DEERFIELD MANAGEMENT COMPANY, L.P. — 13F Holdings & Portfolio

CIK 1009258 · latest 13F-HR filed 2026-05-15

DEERFIELD MANAGEMENT COMPANY, L.P. manages $8.48B in 13F-reported U.S. long-equity assets across 82 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are NUVL (20.85%), BROOKDALE SR LIVING INC (5.96%), COGT (4.11%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 12 new positions, exited 79, added to 27, and trimmed 30.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

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AUM

$8.48B

Long-equity book

Holdings

82

Distinct positions

Period

2026-03-31

Filed 2026-05-15

Q/Q Activity

+12 / −79 / ↑27 / ↓30

vs 2025-12-31

Firm Profile & Key People
Name Title / Status Ownership Type

Top Adds (vs prior quarter)

  • BROOKDALE SR LIVING INC$77.9M +18.2%
  • XENON PHARMACEUTICALS INC$69.7M +286.7%
  • UNITED THERAPEUTICS CORP DEL$63.4M +30.6%
  • TANGO THERAPEUTICS INC$61.0M +236.8%
  • DAY ONE BIOPHARMACEUTICALS I$45.1M +130.0%
Show all 27

Top Trims

  • NEUROCRINE BIOSCIENCES INC-$87.6M -52.2%
  • CENTENE CORP DEL-$71.6M -27.0%
  • VERA THERAPEUTICS INC-$55.8M -27.2%
  • ARS PHARMACEUTICALS INC-$27.2M -31.1%
  • CERTARA INC-$24.3M -35.3%
Show all 30

New Positions

  • ARROWHEAD PHARMACEUTICALS IN$207.2M
  • INDIVIOR PHARMACEUTICALS INC$94.4M
  • SYNDAX PHARMACEUTICALS INC$88.3M
  • DIANTHUS THERAPEUTICS INC$85.6M
  • PFIZER INC$85.4M
Show all 12

Exited Positions

  • INDIVIOR PLC$121.7M
  • PHREESIA INC$33.8M
  • LANTHEUS HLDGS INC$28.9M
  • VENTAS INC$27.4M
  • SPYRE THERAPEUTICS INC$23.3M
Show all 79
All Holdings

