 2026-10-14
15 VHT Vanguard Health Care ETF Vanguard 0.46% $100.7M — 2026-09-30
16 SCHG Schwab U.S. Large-Cap Growth ETF Nport 0.14% $85.3M — 2026-05-31
17 TCAF T. Rowe Price Capital Appreciation Equity ETF Nport 1.01% $74.8M — 2026-06-30
18 JEPQ JPMorgan Nasdaq Equity Premium Income ETF JPMorgan 0.16% $71.2M $44.1B 2026-10-15
19 FBT First Trust NYSE® Arca® Biotechnology Index Fund First Trust 2.37% $68.6M $2.9B 2026-10-14
20 VONG Vanguard Russell 1000 Growth ETF Vanguard 0.10% $53.7M — 2026-09-30
21 CGBL Capital Group Core Balanced ETF Capitalgroup 0.58% $45.2M $7.8B 2026-10-14
22 SCHX Schwab U.S. Large-Cap ETF Nport 0.06% $42.4M — 2026-05-31
23 ITOT iShares Core S&P Total U.S. Stock Market ETF iShares (BlackRock) 0.04% $39.0M $97.1B 2026-10-14
24 VV Vanguard Morningstar Large-Cap ETF Vanguard 0.05% $38.9M — 2026-09-30
25 QQEW First Trust Nasdaq-100 Select Equal Weight ETF First Trust 1.92% $35.4M $1.8B 2026-10-14
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

Trailing P/E
39.03
TTM Diluted EPS
$5.94
TTM Revenue
$4.80B
TTM Net Income
$807.99M
TTM Op. Cash Flow
$885.89M
Quarterly figures (12 quarters)
QuarterPeriod EndRevenueNet IncomeDiluted EPSOp. Cash Flow
Q2 '262026-06-30$1.29B$164.49M$1.21$326.72M
Q1 '262026-03-31$1.17B$205.99M$1.51$70.50M
Q4 '252025-12-31$1.10B$186.42M$1.38$163.56M
Q3 '252025-09-30$1.25B$251.08M$1.84$325.11M
Q2 '252025-06-30$773.69M$-72.23M$-0.55$129.81M
Q1 '252025-03-31$594.19M$-18.25M$-0.14$-120.31M
Q4 '242024-12-31$593.17M$-83.76M$-0.65$-94.66M
Q3 '242024-09-30$500.92M$-111.57M$-0.87$43.71M
Q2 '242024-06-30$659.83M$-16.89M$-0.13$124.16M
Q1 '242024-03-31$494.33M$-65.94M$-0.52$-81.52M
Q4 '232023-12-31$439.72M$-137.87M$-1.09$-29.80M
Q3 '232023-09-30$750.53M$147.75M$1.15$359.41M
Q2 2026 • period ending 2026-06-30 • filed 2026-07-30
Valuation

Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.

Price Multiples
  • P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
  • P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
  • P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
  • EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
  • EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
Profitability & Yields
  • ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
  • ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
  • Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
  • FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
Balance Sheet
  • Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
  • Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
Reading the history chart
  • Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
  • Multiples expanding while earnings are flat = sentiment-driven rally.
  • Multiples compressing while earnings grow = value coming from fundamentals.
P/E
39.03
P/B
23.48
P/S
6.62
EV/EBITDA
29.49
EV/Sales
6.47
ROE
59.7%
ROA
14.5%
Div Yield
0.00%
FCF Yield
2.79%
Debt/Equity
0.75
Current Ratio
—
Market Cap
$31.79B
as of 2026-10-16
Short Interest & Float

Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.

Metric definitions
  • Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
  • SI % of Float — short interest / free float. The key crowding metric.
  • Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
  • Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
  • Free Float — shares available for public trading (total shares minus insider / restricted).
  • Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
How to read the signals
  • SI % of Float < 5% — typical, no particular signal.
  • 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
  • 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
  • >30% — extreme; borrow is likely expensive and squeeze risk is material.
  • Days to Cover > 5 combined with high SI% amplifies squeeze potential.
History chart
  • Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
  • A sudden drop in SI after a rally may indicate a squeeze in progress.

Short interest is reported mid-month and end-of-month; short volume is daily.

Short Interest
7.71M
SI % of Float
5.77%
Days to Cover
6.45
Short Vol Ratio
40.5%
Free Float
133.61M
Float %
99.9%
Short interest 2026-09-30 • Short volume 2026-10-16 • Float 2026-08-24