PRLD Prelude Therapeutics Incorporated
XNAS
3.70
Delayed
Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Fibonacci levels Insider trading
Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.
- 52-Week Range
- $1.17 – $6.83
- YTD
- +35.53%
- Straddle Price
- $1.27
- P/C Vol Ratio
- 50.00
- Market Cap
- $0.3B
- Open
- $3.63
- Day Range
- $3.40 – $3.74
- Volume
- 236,859
- Prev Close
- $3.63
A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.
- DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
- Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
- DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
- P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
- Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
- Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
- Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
- Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
| 10-yr Treasury (rf) | 4.96% |
| Beta vs SPY | 1.15 |
| Cost of Equity (CAPM) | 11.27% (VRP-adj) |
| WACC | 11.44% |
| Volatility Risk Premium | +152.0pp (IV − HV30), ERP adj +50bps |
| Effective Tax Rate | 21.0% |
| Rev. Growth (YoY, DCF input) | -10.0% |
| DCF Horizon | 10 years explicit + fade |
| Free Cash Flow (TTM) | $-0.0B |
| Return on Equity (TTM) | -45.2% |
| Book / Price | 42.9% — banking bias active (P/B is primary) |
| Gross Margin (TTM) | 100.0% |
| FCF Margin (TTM) | -148.3% |
| Debt / Equity | 0.00 |
| Quality Score | 2/6 — normal (10y DCF) |
| SMA 50 | $4.61 (Market Anchor value) |
| SMA 20 / Bollinger Mid | $3.66 |
| Bollinger Width / SMA20 | 637.2% (drives anchor stability) |
| Net Debt | $-0.0B |
| Market Cap | $0B |
| Method | Implied Price | Weight | Detail |
|---|---|---|---|
| DCF | n/a | 0% | |
| DDM (Gordon) | n/a | 0% | |
| Peer P/E | n/a | 0% | median 39.5× · 3 peers |
| Peer EV/EBITDA | n/a | 0% | median 19.2× · 3 peers |
| Peer P/B | $5.58 | 50% | median 3.5× · 3 peers |
| Peer P/S | $1.03 | 50% | median 3.9× · 3 peers |
| Market Anchor (SMA50) | $4.61 | 0% | stability 0% (BB-width) |
| Options Expected (B-L 30d) | n/a | 0% |

- Industry (SIC)
- PHARMACEUTICAL PREPARATIONS (2834) · industry map
- Exchange
- XNAS
- Market Cap
- $0.3B
- Employees
- 79
- List Date
- 2020-09-25
- CIK
- 0001678660
- Next Earnings
- 2026-11-11 (Pre-Market)
- EPS Forecast
- ($0.14) (2 est.)
- Headquarters
- Wilmington, DE
- Homepage
- https://www.preludetx.com
Prelude Therapeutics Incorp is a precision oncology company developing medicines in areas of high unmet need for cancer patients. Its pipeline features selective KAT6A degraders and mutant selective JAK2V617F JH2 inhibitors, new approaches to clinically validated targets with transformative potential for patients. The company is also leveraging its expertise in targeted protein degradation to discover and develop next-generation degrader antibody conjugates (DACs) with novel payloads.
Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.
