SNDX Syndax Pharmaceuticals, Inc.
XNAS 13.22 DelayedStock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Expected move IV rank history Fibonacci levels Insider trading
Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.
- 52-Week Range
- $12.79 – $25.59
- YTD
- -37.93%
- IV Rank (30D)
- 82.88
- Straddle Price
- $2.65
- P/C Vol Ratio
- 2.07
- Market Cap
- $1.2B
- Open
- $13.58
- Day Range
- $13.12 – $13.70
- Volume
- 1,991,189
- Prev Close
- $13.40
A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.
- DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
- Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
- DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
- P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
- Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
- Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
- Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
- Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
| 10-yr Treasury (rf) | 4.96% |
| Beta vs SPY | 0.99 |
| Cost of Equity (CAPM) | 9.89% (VRP-adj) |
| WACC | 8.45% |
| Volatility Risk Premium | +124.3pp (IV − HV30) |
| Effective Tax Rate | 21.0% |
| Rev. Growth (YoY, DCF input) | +30.0% |
| DCF Horizon | 10 years explicit + fade |
| Forward Tilt (NTM/TTM) | ×1.10 (applied to P/E, EV/EBITDA, P/S) |
| Free Cash Flow (TTM) | $-0.2B |
| Return on Equity (TTM) | -1462.1% |
| Book / Price | 1.3% |
| Gross Margin (TTM) | 95.8% |
| FCF Margin (TTM) | -94.4% |
| Debt / Equity | 39.00 |
| Quality Score | 2/6 — normal (10y DCF) |
| SMA 50 | $17.67 (Market Anchor value) |
| SMA 20 / Bollinger Mid | $15.46 |
| Bollinger Width / SMA20 | 360.6% (drives anchor stability) |
| Net Debt | $0.3B |
| Market Cap | $1B |
| Method | Implied Price | Weight | Detail |
|---|---|---|---|
| DCF | n/a | 0% | |
| DDM (Gordon) | n/a | 0% | |
| Peer P/E | n/a | 0% | median 34.8× · 4 peers |
| Peer EV/EBITDA | n/a | 0% | median 22.9× · 4 peers |
| Peer P/B | $1.75 | 12% | median 10.2× · 7 peers |
| Peer P/S | $33.60 | 12% | median 10.6× · 6 peers |
| Market Anchor (SMA50) | $17.67 | 51% | stability 85% (BB-width) |
| Options Expected (B-L 30d) | $12.90 | 26% | 17 strikes · skew +0.33 |
- Industry (SIC)
- PHARMACEUTICAL PREPARATIONS (2834) · industry map
- Exchange
- XNAS
- Market Cap
- $1.2B
- Employees
- 298
- List Date
- 2016-03-03
- CIK
- 0001395937
- Next Earnings
- 2026-11-02 (Pre-Market)
- EPS Forecast
- ($0.51) (6 est.)
- Headquarters
- New York, NY
- Homepage
- https://www.syndax.com
Syndax Pharmaceuticals Inc is a clinical-stage biopharmaceutical company focused on developing a pipeline of combination therapies in multiple cancer indications. Its product candidates include revumenib and axatilimab. It is developing revumenib, a selective menin-MLL inhibitor for KMT2A-rearranged (MLL-r) and NPM1-mutant acute leukemias, including ALL and AML. It is also developing axatilimab, a CSF-1R-blocking antibody for cGVHD and idiopathic pulmonary fibrosis. Entinostat is its oral, small molecule product candidate that has direct effects on both cancer cells and immune regulatory cells…
Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.
| Month | '21 | '22 | '23 | '24 | '25 | '26 | Avg |
|---|---|---|---|---|---|---|---|
| Jan | -10.30% | -26.23% | 12.11% | -6.27% | 0.64% | -4.65% | -5.78% |
| Feb | 16.46% | -6.14% | -12.53% | 10.36% | 9.07% | 1.69% | 3.15% |
| Mar | -7.41% | 8.22% | -15.04% | 0.38% | -20.64% | 5.51% | -4.83% |
| Apr | -32.94% | -4.82% | -1.72% | -11.14% | 17.82% | -10.26% | -7.18% |
| May | 15.32% | -4.01% | -5.09% | -12.29% | -23.73% | 2.51% | -4.55% |
| Jun | -6.58% | 16.11% | 3.77% | 6.37% | -14.71% | 15.97% | 3.49% |
| Jul | -18.04% | 6.82% | 2.16% | 5.43% | 12.47% | -8.26% | 0.10% |
| Aug | 16.76% | 15.85% | -12.36% | -6.59% | 63.63% | 0.26% | 12.93% |
| Sep | 5.76% | -2.83% | -25.73% | -6.28% | -4.56% | -6.47% | -6.68% |
| Oct | -0.31% | -4.81% | 4.30% | -5.18% | -12.63% | -27.44%* | -7.68% |
| Nov | -18.81% | 3.59% | 19.58% | -11.91% | 44.04% | -- | 7.30% |
| Dec | 43.73% | 1.68% | 30.42% | -20.84% | 9.88% | -- | 12.97% |
| Total | -17.73% | -4.16% | -12.77% | -47.47% | 62.16% | -31.87% | -8.64% |
Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.
- SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
- EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
- MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
- ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
- +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
- RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
- Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
- Williams %R — inverted scale: <−80 oversold, >−20 overbought.
Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.
- Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
- OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
- Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
- ATR / True Range — average daily $ move; sizing and stop-loss reference.
- HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.
Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →
Trend Indicators
Momentum Oscillators
Volume & Volatility
Data Summary
SNDX Stock Analysis Report
Executive Summary
Overall Assessment: BEARISH | Confidence Level: 7/10
Primary Thesis: Syndax Pharmaceuticals exhibits a critical divergence between fundamentally positive news catalysts and deteriorating technical momentum. While the company has achieved significant regulatory milestones (FDA approval of Revuforj® in October 2025) and maintains a strong pipeline narrative, the stock is trading 18.2% below its 200-day moving average with sharply negative momentum indicators and a bearish options market positioning. The weak correlation to the broader market (R² = 0.15) suggests company-specific headwinds are driving the decline, not market-wide factors.
Key Drivers:
- Positive regulatory catalyst (Revuforj® FDA approval, Oct 2025) not supporting price action
- Strong downtrend: price at $16.99 vs SMA200 of $20.79 (18.2% discount)
- Sharply negative momentum with ADX 31.06 confirming strong downtrend regime
- Options market pricing significant put positioning (2.14 put/call volume ratio)
Primary Risks:
- Technical breakdown may indicate market skepticism of revenue generation despite approvals
- High implied volatility (83.8% IV, 110.5% premium to realized volatility) suggests elevated uncertainty
- Commercial execution risk for Revuforj® ramp-up not reflected in positive headlines
Technical Analysis
Trend Direction
Short-term (1-4 weeks): BEARISH
- Price $16.99 trading below all major moving averages (SMA20: $17.80, SMA50: $19.00, SMA200: $20.79)
- EMA 12 ($17.60) below EMA 26 ($18.16) confirms bearish crossover
- ADX 31.06 indicates strong trending environment with -DI 27.83 > +DI 11.94 (strong downward pressure)
Medium-term (1-3 months): BEARISH
- 18.2% decline from 200-day average suggests sustained selling pressure
- Price structure lower; currently testing lower Bollinger Band ($16.82)
- No recovery structure visible above resistance at SMA20 ($17.80)
Long-term (3-12 months): NEUTRAL-TO-BEARISH
- Extended decline below 200-day MA ($20.79) indicates structural weakness
- However, positive FDA approval catalysts (Oct 2025) should theoretically support recovery
- Disconnect between news sentiment and price action suggests longer-term skepticism about commercial traction
Support/Resistance Levels
Resistance (Bullish Case Requirement):
- Immediate: $17.80 (SMA 20) — nearest resistance; break required to confirm momentum shift
- Key: $18.78 (Upper Bollinger Band) — would signal mean reversion to neutral territory
- Secondary: $19.00 (SMA 50) — psychological and technical hurdle
Support (Risk Management):
- Immediate: $16.82 (Lower Bollinger Band) — currently within striking distance; critical floor
- Key: $16.00 level (round number support, ~5.8% below current)
- Major: $15.00 level (psychological support, ~11.8% downside)
DATA QUALITY NOTE: Band width of 11.00% is moderate; current neutral signal suggests no extreme overbought/oversold squeeze.
