ORBIMED ADVISORS LLC — 13F Holdings & Portfolio
CIK 1055951 · latest 13F-HR filed 2026-08-14
ORBIMED ADVISORS LLC manages $5.40B in 13F-reported U.S. long-equity assets across 129 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are EWTX (11.68%), ELVN (6.37%), LLY (5.73%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 35 new positions, exited 21, added to 52, and trimmed 22.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$5.40B
Long-equity book
129
Distinct positions
2026-06-30
Filed 2026-08-14
+35 / −21 / ↑52 / ↓22
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Share-count changes vs the prior 13F.
Top Adds (vs prior quarter)
- EDGEWISE THERAPEUTICS INC$141.7M +29.0%
- ELI LILLY & CO$91.5M +42.0%
- MBX BIOSCIENCES INC$80.7M +74.3%
- COGENT BIOSCIENCES INC$52.7M +424.8%
- UNIQURE NV$48.3M +138.4%
Top Trims
- BOSTON SCIENTIFIC CORP-$86.2M -57.7%
- COMPASS THERAPEUTICS INC-$47.2M -58.6%
- DISC MEDICINE INC-$42.1M -61.7%
- ALNYLAM PHARMACEUTICALS INC-$34.3M -87.0%
- INTUITIVE SURGICAL INC-$33.4M -34.7%
New Positions
- UNITEDHEALTH GROUP INC$67.0M
- ASCENDIS PHARMA A/S$65.2M
- HUMANA INC$65.2M
- ODYSSEY THERAPEUTICS INC$56.2M
- ARCUTIS BIOTHERAPEUTICS INC$53.5M
Exited Positions
- MYRIAD GENETICS INC$122.9M
- PFIZER INC$54.7M
- DANAHER CORP DEL$50.4M
- AVITA MEDICAL INC$42.5M
- ASCENDIS PHARMA A/S$41.6M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | EDGEWISE THERAPEUTICS INC | EWTX | 28036F105 | $630.5M | 11.68% | 15,518,492 | SH |
| 2 | ENLIVEN THERAPEUTICS INC | ELVN | 29337E102 | $343.9M | 6.37% | 6,776,632 | SH |
| 3 | ELI LILLY & CO | LLY | 532457108 | $309.3M | 5.73% | 257,900 | SH |
| 4 | MBX BIOSCIENCES INC | MBX | 55287L101 | $189.3M | 3.51% | 3,428,736 | SH |
| 5 | SINOVAC BIOTECH LTD | SVA | P8696W104 | $184.5M | 3.42% | 2,718,735 | SH |
| 6 | ASTRAZENECA PLC | AZN | G0593M107 | $171.1M | 3.17% | 915,700 | SH |
| 7 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $118.6M | 2.20% | 2,209,400 | SH |
| 8 | SIONNA THERAPEUTICS INC | SION | 829401108 | $112.4M | 2.08% | 2,555,877 | SH |
| 9 | CORVUS PHARMACEUTICALS INC | CRVS | 221015100 | $107.0M | 1.98% | 7,165,006 | SH |
| 10 | ARRIVENT BIOPHARMA INC | AVBP | 04272N102 | $105.2M | 1.95% | 3,027,328 | SH |
| 11 | GUARDANT HEALTH INC | GH | 40131M109 | $87.6M | 1.62% | 583,700 | SH |
| 12 | ARGENX SE | ARGX | 04016X101 | $86.2M | 1.60% | 92,880 | SH |
| 13 | MERCK & CO INC | MRK | 58933Y105 | $85.2M | 1.58% | 663,400 | SH |
| 14 | UNIQURE NV | QURE | N90064101 | $83.3M | 1.54% | 1,807,486 | SH |
| 15 | PRAXIS PRECISION MEDICINES I | PRAX | 74006W207 | $77.0M | 1.43% | 230,100 | SH |
| 16 | EDWARDS LIFESCIENCES CORP | EW | 28176E108 | $75.5M | 1.40% | 834,900 | SH |
| 17 | PRELUDE THERAPEUTICS INC | PRLD | 74065P101 | $73.2M | 1.36% | 13,724,571 | SH |
| 18 | ABIVAX SA | ABVX | 00370M103 | $72.8M | 1.35% | 546,522 | SH |
| 19 | DYNE THERAPEUTICS INC | DYN | 26818M108 | $71.9M | 1.33% | 3,235,684 | SH |
