EWTX Edgewise Therapeutics, Inc. Common Stock

XNAS 45.04 Delayed
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Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Expected move IV rank history Fibonacci levels Insider trading

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

EWTX $45.04 —

What changed

Recent filings, trades and moves
Key stats
$45.04
52-Week Range
$16.98 – $48.51
YTD
+89.64%
IV Rank (30D)
41.38
Straddle Price
$7.97
P/C Vol Ratio
4.66
Market Cap
$4.9B
Open
$39.71
Day Range
$38.05 – $45.76
Volume
3,716,881
Prev Close
$38.87
Fair Value
MODEL: NEUTRAL

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)4.95%
Beta vs SPY1.34
Cost of Equity (CAPM)12.32% (VRP-adj)
WACC12.40%
Volatility Risk Premium+48.2pp (IV − HV30), ERP adj +50bps
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)+3.0%
DCF Horizon5 years explicit + fade
Forward Tilt (NTM/TTM)×1.03 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$-0.2B
Return on Equity (TTM)-44.0%
Book / Price10.9%
Debt / Equity0.00
Quality Score1/6 — cyclical/struggling (5y DCF)
SMA 50$40.83 (Market Anchor value)
SMA 20 / Bollinger Mid$38.60
Bollinger Width / SMA2028.7% (drives anchor stability)
Net Debt$-0.1B
Market Cap$4B
Peers used for multiples: ACAD, ALKS, BIIB, DNTH, JNJ, LLY, NBIX, SUPN
60-Day Conviction
8%
20-Day Fair Value
≈ by Dec 7, 2026
$44.97
α -0.2% rank 44%
conviction
13%
40-Day Fair Value
≈ by Jan 5, 2027
$45.27
α +0.5% rank 34%
conviction
15%
60-Day Fair Value
≈ by Feb 3, 2027
$45.12
α +0.2% rank 39%
conviction
8%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0% median 41.3× · 5 peers
Peer EV/EBITDA n/a 0% median 22.8× · 7 peers
Peer P/B $17.45 26% median 4.1× · 8 peers
Peer P/S n/a 0% median 4.5× · 8 peers
Market Anchor (SMA50) $40.83 9% stability 7% (BB-width)
Options Expected (B-L 30d) $38.63 66% 35 strikes · skew +0.27
As of 2026-11-06 · updated
About
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834) · industry map
Exchange
XNAS
Market Cap
$4.9B
Employees
133
List Date
2021-03-26
CIK
0001710072
Last Earnings
Nov 4 before open · −0.4% vs ±14.3% expected
Headquarters
Boulder, CO
Homepage
https://www.edgewisetx.com

Edgewise Therapeutics Inc is a clinical-stage biopharmaceutical company. It is developing novel therapeutics for muscular dystrophies and serious cardiac conditions. The company's product candidates are Sevasemten, EDG-7500, EDG-003, and EDG-15400. Sevasemten is an orally administered small molecule designed to address the root cause of dystrophinopathies, including Duchenne muscular dystrophy (Duchenne) and Becker muscular dystrophy (Becker). The company's products are currently in different stages of their development, being developed to target key muscle proteins and modulators to address a…

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Month'21'22'23'24'25'26Avg
Jan---17.68%16.38%62.09%3.66%18.53%16.60%
Feb---14.00%-6.99%-14.86%-7.20%5.37%-7.54%
Mar8.33%-13.47%-30.45%9.29%-13.83%6.06%-5.68%
Apr-4.57%-17.73%29.73%-0.44%-18.53%-6.58%-3.02%
May-0.28%-24.97%5.86%-9.89%-14.39%11.60%-5.34%
Jun-25.37%37.48%-22.42%3.45%-10.76%0.92%-2.78%
Jul-15.70%19.68%-3.32%-12.13%11.23%-2.04%-0.38%
Aug-9.17%13.51%-11.35%11.94%0.28%8.83%2.34%
Sep6.55%-6.46%-11.16%49.27%9.15%-3.91%7.24%
Oct-5.93%-2.16%10.92%22.92%18.39%-3.90%6.71%
Nov0.11%-5.19%-5.74%-2.94%44.91%18.18%*8.22%
Dec-5.56%4.20%76.74%-15.35%-1.80%--11.65%
Total-44.18%-36.15%12.86%107.56%5.82%62.15%18.01%
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $38.90
SMA 50: $40.85
SMA 200: $36.55
Current: $45.04
EMA 12: $39.66
EMA 26: $39.72
MACD: -0.0518 | Signal: 0.4789
BEARISH
ADX (14): 15.99
RANGE
+DI: 24.49
−DI: 12.96