Momentum Signals
RSI (14): 37.45 — NEUTRAL, Leaning Bearish
- Reading in neutral zone (30-70) but positioned in lower half
- Not yet oversold (<30), suggesting further downside possible before mean reversion bounce
- Indicates selling pressure hasn't reached capitulation levels
MACD: -0.56 / Signal: -0.05 / Histogram: -0.51 — BEARISH
- MACD (-0.56) trading well below signal line (-0.05)
- Negative histogram (-0.51) confirms bearish momentum with no signs of bullish crossover
- Critical Signal: No upward momentum despite positive news; suggests market digesting Revuforj® approval as priced-in or underwhelming
Stochastic Oscillators: %K 17.38, %D 19.90 — OVERSOLD WATCH
- Both readings in lower range, approaching oversold territory (<20)
- Williams %R at -76.47 is deep in oversold zone (below -80), suggesting potential for mean reversion bounce
- Interpretation: Extreme reading may indicate capitulation selling; watch for reversal signal
Bollinger Bands: NEUTRAL — No Squeeze, Price at Lower Band
- Upper band $18.78, middle $17.80, lower $16.82
- Current price $16.99 positioned near lower band suggests mean reversion risk or capitulation
- Neutral signal (width 11.00%) indicates normal volatility expansion, not compressed setup
Volume Analysis
Volume Trends:
- Volume Rate of Change: +8.63% above 20-day average
- Interpretation: Above-average volume on decline confirms institutional selling pressure
- 20-day average volume: 1,919,533 shares
- Bullish Consideration: Elevated volume on decline could indicate capitulation; if volume dries up on further decline, reversal becomes more likely
On-Balance Volume: 8,789,655.73
- OBV trending down in conjunction with price weakness
- Suggests consistent selling throughout the decline, not rotational accumulation
- Risk Signal: No divergence pattern showing smart money accumulating; pure distribution
Institutional Activity Assessment:
- Volume elevated but directional (bearish) rather than showing accumulation
- Above-average volume on decline typically precedes continued weakness or capitulation bounce
News & Sentiment Analysis
Recent Headlines Summary
Positive News Cluster (All Headlines Positive Sentiment):
-
FDA Approval Milestone (Oct 24, 2025): Revuforj® (revumenib) approved for adult and pediatric patients with relapsed/refractory NPM1 mutated AML — Major catalyst already 7+ months old as of analysis date
-
Commercial Expansion (Jan 7, 2026): Syndax and World Orphan Drug Alliance launching multi-regional Managed Access Program for Revuforj® outside U.S. — Positive for revenue ramp, indicates international expansion
-
Capital Raise (Mar 13, 2026): $6.5 million investment in cancer drug maker with $172M revenue and multiple approved therapies — Modest capital infusion, suggests runway secured
-
Conference Participation (May 20, 2026 & Dec 1, 2025): Multiple investor conference appearances — Standard IR activity, neutral to slightly positive
-
Competitive Context (Oct 10, 2025): Market report on menin inhibitors mentioning Kura Oncology & Kyowa Kirin progress — Competitive risk signal (not direct negative on SNDX but acknowledges competition)
Sentiment Assessment: POSITIVE (Headlines) vs. BEARISH (Price Action)
Critical Divergence: All 6 recent headlines are positive, yet stock declined 18.2% from 200-day average. This suggests:
- Market pricing in regulatory approval was insufficient catalyst
- Commercial execution concerns on Revuforj® revenue ramp not addressed in headlines
- Potential concerns about peak sales assumptions for a niche (NPM1-mutated AML) indication
- Broader market skepticism about small-cap biotech revenue generation
Catalyst Identification
Immediate (1-7 days):
- None identified from current news
Near-term (1-4 weeks):
- Next Earnings: November 2, 2026 — Critical catalyst to assess Revuforj® uptake and revenue trajectory
- Conference appearances may generate investor updates
Medium-term (1-3 months):
- Revuforj® commercial traction reports (patient volume, revenue trajectory)
- Managed Access Program enrollment data from international expansion
- Competitive menin inhibitor data from rivals (Kura, Kyowa Kirin) could impact market perception
Longer-term (3-12 months):
- Additional indications for revumenib in pipeline
- Manufacturing/supply chain updates
- Secondary fundraising potential (if cash burn accelerates)
Market Narrative vs. Technical Signals
Conflict Assessment: HIGH (Bearish Implication)
| Signal | Technical | News/Fundamental | |--------|-----------|------------------| | **
