DEERFIELD MANAGEMENT COMPANY, L.P. — 13F Holdings & Portfolio
CIK 1009258 · latest 13F-HR filed 2026-08-14
DEERFIELD MANAGEMENT COMPANY, L.P. manages $9.59B in 13F-reported U.S. long-equity assets across 82 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are NUVL (22.22%), BROOKDALE SR LIVING INC (6.11%), RVMD (4.67%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 13 new positions and exited 13; 39 existing positions rose in reported value and 18 fell.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
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AUM
$9.59B
Long-equity book
Holdings
82
Distinct positions
Period
2026-06-30
Filed 2026-08-14
Q/Q Activity
+13 / −13 / ↑39 / ↓18
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
Portfolio map
Q2 26NUVL22.2% · 0%BROOKDALE SR6.1% · 0%RVMD4.7% · +4%PRAX3.4% · 0%VTRS3.3% · 0%CNC3.3% · -17%RVMDW2.6% · newUTHR2.6% · 0%ARWR2.5% · 0%LEGN2.5% · +6%COGT2.0% · -45%GMAB2.0% · +179%BKD2.0% · 0%VERA1.8% · +5%IONS1.6% · 0%CELC1.6% · -15%BCRX1.6% · +0%NAMS1.5% · 0%ACHC1.4% · 0%TNGX1.4% · +1%AHCO1.2% · 0%PHVS1.2% · +8%CELC1.2% · newARWR1.2% · -12%DNTH1.1% · +10%LRMR1.1% · 0%MLYS1.1% · newALHC1.1% · 0%IDYA1.1% · +77%XENE1.0% · 0%IONS1.0% · 0%SVRA0.9% · 0%LNTH0.9% · -9%SNDX0.9% · 0%ZBIO0.8% · +3%BMRN0.8% · +56%PFE0.8% · 0%INDV0.7% · -47%BIO0.7% · 0%SPRY0.6% · 0%STOK0.6% · 0%GPCR0.6% · +41%NVST0.6% · 0%INSP0.6% · -52%CDNA0.6% · -9%BSX0.6% · newBLTE0.6% · +18%PBLS0.5% · newCERT0.5% · -4%IRON0.5% · 0%LIVN0.5% · 0%BBOT0.4% · 0%TYRA0.3% · +85%MNPR0.3% · 0%SION0.3% · -30%IMCR0.3% · 0%AVLN0.3% · newFHTX0.2% · 0%BBNX0.2% · 0%ALNY0.2% · 0%
Box size = position value; colour = change in share count vs the prior quarter (green added, red trimmed, blue new). Rows split across managers or share classes are combined. Click a box for the stock.
Sector mix
% of 13F valueSectors from each company's SIC code; funds and ETFs grouped separately.
Biggest buys and sells
Q1 26 → Q2 26Estimated from the change in shares held × the quarter-end price, so price moves alone don't count as buying. New and exited positions are included.
13F assets and positions
4 quartersTotal reported 13F value (bars) and number of positions (line) each quarter. Value changes include market moves.
Top positions over time
reported valueThe eight largest current positions, valued at each quarter end.
Concentration
top 10 = 53.2%Cumulative share of the portfolio held in the largest N positions.
Firm Profile & Key People
As of the firm’s regulatory filing dated Jul 31, 2026.
Assets Under Management
$19.08B
Discretionary
$19.08B
Employees
189
Accounts
12
Address
345 PARK AVENUE SOUTH
12TH FLOOR
NEW YORK, NY 10010
12TH FLOOR
NEW YORK, NY 10010
Phone
(212) 551-1600
This firm reports 3 disclosure items on its registration.
| Name | Title / Status | Ownership | Type |
|---|---|---|---|
| DEERFIELD MANAGER HOLDINGS, LP Control | LIMITED PARTNER since Jun 2025 | 75% or more | Domestic Entity |
| DEERFIELD UGP, LLC Control | GENERAL PARTNER since Jun 2025 | Less than 5% | Domestic Entity |
| FLYNN, JAMES, EDWARD Control | PRESIDENT since Jan 2005 | Less than 5% | Individual |
| ISLER, JONATHAN, DAVID Control | CHIEF FINANCIAL OFFICER, FUNDS since Jul 2012 | Less than 5% | Individual |
| SENDROWSKI, BRYAN, SCOTT Control | CHIEF FINANCIAL OFFICER since Jan 2023 | Less than 5% | Individual |
| SNETIKER, ROBERT, TODD Control | GENERAL COUNSEL AND CHIEF COMPLIANCE OFFICER since May 2023 | Less than 5% | Individual |
| DEERFIELD UGP, LLC Control Indirect owner via DEERFIELD MANAGER HOLDINGS, LP | GENERAL PARTNER since Jun 2025 | General partner, trustee or manager | Domestic Entity |
| FLYNN, JAMES, EDWARD Control Indirect owner via DEERFIELD MANAGER HOLDINGS, LP | LIMITED PARTNER since Jun 2025 | 25–50% | Individual |
| FLYNN, JAMES, EDWARD Control Indirect owner via DEERFIELD UGP, LLC | MANAGER since Jun 2025 | General partner, trustee or manager | Individual |
Ownership & leadership changes · 10 filings with changes since Feb 10, 2012
From the firm’s regulatory filings, newest first. Dates are filing dates: a filing that no longer lists someone does not say when they left.
