Ionis Pharmaceuticals, Inc. Common Stock(IONS)

Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership.

IONS iron condor setups IONS expected move IONS IV rank history IONS Fibonacci levels IONS insider trading

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

IONS $47.25 —
Snapshot
$47.25
52-Week Range
$46.72 – $86.74
YTD
-40.69%
IV Rank (30D)
93.45
Straddle Price
$5.22
P/C Vol Ratio
1.79
Market Cap
$8.5B
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)4.95%
Beta vs SPY0.79
Cost of Equity (CAPM)8.90% (VRP-adj)
WACC8.58%
Volatility Risk Premium+39.4pp (IV − HV30)
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)+30.0%
DCF Horizon10 years explicit + fade
Forward Tilt (NTM/TTM)×1.10 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$-0.6B
Return on Equity (TTM)-128.5%
Book / Price5.3%
Gross Margin (TTM)98.2%
FCF Margin (TTM)-64.2%
Debt / Equity3.01
Quality Score2/6 — normal (10y DCF)
SMA 50$58.67 (Market Anchor value)
SMA 20 / Bollinger Mid$59.09
Bollinger Width / SMA2034.8% (drives anchor stability)
Net Debt$1.0B
Market Cap$8B
Peers used for multiples: ABBV, ALNY, BMY, JNJ, LLY, MRK, REGN, VRTX
Model Conviction
87%
20-Day Fair Value
≈ by Oct 14, 2026
$49.62
α +5.0% rank 68%
40-Day Fair Value
≈ by Nov 12, 2026
$58.87
α +24.6% rank 72%
60-Day Fair Value
≈ by Dec 11, 2026
$54.65
α +15.7% rank 62%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0% median 33.8× · 8 peers
Peer EV/EBITDA n/a 0% median 22.0× · 8 peers
Peer P/B $20.37 19% median 7.5× · 7 peers
Peer P/S $39.85 19% median 6.7× · 8 peers
Market Anchor (SMA50) $58.67 63% stability 66% (BB-width)
Options Expected (B-L 30d) n/a 0%
As of 2026-09-15 · updated
Info
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834)
Exchange
XNAS
Market Cap
$8.5B

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ioni…

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
MonthAvg ReturnYears of Data
Jan -2.05% 11
Feb -1.70% 11
Mar -3.21% 11
Apr +2.12% 11
May -5.33% 11
Jun +5.30% 11
Jul +0.54% 11
Aug +0.84% 11
Sep -2.15% 11
Oct -2.51% 10
Nov +8.93% 10
Dec +0.54% 11
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $58.52
SMA 50: $57.95
SMA 200: $72.74
Current: $47.25
EMA 12: $55.29
EMA 26: $57.31
MACD: -2.0241 | Signal: -1.1891
BEARISH
ADX (14): 27.54
TREND
+DI: 11.55
−DI: 50.04

Momentum Oscillators

RSI (14): 24.14
OVERSOLD
Stoch %K: 7.10
Stoch %D: 16.31
Williams %R: -96.82

Volume & Volatility

BB Upper: $66.50
BB Lower: $50.55
OVERSOLD
OBV: 19,639,914
Vol SMA 20: 3,229,900
Vol ROC: 236.42%
ATR: $2.46
True Range: $4.72
HV 20: 48.3%
HV 30: 45.2%
HV 60: 71.5%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-09-17T00:00:00 – 2026-09-15T00:00:00
AI Analysis

Choose Frenzy-Fast™ for quick analysis or Frenzy-Pro™ for comprehensive analysis.

Analysis includes technical indicators, news sentiment, risk assessment, and specific price levels to watch.

