DAVID E I PYOTT
CIK 1051578 · Chairman of the Board and CEO · last filed 2026-09-17
DAVID E I PYOTT is a Chairman of the Board and CEO who has filed 132 SEC Form 4 insider transactions across 7 companies since 2007. The most recent filing, for TARS, was dated Sep 17, 2026. Across all open-market trades the lifetime net is −$267.5M, making them a net seller over the disclosed history. Current disclosed insider exposure totals $40.4M across reported positions. 22 SEC filings were submitted jointly with ALNYLAM PHARMACEUTICALS, INC.
"Disclosed insider exposure" sums this person's most-recently-reported share counts across each company they're an insider in, multiplied by the current underlying price. It is not net worth — it misses retail holdings, private investments, real estate, index funds, and any company where the person isn't an SEC-reporting insider. For informational purposes only.
$40.37M
7
132
-$267.52M
Charts
Trading activity, where the exposure sits, and each trade against the stock price.
Filer Profile
HENRI A. TERMEER SQUARE
CAMBRIDGE, MA 02142
Holdings By Company
| Symbol | Role | Shares | Price | Disclosed Exposure | Lifetime OM Net | Filings | Latest Filed |
|---|---|---|---|---|---|---|---|
| TARS | Director | 10,958 | $73.53 | $805.7K | $0 | 4 | 2026-09-17 |
| ALNY | Director | 32,391 | $222.25 | $7.20M | -$9.50M | 18 | 2026-06-03 |
| PLRX | Director | — | $1.03 | — | $0 | 7 | 2025-06-09 |
| BMRN | Director | 49,750 | $57.71 | $2.87M | $1.00M | 11 | 2024-05-23 |
| AVY | Director | 18,684 | $171.28 | $3.20M | -$1.33M | 50 | 2020-04-24 |
| ALLERGAN INC (AGN) Delisted | Chairman of the Board and CEO | 169,275 | — | — | -$250.59M | 25 | 2015-02-24 |
| EW | Director | 307,440 | $85.52 | $26.29M | -$7.10M | 13 | 2013-05-17 |
Recent Filings
132 filings| Filed | Symbol | Action | Net Shares | Net $ | Link |
|---|---|---|---|---|---|
| 2026-09-17 | TARS | Exer (M) | +201 | $0 | EDGAR |
| 2026-06-29 | TARS | Grant (A) | — | $0 | EDGAR |
| 2026-06-03 | ALNY | Mixed | — | -$1.15M | EDGAR |
| 2026-06-01 | ALNY | Notice (144) | −3,830 | -$1.15M | EDGAR |
| 2026-05-22 | ALNY | Grant (A) | +671 | $0 | EDGAR |
| 2026-04-28 | TARS | Exer (M) | +1,383 | $0 | EDGAR |
| 2026-02-20 | TARS | Grant (A) | — | $0 | EDGAR |
| 2025-06-09 | PLRX | Grant (A) | — | $0 | EDGAR |
| 2025-05-12 | ALNY | Grant (A) | +775 | $0 | EDGAR |
| 2025-03-25 | ALNY | Mixed | — | -$1.56M | EDGAR |
Notice (144 / 144/A): Form 144 is a notice of intent to sell restricted/control stock under Rule 144, filed before the sale; 144/A is an amendment. Many notices are pre-scheduled under Rule 10b5-1 plans. A Form 4 with code S typically follows within a few days when the planned sale executes; missing follow-up Form 4s suggest the notice was cancelled or modified.