| Month | '21 | '22 | '23 | '24 | '25 | '26 | Avg |
|---|---|---|---|---|---|---|---|
| Jan | -3.72% | -24.89% | 27.09% | -19.41% | -12.00% | -32.23% | -10.86% |
| Feb | -10.29% | -13.69% | -14.11% | 31.50% | -31.62% | 35.96% | -0.37% |
| Mar | -35.99% | -18.54% | -3.88% | 3.27% | 12.28% | 26.20% | -2.78% |
| Apr | 0.46% | -36.69% | -2.12% | -19.62% | 24.59% | 51.59% | 3.04% |
| May | -14.13% | -13.58% | -9.42% | 3.22% | -3.54% | -16.60% | -9.01% |
| Jun | -13.22% | 23.99% | -19.06% | 3.25% | -10.77% | 39.53% | 3.95% |
| Jul | 12.03% | -5.66% | -13.50% | 68.97% | -2.51% | -6.69% | 8.77% |
| Aug | 12.48% | 42.57% | 1.08% | -7.96% | 46.08% | 27.56% | 20.30% |
| Sep | -15.72% | -13.82% | -15.57% | -59.41% | 27.43% | -28.78% | -17.64% |
| Oct | -44.61% | -1.76% | -38.88% | -40.89% | 5.30% | -2.37%* | -20.54% |
| Nov | -22.00% | 0.30% | 77.96% | -15.32% | -57.79% | -- | -3.37% |
| Dec | -9.45% | -8.62% | 32.40% | 21.43% | 87.10% | -- | 24.57% |
| Total | -82.80% | -62.61% | -19.96% | -64.03% | 9.34% | 69.76% | -25.05% |
Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.
- SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
- EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
- MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
- ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
- +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
- RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
- Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
- Williams %R — inverted scale: <−80 oversold, >−20 overbought.
Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.
- Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
- OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
- Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
- ATR / True Range — average daily $ move; sizing and stop-loss reference.
- HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.
Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →
Trend Indicators
Momentum Oscillators
Volume & Volatility
Data Summary
LLM Stock Analysis Report
SYMBOL: PRLD CURRENT PRICE: $4.27
Executive Summary Overall Assessment: NEUTRAL (Confidence Level: 7/10) Key Drivers and Primary Risks: + Strong technical momentum, with MACD and RSI in bullish territories. + Recent positive news headlines on cancer research and clinical trial data. + High volatility, with beta exceeding market (2.09 vs SPY). + Options market pricing a potential move of $1.25 by expiration.
Technical Analysis Trend Direction: SHORT-TERM (1-4 weeks): UPTREND; MEDIUM-TERM (1-3 months): UPTREND Support/Resistance Levels: + Lower Bollinger Band: $4.07 + Middle Bollinger Band: $4.61 + Upper Bollinger Band: $5.15 Momentum Signals: + RSI (14): 46.70 (NEUTRAL) + MACD: Bullish crossover above signal line + Bollinger Bands: Neutral, with price touching the middle band
News & Sentiment Analysis Recent Headlines Summary: Positive news on cancer research and clinical trial data. Sentiment Assessment: POSITIVE Catalyst Identification: Upcoming healthcare conferences, FDA approvals, or product launches.
Risk & Volatility Assessment Beta Interpretation: HIGH RISK (2.09 vs SPY) Volatility Regime: CURRENT VOLATILITY: HIGH (1.99); HISTORICAL VOLATILITY: 98.2% (HV20), 127.9% (HV30), and 118.5% (HV60)
Market Context & Positioning Sector Performance: Relative strength vs sector/market Institutional Activity: Institutional interest signals through volume patterns. Correlation Analysis: PRLD moves more than the market (0.13 R-squared interpretation).
Key Levels & Action Items Critical Price Levels: Support: $4.07; Resistance: $5.15 Breakout/Breakdown Levels: Short-term support at $4.27, potential breakout above $5.15. Time-Sensitive Catalysts: Upcoming healthcare conferences, FDA approvals, or product launches. Risk Management: Stop-loss levels and position sizing considerations based on volatility and risk appetite.
Conclusion: PRLD's technical momentum is strong, with MACD and RSI in bullish territories. Recent positive news headlines support this trend. However, the stock's high volatility and beta exceeding market highlight potential risks. Options market pricing a potential move of $1.25 by expiration suggests opportunities for traders to take advantage of price movements. Overall, I maintain a NEUTRAL outlook with caution due to the company's high-risk profile.