Earnings History
8 of 8 under expected move
Avg Expected Move
10.18%
Avg Actual Move
3.04%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2024-11-06 Pre-Market 9.90% 1.67% 0.17x Within
2025-02-19 Pre-Market 9.03% 0.57% 0.06x Within
2025-04-30 Pre-Market 10.43% 3.91% 0.37x Within
2025-07-30 Pre-Market 12.30% 4.56% 0.37x Within
2025-10-29 Pre-Market 11.32% 2.30% 0.20x Within
2026-02-25 Pre-Market 11.14% 4.81% 0.43x Within
2026-04-29 Pre-Market 7.31% 4.25% 0.58x Within
2026-07-29 Pre-Market 10.04% 2.28% 0.23x Within
Options Activity
IV Rank (30D)
93.45
IV Rank (7D)
100
Avg IV
96.1%
Straddle (30D)
$5.22
Straddle (7D)
$2.33
P/C Volume
1.79
Spread Scanner GPU
Full Algorithm Docs ↗

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
ATM — / Wing —
30 DTE / 10d —
— pts EXTREME
ATM — / Wing —

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)
Straddle Price (30 DTE)
Beta Analysis
Beta (1Y vs SPY)
0.40
Correlation (SPY)
12.4%
R²
0.02
Ann. Volatility
41.0%
SPY Volatility
12.9%

Low volatility - stock moves less than market

Beta & Alpha Over Time
Institutional Ownership (13F)
Latest filings — 2026-06-30
Diluted shares outstanding: 162,517,000 (as of 2026-06-30)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