Mar 26, 2026 filing
- No longer listedCLARK, DAVID, JUSTUS · GENERAL COUNSEL · Less than 5% · control person · listed since Jan 2011
- ChangedFLYNN, JAMES, EDWARD · indirect via DEERFIELD MANAGER HOLDINGS, LP: ownership 75% or more → 25–50%
- ChangedSNETIKER, ROBERT, TODD · title CHIEF COMPLIANCE OFFICER → GENERAL COUNSEL AND CHIEF COMPLIANCE OFFICER
Jul 23, 2025 filing
- No longer listedCAZ�, ALEXIS · CHIEF OPERATING OFFICER · Less than 5% · control person · listed since Jan 2020
- No longer listedFLYNN MANAGEMENT LLC · GENERAL PARTNER · 10–25% · control person · listed since Jan 2005
- No longer listedFLYNN, JAMES, EDWARD · SOLE MEMBER · 75% or more · indirect via FLYNN MANAGEMENT LLC · control person · listed since Jan 2005
- AddedDEERFIELD MANAGER HOLDINGS, LP · LIMITED PARTNER · 75% or more · control person
- AddedDEERFIELD UGP, LLC · GENERAL PARTNER · Less than 5% · control person
- AddedDEERFIELD UGP, LLC · GENERAL PARTNER · General partner, trustee or manager · indirect via DEERFIELD MANAGER HOLDINGS, LP · control person
- AddedFLYNN, JAMES, EDWARD · LIMITED PARTNER · 75% or more · indirect via DEERFIELD MANAGER HOLDINGS, LP · control person
- AddedFLYNN, JAMES, EDWARD · MANAGER · General partner, trustee or manager · indirect via DEERFIELD UGP, LLC · control person
- ChangedFLYNN, JAMES, EDWARD · ownership 75% or more → Less than 5%
Feb 20, 2024 filing
- ChangedFLYNN MANAGEMENT LLC · ownership 75% or more → 10–25%
- ChangedFLYNN, JAMES, EDWARD · ownership Less than 5% → 75% or more
May 31, 2023 filing
- No longer listedBRANCACCIO, MARIAN, LYIA · CHIEF COMPLIANCE OFFICER · Less than 5% · control person · listed since Jan 2014
- AddedSNETIKER, ROBERT, TODD · CHIEF COMPLIANCE OFFICER · Less than 5% · control person
Mar 31, 2023 filing
- AddedSENDROWSKI, BRYAN, SCOTT · CHIEF FINANCIAL OFFICER · Less than 5% · control person
- ChangedISLER, JONATHAN, DAVID · title CHIEF FINANCIAL OFFICER → CHIEF FINANCIAL OFFICER, FUNDS
Mar 31, 2021 filing
- ChangedCAZ�, ALEXIS · title MANAGING DIRECTOR → CHIEF OPERATING OFFICER
Jan 26, 2021 filing
- No longer listedKARNAL, ALEXANDER, THOMAS · MANAGING DIRECTOR, PORTFOLIO MANAGER · Less than 5% · control person · listed since Jan 2020
Mar 30, 2020 filing
- No longer listedNOY, KAREN, ARNONE · CHIEF ADMINISTRATIVE OFFICER · Less than 5% · control person · listed since Jan 2005
- AddedCAZ�, ALEXIS · MANAGING DIRECTOR · Less than 5% · control person
- AddedKARNAL, ALEXANDER, THOMAS · MANAGING DIRECTOR, PORTFOLIO MANAGER · Less than 5% · control person
Jan 3, 2014 filing
- AddedBRANCACCIO, MARIAN, LYIA · CHIEF COMPLIANCE OFFICER · Less than 5% · control person
- AddedNOY, KAREN, ARNONE · CHIEF ADMINISTRATIVE OFFICER · Less than 5% · control person
- ChangedCLARK, DAVID, JUSTUS · title CHIEF COMPLIANCE OFFICER → GENERAL COUNSEL
Sep 28, 2012 filing
- No longer listedLEVINE, DARREN, SCOTT · CHIEF FINANCIAL OFFICER · Less than 5% · control person · listed since Jan 1994
- AddedISLER, JONATHAN, DAVID · CHIEF FINANCIAL OFFICER · Less than 5% · control person
Older changes (1 more filing)
Feb 10, 2012 filing (earliest on record)
- ListedCLARK, DAVID, JUSTUS · CHIEF COMPLIANCE OFFICER · Less than 5% · control person
- ListedFLYNN MANAGEMENT LLC · GENERAL PARTNER · 75% or more · control person
- ListedFLYNN, JAMES, EDWARD · PRESIDENT · Less than 5% · control person
- ListedFLYNN, JAMES, EDWARD · SOLE MEMBER · 75% or more · indirect via FLYNN MANAGEMENT LLC · control person
- ListedLEVINE, DARREN, SCOTT · CHIEF FINANCIAL OFFICER · Less than 5% · control person
Quarter-over-quarter changes
Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.