| 20 | NATERA INC | NTRA | 632307104 | $71.1M | 1.32% | 262,000 | SH |
| 21 | CG ONCOLOGY INC | CGON | 156944100 | $69.1M | 1.28% | 972,800 | SH |
| 22 | UNITEDHEALTH GROUP INC | UNH | 91324P102 | $67.0M | 1.24% | 161,100 | SH |
| 23 | ARS PHARMACEUTICALS INC | SPRY | 82835W108 | $66.4M | 1.23% | 8,288,510 | SH |
| 24 | ASCENDIS PHARMA A/S | ASND | K08588103 | $65.2M | 1.21% | 244,456 | SH |
| 25 | HUMANA INC | HUM | 444859102 | $65.2M | 1.21% | 164,100 | SH |
| 26 | COGENT BIOSCIENCES INC | COGT | 19240Q201 | $65.1M | 1.21% | 1,681,300 | SH |
| 27 | BOSTON SCIENTIFIC CORP | BSX | 101137107 | $63.3M | 1.17% | 1,483,200 | SH |
| 28 | INTUITIVE SURGICAL INC | ISRG | 46120E602 | $62.8M | 1.16% | 157,900 | SH |
| 29 | MINERALYS THERAPEUTICS INC | MLYS | 603170101 | $56.9M | 1.05% | 2,110,300 | SH |
| 30 | ODYSSEY THERAPEUTICS INC | ODTX | 67613T104 | $56.2M | 1.04% | 3,001,198 | SH |
| 31 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $53.9M | 1.00% | 892,471 | SH |
| 32 | ARCUTIS BIOTHERAPEUTICS INC | ARQT | 03969K108 | $53.5M | 0.99% | 2,042,000 | SH |
| 33 | BRISTOL-MYERS SQUIBB CO | BMY | 110122108 | $53.3M | 0.99% | 925,000 | SH |
| 34 | Q32 BIO INC | QTTB | 746964105 | $52.6M | 0.97% | 4,127,987 | SH |
| 35 | STRYKER CORPORATION | SYK | 863667101 | $50.1M | 0.93% | 159,100 | SH |
| 36 | CARIS LIFE SCIENCES INC | CAI | 142152107 | $50.0M | 0.93% | 2,806,811 | SH |
| 37 | SPDR SERIES TRUST Put | XBI | 78464A870 | $47.5M | 0.88% | 300,000 | SH |
| 38 | THERMO FISHER SCIENTIFIC INC | TMO | 883556102 | $45.5M | 0.84% | 90,700 | SH |
| 39 | PALVELLA THERAPEUTICS INC NE | PVLA | 697947109 | $44.7M | 0.83% | 292,360 | SH |
| 40 | ELEVANCE HEALTH INC FORMERLY | ELV | 036752103 | $44.4M | 0.82% | 114,700 | SH |
| 41 | SHATTUCK LABS INC | STTK | 82024L103 | $43.8M | 0.81% | 6,306,127 | SH |
| 42 | UPSTREAM BIO INC | UPB | 91678A107 | $39.4M | 0.73% | 5,693,589 | SH |
| 43 | CRINETICS PHARMACEUTICALS IN | CRNX | 22663K107 | $37.4M | 0.69% | 999,000 | SH |
| 44 | RHYTHM PHARMACEUTICALS INC | RYTM | 76243J105 | $35.9M | 0.66% | 322,900 | SH |
| 45 | SYNDAX PHARMACEUTICALS INC | SNDX | 87164F105 | $33.7M | 0.62% | 1,542,000 | SH |
| 46 | FORTE BIOSCIENCES INC | FBRX | 34962G208 | $33.5M | 0.62% | 1,577,705 | SH |
| 47 | COMPASS THERAPEUTICS INC | CMPX | 20454B104 | $33.3M | 0.62% | 15,219,994 | SH |
| 48 | NEKTAR THERAPEUTICS | NKTR | 640268306 | $32.5M | 0.60% | 465,346 | SH |
| 49 | KRYSTAL BIOTECH INC | KRYS | 501147102 | $30.9M | 0.57% | 83,200 | SH |
| 50 | PRELUDE THERAPEUTICS INC | WSDDF | 000000000 | $30.3M | 0.56% | 5,680,186 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $5.40B | 129 | 0001172661-26-003740 |
| 2026-03-31 | 2026-05-15 | $5.05B | 114 | 0001172661-26-002369 |
| 2025-12-31 | 2026-02-17 | $4.90B | 108 | 0001172661-26-001119 |
| 2025-09-30 | 2025-11-14 | $4.26B | 110 | 0001172661-25-005047 |
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