539 filers791,499,538 shares$15.67B value487.03% of float
# Filer Shares Value % of Total % of Float Period
1 FMR LLC Custodian 31,635,956 $1.96B 12.54% 19.47% 2026-06-30
2 Capital World Investors 21,669,226 $1.72B 10.97% 13.33% 2026-06-30
3 VANGUARD GROUP INC Custodian 16,440,459 $1.30B 8.30% 10.12% 2025-12-31
4 BlackRock, Inc. Custodian 22,129,660 $866.53M 5.53% 13.62% 2026-06-30
5 WELLINGTON MANAGEMENT GROUP LLP Custodian 19,218,415 $624.64M 3.99% 11.83% 2026-06-30
6 VANGUARD PORTFOLIO MANAGEMENT LLC 7,859,529 $623.18M 3.98% 4.84% 2026-06-30
7 VANGUARD CAPITAL MANAGEMENT LLC 7,211,497 $571.80M 3.65% 4.44% 2026-06-30
8 TWO SIGMA INVESTMENTS, LP Custodian 6,252,342 $495.75M 3.16% 3.85% 2026-06-30
9 ROYAL BANK OF CANADA Custodian 6,282,479 $490.37M 3.13% 3.87% 2026-06-30
10 STATE STREET CORP 19,359,848 $367.07M 2.34% 11.91% 2026-06-30
11 GEODE CAPITAL MANAGEMENT, LLC Custodian 3,584,024 $294.75M 1.88% 2.21% 2026-06-30
12 DEERFIELD MANAGEMENT COMPANY, L.P. 61,979,669 $250.07M 1.60% 38.14% 2026-06-30
13 JPMORGAN CHASE & CO Custodian 3,224,717 $217.07M 1.39% 1.98% 2026-06-30
14 Artisan Partners Limited Partnership 2,640,024 $209.33M 1.34% 1.62% 2026-06-30
15 Tweedy, Browne Co LLC 2,280,311 $180.81M 1.15% 1.40% 2026-06-30
16 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME Custodian 42,554,672 $179.23M 1.14% 26.18% 2026-06-30
17 Deep Track Capital, LP 2,200,000 $174.44M 1.11% 1.35% 2026-06-30
18 GOLDMAN SACHS GROUP INC Custodian 2,109,945 $167.30M 1.07% 1.30% 2026-06-30
19 BAKER BROS. ADVISORS LP 2,047,727 $162.36M 1.04% 1.26% 2026-06-30
20 AMERICAN CENTURY COMPANIES INC 1,947,076 $154.38M 0.99% 1.20% 2026-06-30
21 CITADEL ADVISORS LLC Custodian 86,703,284 $153.45M 0.98% 53.35% 2026-06-30
22 TENOR CAPITAL MANAGEMENT Co., L.P. 94,682,000 $147.77M 0.94% 58.26% 2026-06-30
23 FRANKLIN RESOURCES INC Custodian 1,623,377 $128.72M 0.82% 1.00% 2026-06-30
24 BARCLAYS PLC Custodian 1,849,136 $127.50M 0.81% 1.14% 2026-06-30
25 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,605,054 $127.26M 0.81% 0.99% 2026-06-30
29 filers$394.59M notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $103.11M 26.13% 2026-06-30
2 Caption Management, LLC $49.95M 12.66% 2026-06-30
3 JANE STREET GROUP, LLC Custodian $44.05M 11.16% 2026-06-30
4 Ikarian Capital, LLC $31.72M 8.04% 2026-06-30
5 Integral Health Asset Management, LLC $23.79M 6.03% 2026-06-30
6 MILLENNIUM MANAGEMENT LLC Custodian $20.42M 5.17% 2026-06-30
7 CITADEL ADVISORS LLC Custodian $18.43M 4.67% 2026-06-30
8 JPMORGAN CHASE & CO Custodian $13.31M 3.37% 2026-06-30
9 CITIGROUP INC Custodian $12.00M 3.04% 2026-06-30
10 IMC-Chicago, LLC Custodian $10.13M 2.57% 2026-06-30
11 BOOTHBAY FUND MANAGEMENT, LLC $9.49M 2.41% 2026-06-30
12 SIG BROKERAGE, LP $8.52M 2.16% 2026-06-30
13 Lighthouse Investment Partners, LLC $7.93M 2.01% 2026-06-30
14 D. E. Shaw & Co., Inc. Custodian $6.94M 1.76% 2026-06-30
15 GROUP ONE TRADING LLC Custodian $5.71M 1.45% 2026-06-30
16 BANK OF MONTREAL /CAN/ Custodian $4.95M 1.25% 2026-06-30
17 NOMURA HOLDINGS INC $4.71M 1.19% 2026-06-30
18 SIMPLEX TRADING, LLC Custodian $3.39M 0.86% 2026-06-30
19 DLD Asset Management, LP $3.17M 0.80% 2026-06-30
20 J. Goldman & Co LP $3.14M 0.80% 2026-06-30
21 TUDOR INVESTMENT CORP ET AL $2.85M 0.72% 2026-06-30
22 Walleye Capital LLC $2.20M 0.56% 2026-06-30
23 Point72 Asset Management, L.P. $1.61M 0.41% 2026-06-30
24 WOLVERINE TRADING, LLC Custodian $1.55M 0.39% 2025-09-30
25 WOLVERINE ASSET MANAGEMENT LLC $792.90K 0.20% 2026-06-30