Top Adds (vs prior quarter)
- NUVALENT INC$363.1M +20.5%
- REVOLUTION MEDICINES INC$224.6M +100.5%
- GENMAB A/S$122.5M +185.5%
- CENTENE CORP DEL$120.9M +62.4%
- LEGEND BIOTECH CORP$95.9M +69.0%
Top Trims
- COGENT BIOSCIENCES INC-$154.4M -44.3%
- INSPIRE MED SYS INC-$81.6M -58.5%
- NEOGENOMICS INC-$54.5M -81.7%
- LARIMAR THERAPEUTICS INC-$51.6M -32.2%
- CELCUITY INC-$43.8M -22.4%
New Positions
- REVOLUTION MEDICINES INC$251.7M
- CELCUITY INC$113.8M
- MINERALYS THERAPEUTICS INC$106.8M
- BOSTON SCIENTIFIC CORP$56.1M
- PARABILIS MEDICINES INC$51.5M
Exited Positions
- MIRUM PHARMACEUTICALS INC$209.4M
- CATALYST PHARMACEUTICALS INC$97.6M
- NEUROCRINE BIOSCIENCES INC$80.4M
- DAY ONE BIOPHARMACEUTICALS I$79.8M
- ENHABIT INC$66.9M
DEERFIELD MANAGEMENT COMPANY, L.P. Holdings (2026-06-30)
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | NUVALENT INC | NUVL | 670703107 | $2.13B | 22.22% | 17,248,450 | SH |
| 2 | BROOKDALE SR LIVING INC | — | 112463AF1 | $585.7M | 6.11% | 306,885,000 | PRN |
| 3 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $448.0M | 4.67% | 2,392,000 | SH |
| 4 | PRAXIS PRECISION MEDICINES I | PRAX | 74006W207 | $322.5M | 3.36% | 963,351 | SH |
| 5 | VIATRIS INC | VTRS | 92556V106 | $320.9M | 3.35% | 20,206,170 | SH |
| 6 | CENTENE CORP DEL | CNC | 15135B101 | $314.6M | 3.28% | 4,901,000 | SH |
| 7 | REVOLUTION MEDICINES INC | RVMDW | 76155XAA8 | $251.7M | 2.63% | 200,000,000 | PRN |
| 8 | UNITED THERAPEUTICS CORP DEL | UTHR | 91307C102 | $247.6M | 2.58% | 457,000 | SH |
| 9 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 04280AAC4 | $240.5M | 2.51% | 200,000,000 | PRN |
| 10 | LEGEND BIOTECH CORP | LEGN | 52490G102 | $235.0M | 2.45% | 8,137,638 | SH |
| 11 | COGENT BIOSCIENCES INC | COGT | 19240Q201 | $193.7M | 2.02% | 5,006,104 | SH |
| 12 | GENMAB A/S | GMAB | 372303206 | $188.6M | 1.97% | 6,865,000 | SH |
| 13 | BROOKDALE SR LIVING INC | BKD | 112463104 | $187.2M | 1.95% | 11,637,032 | SH |
| 14 | VERA THERAPEUTICS INC | VERA | 92337R101 | $168.1M | 1.75% | 3,916,400 | SH |
| 15 | IONIS PHARMACEUTICALS INC | IONS | 462222100 | $157.0M | 1.64% | 1,979,669 | SH |
| 16 | CELCUITY INC | CELC | 15102K100 | $151.8M | 1.58% | 1,451,014 | SH |
| 17 | BIOCRYST PHARMACEUTICALS INC | BCRX | 09058V103 | $151.0M | 1.57% | 15,096,403 | SH |
| 18 | NEWAMSTERDAM PHARMA COMPANY | NAMS | N62509109 | $144.5M | 1.51% | 4,264,789 | SH |
| 19 | ACADIA HEALTHCARE COMPANY IN | ACHC | 00404A109 | $133.5M | 1.39% | 4,520,000 | SH |
| 20 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $131.0M | 1.37% | 4,190,611 | SH |
| 21 | ADAPTHEALTH CORP | AHCO | 00653Q102 | $119.6M | 1.25% | 11,477,730 | SH |
| 22 | PHARVARIS N V | PHVS | N69605108 | $116.7M | 1.22% | 3,376,042 | SH |
| 23 | CELCUITY INC | CELC | 15102KAB6 | $113.8M | 1.19% | 100,000,000 | PRN |