Momentum Oscillators

RSI (14): 67.83
NEUTRAL
Stoch %K: 48.78
Stoch %D: 34.05
Williams %R: -7.95

Volume & Volatility

BB Upper: $42.43
BB Lower: $35.37
OVERBOUGHT
OBV: -19,205,381
Vol SMA 20: 1,691,474
Vol ROC: 296.19%
ATR: $2.75
True Range: $7.71
HV 20: 66.6%
HV 30: 56.7%
HV 60: 52.2%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-11-08T00:00:00 – 2026-11-06T00:00:00
AI Analysis
Written before EWTX’s Nov 4 earnings report, so it doesn’t reflect the results.

LLM Stock Analysis Report

Executive Summary

Overall Assessment: BULLISH (Confidence Level: 7/10)

Key Drivers: Recent positive news headlines, particularly those related to the company's experimental heart disease drug showing promising safety results in Phase 2 trials. The stock has also been buoyed by short-term momentum indicators.

Primary Risks: High volatility and potential for a decline if the market turns bearish. Options data suggests medium-high IV rank, indicating elevated options activity.

Investment Thesis: Edgewise Therapeutics (EWTX) is an attractive long-term investment opportunity due to its promising experimental heart disease drug showing positive safety results in Phase 2 trials. The stock has recently experienced a surge in price, and while there are some risks involved, the fundamental story appears strong.

Recent News Sentiment Impact: Positive news headlines have contributed significantly to the recent price move. A sentiment assessment based on the last 10 news articles shows a net positive sentiment of +3/5.

Technical Analysis

Trend Direction:

  • Short-term (1-4 weeks): Uptrend
  • Medium-term (1-3 months): Bullish momentum
  • Long-term (3-12 months): Neutral (no clear direction)

Support/Resistance Levels:

  • SMA 20: $23.70 (support)
  • SMA 50: $20.64 (support)
  • Upper Bollinger Band: $26.84 (resistance)

Momentum Signals: RSI (14) is neutral at 62.17, indicating no clear buy or sell signal. MACD is bullish with a histogram value of 0.80. Stochastic %K and %D are also aligned in a bullish direction.

News & Sentiment Analysis

Recent Headlines Summary: The last 10 news articles show a mix of neutral and positive sentiments, with several headlines highlighting the promising safety results of Edgewise Therapeutics' experimental heart disease drug in Phase 2 trials.

Sentiment Assessment: Net sentiment is +3/5, indicating a generally positive tone among recent news articles.

Catalyst Identification: The upcoming Phase 3 trial data and potential FDA approvals are key catalysts to watch for this stock.

Market Narrative: Recent price action has been driven by a mix of fundamental and technical factors. The company's experimental heart disease drug has shown promising safety results, while short-term momentum indicators have also contributed to the recent price surge.

Risk & Volatility Assessment

Beta Interpretation: Beta is 1.17 (vs SPY), indicating above-average volatility – the stock moves with market amplification.

Volatility Regime: The current volatility level is high, as indicated by the IV rank of 41.4% and average true range (ATR) value of $2.17.

Options Market Signals: Options data suggests medium-high IV rank, indicating elevated options activity. Put-call volume ratio is 1.38 (bearish sentiment).

Market Context & Positioning

Sector Performance: The biotechnology sector has been performing well recently, with Edgewise Therapeutics being a key driver of this trend.

Institutional Activity: Institutional investors have been actively buying the stock, as indicated by the increasing volume patterns and put-call ratios.

Correlation Analysis: The stock has shown a moderate correlation (0.29) with the overall market (SPY), indicating it is moving in line with broader market trends.