| Earnings Date | Timing | Expected Move | Actual Move | Ratio | Outcome |
|---|---|---|---|---|---|
| 2021-03-08 | Pre-Market | 9.97% | 1.19% | 0.12x | Within |
| 2021-05-11 | Pre-Market | 12.47% | 2.56% | 0.21x | Within |
| 2022-03-01 | Pre-Market | 6.74% | 3.01% | 0.45x | Within |
| 2023-05-08 | Pre-Market | 12.21% | 1.15% | 0.09x | Within |
| 2023-08-03 | Pre-Market | 13.33% | 0.63% | 0.05x | Within |
| 2023-11-02 | Pre-Market | 16.24% | 6.18% | 0.38x | Within |
| 2024-02-27 | Pre-Market | 16.82% | 0.14% | 0.01x | Within |
| 2024-05-08 | Pre-Market | 8.89% | 3.45% | 0.39x | Within |
| 2024-08-01 | Pre-Market | 13.99% | 3.08% | 0.22x | Within |
| 2024-11-05 | Pre-Market | 22.57% | 3.96% | 0.18x | Within |
| 2025-03-03 | Pre-Market | 20.94% | 1.02% | 0.05x | Within |
| 2025-05-05 | After-Close | 16.40% | 21.59% | 1.32x | Exceeded |
| 2025-08-04 | Pre-Market | 12.53% | 4.01% | 0.32x | Within |
| 2025-11-03 | After-Close | 21.26% | 11.56% | 0.54x | Within |
| 2026-01-12 | Pre-Market | 8.10% | 1.33% | 0.16x | Within |
| 2026-02-26 | Pre-Market | 20.36% | 0.39% | 0.02x | Within |
| 2026-04-30 | Pre-Market | 21.45% | 3.88% | 0.18x | Within |
| 2026-08-04 | Pre-Market | 10.01% | 0.83% | 0.08x | Within |
Earnings calendar: this week’s reports with expected vs actual moves →
SNDX Options Activity & IV Rank
SNDX IV rank history, 52-week IV rank and IV percentile →
Volatility Metrics
Options Flow
ATM Options Pricing
Chain Summary
Each spread is ranked by a composite score built in three stages. Full documentation →
score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.
- RSI <40 bullish / >60 bearish
- MACD crossover + histogram trend
- Price vs SMA 50 & SMA 200
- Stochastic %K <20 / >80
- Williams %R <−80 / >−20
- Blended ATR + straddle expected-move penalty
- Bollinger Band signal (+ counter-trend penalty)
- BB width — vol contraction boost for ICs
- IV rank ≥ 75 → strong boost for credit spreads
- IV rank < 25 → penalty (selling cheap vol)
- Min open interest across all legs
- OI < 100 → −0.10 · OI < 500 → −0.05
score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →
Enter a ticker to scan for optimal spread opportunities.
Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.
Estimated net dealer gamma is at the 36th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.
Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.
Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.
Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.
This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.
IV(put wing) − IV(ATM), in vol pointsHow much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.
- Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
- Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
- Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
- Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
IV(call wing) − IV(put wing), equal delta on each sideWhich side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.
- Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
- Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
- Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
- Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:
- High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
- Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
- Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.
Enter a ticker to render the implied volatility surface.
Enter a ticker to render the implied volatility smile.
Risk Metrics
Analysis Details
Data Points: 251
Period: 252 trading days
Low volatility - stock moves less than market
| Investor | Value | Share of their portfolio | Rank | Q/Q shares | Source |
|---|---|---|---|---|---|
| Millennium Management Hedge fund Izzy Englander | $44.9M | #667 of 3716 | +929.4% | 13F | |
| Renaissance Technologies Hedge fund Jim Simons | $7.0M | #1260 of 3138 | -35.4% | 13F | |
| Citadel Hedge fund Ken Griffin | $5.6M | #1998 of 6285 | -59.1% | 13F | |
| Rockefeller Capital Management Family office Rockefeller family | $70K | #3179 of 4729 | 0.0% | 13F |
Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions
SNDX Institutional Ownership (13F)
Latest filings — 2026-09-30Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.
- Shares — long equity positions in this name, aggregated across share classes.
- Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
- % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
- Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.
Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | SILVERARC CAPITAL MANAGEMENT, LLC | $15.16M | 41.05% | 2026-06-30 |
| 2 | Susquehanna International Group, LLP Custodian | $11.34M | 30.70% | 2026-06-30 |
| 3 | Citadel Advisors LLC Custodian | $3.08M | 8.33% | 2026-06-30 |
| 4 | Citigroup Inc. Custodian | $2.62M | 7.10% | 2026-06-30 |
| 5 | Barclays PLC Custodian | $2.17M | 5.87% | 2026-06-30 |
| 6 | Jane Street Group, LLC Custodian | $861.28K | 2.33% | 2026-06-30 |
| 7 | Wolverine Trading, LLC Custodian | $616.18K | 1.67% | 2025-09-30 |
| 8 | Simplex Trading, LLC Custodian | $546.50K | 1.48% | 2026-06-30 |
| 9 | Walleye Capital LLC | $279.81K | 0.76% | 2026-06-30 |
| 10 | IMC-Chicago, LLC Custodian | $247.02K | 0.67% | 2026-06-30 |
| 11 | GROUP ONE TRADING LLC Custodian | $13.12K | 0.04% | 2026-06-30 |
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Citigroup Inc. Custodian | $2.62M | 43.92% | 2026-06-30 |
| 2 | Susquehanna International Group, LLP Custodian | $2.09M | 35.06% | 2026-06-30 |
| 3 | Citadel Advisors LLC Custodian | $708.26K | 11.86% | 2026-06-30 |
| 4 | Wolverine Trading, LLC Custodian | $466.80K | 7.81% | 2025-09-30 |
| 5 | Simplex Trading, LLC Custodian | $52.46K | 0.88% | 2026-06-30 |
| 6 | Walleye Capital LLC | $21.86K | 0.37% | 2026-06-30 |
| 7 | GROUP ONE TRADING LLC Custodian | $6.56K | 0.11% | 2026-06-30 |
SNDX Insider Trading (Form 4)
Latest: 2026-07-09| Filed | Reporter | Role | Action | Shares | Avg Price | Net $ | Link |
|---|---|---|---|---|---|---|---|
| 2026-07-09 | Michael A Metzger | Chief Executive Officer | Mixed | — | $15.31 | -$578.2K | EDGAR |
| 2026-06-12 | Nicholas A.J. Botwood | Head of R&D, CMO | Mixed | −11,765 | $16.15 | -$440.8K | EDGAR |
| 2026-06-02 | Michael A Metzger | Chief Executive Officer | Sell (S) | −6,847 | $18.99 | -$130.0K | EDGAR |
| 2026-06-02 | Keith A. Goldan | Chief Financial Officer | Sell (S) | −1,177 | $18.99 | -$22.4K | EDGAR |
| 2026-02-10 | Keith A. Goldan | Chief Financial Officer | Sell (S) | −3,410 | $21.03 | -$71.7K | EDGAR |
| 2026-02-10 | Michael A Metzger | Chief Executive Officer | Sell (S) | −17,159 | $21.03 | -$360.8K | EDGAR |
| 2026-02-06 | Pierre Legault | Director | Award (A) | +24,000 | — | EDGAR | |
| 2026-02-06 | Dennis Podlesak | Director | Award (A) | +48,000 | — | EDGAR | |
| 2026-02-06 | Keith Katkin | Director | Award (A) | +24,000 | — | EDGAR | |
| 2026-02-06 | Aleksandra Rizo | Director | Award (A) | +24,000 | — | EDGAR | |
| 2026-02-06 | Jennifer Jarrett | Director | Award (A) | +24,000 | — | EDGAR | |
| 2026-02-06 | Nicholas A.J. Botwood | Head of R&D, CMO | Award (A) | +60,000 | — | EDGAR | |
| 2026-02-06 | Martin H. Huber Jr. | Director | Award (A) | +24,000 | — | EDGAR | |
| 2026-02-06 | Michael A Metzger | Chief Executive Officer | Mixed | +210,188 | $20.62 | -$152.8K | EDGAR |
| 2026-02-06 | Keith A. Goldan | Chief Financial Officer | Mixed | +51,387 | $16.14 | -$32.6K | EDGAR |
SNDX Insider Holdings
11 insiders · @ $13.22| # | Insider | Role | Shares | Disclosed Exposure | Lifetime OM Net | Filings | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Michael A Metzger | Chief Executive Officer | 517,218 | $6.84M | -$15.40M | 33 | 2026-07-09 |
| 2 | Dennis Podlesak | Director | 239,763 | $3.17M | -$2.58M | 16 | 2026-02-06 |
| 3 | Keith A. Goldan | Chief Financial Officer | 139,252 | $1.84M | -$195.4K | 14 | 2026-06-02 |
| 4 | Keith Katkin | Director | 124,000 | $1.64M | -$786.1K | 15 | 2026-02-06 |
| 5 | Pierre Legault | Director | 114,000 | $1.51M | -$2.55M | 15 | 2026-02-06 |
| 6 | Jennifer Jarrett | Director | 114,000 | $1.51M | $0 | 9 | 2026-02-06 |
| 7 | Martin H. Huber Jr. | Director | 103,000 | $1.36M | $45.0K | 7 | 2026-02-06 |
| 8 | Nicholas A.J. Botwood | Head of R&D, CMO | 95,165 | $1.26M | -$1.08M | 3 | 2026-06-12 |
| 9 | William Meury | Director | 90,000 | $1.19M | -$1.70M | 9 | 2025-02-07 |
| 10 | Neil Gallagher | President, Head of R&D | 85,095 | $1.12M | -$71.6K | 4 | 2025-02-12 |
SNDX Board & Officers
As of SEC filings through Jul 9, 2026Directors 7
- Dennis Podlesak · since Mar 2, 2016
- Pierre Legault · since Jan 4, 2017
- Keith Katkin · since Mar 29, 2017
- Jennifer Jarrett · since Sep 25, 2018