20 filers$250.74M notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $65.18M 26.00% 2026-06-30
2 JANE STREET GROUP, LLC Custodian $43.07M 17.18% 2026-06-30
3 CITADEL ADVISORS LLC Custodian $30.65M 12.22% 2026-06-30
4 Caption Management, LLC $27.43M 10.94% 2026-06-30
5 Ikarian Capital, LLC $23.79M 9.49% 2026-06-30
6 JPMORGAN CHASE & CO Custodian $13.31M 5.31% 2026-06-30
7 IMC-Chicago, LLC Custodian $9.90M 3.95% 2026-06-30
8 BOOTHBAY FUND MANAGEMENT, LLC $7.30M 2.91% 2026-06-30
9 SIG BROKERAGE, LP $6.54M 2.61% 2026-06-30
10 SIMPLEX TRADING, LLC Custodian $5.15M 2.05% 2026-06-30
11 LMR Partners LLP $4.08M 1.63% 2026-06-30
12 BARCLAYS PLC Custodian $3.96M 1.58% 2026-06-30
13 WOLVERINE ASSET MANAGEMENT LLC $2.78M 1.11% 2026-06-30
14 GROUP ONE TRADING LLC Custodian $2.25M 0.90% 2026-06-30
15 PEAK6 LLC $1.61M 0.64% 2026-06-30
16 CITIGROUP INC Custodian $1.43M 0.57% 2026-06-30
17 Point72 Asset Management, L.P. $1.10M 0.44% 2026-06-30
18 WOLVERINE TRADING, LLC Custodian $686.40K 0.27% 2025-09-30
19 TUDOR INVESTMENT CORP ET AL $269.59K 0.11% 2026-06-30
20 Walleye Capital LLC $253.73K 0.10% 2026-06-30
Insider Activity
Latest: 2026-09-02
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-09-02 C FRANK BENNETT EVP, Chief Scientific Officer Other (J) +110 $51.31 $5.6K EDGAR
2026-09-02 Brian Birchler EVP, Corp and Development Ops Other (J) +58 $51.31 $3.0K EDGAR
2026-09-02 PATRICK R. O'NEIL EVP CLO & General Counsel Other (J) +63 $51.31 $3.2K EDGAR
2026-09-02 Brett P Monia Chief Executive Officer Other (J) +98 $51.31 $5.0K EDGAR
2026-07-31 Michael R Hayden Director Buy (P) +20,000 $52.94 $1.06M EDGAR
2026-07-17 LUDWIG HANTSON Director Grant (A) +3,399 RSU — EDGAR
2026-07-17 Peter N Reikes Director Grant (A) +3,399 RSU — EDGAR
2026-07-17 JOAN E HERMAN Director Exer (M) +5,220 — EDGAR
2026-07-17 SPENCER R BERTHELSEN Director Exer (M) +5,220 — EDGAR
2026-07-09 Holly B. Kordasiewicz EVP, Chief Development Officer Sell (S) −362 $84.30 -$30.5K EDGAR
2026-07-09 Allene M. Diaz Director Mixed — $66.26 -$387.3K EDGAR
2026-07-09 C FRANK BENNETT EVP, Chief Scientific Officer Mixed −5,536 $84.95 -$1.74M EDGAR
2026-07-06 SPENCER R BERTHELSEN Director Grant (A) +7,670 opt — EDGAR
2026-07-06 JOAN E HERMAN Director Grant (A) +7,670 RSU — EDGAR
2026-07-06 Michael R Hayden Director Grant (A) +7,670 opt — EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.
Insider Holdings
28 insiders · @ $47.25
Officers, directors, and 10%+ owners ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 STANLEY T CROOKE Exec Chairman of the Board 496,412 $23.46M -$50.31M 51 2021-01-28
2 ELIZABETH L HOUGEN EVP, Finance & CFO 254,221 $12.01M -$27.72M 58 2026-03-18
3 Brett P Monia Chief Executive Officer 242,760 $11.47M -$62.52M 76 2026-09-02
4 SPENCER R BERTHELSEN Director 161,303 $7.62M -$4.88M 28 2026-07-17
5 Brian Birchler EVP, Corp and Development Ops 102,883 $4.86M -$4.04M 21 2026-09-02
6 Richard S Geary EVP, Chief Development Officer 77,957 $3.68M -$23.74M 60 2025-11-07
7 Michael R Hayden Director 73,298 $3.46M $1.72M 21 2026-07-31
8 Eugene Schneider EVP, Chf Clinical Develop Ofcr 63,890 $3.02M -$5.94M 26 2026-03-23
9 C FRANK BENNETT EVP, Chief Scientific Officer 60,128 $2.84M -$31.71M 72 2026-09-02
10 PATRICK R. O'NEIL EVP CLO & General Counsel 59,205 $2.80M -$30.73M 84 2026-09-02
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.
Notice of Proposed Sale (Form 144)
Latest: 2026-07-07
Last 30d: 0 filings  ·  Last 90d: 9 filings · $13.6M notice value · 9 unique filers · 100% under 10b5-1 plans