Note: This analysis focuses on risk/reward assessment only and does not provide buy/sell recommendations.
| Earnings Date | Timing | Expected Move | Actual Move | Ratio | Outcome |
|---|---|---|---|---|---|
| 2023-05-08 | Pre-Market | 22.73% | 2.15% | 0.09x | Within |
| 2023-08-03 | Pre-Market | 72.80% | 3.73% | 0.05x | Within |
| 2023-11-01 | Pre-Market | 134.92% | 10.06% | 0.07x | Within |
| 2024-05-07 | Pre-Market | 39.69% | 3.39% | 0.09x | Within |
| 2024-08-12 | Pre-Market | 35.29% | 6.86% | 0.19x | Within |
| 2024-11-06 | Pre-Market | 144.26% | 2.33% | 0.02x | Within |
| 2025-03-10 | Pre-Market | 835.60% | 8.97% | 0.01x | Within |
| 2025-05-06 | After-Close | 813.44% | 3.98% | 0.00x | Within |
| 2025-08-14 | Pre-Market | 771.78% | 4.19% | 0.01x | Within |
| 2025-11-12 | Pre-Market | 272.22% | 8.89% | 0.03x | Within |
| 2026-03-10 | Pre-Market | 33.17% | 16.50% | 0.50x | Within |
| 2026-05-12 | Pre-Market | 16.67% | 3.33% | 0.20x | Within |
| 2026-08-11 | After-Close | 21.62% | 7.71% | 0.36x | Within |
Earnings calendar: this week’s reports with expected vs actual moves →
PRLD Options Activity & IV Rank
Volatility Metrics
Options Flow
ATM Options Pricing
Chain Summary
Each spread is ranked by a composite score built in three stages. Full documentation →
score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.
- RSI <40 bullish / >60 bearish
- MACD crossover + histogram trend
- Price vs SMA 50 & SMA 200
- Stochastic %K <20 / >80
- Williams %R <−80 / >−20
- Blended ATR + straddle expected-move penalty
- Bollinger Band signal (+ counter-trend penalty)
- BB width — vol contraction boost for ICs
- IV rank ≥ 75 → strong boost for credit spreads
- IV rank < 25 → penalty (selling cheap vol)
- Min open interest across all legs
- OI < 100 → −0.10 · OI < 500 → −0.05
score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →
Enter a ticker to scan for optimal spread opportunities.
Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.
Estimated net dealer gamma is at the 54th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.
Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.
Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.
Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.
This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.
IV(put wing) − IV(ATM), in vol pointsHow much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.
- Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
- Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
- Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
- Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
IV(call wing) − IV(put wing), equal delta on each sideWhich side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.
- Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
- Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
- Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
- Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:
- High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
- Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
- Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.
Enter a ticker to render the implied volatility surface.
Enter a ticker to render the implied volatility smile.
Risk Metrics
Analysis Details
Data Points: 251
Period: 252 trading days
High volatility - stock moves more than market
| Investor | Value | Share of their portfolio | Rank | Q/Q shares | Source |
|---|---|---|---|---|---|
| Millennium Management Hedge fund Izzy Englander | $4.5M | #2115 of 3716 | +120.8% | 13F | |
| Renaissance Technologies Hedge fund Jim Simons | $1.5M | #2123 of 3138 | +2.2% | 13F | |
| Citadel Hedge fund Ken Griffin | $120K | #5705 of 6285 | -81.9% | 13F |
Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions
PRLD Institutional Ownership (13F)
Latest filings — 2026-09-30Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.
- Shares — long equity positions in this name, aggregated across share classes.
- Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
- % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
- Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.
Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Susquehanna International Group, LLP Custodian | $591.63K | 58.05% | 2026-06-30 |
| 2 | Jane Street Group, LLC Custodian | $341.65K | 33.53% | 2026-06-30 |
| 3 | Citadel Advisors LLC Custodian | $85.81K | 8.42% | 2026-06-30 |
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Susquehanna International Group, LLP Custodian | $339.52K | 55.34% | 2026-06-30 |
| 2 | Citadel Advisors LLC Custodian | $166.83K | 27.19% | 2026-06-30 |
| 3 | Jane Street Group, LLC Custodian | $107.13K | 17.46% | 2026-06-30 |
PRLD Insider Trading (Form 4)
Latest: 2026-06-10| Filed | Reporter | Role | Action | Shares | Avg Price | Net $ | Link |
|---|---|---|---|---|---|---|---|
| 2026-06-10 | Paul A Friedman | Director | Grant (A) | +38,000 opt | — | EDGAR | |
| 2026-06-10 | David P Bonita | Director | Grant (A) | +38,000 opt | — | EDGAR | |
| 2026-06-10 | Victor Sandor | Director | Grant (A) | +38,000 opt | — | EDGAR | |
| 2026-06-10 | Katina Dorton | Director | Grant (A) | +38,000 opt | — | EDGAR | |
| 2026-06-10 | Martin Babler | Director | Grant (A) | +38,000 opt | — | EDGAR | |
| 2026-06-10 | Julian Baker | Director | Grant (A) | +456,000 opt | — | EDGAR | |
| 2026-05-04 | Charles Q Morris | Chief Medical Officer | Grant (A) | +450,000 opt | — | EDGAR | |
| 2026-04-28 | Rajeev M. Shah | 10%+ Owner | Other (J) | −5,628,000 | — | EDGAR | |
| 2026-04-23 | David P Bonita | Director | Buy (P) | +2,815,315 | $4.44 | $12.50M | EDGAR |
| 2026-04-23 | ORBIMED CAPITAL LLC | Director | Buy (P) | +11,261,260 | $4.44 | $50.00M | EDGAR |
| 2026-04-22 | BAKER BROS. ADVISORS LP | Director | Buy (P) | +13,513,512 RSU | — | EDGAR | |
| 2026-02-05 | Peggy Scherle | Chief Scientific Officer | Grant (A) | +230,000 opt | — | EDGAR | |
| 2026-02-05 | Krishna Vaddi | CEO | Grant (A) | +837,000 opt | — | EDGAR | |
| 2026-02-05 | Bryant David Lim | CLO, CFO, Corp Sec. | Grant (A) | +275,000 opt | — | EDGAR | |
| 2026-02-05 | Andrew Combs | Chief Chemistry Officer | Grant (A) | +230,000 opt | — | EDGAR |
PRLD Insider Holdings
10 insiders · @ $3.70| # | Insider | Role | Shares | Disclosed Exposure | Lifetime OM Net | Filings | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Rajeev M. Shah | 10%+ Owner | 6,475,882 | $23.96M | $0 | 1 | 2026-04-28 |
| 2 | Krishna Vaddi | CEO | 2,422,951 | $8.96M | $873.7K | 18 | 2026-02-05 |
| 3 | ORBIMED CAPITAL LLC | Director | 1,126,126 | $4.17M | $65.00M | 3 | 2026-04-23 |
| 4 | David P Bonita | Director | 1,126,126 | $4.17M | $41.00M | 10 | 2026-06-10 |
| 5 | Paul A Friedman | Director | 500,098 | $1.85M | $0 | 7 | 2026-06-10 |
| 6 | Andrew Combs | Chief Chemistry Officer | 480,123 | $1.78M | $268.7K | 11 | 2026-02-05 |
| 7 | Peggy Scherle | Chief Scientific Officer | 176,234 | $652.1K | -$2.26M | 12 | 2026-02-05 |
| 8 | Jane Huang | President, CMO | 86,917 | $321.6K | -$81.3K | 15 | 2025-10-07 |
| 9 | Bryant David Lim | CLO, CFO, Corp Sec. | 27,400 | $101.4K | $35.6K | 7 | 2026-02-05 |
| 10 | Mardi Dier | Director | 10,000 | $37.0K | $190.0K | 7 | 2025-06-13 |
PRLD Board & Officers
As of SEC filings through Jun 10, 2026Directors 17
- 667, L.p. (entity) · since Sep 24, 2020