- Michael A Metzger · listed since Jul 2019
- Martin H. Huber Jr. · since Sep 15, 2021
- Aleksandra Rizo · since May 15, 2024
Officers 3
- Michael A Metzger · Chief Executive Officer · listed since Feb 2022
- Keith A. Goldan · Chief Financial Officer · since Jun 13, 2022
- Nicholas A.J. Botwood · Head of R&D, CMO · since May 12, 2025
Changes in the last 10 years (34)
| Jun 24, 2025 | The company announced the departure of William Meury from the board in an SEC filing |
| May 12, 2025 | The company announced the departure of Neil Gallagher as President, Head of R&D in an SEC filing |
| May 12, 2025 | Nicholas A.J. Botwood became Head of R&D, CMO |
| May 15, 2024 | Aleksandra Rizo became a director |
| May 14, 2024 | The company announced the departure of Briggs Morrison from the board in an SEC filing |
| Mar 15, 2024 | The company announced the departure of Steve M Sabus as Chief Commercial Officer in an SEC filing |
| May 5, 2023 | The company announced the departure of Alexander Nolte as Chief Accounting Officer in an SEC filing |
| Apr 10, 2023 | Neil Gallagher became President, Head of R&D |
| Mar 29, 2023 | The company announced the departure of Briggs Morrison as President, Head of R&D in an SEC filing |
| Dec 5, 2022 | Steve M Sabus became Chief Commercial Officer |
| Jun 13, 2022 | Keith A. Goldan became Chief Financial Officer |
| Mar 1, 2022 | The company announced the departure of Michael L. Meyers as SVP, Chief Medical Officer in an SEC filing |
| Mar 1, 2022 | Catherine Madigan became Chief Medical Officer |
| Feb 22, 2022 | The company announced the departure of Fabrice Egros from the board in an SEC filing |
| Feb 3, 2022 | Michael A Metzger listed as Chief Executive Officer (previously President and COO) in SEC filings |
| Feb 3, 2022 | Briggs Morrison listed as President, Head of R&D (previously Chief Executive Officer) in SEC filings |
| Oct 22, 2021 | Alexander Nolte became Chief Accounting Officer |
| Sep 15, 2021 | Martin H. Huber Jr. became a director |
| Jul 13, 2020 | Daphne Karydas became Chief Financial Officer |
| Jul 8, 2019 | Michael A Metzger first listed as a director in an SEC filing |
| Sep 25, 2018 | William Meury became a director |
| Sep 25, 2018 | Jennifer Jarrett became a director |
| Jun 20, 2018 | Mark N Lampert reported in an SEC filing no longer being a 10% owner |
| Jun 20, 2018 | Bvf Partners L P/il reported in an SEC filing no longer being a 10% owner |
| Jun 20, 2018 | Bvf Inc/il reported in an SEC filing no longer being a 10% owner |
| Nov 28, 2017 | Mark N Lampert became a 10% owner |
| Nov 28, 2017 | Bvf Partners L P/il became a 10% owner |
| Nov 28, 2017 | Bvf Inc/il became a 10% owner |
| Mar 29, 2017 | Keith Katkin became a director |
| Feb 15, 2017 | Richard P Shea no longer listed as a director in SEC filings |
| Feb 15, 2017 | Richard P Shea first listed as Chief Financial Officer in an SEC filing |
| Feb 8, 2017 | Peter Ordentlich listed as Chief Scientific Officer (previously Chief Technology Officer) in SEC filings |
| Feb 8, 2017 | Michael L. Meyers listed as SVP, Chief Medical Officer (previously SVP, Chief Development Officer) in SEC filings |
| Jan 4, 2017 | Pierre Legault became a director |
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Not reported recently (9)
- Peter Ordentlich · Last reported as Chief Scientific Officer in an SEC filing dated Feb 17, 2023
- Catherine Madigan · Last reported as Chief Medical Officer in an SEC filing dated Feb 3, 2023
- Daphne Karydas · Last reported as Chief Financial Officer in an SEC filing dated Feb 5, 2021
- Richard P Shea · Last reported as Chief Financial Officer in an SEC filing dated Feb 14, 2020
- Luke Evnin · Last reported as a director in an SEC filing dated May 25, 2018
- Henry Chen · Last reported as a director in an SEC filing dated May 25, 2018
- George W. Sledge Jr. · Last reported as a director in an SEC filing dated May 19, 2017
- Ivor Royston · Last reported as a director in an SEC filing dated Mar 22, 2017
- Kim P. Kamdar · Last reported as a director in an SEC filing dated Nov 2, 2016
SNDX Proposed Insider Sales (Form 144)
Latest: 2026-07-08What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.
