Amicus Therapeutics, Inc(FOLD)

Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership.

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

FOLD $14.49
Snapshot
$14.49
52-Week Range
$5.92 – $14.50
YTD
+1.54%
IV Rank (30D)
13.31
Straddle Price
$0.53
P/C Vol Ratio
1.03
Market Cap
$4.5B
Info
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834)
Exchange
XNAS
Market Cap
$4.5B

Amicus Therapeutics Inc is a biotechnology company focused to develop and deliver transformative medicines for people living with rare diseases. It has a portfolio of product opportunities, including oral precision medicine for people living with Fabry disease who have amenable genetic variants; a clinical-stage, treatment paradigm for Pompe disease, and a rare disease gene therapy portfolio. The company has one segment focused on the discovery, development, and commercialization of therapies to treat a range of devastating rare and orphan diseases.

Summary
composite
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Insufficient price history — listed 6990 days ago. Seasonality patterns need at least one full year of data.
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators
SMA 20: $14.46
SMA 50: $14.40
SMA 200: $10.84
Current: $14.49
EMA 12: $14.46
EMA 26: $14.44
MACD: 0.0259 | Signal: -0.0047
BULLISH
ADX (14): 67.96
STRONG TREND
+DI: 31.28
−DI: 4.03
Momentum Oscillators
RSI (14): 72.15
OVERBOUGHT
Stoch %K: 66.67
Stoch %D: 62.96
Williams %R: -20.00
Volume & Volatility
BB Upper: $14.49
BB Lower: $14.42
OVERBOUGHT
OBV: 267,375,257
Vol SMA 20: 2,809,931
Vol ROC: 159.58%
ATR: $0.02
True Range: $0.04
HV 20: 1.6%
HV 30: 1.7%
HV 60: 1.7%

Data Summary
Data Points: 500
Last Updated:
Date Range: 2024-04-26T00:00:00 – 2026-04-24T00:00:00
AI Analysis

Choose Frenzy-Fast™ for quick analysis or Frenzy-Pro™ for comprehensive analysis.

Analysis includes technical indicators, news sentiment, risk assessment, and specific price levels to watch.

News
Earnings History
7 of 7 under expected move
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2024-08-08 After-Close 13.47% 1.41% 0.10x Within
2024-11-06 After-Close 6.36% 3.68% 0.58x Within
2025-01-13 After-Close 3.79% 0.22% 0.06x Within
2025-05-01 Pre-Market 14.64% 12.75% 0.87x Within
2025-07-31 After-Close 14.19% 5.51% 0.39x Within
2025-11-04 Pre-Market 11.94% 0.11% 0.01x Within
2026-02-20 After-Close 54.37% 0.00% 0.00x Within
Options Activity
IV Rank (30D)
13.31
IV Rank (7D)
13.31
Avg IV
99.5%
Straddle (30D)
$0.53
Straddle (7D)
$0.53
P/C Volume
1.03
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d
pts EXTREME
ATM — / Wing —
30 DTE / 10d
pts EXTREME
ATM — / Wing —

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)
Straddle Price (30 DTE)
Beta Analysis
Insufficient price history — listed 6990 days ago. Beta and correlation vs SPY require ~1 year of daily returns to be statistically meaningful.
Institutional Ownership (13F)
Latest filings — 2026-03-31
Diluted shares outstanding: 308,685,181 (as of 2025-12-31)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