| 24 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 04280A100 | $113.2M | 1.18% | 1,389,055 | SH |
| 25 | DIANTHUS THERAPEUTICS INC | DNTH | 252828108 | $109.7M | 1.14% | 1,125,313 | SH |
| 26 | LARIMAR THERAPEUTICS INC | LRMR | 517125100 | $108.6M | 1.13% | 35,606,974 | SH |
| 27 | MINERALYS THERAPEUTICS INC | MLYS | 603170101 | $106.8M | 1.11% | 3,958,000 | SH |
| 28 | ALIGNMENT HEALTHCARE INC | ALHC | 01625VAB0 | $103.8M | 1.08% | 61,000,000 | PRN |
| 29 | IDEAYA BIOSCIENCES INC | IDYA | 45166A102 | $101.2M | 1.06% | 2,714,503 | SH |
| 30 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $97.5M | 1.02% | 1,615,696 | SH |
| 31 | IONIS PHARMACEUTICALS INC | IONS | 462222AF7 | $93.1M | 0.97% | 60,000,000 | PRN |
| 32 | SAVARA INC | SVRA | 805111101 | $83.6M | 0.87% | 13,569,000 | SH |
| 33 | LANTHEUS HLDGS INC | LNTH | 516544103 | $83.5M | 0.87% | 752,999 | SH |
| 34 | SYNDAX PHARMACEUTICALS INC | SNDX | 87164F105 | $82.6M | 0.86% | 3,779,900 | SH |
| 35 | ZENAS BIOPHARMA INC | ZBIO | 98937LAA3 | $80.3M | 0.84% | 67,200,000 | PRN |
| 36 | BIOMARIN PHARMACEUTICAL INC | BMRN | 09061G101 | $76.3M | 0.80% | 1,332,836 | SH |
| 37 | PFIZER INC | PFE | 717081103 | $73.2M | 0.76% | 3,040,000 | SH |
| 38 | INDIVIOR PHARMACEUTICALS INC | INDV | 45579U109 | $67.7M | 0.71% | 1,648,895 | SH |
| 39 | BIO RAD LABS INC | BIO | 090572207 | $66.4M | 0.69% | 226,070 | SH |
| 40 | ARS PHARMACEUTICALS INC | SPRY | 82835W108 | $60.1M | 0.63% | 7,503,812 | SH |
| 41 | STOKE THERAPEUTICS INC | STOK | 86150R107 | $59.7M | 0.62% | 1,823,500 | SH |
| 42 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $58.3M | 0.61% | 1,086,000 | SH |
| 43 | ENVISTA HOLDINGS CORPORATION | NVST | 29415F104 | $58.2M | 0.61% | 2,210,100 | SH |
| 44 | INSPIRE MED SYS INC | INSP | 457730109 | $57.9M | 0.60% | 1,296,862 | SH |
| 45 | CAREDX INC | CDNA | 14167L103 | $56.9M | 0.59% | 1,997,618 | SH |
| 46 | BOSTON SCIENTIFIC CORP | BSX | 101137107 | $56.1M | 0.59% | 1,315,000 | SH |
| 47 | BELITE BIO INC | BLTE | 07782B104 | $55.0M | 0.57% | 357,199 | SH |
| 48 | PARABILIS MEDICINES INC | PBLS | 698955101 | $51.5M | 0.54% | 1,880,704 | SH |
| 49 | CERTARA INC | CERT | 15687V109 | $49.2M | 0.51% | 7,512,928 | SH |
| 50 | DISC MEDICINE INC | IRON | 254604101 | $48.1M | 0.50% | 657,000 | SH |
Filing History
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $9.59B | 82 | 0001213900-26-089991 |
| 2026-03-31 | 2026-05-15 | $8.48B | 82 | 0001213900-26-057678 |
| 2025-12-31 | 2026-02-17 | $7.83B | 150 | 0001213900-26-017265 |
| 2025-09-30 | 2025-11-14 | $6.55B | 152 | 0001213900-25-110851 |
Filer Information
Address
345 PARK AVENUE SOUTH, 12TH FLOORNEW YORK, NY 10010
Phone
(212) 551-1600
Filing Manager
DEERFIELD MANAGEMENT COMPANY, L.P.
New York, NY
Signatory
Deerfield UGP, LLC, its general partner
Chief Financial Officer