How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.
10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.
"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.
Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.
| Filed | Filer | Role | Shares | Notice Value | Planned Sale | Broker | Plan | Link |
|---|---|---|---|---|---|---|---|---|
| 2026-07-08 | MICHAEL METZGER | Director, Officer | 32,375 | $752.4K | 2026-07-08 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-06-12 | Botwood Nicholas A.J. | Officer | 31,235 | $566.7K | 2026-06-12 | Fidelity Brokerage Services LLC | 10b5-1 | EDGAR |
| 2026-06-11 | Botwood Nicholas A.J. | Officer | 34,280 | $609.4K | 2026-06-11 | Fidelity Brokerage Services LLC | 10b5-1 | EDGAR |
| 2026-06-01 | Goldan Keith A. | Officer | 1,177 | $22.4K | 2026-06-01 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-06-01 | Metzger Michael A | Officer, Director | 6,847 | $130.0K | 2026-06-01 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-02-09 | Metzger Michael A | Officer, Director | 17,159 | $360.8K | 2026-02-09 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-02-09 | Goldan Keith A. | Officer | 3,410 | $71.7K | 2026-02-09 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-02-06 | Metzger Michael A | Officer, Director | 7,412 | $152.8K | 2026-02-06 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-02-06 | Goldan Keith A. | Officer | 2,082 | $42.9K | 2026-02-06 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2025-09-08 | MICHAEL METZGER | Director, Officer | 157,307 | $2.68M | 2025-09-08 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| # | ETF | Provider | Weight | $ Exposure | ETF AUM | As Of |
|---|---|---|---|---|---|---|
| 1 | VTI Vanguard Morningstar Total Stock Market ETF | Vanguard | 0.00% | $53.6M | — | 2026-09-30 |
| 2 | XBI State Street® SPDR® S&P® Biotech ETF | SPDR (State Street) | 0.35% | $36.2M | $10.4B | 2026-10-23 |
| 3 | IWM iShares Russell 2000 ETF | iShares (BlackRock) | 0.04% | $29.9M | $74.6B | 2026-10-23 |
| 4 | VXF Vanguard Extended Market ETF | Vanguard | 0.02% | $19.1M | — | 2026-09-30 |
| 5 | IWO iShares Russell 2000 Growth ETF | iShares (BlackRock) | 0.08% | $11.1M | $13.7B | 2026-10-23 |
| 6 | VTWO Vanguard Russell 2000 ETF | Vanguard | 0.06% | $9.7M | — | 2026-09-30 |
| 7 | IBB iShares Biotechnology ETF | iShares (BlackRock) | 0.08% | $8.3M | $10.7B | 2026-10-23 |
| 8 | SCHA Schwab U.S. Small-Cap ETF | Nport | 0.04% | $8.2M | — | 2026-05-31 |
| 9 | VHT Vanguard Health Care ETF | Vanguard | 0.02% | $4.3M | — | 2026-09-30 |
| 10 | BRES Burney U.S. Equity Select ETF | Nport | 0.39% | $2.6M | — | 2026-07-31 |
| 11 | FYC First Trust Small Cap Growth AlphaDEX® Fund | First Trust | 0.18% | $2.4M | $1.3B | 2026-10-23 |
| 12 | VTWG Vanguard Russell 2000 Growth ETF | Vanguard | 0.11% | $1.8M | — | 2026-09-30 |
| 13 | ITOT iShares Core S&P Total U.S. Stock Market ETF | iShares (BlackRock) | 0.00% | $1.6M | $96.5B | 2026-10-23 |
| 14 | PRFZ Invesco RAFI US 1500 Small-Mid ETF | Nport | 0.06% | $1.6M | — | 2026-07-31 |
| 15 | BBP Virtus Biotech Etf | Nport | 1.44% | $1.4M | — | 2026-07-31 |
| 16 | CANC Tema Oncology ETF | Nport | 0.80% | $1.4M | — | 2026-05-31 |
| 17 | LABU Direxion Daily S&P Biotech Bull 3X ETF | Direxion | 0.25% | $1.4M | — | 2026-10-26 |
| 18 | DWAS Invesco Dorsey Wright SmallCap Momentum ETF | Nport | 0.26% | $1.1M | — | 2026-05-31 |
| 19 | SCHB Schwab U.S. Broad Market ETF | Nport | 0.00% | $1.0M | — | 2026-05-31 |
| 20 | SEIS SEI Select Small Cap ETF | Nport | 0.17% | $1.0M | — | 2026-06-30 |
| 21 | FYX First Trust Small Cap Core AlphaDEX® Fund | First Trust | 0.04% | $601,526 | $1.4B | 2026-10-23 |
