Ishara Investments LP — 13F Holdings & Portfolio
CIK 2111609 · latest 13F-HR filed 2026-08-14
Ishara Investments LP manages $136.1M in 13F-reported U.S. long-equity assets across 41 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are ACAD (7.62%), XERS (7.16%), BMRN (6.03%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 16 new positions, exited 11, added to 15, and trimmed 7.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
LOS ANGELES, CA 90034
$136.1M
Long-equity book
41
Distinct positions
2026-06-30
Filed 2026-08-14
+16 / −11 / ↑15 / ↓7
vs 2026-03-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- ACADIA PHARMACEUTICALS INC$7.6M +278.9%
- XERIS BIOPHARMA HOLDINGS INC$3.8M +63.9%
- ANNEXON INC$3.7M +385.0%
- BIOMARIN PHARMACEUTICAL INC$3.6M +77.3%
- ULTRAGENYX PHARMACEUTICAL IN$3.2M +87.5%
Top Trims
- AXSOME THERAPEUTICS INC.-$2.9M -42.1%
- VERA THERAPEUTICS INC-$2.9M -86.7%
- IMMATICS N.V-$1.2M -79.4%
- SCHOLAR ROCK HLDG CORP-$1.1M -40.1%
- SIONNA THERAPEUTICS INC-$621.9K -31.5%
New Positions
- AGIOS PHARMACEUTICALS INC$6.1M
- INSMED INC$5.5M
- CRINETICS PHARMACEUTICALS IN$5.4M
- TONIX PHARMACEUTICALS HLDG C$4.3M
- BRIDGEBIO PHARMA INC$4.3M
Exited Positions
- KALVISTA PHARMACEUTICALS INC$5.6M
- AMICUS THERAPEUTIC$5.3M
- VERASTEM INC$4.3M
- ARROWHEAD PHARMACEUTICALS IN$3.5M
- MOONLAKE IMMUNOTHERAPEUTICS$3.2M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | ACADIA PHARMACEUTICALS INC | ACAD | 004225108 | $10.4M | 7.62% | 410,000 | SH |
| 2 | XERIS BIOPHARMA HOLDINGS INC | XERS | 98422E103 | $9.7M | 7.16% | 1,230,000 | SH |
| 3 | BIOMARIN PHARMACEUTICAL INC | BMRN | 09061G101 | $8.2M | 6.03% | 143,500 | SH |
| 4 | PRAXIS PRECISION MEDICINES I | PRAX | 74006W207 | $7.5M | 5.55% | 22,550 | SH |
| 5 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 90400D108 | $6.8M | 5.03% | 205,000 | SH |
| 6 | AGIOS PHARMACEUTICALS INC | AGIO | 00847X104 | $6.1M | 4.47% | 164,000 | SH |
| 7 | INSMED INC | INSM | 457669307 | $5.5M | 4.01% | 51,250 | SH |
| 8 | CRINETICS PHARMACEUTICALS IN | CRNX | 22663K107 | $5.4M | 3.95% | 143,500 | SH |
| 9 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 98943L107 | $5.0M | 3.65% | 1,025,000 | SH |
| 10 | VAXCYTE INC | PCVX | 92243G108 | $4.8M | 3.50% | 82,000 | SH |
| 11 | ANNEXON INC | ANNX | 03589W102 | $4.7M | 3.44% | 820,000 | SH |
| 12 | TRAVERE THERAPEUTICS INC | TVTX | 89422G107 | $4.7M | 3.42% | 82,000 | SH |
| 13 | TONIX PHARMACEUTICALS HLDG C | TNXP | 890260839 | $4.3M | 3.17% | 338,250 | SH |