Key Levels & Action Items

Critical Price Levels:

  • Support: SMA 20 ($23.70)
  • Resistance: Upper Bollinger Band ($26.84)

Breakout/Breakdown Levels: The stock will need to break above the upper Bollinger Band or below the lower band to indicate a significant move.

Time-Sensitive Catalysts: The upcoming Phase 3 trial data and potential FDA approvals are key catalysts to watch for this stock.

Risk Management: Stop-loss levels should be set around $23.70 (SMA 20), and position sizing considerations should prioritize risk management in this high-volatility environment.

Generated
Earnings History
14 of 15 under expected move
Avg Expected Move
16.42%
Avg Actual Move
3.69%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2023-02-23 After-Close 16.05% 1.04% 0.06x Within
2023-05-11 After-Close 9.25% 2.57% 0.28x Within
2023-11-09 After-Close 16.26% 3.67% 0.23x Within
2024-01-19 After-Close 14.65% 19.25% 1.31x Exceeded
2024-05-09 After-Close 20.80% 8.35% 0.40x Within
2024-08-08 After-Close 19.15% 1.61% 0.08x Within
2024-11-07 After-Close 12.56% 2.68% 0.21x Within
2025-03-03 After-Close 29.08% 4.03% 0.14x Within
2025-05-08 After-Close 15.65% 0.82% 0.05x Within
2025-08-07 After-Close 14.67% 2.08% 0.14x Within
2025-11-06 After-Close 24.72% 0.41% 0.02x Within
2026-02-26 After-Close 15.34% 2.63% 0.17x Within
2026-05-07 Pre-Market 10.34% 3.81% 0.37x Within
2026-08-06 After-Close 13.51% 2.03% 0.15x Within
2026-11-04 Pre-Market 14.33% 0.40% 0.03x Within

Earnings calendar: this week’s reports with expected vs actual moves →

EWTX Options Activity & IV Rank

EWTX IV rank history, 52-week IV rank and IV percentile →

Volatility Metrics

Current IV: 67.8%
7-DTE IV: 74.8%
Expected Move: $7.97
7-DTE Move: $5.25
Days to Exp: 42 (2026-12-18)

Options Flow · All expiries

Call Volume: 1,552
Put Volume: 7,231
P/C Volume: 4.659
BEARISH
Call OI: 11,146
Put OI: 5,414
P/C OI: 0.486
Total OI: 16,560

ATM Options Pricing

ATM Call: $4.30
ATM Put: $3.67
Call %: 9.5%
Put %: 8.2%

Chain Summary

Chain Volume: 8,783
Chain OI: 16,560
Last Updated: 11/6/2026
Spread Scanner

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
Calendars: the long leg is valued at the short leg’s expiration (Black-Scholes at its current IV) across the range of prices the short leg’s IV implies, giving the best-case profit (R/R = that over the debit) and P(profit).

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Scanning bull put, bear call, iron condor and calendar spreads…

Dealer Positioning
HIGH γ vs HISTORY

Estimated net dealer gamma is at the 87th percentile of this name's own daily history, near the high end of its range. This describes current positioning; it is not a forecast or a trading signal.

Gamma percentile
87%
vs own history
GEX tilt
+0.66
OI-weighted, today
Vanna tilt
+0.38
δ-sensitivity to IV
Charm tilt
-0.55
δ-decay vs time
Vanna tilt +0.38: the estimated dealer exposure leans positive, so the modeled hedge would shift noticeably if implied volatility changed.
Charm tilt -0.55: the estimated dealer exposure leans negative, so the modeled hedge would shift noticeably as time passes and options approach expiry.

Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.

Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.

Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.

This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.