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 NUVALENT INC NUVL 670703107 $1.77B 20.85% 17,248,450 SH
2 BROOKDALE SR LIVING INC 112463AF1 $505.4M 5.96% 306,885,000 PRN
3 COGENT BIOSCIENCES INC COGT 19240Q201 $348.1M 4.11% 9,043,903 SH
4 PRAXIS PRECISION MEDICINES I PRAX 74006W207 $310.4M 3.66% 963,351 SH
5 VIATRIS INC VTRS 92556V106 $273.0M 3.22% 20,206,170 SH
6 UNITED THERAPEUTICS CORP DEL UTHR 91307C102 $271.0M 3.20% 457,000 SH
7 REVOLUTION MEDICINES INC RVMD 76155X100 $223.4M 2.64% 2,297,000 SH
8 MIRUM PHARMACEUTICALS INC MIRM 604749AB7 $209.4M 2.47% 70,000,000 PRN
9 ARROWHEAD PHARMACEUTICALS IN ARWR 04280AAC4 $207.2M 2.44% 200,000,000 PRN
10 CELCUITY INC CELC 15102K100 $195.6M 2.31% 1,714,000 SH
11 CENTENE CORP DEL CNC 15135B101 $193.7M 2.29% 5,917,091 SH
12 LARIMAR THERAPEUTICS INC LRMR 517125100 $160.2M 1.89% 35,606,974 SH
13 BROOKDALE SR LIVING INC BKD 112463104 $159.2M 1.88% 11,637,032 SH
14 VERA THERAPEUTICS INC VERA 92337R101 $149.7M 1.77% 3,722,100 SH
15 IONIS PHARMACEUTICALS INC IONS 462222100 $148.7M 1.75% 1,979,669 SH
16 BIOCRYST PHARMACEUTICALS INC BCRX 09058V103 $143.2M 1.69% 15,038,000 SH
17 INSPIRE MED SYS INC INSP 457730109 $139.4M 1.64% 2,703,238 SH
18 LEGEND BIOTECH CORP LEGN 52490G102 $139.1M 1.64% 7,687,638 SH
19 ADAPTHEALTH CORP AHCO 00653Q102 $136.6M 1.61% 11,477,730 SH
20 NEWAMSTERDAM PHARMA COMPANY NAMS N62509109 $136.5M 1.61% 4,264,789 SH
21 ACADIA HEALTHCARE COMPANY IN ACHC 00404A109 $105.7M 1.25% 4,520,000 SH
22 ARROWHEAD PHARMACEUTICALS IN ARWR 04280A100 $98.6M 1.16% 1,573,297 SH
23 CATALYST PHARMACEUTICALS INC CPRX 14888U101 $97.6M 1.15% 3,943,600 SH
24 INDIVIOR PHARMACEUTICALS INC INDV 45579U109 $94.4M 1.11% 3,097,790 SH
25 XENON PHARMACEUTICALS INC XENE 98420N105 $94.0M 1.11% 1,615,696 SH
26 IONIS PHARMACEUTICALS INC IONS 462222AF7 $90.6M 1.07% 60,000,000 PRN
27 PHARVARIS N V PHVS N69605108 $88.3M 1.04% 3,126,042 SH
28 SYNDAX PHARMACEUTICALS INC SNDX 87164F105 $88.3M 1.04% 3,779,900 SH
29 TANGO THERAPEUTICS INC TNGX 87583X109 $86.8M 1.02% 4,146,813 SH
30 ALIGNMENT HEALTHCARE INC ALHC 01625VAB0 $85.9M 1.01% 61,000,000 PRN
31 DIANTHUS THERAPEUTICS INC DNTH 252828108 $85.6M 1.01% 1,019,813 SH
32 PFIZER INC PFE 717081103 $85.4M 1.01% 3,040,000 SH
33 NEUROCRINE BIOSCIENCES INC NBIX 64125C109 $80.4M 0.95% 610,000 SH
34 DAY ONE BIOPHARMACEUTICALS I DAWN 23954D109 $79.8M 0.94% 3,723,131 SH
35 SAVARA INC SVRA 805111101 $74.1M 0.87% 13,569,000 SH
36 ZENAS BIOPHARMA INC ZBIO 98937LAA3 $67.3M 0.79% 65,000,000 PRN
37 ENHABIT INC EHAB 29332G102 $66.9M 0.79% 4,747,746 SH
38 NEOGENOMICS INC NEO 64049MAB6 $66.7M 0.79% 72,689,000 PRN
39 GENMAB A/S GMAB 372303206 $66.1M 0.78% 2,462,000 SH
40 BIO RAD LABS INC BIO 090572207 $63.0M 0.74% 226,070 SH
41 LANTHEUS HLDGS INC LNTH 516544103 $62.8M 0.74% 827,999 SH
42 ARS PHARMACEUTICALS INC SPRY 82835W108 $60.3M 0.71% 7,503,812 SH
43 STOKE THERAPEUTICS INC STOK 86150R107 $59.4M 0.70% 1,823,500 SH
44 ENVISTA HOLDINGS CORPORATION NVST 29415F104 $56.1M 0.66% 2,210,100 SH
45 IDEAYA BIOSCIENCES INC IDYA 45166A102 $51.0M 0.60% 1,530,008 SH
46 BELITE BIO INC BLTE 07782B104 $48.5M 0.57% 304,013 SH
47 BIOMARIN PHARMACEUTICAL INC BMRN 09061G101 $48.1M 0.57% 851,556 SH
48 KYMERA THERAPEUTICS INC KYMR 501575104 $46.7M 0.55% 561,170 SH
49 CERTARA INC CERT 15687V109 $44.5M 0.53% 7,808,605 SH
50 BRIDGEBIO ONCOLOGY THERAPEUT BBOT 107924102 $43.7M 0.52% 4,885,446 SH
Filing History
Period Filed AUM Holdings Accession
2026-03-31 2026-05-15 $8.48B 82 0001213900-26-057678
2025-12-31 2026-02-17 $7.83B 150 0001213900-26-017265
2025-09-30 2025-11-14 $6.55B 152 0001213900-25-110851