PERCEPTIVE ADVISORS LLC — 13F Holdings & Portfolio

CIK 1224962 · latest 13F-HR filed 2026-05-29

PERCEPTIVE ADVISORS LLC manages $5.12B in 13F-reported U.S. long-equity assets across 94 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are PRAX (12.82%), CELC (6.97%), ASND (6.84%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 0 new positions, exited 0, added to 1, and trimmed 0.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

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AUM

$5.12B

Long-equity book

Holdings

94

Distinct positions

Period

2026-03-31

Filed 2026-05-29

Q/Q Activity

+0 / −0 / ↑1 / ↓0

vs 2026-03-31

Firm Profile & Key People
Name Title / Status Ownership Type

Top Adds (vs prior quarter)

  • ADAGIO MED HLDGS INC$6.7M +153.3%
Show all 1

Top Trims

  • No decreased positions.
Show all 0

New Positions

  • No new positions this quarter.
Show all 0

Exited Positions

  • No exits this quarter.
Show all 0
All Holdings

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 PRAXIS PRECISION MEDICINES I PRAX 74006W207 $656.0M 12.82% 2,035,986 SH
2 CELCUITY INC CELC 15102K100 $356.9M 6.97% 3,127,200 SH
3 ASCENDIS PHARMA A/S ASND 04351P101 $350.3M 6.84% 1,531,421 SH
4 ROIVANT SCIENCES LTD ROIV G76279101 $229.5M 4.48% 8,285,461 SH
5 CENTESSA PHARMACEUTICALS PLC CNTA 152309100 $208.9M 4.08% 5,258,903 SH
6 RHYTHM PHARMACEUTICALS INC RYTM 76243J105 $206.4M 4.03% 2,373,795 SH
7 SPYRE THERAPEUTICS INC SYRE 00773J202 $190.8M 3.73% 3,783,225 SH
8 NUVALENT INC NUVL 670703107 $161.9M 3.16% 1,580,505 SH
9 EDGEWISE THERAPEUTICS INC EWTX 28036F105 $139.4M 2.72% 4,423,974 SH
10 PROTAGONIST THERAPEUTICS INC PTGX 74366E102 $129.7M 2.54% 1,230,879 SH
11 APOGEE THERAPEUTICS INC APGE 03770N101 $129.7M 2.53% 1,540,384 SH
12 TRAVERE THERAPEUTICS INC TVTX 89422G107 $123.1M 2.40% 4,142,551 SH
13 AMYLYX PHARMACEUTICALS INC AMLX 03237H101 $115.2M 2.25% 8,284,882 SH
14 IMMATICS N.V IMTX N44445109 $102.2M 2.00% 10,383,456 SH
15 RELAY THERAPEUTICS INC RLAY 75943R102 $97.0M 1.90% 9,751,141 SH
16 INHIBRX BIOSCIENCES INC INBX 45720N103 $97.0M 1.90% 1,442,707 SH
17 MEIRAGTX HLDGS PLC MGTX G59665102 $89.3M 1.75% 10,326,103 SH
18 ZYMEWORKS INC ZYME 98985Y108 $87.9M 1.72% 3,510,078 SH
19 SOLID BIOSCIENCES INC SLDB 83422E204 $85.7M 1.68% 11,906,646 SH
20 DYNE THERAPEUTICS INC DYN 26818M108 $84.6M 1.65% 4,668,839 SH
21 BIOCRYST PHARMACEUTICALS INC BCRX 09058V103 $70.8M 1.38% 7,434,033 SH
22 ORUKA THERAPEUTICS INC ORKA 687604108 $68.4M 1.34% 1,395,501 SH
23 ARTIVION INC AORT 228903100 $60.0M 1.17% 1,637,290 SH
24 NURIX THERAPEUTICS INC NRIX 67080M103 $57.5M 1.12% 3,710,877 SH
25 MODERNA INC Put MRNA 60770K107 $50.8M 0.99% 1,000,000 SH
26 NAUTILUS BIOTECHNOLOGY INC NAUT 63909J108 $48.9M 0.95% 12,594,211 SH
27 CYTOMX THERAPEUTICS INC. CTMX 23284F105 $47.5M 0.93% 10,098,824 SH
28 ALTO NEUROSCIENCE INC ANRO 02157Q109 $45.2M 0.88% 2,009,893 SH
29 ENGENE HOLDINGS INC ENGNW 29286M105 $39.7M 0.78% 5,827,506 SH
30 IMMUNOVANT INC IMVT 45258J102 $39.7M 0.78% 1,597,383 SH
31 INTUITIVE SURGICAL INC ISRG 46120E602 $39.4M 0.77% 85,419 SH
32 IONIS PHARMACEUTICALS INC IONS 462222100 $37.8M 0.74% 504,000 SH
33 DAY ONE BIOPHARMACEUTICALS I DAWN 23954D109 $37.6M 0.74% 1,755,799 SH
34 ABIVAX SA ABVX 00370M103 $36.6M 0.72% 328,884 SH
35 CORVUS PHARMACEUTICALS INC CRVS 221015100 $33.5M 0.66% 2,292,441 SH
36 REPLIGEN CORP RGEN 759916109 $33.1M 0.65% 280,541 SH
37 JAZZ PHARMACEUTICALS PLC JAZZ G50871105 $32.1M 0.63% 170,000 SH
38 DAMORA THERAPEUTICS INC DMRA 36322Q206 $31.7M 0.62% 1,223,000 SH
39 X4 PHARMACEUTICALS INC XFOR 98420X202 $27.8M 0.54% 6,737,648 SH
40 GUARDANT HEALTH INC GH 40131M109 $27.7M 0.54% 300,000 SH
41 BRIGHT MINDS BIOSCIENCES INC DRUG 10919W405 $27.5M 0.54% 377,544 SH
42 INVIVYD INC IVVD 00534A102 $27.1M 0.53% 20,859,303 SH
43 SIONNA THERAPEUTICS INC SION 829401108 $26.4M 0.52% 658,439 SH
44 AXSOME THERAPEUTICS INC. AXSM 05464T104 $25.3M 0.50% 149,950 SH
45 REVOLUTION MEDICINES INC RVMD 76155X100 $25.1M 0.49% 258,600 SH
46 SAB BIOTHERAPEUTICS INC SABS 78397T202 $24.6M 0.48% 6,431,743 SH
47 BELITE BIO INC BLTE 07782B104 $24.2M 0.47% 151,979 SH
48 TENAX THERAPEUTICS INC TENX 88032L605 $23.2M 0.45% 1,447,782 SH
49 AXOGEN INC AXGN 05463X106 $23.1M 0.45% 697,312 SH
50 VIRIDIAN THERAPEUTICS INC VRDN 92790C104 $22.9M 0.45% 1,170,829 SH
Filing History
Period Filed AUM Holdings Accession
2026-03-31 2026-05-15 $5.11B 94 0001012975-26-000443
2026-03-31 2026-05-29 $5.12B 94 0001012975-26-000499
2025-12-31 2026-02-17 $5.61B 116 0001012975-26-000155
2025-09-30 2025-11-14 $3.46B 93 0001012975-25-000762