285 filers324,463,634 shares$4.45B value105.11% of float
# Filer Shares Value % of Total % of Float Period
1 BlackRock, Inc. Custodian 33,879,048 $489.89M 11.00% 10.98% 2026-03-31
2 VANGUARD GROUP INC Custodian 29,702,696 $422.97M 9.50% 9.62% 2025-12-31
3 UBS Group AG Custodian 15,957,913 $230.75M 5.18% 5.17% 2026-03-31
4 Pentwater Capital Management LP 14,000,000 $202.44M 4.55% 4.54% 2026-03-31
5 STATE STREET CORP 12,893,897 $186.45M 4.19% 4.18% 2026-03-31
6 FIL Ltd 12,560,028 $181.62M 4.08% 4.07% 2026-03-31
7 GOLDMAN SACHS GROUP INC Custodian 11,556,008 $167.10M 3.75% 3.74% 2026-03-31
8 Qube Research & Technologies Ltd 8,809,340 $127.38M 2.86% 2.85% 2026-03-31
9 GEODE CAPITAL MANAGEMENT, LLC Custodian 8,535,918 $123.45M 2.77% 2.77% 2026-03-31
10 O'Connor Alternative Investments LLC 8,444,992 $122.11M 2.74% 2.74% 2026-03-31
11 MILLENNIUM MANAGEMENT LLC Custodian 7,908,459 $114.36M 2.57% 2.56% 2026-03-31
12 JPMORGAN CHASE & CO Custodian 6,749,190 $97.39M 2.19% 2.19% 2026-03-31
13 AQR Arbitrage LLC 5,843,849 $84.50M 1.90% 1.89% 2026-03-31
14 SOROS FUND MANAGEMENT LLC 5,753,186 $83.19M 1.87% 1.86% 2026-03-31
15 MORGAN STANLEY Custodian 5,479,689 $78.03M 1.75% 1.78% 2025-12-31
16 Kryger Capital LLC 4,554,174 $65.85M 1.48% 1.48% 2026-03-31
17 ALLIANCEBERNSTEIN L.P. 4,316,272 $61.46M 1.38% 1.40% 2026-03-31
18 CITIGROUP INC Custodian 4,226,882 $61.12M 1.37% 1.37% 2026-03-31
19 Magnetar Financial LLC 3,986,058 $57.64M 1.29% 1.29% 2026-03-31
20 BANK OF AMERICA CORP /DE/ Custodian 3,899,490 $56.39M 1.27% 1.26% 2026-03-31
21 Weiss Asset Management LP 3,872,902 $56.00M 1.26% 1.25% 2026-03-31
22 BALYASNY ASSET MANAGEMENT L.P. 3,827,513 $55.35M 1.24% 1.24% 2026-03-31
23 TIG Advisors, LLC 3,825,445 $55.32M 1.24% 1.24% 2026-03-31
24 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 3,643,352 $52.68M 1.18% 1.18% 2026-03-31
25 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 3,559,972 $51.48M 1.16% 1.15% 2026-03-31
9 filers$9.44M notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $5.55M 58.77% 2026-03-31
2 CITIGROUP INC Custodian $1.45M 15.33% 2026-03-31
3 CITADEL ADVISORS LLC Custodian $614.55K 6.51% 2026-03-31
4 TUDOR INVESTMENT CORP ET AL $542.25K 5.75% 2026-03-31
5 Walleye Trading LLC $516.22K 5.47% 2026-03-31
6 JANE STREET GROUP, LLC Custodian $229.91K 2.44% 2026-03-31
7 WOLVERINE TRADING, LLC Custodian $227.08K 2.41% 2025-09-30
8 GROUP ONE TRADING LLC Custodian $224.13K 2.38% 2026-03-31
9 SIMPLEX TRADING, LLC Custodian $89.65K 0.95% 2026-03-31
7 filers$6.92M notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $1.94M 28.03% 2026-03-31
2 Walleye Trading LLC $1.69M 24.37% 2026-03-31
3 CITIGROUP INC Custodian $1.45M 20.90% 2026-03-31
4 JANE STREET GROUP, LLC Custodian $1.05M 15.17% 2026-03-31
5 GROUP ONE TRADING LLC Custodian $352.82K 5.10% 2026-03-31
6 SIMPLEX TRADING, LLC Custodian $281.97K 4.08% 2026-03-31
7 WOLVERINE TRADING, LLC Custodian $162.77K 2.35% 2025-09-30
Insider Activity
Latest: 2026-04-27
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-04-27 Simon N.R. Harford Chief Financial Officer Disp (D) −143,595 $14.50 -$2.08M EDGAR
2026-04-27 GLENN SBLENDORIO Director Disp (D) −142,564 $14.50 -$2.07M EDGAR
2026-04-27 Samantha Prout Chief Accounting Officer Disp (D) −125,951 $14.50 -$1.83M EDGAR
2026-04-27 MICHAEL RAAB Director Disp (D) −115,857 $14.50 -$1.68M EDGAR
2026-04-27 Ellen Rosenberg Chief Legal Officer Disp (D) −478,898 $14.50 -$6.94M EDGAR
2026-04-27 Jeff Castelli Chief Development Officer Disp (D) −427,089 $14.50 -$6.19M EDGAR
2026-04-27 EIRY ROBERTS Director Disp (D) −76,275 $14.50 -$1.11M EDGAR
2026-04-27 BURKE W WHITMAN Director Disp (D) −118,598 $14.50 -$1.72M EDGAR
2026-04-27 David Michael Clark Chief People Officer Disp (D) −221,811 $14.50 -$3.22M EDGAR
2026-04-27 Lynn Dorsey Bleil Director Disp (D) −113,941 $14.50 -$1.65M EDGAR
2026-04-27 Bradley L Campbell President and CEO Disp (D) −1,008,680 $14.50 -$14.63M EDGAR
2026-04-27 MARGARET G MCGLYNN Director Disp (D) −94,631 $14.50 -$1.37M EDGAR
2026-04-27 CRAIG A WHEELER Director Disp (D) −84,631 $14.50 -$1.23M EDGAR
2026-04-27 Michael Aaron Kelly Director Disp (D) −72,468 $14.50 -$1.05M EDGAR
2026-03-04 Bradley L Campbell President and CEO Sell (S) −22,500 $14.35 -$322.8K EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.
Insider Holdings
66 insiders · @ $14.49
Officers, directors, and 10%+ owners ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 PERCEPTIVE ADVISORS LLC 10%+ Owner 20,724,424 $300.30M $0 1 2019-02-19
2 JOSEPH EDELMAN 10%+ Owner 20,694,424 $299.86M $185.21M 16 2018-10-05
3 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD 10%+ Owner 15,239,444 $220.82M $940.5K 1 2015-10-08
4 Jeremy Green 10%+ Owner 12,956,446 $187.74M $954.7K 1 2016-06-13
5 KRISHNA KITTU KOLLURI 10%+ Owner 4,584,311 $66.43M $36.91M 1 2012-03-09
6 M JAMES BARRETT Director 4,584,311 $66.43M $5.27M 5 2013-06-17
7 CHL Medical Partners II Side Fund, L.P. 10%+ Owner 4,084,011 $59.18M $0 1 2007-06-07
8 CHL Medical Partners II, L.P. 10%+ Owner 4,084,010 $59.18M $0 1 2007-06-07
9 Garden State Life Sciences Venture Fund L P 10%+ Owner 2,484,584 $36.00M $0 1 2007-06-07
10 QUAKER BIO VENTURES LP 10%+ Owner 2,484,584 $36.00M $0 1 2007-06-07
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.
Notice of Proposed Sale (Form 144)
Latest: 2026-03-02
Last 30d: 0 filings  ·  Last 90d: 0 filings