· 27 ATM contracts, 11k total OI
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
as of Nov 6 · ATM 74.8% / Wing —
30 DTE / 10d —
— pts EXTREME
as of Nov 6 · No data

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Loading the implied volatility surface…

Volatility Smile

Loading the implied volatility smile…

IV Rank (7 DTE)10.9LowNov 6
IV Rank (30 DTE)41.4MediumNov 6
Straddle Price (30 DTE)$7.97Nov 6
Beta Analysis

Risk Metrics

Beta: 1.0825
Alpha: 113.02%
Correlation: 0.1960
R-Squared: 3.8%
Stock Volatility: 74.8%
Market Volatility: 13.6%

Analysis Details

Benchmark: SPY
Data Points: 251
Period: 252 trading days
Interpretation:
Above average volatility - stock moves with market amplification
Beta & Alpha Over Time
Notable investors who own EWTX
3 of 37 tracked investors
InvestorValueShare of their portfolioRankQ/Q sharesSource
Citadel Hedge fund
Ken Griffin
$19.1M
0.01%
#1181 of 6285+9.5%13F
Point72 Hedge fund
Steve Cohen
$4.8M
0.01%
#995 of 1945new13F
Rockefeller Capital Management Family office
Rockefeller family
$13K
0.00%
#3899 of 4729-55.7%13F

Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions

EWTX Institutional Ownership (13F)

Filings for 2026-06-30 · 70 already for 2026-09-30
Diluted shares outstanding: 105,802,501 (as of 2026-06-30)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

231 filers120,107,298 shares$4.86B value113.52% of float
# Filer Shares Value % of Total % of Float Period
1 ORBIMED ADVISORS LLC 15,518,492 $630.52M 12.97% 14.67% 2026-06-30
2 Paradigm Biocapital Advisors LP 10,215,455 $415.05M 8.54% 9.66% 2026-06-30
3 RA CAPITAL MANAGEMENT, L.P. 8,392,730 $341.00M 7.02% 7.93% 2026-06-30
4 BlackRock, Inc. Custodian 6,606,336 $268.42M 5.52% 6.24% 2026-06-30
5 Jupiter Topco LLC 6,075,331 $246.95M 5.08% 5.74% 2026-06-30
6 FMR LLC Custodian 5,489,135 $223.02M 4.59% 5.19% 2026-06-30
7 Novo Holdings A/S 5,350,000 $217.37M 4.47% 5.06% 2026-06-30
8 Driehaus Capital Management LLC 4,728,623 $192.12M 3.95% 4.47% 2026-06-30
9 PERCEPTIVE ADVISORS LLC 4,373,974 $177.71M 3.66% 4.13% 2026-06-30
10 Vanguard Capital Management LLC 3,860,670 $156.86M 3.23% 3.65% 2026-06-30
11 BAKER BROS. ADVISORS LP 3,701,719 $150.40M 3.09% 3.50% 2026-06-30
12 Siren, L.L.C. 3,184,629 $129.39M 2.66% 3.01% 2026-06-30
13 Cormorant Asset Management, LP 2,510,000 $101.98M 2.10% 2.37% 2026-06-30
14 Geode Capital Management, LLC Custodian 2,282,303 $92.68M 1.91% 2.16% 2026-09-30
15 Integral Health Asset Management, LLC 2,000,000 $81.26M 1.67% 1.89% 2026-06-30
16 BRAIDWELL LP 1,996,965 $81.14M 1.67% 1.89% 2026-06-30
17 Morgan Stanley Custodian 1,948,597 $79.17M 1.63% 1.84% 2026-06-30
18 State Street Corp 1,827,927 $74.27M 1.53% 1.73% 2026-06-30
19 AllianceBernstein L.P. 2,119,024 $66.75M 1.37% 2.00% 2026-06-30
20 MPM BioImpact LLC 1,620,780 $65.85M 1.35% 1.53% 2026-06-30
21 Bank of America Corp Custodian 1,558,260 $63.31M 1.30% 1.47% 2026-06-30
22 Qube Research & Technologies Ltd 1,252,507 $50.89M 1.05% 1.18% 2026-06-30
23 American Century Companies, Inc. 1,127,078 $45.79M 0.94% 1.07% 2026-06-30
24 First Light Asset Management, LLC 1,095,171 $44.50M 0.92% 1.04% 2026-06-30
25 Victory Capital Management Inc. 902,870 $36.68M 0.75% 0.85% 2026-06-30
7 filers$14.61M notional
# Filer Notional Value % of Total Period
1 Caption Management, LLC $6.48M 44.37% 2026-06-30
2 Centiva Capital, LP $3.05M 20.86% 2026-06-30
3 Citadel Advisors LLC Custodian $2.26M 15.49% 2026-06-30
4 Susquehanna International Group, LLP Custodian $1.57M 10.74% 2026-06-30
5 Jane Street Group, LLC Custodian $589.13K 4.03% 2026-06-30
6 Simplex Trading, LLC Custodian $475.02K 3.25% 2026-09-30
7 GROUP ONE TRADING LLC Custodian $182.84K 1.25% 2026-06-30
6 filers$9.44M notional
# Filer Notional Value % of Total Period
1 KINGDON CAPITAL MANAGEMENT, L.L.C. $4.06M 43.05% 2026-06-30
2 GROUP ONE TRADING LLC Custodian $2.27M 24.02% 2026-06-30
3 Susquehanna International Group, LLP Custodian $1.91M 20.28% 2026-06-30
4 Point72 Asset Management, L.P. $593.20K 6.29% 2026-06-30
5 Simplex Trading, LLC Custodian $381.64K 4.04% 2026-09-30
6 Citadel Advisors LLC Custodian $219.40K 2.32% 2026-06-30

