PERCEPTIVE ADVISORS LLC — 13F Holdings & Portfolio
CIK 1224962 · latest 13F-HR filed 2026-08-14
PERCEPTIVE ADVISORS LLC manages $6.66B in 13F-reported U.S. long-equity assets across 109 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are PRAX (10.23%), SYRE (5.76%), CELC (5.02%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 23 new positions and exited 13; 46 existing positions rose in reported value and 23 fell.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
Long-equity book
Distinct positions
Filed 2026-08-14
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.
Top Adds (vs prior quarter)
- SPYRE THERAPEUTICS INC$192.7M +101.0%
- RELAY THERAPEUTICS INC$166.9M +172.0%
- TRAVERE THERAPEUTICS INC$90.1M +73.2%
- TANGO THERAPEUTICS INC$88.7M +524.4%
- RHYTHM PHARMACEUTICALS INC$80.7M +39.1%
Top Trims
- NAUTILUS BIOTECHNOLOGY INC-$27.1M -55.5%
- ABIVAX SA-$26.8M -73.1%
- DYNE THERAPEUTICS INC-$24.9M -29.4%
- CELCUITY INC-$22.4M -6.3%
- GUARDANT HEALTH INC-$21.5M -77.6%
New Positions
- ASCENDIS PHARMA A/S$310.4M
- KARDIGAN INC$195.6M
- AVALYN PHARMACEUTICALS INC$88.1M
- BIOGEN INC$59.7M
- UNITEDHEALTH GROUP INC$48.5M
Exited Positions
- ASCENDIS PHARMA A/S$350.3M
- CENTESSA PHARMACEUTICALS PLC$208.9M
- ENGENE HOLDINGS INC$39.7M
- DAY ONE BIOPHARMACEUTICALS I$37.6M
- BRIGHT MINDS BIOSCIENCES INC$27.5M
PERCEPTIVE ADVISORS LLC Holdings (2026-06-30)
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | PRAXIS PRECISION MEDICINES I | PRAX | 74006W207 | $681.6M | 10.23% | 2,035,986 | SH |
| 2 | SPYRE THERAPEUTICS INC | SYRE | 00773J202 | $383.5M | 5.76% | 4,319,496 | SH |
| 3 | CELCUITY INC | CELC | 15102K100 | $334.5M | 5.02% | 3,197,200 | SH |
| 4 | ASCENDIS PHARMA A/S | ASND | K08588103 | $310.4M | 4.66% | 1,163,721 | SH |
| 5 | RHYTHM PHARMACEUTICALS INC | RYTM | 76243J105 | $287.2M | 4.31% | 2,586,295 | SH |
| 6 | ROIVANT SCIENCES LTD | ROIV | G76279101 | $286.1M | 4.30% | 8,085,461 | SH |
| 7 | RELAY THERAPEUTICS INC | RLAY | 75943R102 | $263.9M | 3.96% | 14,106,187 | SH |
| 8 | TRAVERE THERAPEUTICS INC | TVTX | 89422G107 | $213.2M | 3.20% | 3,752,574 | SH |
| 9 | KARDIGAN INC | KARD | 485925101 | $195.6M | 2.94% | 8,200,662 | SH |
| 10 | NUVALENT INC | NUVL | 670703107 | $195.2M | 2.93% | 1,580,505 | SH |
| 11 | EDGEWISE THERAPEUTICS INC | EWTX | 28036F105 | $177.7M | 2.67% | 4,373,974 | SH |
| 12 | APOGEE THERAPEUTICS INC | APGE | 03770N101 | $173.6M | 2.61% | 1,308,113 | SH |
| 13 | AMYLYX PHARMACEUTICALS INC | AMLX | 03237H101 | $149.7M | 2.25% | 8,334,882 | SH |
| 14 | MEIRAGTX HLDGS PLC | MGTX | G59665102 | $145.7M | 2.19% | 10,786,658 | SH |
| 15 | ORUKA THERAPEUTICS INC | ORKA | 687604108 | $128.0M | 1.92% | 1,345,063 | SH |
| 16 | INHIBRX BIOSCIENCES INC | INBX | 45720N103 | $123.0M | 1.85% | 1,297,763 | SH |
| 17 | PROTAGONIST THERAPEUTICS INC | PTGX | 74366E102 | $120.4M | 1.81% | 981,879 | SH |
| 18 | SOLID BIOSCIENCES INC | SLDB | 83422E204 | $118.9M | 1.79% | 11,906,646 | SH |
| 19 | ZYMEWORKS INC | ZYME | 98985Y108 | $109.3M | 1.64% | 4,182,953 | SH |