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. Amendments (Form 144/A) and post-cancellation refilings can inflate this if you sum naively; the rollup above excludes filings with zero stated value.

Source & freshness: Parsed directly from EDGAR primary-doc XML. Daily refresh; new filings typically appear here the morning after they hit EDGAR.

Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-03-02 BRADLEY CAMPBELL Director, Officer 22,500 $323.3K 2026-03-02 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-01-20 BRADLEY CAMPBELL Director, Officer 75,000 $1.07M 2026-01-20 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-12-19 DAVID CLARK Officer 25,642 $279.2K 2025-12-19 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-12-15 BRADLEY CAMPBELL Director, Officer 77,926 $822.1K 2025-12-15 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-12-15 DAVID CLARK Officer 25,643 $270.5K 2025-12-15 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-12-01 BRADLEY CAMPBELL Director, Officer 14,587 $144.8K 2025-12-01 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-11-26 ELLEN ROSENBERG Officer 23,621 $233.1K 2025-11-26 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-11-25 ELLEN ROSENBERG Officer 36,000 $356.0K 2025-11-25 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-11-24 JEFFREY CASTELLI Officer 76,158 $728.1K 2025-11-24 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2025-11-24 DAVID CLARK Officer 25,643 $245.1K 2025-11-24 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed.
ETF Holders
# ETF Provider Weight $ Exposure ETF AUM As Of
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

P/B Ratio16.6
P/S Ratio7.2
EV/EBITDA112.7
TTM Revenue$0.6B
TTM Net Income$-0.0B
TTM EPS$-0.09
ROE-9.9%
Debt/Equity1.43