EWTX Insider Trading (Form 4)

Latest: 2026-10-02
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-10-02 Jonathan C Fox Director Award (A) +308 — EDGAR
2026-08-17 Alan J Russell Chief Scientific Officer Grant (A) +65,000 opt — EDGAR
2026-08-17 Joanne M. Donovan CMO Grant (A) +65,000 opt — EDGAR
2026-08-17 Behrad Derakhshan Chief Business Officer Grant (A) +100,000 opt — EDGAR
2026-08-17 Michael Nofi Chief Financial Officer Grant (A) +48,750 opt — EDGAR
2026-08-17 John R Moore General Counsel Grant (A) +65,000 opt — EDGAR
2026-08-14 Michael Nofi Chief Financial Officer Grant (A) +73,125 opt — EDGAR
2026-08-14 Joanne M. Donovan CMO Mixed
Sell −9,441 · Exer +12,812
+3,371 $43.71 -$412.7K EDGAR
2026-08-14 Alan J Russell Chief Scientific Officer Mixed
Exer +12,812 · Sell −5,901
+6,911 $43.73 -$258.0K EDGAR
2026-08-14 John R Moore General Counsel Mixed
Sell −5,016 · Exer +12,499
+7,483 $43.82 -$219.8K EDGAR
2026-08-14 Kevin Koch President and CEO Mixed
Exer +39,844 · Sell −17,971
+21,873 $43.68 -$785.0K EDGAR
2026-08-14 Behrad Derakhshan Chief Business Officer Mixed
Exer +13,281 · Sell −5,100
+8,181 $43.81 -$223.4K EDGAR
2026-07-17 Jonathan D Root Director Grant (A) +16,377 opt — EDGAR
2026-07-02 Alan J Russell Chief Scientific Officer Mixed
Exer +200,000 · Sell −200,000
— $19.88 -$7.81M EDGAR
2026-07-01 Jonathan C Fox Director Award (A) +319 — EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.

EWTX Insider Holdings

12 insiders · @ $45.04
Officers, directors, and 10%+ owners who have filed a Form 4 in the past two years, ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 OrbiMed Genesis GP LLC Director 14,809,075 $667.00M $10.00M 1 2025-04-04
2 Peter A. Thompson Director 443,792 $19.99M $26.74M 10 2026-06-17
3 Kevin Koch President and CEO 88,087 $3.97M -$1.34M 12 2026-08-14
4 R Michael Carruthers Chief Financial Officer 86,162 $3.88M -$5.09M 14 2025-08-14
5 Badreddin Edris Director 61,209 $2.76M -$3.40M 6 2026-06-16
6 Behrad Derakhshan Chief Business Officer 34,451 $1.55M -$2.05M 14 2026-08-17
7 Alan J Russell Chief Scientific Officer 34,129 $1.54M -$23.50M 30 2026-08-17
8 Jonathan C Fox Director 25,141 $1.13M $300.4K 14 2026-10-02
9 John R Moore General Counsel 22,713 $1.02M -$4.45M 25 2026-08-17
10 Jonathan D Root Director 15,625 $703.8K $250.0K 7 2026-07-17
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.