| 20 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $105.6M | 1.58% | 3,377,000 | SH |
| 21 | IMMATICS N.V | IMTX | N44445109 | $105.2M | 1.58% | 10,383,456 | SH |
| 22 | NURIX THERAPEUTICS INC | NRIX | 67080M103 | $104.8M | 1.57% | 4,320,422 | SH |
| 23 | BIOCRYST PHARMACEUTICALS INC | BCRX | 09058V103 | $103.1M | 1.55% | 10,308,888 | SH |
| 24 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $98.8M | 1.48% | 527,600 | SH |
| 25 | AVALYN PHARMACEUTICALS INC | AVLN | 05348Y105 | $88.1M | 1.32% | 2,675,296 | SH |
| 26 | MODERNA INC Put | MRNA | 60770K107 | $70.0M | 1.05% | 1,000,000 | SH |
| 27 | DYNE THERAPEUTICS INC | DYN | 26818M108 | $59.7M | 0.90% | 2,689,235 | SH |
| 28 | BIOGEN INC | BIIB | 09062X103 | $59.7M | 0.90% | 276,173 | SH |
| 29 | IMMUNOVANT INC | IMVT | 45258J102 | $52.3M | 0.79% | 1,357,383 | SH |
| 30 | UNITEDHEALTH GROUP INC | UNH | 91324P102 | $48.5M | 0.73% | 116,806 | SH |
| 31 | SPDR SERIES TRUST Put | XBI | 78464A870 | $47.5M | 0.71% | 300,000 | SH |
| 32 | IONIS PHARMACEUTICALS INC | IONS | 462222100 | $44.9M | 0.67% | 566,000 | SH |
| 33 | SUTRO BIOPHARMA INC | STRO | 869367201 | $43.3M | 0.65% | 1,304,846 | SH |
| 34 | ALTO NEUROSCIENCE INC | ANRO | 02157Q109 | $42.5M | 0.64% | 1,609,893 | SH |
| 35 | JAZZ PHARMACEUTICALS PLC | JAZZ | G50871105 | $41.0M | 0.61% | 170,000 | SH |
| 36 | CORVUS PHARMACEUTICALS INC | CRVS | 221015100 | $39.9M | 0.60% | 2,667,441 | SH |
| 37 | SIONNA THERAPEUTICS INC | SION | 829401108 | $39.8M | 0.60% | 905,000 | SH |
| 38 | CYTOMX THERAPEUTICS INC. | CTMX | 23284F105 | $39.1M | 0.59% | 10,439,185 | SH |
| 39 | ARTIVION INC | AORT | 228903100 | $39.0M | 0.59% | 1,737,290 | SH |
| 40 | X4 PHARMACEUTICALS INC | XFOR | 98420X202 | $37.0M | 0.56% | 7,933,491 | SH |
| 41 | CORCEPT THERAPEUTICS INC | CORT | 218352102 | $34.6M | 0.52% | 398,385 | SH |
| 42 | REPLIGEN CORP | RGEN | 759916109 | $33.9M | 0.51% | 248,212 | SH |
| 43 | ANTERIS TECHNOLOGIES GLOBAL | AVR | 03675P102 | $33.7M | 0.51% | 3,425,476 | SH |
| 44 | RAPPORT THERAPEUTICS INC | RAPP | 75383L102 | $32.2M | 0.48% | 773,342 | SH |
| 45 | DAMORA THERAPEUTICS INC | DMRA | 36322Q206 | $31.8M | 0.48% | 1,223,000 | SH |
| 46 | CHARLES RIV LABS INTL INC | CRL | 159864107 | $31.8M | 0.48% | 140,000 | SH |
| 47 | AXSOME THERAPEUTICS INC. | AXSM | 05464T104 | $29.0M | 0.44% | 118,450 | SH |
| 48 | EYEPOINT INC Put | EYPT | 30233G209 | $28.6M | 0.43% | 2,000,000 | SH |
| 49 | DBV TECHNOLOGIES S A | DBVT | 23306J309 | $27.1M | 0.41% | 1,653,350 | SH |
| 50 | IRHYTHM HOLDINGS INC | IRTC | 450056106 | $26.6M | 0.40% | 223,766 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $6.66B | 109 | 0001012975-26-000777 |
| 2026-03-31 | 2026-05-15 | $5.11B | 94 | 0001012975-26-000443 |
| 2026-03-31 | 2026-05-29 | $5.12B | 94 | 0001012975-26-000499 |
| 2025-12-31 | 2026-02-17 | $5.61B | 116 | 0001012975-26-000155 |
| 2025-09-30 | 2025-11-14 | $3.46B | 93 | 0001012975-25-000762 |
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