| 14 | BRIDGEBIO PHARMA INC | BBIO | 10806X102 | $4.3M | 3.14% | 57,400 | SH |
| 15 | AXSOME THERAPEUTICS INC. | AXSM | 05464T104 | $4.0M | 2.95% | 16,400 | SH |
| 16 | CONTINEUM THERAPEUTICS INC | CTNM | 21217B100 | $3.4M | 2.47% | 205,000 | SH |
| 17 | LEXICON PHARMACEUTICALS INC | LXRX | 528872302 | $3.1M | 2.24% | 1,271,000 | SH |
| 18 | KURA ONCOLOGY INC | KURA | 50127T109 | $3.0M | 2.23% | 276,750 | SH |
| 19 | DBV TECHNOLOGIES S A | DBVT | 23306J309 | $3.0M | 2.22% | 184,500 | SH |
| 20 | GENMAB A/S | GMAB | 372303206 | $2.8M | 2.07% | 102,500 | SH |
| 21 | CYTOKINETICS INC | CYTK | 23282W605 | $2.8M | 2.05% | 32,800 | SH |
| 22 | MINERALYS THERAPEUTICS INC | MLYS | 603170101 | $2.8M | 2.03% | 102,500 | SH |
| 23 | SILENCE THERAPEUTICS PLC | SLN | 82686Q101 | $2.4M | 1.79% | 55,350 | SH |
| 24 | NUVATION BIO INC | NUVB | 67080N101 | $2.1M | 1.54% | 369,000 | SH |
| 25 | WAVE LIFE SCIENCES LTD | WVE | Y95308105 | $1.9M | 1.40% | 328,000 | SH |
| 26 | NEKTAR THERAPEUTICS | NKTR | 640268306 | $1.9M | 1.37% | 26,650 | SH |
| 27 | SCHOLAR ROCK HLDG CORP | SRRK | 80706P103 | $1.7M | 1.24% | 30,750 | SH |
| 28 | ENLIVEN THERAPEUTICS INC | ELVN | 29337E102 | $1.7M | 1.22% | 32,800 | SH |
| 29 | ALNYLAM PHARMACEUTICALS INC | ALNY | 02043Q107 | $1.5M | 1.13% | 5,125 | SH |
| 30 | BEAM THERAPEUTICS INC | BEAM | 07373V105 | $1.4M | 1.03% | 41,000 | SH |
| 31 | SIONNA THERAPEUTICS INC | SION | 829401108 | $1.4M | 0.99% | 123,000 | SH |
| 32 | ORIC PHARMACEUTICALS INC | ORIC | 68622P109 | $1.3M | 0.98% | 123,000 | SH |
| 33 | NEWAMSTERDAM PHARMA COMPANY | NAMS | N62509109 | $1.3M | 0.92% | 36,900 | SH |
| 34 | VERTEX PHARMACEUTICALS INC | VRTX | 92532F100 | $1.2M | 0.90% | 2,460 | SH |
| 35 | ARS PHARMACEUTICALS INC | SPRY | 82835W108 | $1.1M | 0.84% | 143,490 | SH |
| 36 | MONOPAR THERAPEUTICS INC | MNPR | 61023L207 | $1.1M | 0.84% | 12,300 | SH |
| 37 | ERASCA INC | ERAS | 29479A108 | $751.1K | 0.55% | 41,000 | SH |
| 38 | VERA THERAPEUTICS INC | VERA | 92337R101 | $439.8K | 0.32% | 10,250 | SH |
| 39 | IMMATICS N.V | IMTX | N44445109 | $311.5K | 0.23% | 30,750 | SH |
| 40 | MEREO BIOPHARMA GROUP PLC | MREO | 589492107 | $244.2K | 0.18% | 768,750 | SH |
| 41 | GOSSAMER BIO INC | GOSS | 38341P102 | $135.0K | 0.10% | 820,000 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $136.1M | 41 | 0002111609-26-000004 |
| 2026-03-31 | 2026-05-15 | $105.6M | 37 | 0002111609-26-000002 |
| 2025-12-31 | 2026-02-17 | $87.5M | 38 | 0002111609-26-000001 |