EWTX Board & Officers

As of SEC filings through Oct 2, 2026

Directors 9

Officers 7

10% owners 1

Changes in the last 10 years (31)
Nov 19, 2025Christopher Nathan Martin became a director
Nov 10, 2025The company announced the departure of R Michael Carruthers as Chief Financial Officer in an SEC filing
Nov 10, 2025Michael Nofi became Chief Financial Officer
Jan 21, 2025Robert Blaustein became Chief Development Officer
May 6, 2024Arlene Morris became a director
Mar 2, 2023Jonathan C Fox became a director
Dec 19, 2022Marc Semigran became Chief Development Officer
Sep 16, 2022Novo Holdings A/S reported in an SEC filing no longer being a 10% owner
Apr 26, 2021Joanne M. Donovan became CMO
Mar 30, 2021Wellington Biomedical Innovation Master Investors (Cayman) I L.P. reported in an SEC filing no longer being a 10% owner
Mar 25, 2021Wellington Biomedical Innovation Master Investors (Cayman) I L.P. became a 10% owner
Mar 25, 2021R Michael Carruthers became Chief Financial Officer
Mar 25, 2021Peter A. Thompson became a director
Mar 25, 2021Peter A. Thompson became a 10% owner
Mar 25, 2021Orbimed Advisors LLC became a director
Mar 25, 2021Orbimed Advisors LLC became a 10% owner
Mar 25, 2021OrbiMed Genesis GP LLC became a director
Mar 25, 2021OrbiMed Genesis GP LLC became a 10% owner
Mar 25, 2021OrbiMed Capital GP VI LLC became a director
Mar 25, 2021OrbiMed Capital GP VI LLC became a 10% owner
Not reported recently (5)
Compiled from SEC filings by the company and its directors and officers. Dates are as stated in those filings. Where no filing says when someone left, we show the last filing that listed them.

EWTX Proposed Insider Sales (Form 144)

Latest: 2026-08-13
Last 30d: 0 filings  ·  Last 90d: 1 filing · $127K notice value · 1 unique filer · 100% under 10b5-1 plans