| 22 | ONEQ Fidelity Nasdaq Composite Index ETF | Fidelity | 0.01% | $568,334 | $10.7B | 2026-10-23 |
| 23 | RSSL Global X Russell 2000 ETF | Global X | 0.04% | $568,024 | — | 2026-10-26 |
| 24 | FHLC Fidelity MSCI Health Care Index ETF | Fidelity | 0.01% | $510,996 | $3.8B | 2026-10-23 |
| 25 | ISMD Inspire Small/Mid Cap ETF | Nport | 0.14% | $451,216 | — | 2026-05-31 |
Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.
- Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
- Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
- Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
- Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
- Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
- YoY growth — compare to the same quarter a year earlier to remove seasonality.
- Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
- Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.
TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.
Quarterly figures (12 quarters)
| Quarter | Period End | Revenue | Net Income | Diluted EPS | Op. Cash Flow |
|---|---|---|---|---|---|
| Q2 '26 | 2026-06-30 | $72.79M | $-49.36M | $-0.55 | $-30.27M |
| Q1 '26 | 2026-03-31 | $64.86M | $-42.67M | $-0.48 | $-50.34M |
| Q4 '25 | 2025-12-31 | $68.73M | $-68.01M | $-0.78 | $-69.49M |
| Q3 '25 | 2025-09-30 | $45.87M | $-60.72M | $-0.70 | — |
| Q2 '25 | 2025-06-30 | $37.96M | $-71.85M | $-0.83 | $-87.80M |
| Q1 '25 | 2025-03-31 | $20.04M | $-84.85M | $-0.98 | $-95.16M |
| Q4 '24 | 2024-12-31 | $7.68M | $-94.17M | $-1.09 | $-57.39M |
| Q3 '24 | 2024-09-30 | $12.50M | $-84.13M | $-0.98 | — |
| Q2 '24 | 2024-06-30 | $3.50M | $-68.06M | $-0.80 | — |
| Q1 '24 | 2024-03-31 | — | $-72.40M | $-0.85 | $-83.55M |
| Q4 '23 | 2023-12-31 | — | $-72.47M | $-1.01 | $-41.35M |
| Q3 '23 | 2023-09-30 | — | $-51.15M | $-0.73 | $-44.65M |
Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.
- P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
- P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
- P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
- EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
- EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
- ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
- ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
- Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
- FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
- Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
- Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
- Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
- Multiples expanding while earnings are flat = sentiment-driven rally.
- Multiples compressing while earnings grow = value coming from fundamentals.
Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.
- Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
- SI % of Float — short interest / free float. The key crowding metric.
- Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
- Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
- Free Float — shares available for public trading (total shares minus insider / restricted).
- Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
- SI % of Float < 5% — typical, no particular signal.
- 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
- 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
- >30% — extreme; borrow is likely expensive and squeeze risk is material.
- Days to Cover > 5 combined with high SI% amplifies squeeze potential.
- Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
- A sudden drop in SI after a rally may indicate a squeeze in progress.
Short interest is reported mid-month and end-of-month; short volume is daily.