- Baker Bros. Advisors (GP) LLC (entity) · since Sep 24, 2020
- Baker Bros. Advisors LP (entity) · since Sep 24, 2020
- Baker Brothers Life Sciences LP (entity) · since Sep 24, 2020
- David P Bonita · since Sep 24, 2020
- Felix Baker · since Sep 24, 2020
- Julian Baker · since Sep 24, 2020
- Krishna Vaddi · since Sep 24, 2020
- OrbiMed Capital GP VI LLC (entity) · since Sep 24, 2020
- Orbimed Advisors LLC (entity) · since Sep 24, 2020
- Paul A Friedman · since Sep 24, 2020
- Victor Sandor · since Sep 24, 2020
- Orbimed Capital LLC (entity) · on file since Sep 2020
- Martin Babler · since Jul 19, 2021
- Paul C Scherer · since Jun 12, 2025
- Katina Dorton · since Oct 17, 2025
- OrbiMed Genesis GP LLC (entity) · on file since Apr 2026
Officers 6
- Krishna Vaddi · CEO · listed since Feb 2022
- Bryant David Lim · CLO, CFO, Corp Sec. · listed since Feb 2025
- Peggy Scherle · Chief Scientific Officer · since Sep 24, 2020
- Andrew Combs · Chief Chemistry Officer · listed since Mar 2024
- Sean P. Brusky · Chief Business Officer · since Mar 5, 2026
- Charles Q Morris · Chief Medical Officer · since Apr 15, 2026
10% owners 11
- 667, L.p. (entity) · since Sep 24, 2020
- Baker Bros. Advisors (GP) LLC (entity) · since Sep 24, 2020
- Baker Bros. Advisors LP (entity) · since Sep 24, 2020
- Baker Brothers Life Sciences LP (entity) · since Sep 24, 2020
- David P Bonita · since Sep 24, 2020
- Felix Baker · since Sep 24, 2020
- Julian Baker · since Sep 24, 2020
- OrbiMed Capital GP VI LLC (entity) · since Sep 24, 2020
- OrbiMed Genesis GP LLC (entity) · on file since Apr 2026
- Orbimed Advisors LLC (entity) · since Sep 24, 2020
- Orbimed Capital LLC (entity) · on file since Sep 2020
Changes in the last 10 years (60)
| Apr 28, 2026 | Rajeev M. Shah reported in an SEC filing no longer being a 10% owner |
| Apr 28, 2026 | Ra Capital Management, L.p. reported in an SEC filing no longer being a 10% owner |
| Apr 28, 2026 | RA Capital Healthcare Fund LP reported in an SEC filing no longer being a 10% owner |
| Apr 28, 2026 | Peter Kolchinsky reported in an SEC filing no longer being a 10% owner |
| Apr 23, 2026 | OrbiMed Genesis GP LLC first on file as a director |
| Apr 23, 2026 | OrbiMed Genesis GP LLC first on file as a 10% owner |
| Apr 21, 2026 | Rajeev M. Shah became a 10% owner |
| Apr 21, 2026 | Ra Capital Management, L.p. became a 10% owner |
| Apr 21, 2026 | RA Capital Healthcare Fund LP became a 10% owner |
| Apr 21, 2026 | Peter Kolchinsky became a 10% owner |
| Apr 15, 2026 | Charles Q Morris became Chief Medical Officer |
| Mar 5, 2026 | Sean P. Brusky became Chief Business Officer |
| Nov 4, 2025 | The company announced the departure of Jane Huang as President, CMO in an SEC filing |
| Oct 17, 2025 | Katina Dorton became a director |
| Oct 15, 2025 | The company announced the departure of Mardi Dier from the board in an SEC filing |
| Jun 12, 2025 | Paul C Scherer became a director |
| Feb 5, 2025 | Bryant David Lim listed as CLO, CFO, Corp Sec. (previously CLO, Interim CFO, Corp Sec.) in SEC filings |
| May 16, 2024 | Bryant David Lim listed as CLO, Interim CFO, Corp Sec. (previously Chief Legal Officer, Corp Sec.) in SEC filings |