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. Amendments (Form 144/A) and post-cancellation refilings can inflate this if you sum naively; the rollup above excludes filings with zero stated value.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Top 90-day filers: BENNETT C FRANK (1, $5.7M) · Schneider Eugene (1, $3.9M) · KLEIN JOSEPH III (1, $910K) · Diaz Allene M. (1, $864K) · Swayze Eric (1, $839K)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-07-07 Diaz Allene M. Director 10,111 $863.6K 2026-07-07 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-07-07 Kordasiewicz Holly B. Officer 1,287 $108.5K 2026-07-07 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-07-07 BENNETT C FRANK Officer 67,386 $5.72M 2026-07-07 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-07-01 KLEIN JOSEPH III Director 11,518 $910.4K 2026-07-01 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-06-26 Baroldi Mariana Member of immediate family of any of the foregoing 5,635 $451.7K 2026-06-26 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-06-26 O'NEIL PATRICK R. Officer 3,069 $245.5K 2026-06-26 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-06-26 Schneider Eugene Officer 47,884 $3.88M 2026-06-26 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-06-25 Swayze Eric Officer 10,602 $839.3K 2026-06-25 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
2026-06-15 BERTHELSEN SPENCER R Director 8,000 $587.9K 2026-06-15 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-06-12 Kordasiewicz Holly B. Officer 60,846 $4.47M 2026-06-12 Stifel Nicolaus & Company Inc 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed.
Recent SEC Filings
Latest: 2026-05-28
Current reports — material events the company must disclose within 4 business days (earnings releases, M&A, executive changes, etc.).
Filing Date Accession Link
2026-05-28 0001140361-26-023093 EDGAR
2026-04-29 0001140361-26-017637 EDGAR
2026-04-21 0001140361-26-015801 EDGAR
2026-03-09 0001140361-26-008340 EDGAR
2026-02-25 0001140361-26-006718 EDGAR
2026-01-12 0001140361-26-000893 EDGAR
2026-01-07 0001140361-26-000435 EDGAR
2025-11-17 0001193125-25-284609 EDGAR
2025-11-10 0001140361-25-041225 EDGAR
2025-10-29 0001140361-25-039650 EDGAR
Annual report — audited financial statements, MD&A, risk factors. Filed 60–90 days after fiscal year-end.
Filing Date Accession Link
2026-02-26 0000874015-26-000115 EDGAR
2025-02-19 0000874015-25-000089 EDGAR
2024-02-21 0000874015-24-000116 EDGAR
2023-02-22 0000874015-23-000105 EDGAR
2022-02-25 0000874015-22-000079 EDGAR
2021-02-24 0000874015-21-000056 EDGAR
2020-03-02 0001140361-20-004500 EDGAR
Quarterly report — unaudited financials and MD&A. Filed 40–45 days after each of the first three fiscal quarters.
Filing Date Accession Link
2026-04-29 0000874015-26-000177 EDGAR
2025-10-29 0000874015-25-000266 EDGAR
2025-07-30 0000874015-25-000167 EDGAR
2025-04-30 0000874015-25-000123 EDGAR
2024-11-06 0000874015-24-000232 EDGAR
2024-08-01 0000874015-24-000187 EDGAR
2024-05-07 0000874015-24-000142 EDGAR
2023-11-02 0000874015-23-000209 EDGAR
2023-08-09 0000874015-23-000186 EDGAR
2023-05-03 0000874015-23-000136 EDGAR
ETF Holders
# ETF Provider Weight $ Exposure ETF AUM As Of
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

P/B Ratio19.4
P/S Ratio9.8
EV/EBITDA-16.4
TTM Revenue$0.9B
TTM Net Income$-0.6B
TTM EPS$-3.48
ROE-128.5%
Debt/Equity3.01