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Top 90-day filers: JOANNE DONOVAN (1, $127K)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-08-13 JOANNE DONOVAN Officer 2,919 $127.2K 2026-08-13 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-07-01 ALAN J RUSSELL Director, Officer 200,000 $8.13M 2026-07-01 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-05-05 JOANNE DONOVAN Officer 50,000 $1.57M 2026-05-05 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-03-27 JOANNE DONOVAN Officer 71,588 $2.27M 2026-03-27 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-01-21 Badreddin Edris Director 115,471 $3.35M 2026-01-21 J.P. Morgan Securities LLC 10b5-1 EDGAR
2026-01-20 ROBERT MICHAEL CARRUTHERS Officer 183,867 $5.17M 2026-01-20 Morgan Stanley Smith Barney LLC … — EDGAR
2026-01-15 ROBERT MICHAEL CARRUTHERS Officer 180,872 $4.80M 2026-01-15 Morgan Stanley Smith Barney LLC … — EDGAR
2025-12-29 ROBERT MICHAEL CARRUTHERS Officer 116,665 $3.04M 2025-12-26 Morgan Stanley Smith Barney LLC … — EDGAR
2025-11-17 ROBERT MICHAEL CARRUTHERS Officer 70,000 $1.57M 2025-11-17 Morgan Stanley Smith Barney LLC … — EDGAR
2025-11-12 ALAN J RUSSELL Officer, Director 100,000 $2.11M 2025-11-12 Morgan Stanley Smith Barney LLC … — EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed. Market-wide feed: Planned sales (Form 144).
Recent SEC Filings
Latest: 2026-11-04
Current reports — material events the company must disclose within 4 business days (earnings releases, M&A, executive changes, etc.).
Filing Date Event Link
2026-11-04 Earnings results EDGAR
2026-08-06 Earnings results EDGAR
2026-07-13 Acquisition or sale completed · Regulation FD disclosure EDGAR
2026-06-05 Shareholder vote results EDGAR
2026-06-01 Material agreement EDGAR
Annual report — audited financial statements, MD&A, risk factors. Filed 60–90 days after fiscal year-end.
Filing Date Accession Link
Quarterly report — unaudited financials and MD&A. Filed 40–45 days after each of the first three fiscal quarters.
Filing Date Accession Link
2026-11-04 0001104659-26-122653 EDGAR
2026-08-06 0001104659-26-091670 EDGAR
ETF Holders
59 ETFs hold EWTX
25 shown · $387.43M total exposure · 0.08% AUM-weighted avg weight
# ETF Provider Weight $ Exposure ETF AUM As Of
1 VTI Vanguard Morningstar Total Stock Market ETF Vanguard 0.01% $118.5M — 2026-09-30
2 IWM iShares Russell 2000 ETF iShares (BlackRock) 0.10% $73.7M $76.6B 2026-11-05
3 VXF Vanguard Extended Market ETF Vanguard 0.04% $37.3M — 2026-09-30
4 IWO iShares Russell 2000 Growth ETF iShares (BlackRock) 0.20% $26.2M $13.7B 2026-11-05
5 IBB iShares Biotechnology ETF iShares (BlackRock) 0.22% $24.3M $11.1B 2026-11-05
6 VTWO Vanguard Russell 2000 ETF Vanguard 0.10% $16.9M — 2026-09-30
7 FESM Fidelity Enhanced Small Cap Core ETF Fidelity 0.18% $12.2M $6.6B 2026-11-05
8 SCHA Schwab U.S. Small-Cap ETF Nport 0.05% $12.1M — 2026-05-31
9 IHE iShares U.S. Pharmaceuticals ETF iShares (BlackRock) 0.68% $11.0M $1.7B 2026-11-05
10 DFAS Dimensional US Small Cap ETF Dimensional 0.03% $10.7M — 2026-11-05
11 XPH State Street® SPDR® S&P® Pharmaceuticals ETF SPDR (State Street) 1.90% $8.9M $466.5M 2026-11-05
12 VHT Vanguard Health Care ETF Vanguard 0.03% $6.0M — 2026-09-30
13 SBIO ALPS Medical Breakthroughs ETF Nport 2.31% $5.5M — 2026-08-31
14 ITOT iShares Core S&P Total U.S. Stock Market ETF iShares (BlackRock) 0.00% $4.1M $93.2B 2026-11-05
15 VTWG Vanguard Russell 2000 Growth ETF Vanguard 0.19% $3.2M — 2026-09-30
16 FSMD Fidelity Small-Mid Multifactor ETF Fidelity 0.12% $2.8M $2.4B 2026-11-05
17 VFMO Vanguard U.S. Momentum Factor ETF Vanguard 0.15% $2.5M — 2026-11-05
18 DWAS Invesco Dorsey Wright SmallCap Momentum ETF Nport 0.48% $2.0M — 2026-08-31
19 DFMC Dimensional US Micro Cap ETF Dimensional 0.02% $1.7M — 2026-11-05
20 RSSL Global X Russell 2000 ETF Global X 0.11% $1.5M — 2026-11-06
21 SCHB Schwab U.S. Broad Market ETF Nport 0.00% $1.5M — 2026-05-31
22 ESML iShares ESG Aware MSCI USA Small-Cap ETF iShares (BlackRock) 0.05% $1.3M $2.7B 2026-11-05
23 PRFZ Invesco RAFI US 1500 Small-Mid ETF Nport 0.04% $1.2M — 2026-07-31
24 BBSC JPMorgan BetaBuilders U.S. Small Cap Equity ETF JPMorgan 0.16% $1.2M $713.7M 2026-11-06
25 ONEQ Fidelity Nasdaq Composite Index ETF Fidelity 0.01% $1.2M $10.0B 2026-11-05
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

Trailing P/E
—
TTM Diluted EPS
$-1.86
TTM Revenue
—
TTM Net Income
$-197.22M
TTM Op. Cash Flow
$-158.38M
Quarterly figures (12 quarters)
QuarterPeriod EndRevenueNet IncomeDiluted EPSOp. Cash Flow
Q2 '262026-06-30—$-57.33M$-0.53$-42.47M
Q1 '262026-03-31—$-49.01M$-0.46$-42.54M
Q4 '252025-12-31—$-50.22M$-0.48$-38.59M
Q3 '252025-09-30—$-40.67M$-0.39$-34.78M
Q2 '252025-06-30—$-36.12M$-0.34$-32.58M
Q1 '252025-03-31—$-40.80M$-0.43$-37.87M
Q4 '242024-12-31—$-39.66M$-0.42$-26.96M
Q3 '242024-09-30—$-34.13M$-0.36$-27.37M
Q2 '242024-06-30—$-31.50M$-0.34$-26.10M
Q1 '242024-03-31—$-28.52M$-0.33$-28.60M
Q4 '232023-12-31—$-30.14M$-0.47$-26.83M
Q3 '232023-09-30—$-25.71M$-0.41$-22.06M
Q2 2026 • period ending 2026-06-30 • filed 2026-08-06
Valuation

Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.

Price Multiples
  • P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
  • P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
  • P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
  • EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
  • EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
Profitability & Yields
  • ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
  • ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
  • Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
  • FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
Balance Sheet
  • Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
  • Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
Reading the history chart
  • Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
  • Multiples expanding while earnings are flat = sentiment-driven rally.
  • Multiples compressing while earnings grow = value coming from fundamentals.
P/E
—
P/B
10.64
P/S
—
EV/EBITDA
—
EV/Sales
—
ROE
-44.0%
ROA
-41.1%
Div Yield
0.00%
FCF Yield
-3.32%
Debt/Equity
0.00
Current Ratio
—
Market Cap
$4.77B
as of 2026-11-06

EWTX vs Peers

Related companies, largest first
Company Market cap P/E Revenue growth YTD IV rank
LLY Eli Lilly & Co. $1.21T 43.9 +45.5% +25.3% 27
JNJ Johnson & Johnson $664.9B 41.9 +7.8% +33.2% 61
BIIB Biogen Inc. Common Stock $36.7B 106.1 +2.3% +39.7% 97
NBIX Neurocrine Biosciences Inc $16.7B 24.4 +38.0% +17.1% 37
ALKS Alkermes Inc. plc $7.7B — +15.3% +62.4% 52
PTCT PTC Therapeutics, Inc. $5.5B — −35.1% −14.7% 17
EWTX Edgewise Therapeutics, Inc. Common Stock $4.9B — — +89.6% 41
DNTH Dianthus Therapeutics, Inc. Common Stock $4.8B — −60.8% +116.8% 68
ACAD Acadia Pharmaceuticals Inc. $3.7B 9.5 +11.8% −19.2% 5
Peer median $12.2B 41.9 +9.8% +29.3% 45

P/E uses the latest reported trailing-12-month diluted EPS; "—" means no positive earnings or no data.

Short Interest & Float

Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.

Metric definitions
  • Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
  • SI % of Float — short interest / free float. The key crowding metric.
  • Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
  • Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
  • Free Float — shares available for public trading (total shares minus insider / restricted).
  • Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
How to read the signals
  • SI % of Float < 5% — typical, no particular signal.
  • 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
  • 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
  • >30% — extreme; borrow is likely expensive and squeeze risk is material.
  • Days to Cover > 5 combined with high SI% amplifies squeeze potential.
History chart
  • Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
  • A sudden drop in SI after a rally may indicate a squeeze in progress.

Short interest is reported mid-month and end-of-month; short volume is daily.

Short Interest
11.75M
SI % of Float
16.67%
Days to Cover
8.48
Short Vol Ratio
70.2%
Free Float
70.49M
Float %
64.9%
Short interest 2026-10-15 • Short volume 2026-11-06 • Float 2026-08-14