| Apr 8, 2024 | The company announced the departure of Laurent Chardonnet as Chief Financial Officer in an SEC filing |
| Mar 4, 2024 | Andrew Combs listed as Chief Chemistry Officer (previously EVP, Head of Chemistry) in SEC filings |
| Mar 2, 2023 | Bryant David Lim listed as Chief Legal Officer, Corp Sec. (previously Chief Legal Counsel, Corp Sec.) in SEC filings |
| Feb 20, 2023 | Bryant David Lim became Chief Legal Counsel, Corp Sec. |
| Apr 6, 2022 | The company announced the departure of Deborah Morosini as EVP, Chief of Clinical Affairs in an SEC filing |
| Apr 4, 2022 | Jane Huang became President, CMO |
| Feb 17, 2022 | Krishna Vaddi listed as CEO (previously President, CEO) in SEC filings |
| Nov 29, 2021 | Laurent Chardonnet became Chief Financial Officer |
| Nov 5, 2021 | The company announced the departure of Brian Piper as Chief Financial Officer in an SEC filing |
| Jul 19, 2021 | Martin Babler became a director |
| Sep 29, 2020 | Orbimed Capital LLC first on file as a director |
| Sep 29, 2020 | Orbimed Capital LLC first on file as a 10% owner |
| Sep 24, 2020 | Victor Sandor became a director |
| Sep 24, 2020 | Peggy Scherle became Chief Scientific Officer |
| Sep 24, 2020 | Paul A Friedman became a director |
| Sep 24, 2020 | Orbimed Advisors LLC became a director |
| Sep 24, 2020 | Orbimed Advisors LLC became a 10% owner |
| Sep 24, 2020 | OrbiMed Capital GP VI LLC became a director |
| Sep 24, 2020 | OrbiMed Capital GP VI LLC became a 10% owner |
| Sep 24, 2020 | Mardi Dier became a director |
| Sep 24, 2020 | Krishna Vaddi became a director |
| Sep 24, 2020 | Krishna Vaddi became President, CEO |
| Sep 24, 2020 | Kelvin Neu became a director |
| Sep 24, 2020 | Julian Baker became a director |
| Sep 24, 2020 | Julian Baker became a 10% owner |
| Sep 24, 2020 | Felix Baker became a director |
| Sep 24, 2020 | Felix Baker became a 10% owner |
| Sep 24, 2020 | Deborah Morosini became EVP, Chief of Clinical Affairs |
| Sep 24, 2020 | David P Bonita became a director |
| Sep 24, 2020 | David P Bonita became a 10% owner |
| Sep 24, 2020 | David J Mauro became Chief Medical Officer |
| Sep 24, 2020 | Christopher Pierce became EVP and Chief of Business Oper |
| Sep 24, 2020 | Brian Piper became Chief Financial Officer |
| Sep 24, 2020 | Baker Brothers Life Sciences LP became a director |
| Sep 24, 2020 | Baker Brothers Life Sciences LP became a 10% owner |
| Sep 24, 2020 | Baker Bros. Advisors LP became a director |
| Sep 24, 2020 | Baker Bros. Advisors LP became a 10% owner |
| Sep 24, 2020 | Baker Bros. Advisors (GP) LLC became a director |
| Sep 24, 2020 | Baker Bros. Advisors (GP) LLC became a 10% owner |
| Sep 24, 2020 | Andrew Combs became EVP, Head of Chemistry |
| Sep 24, 2020 | 667, L.p. became a director |
| Sep 24, 2020 | 667, L.p. became a 10% owner |
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Not reported recently (3)
- David J Mauro · Last reported as Chief Medical Officer in an SEC filing dated Oct 6, 2021
- Christopher Pierce · Last reported as EVP and Chief of Business Oper in an SEC filing dated Sep 7, 2021
- Kelvin Neu · Last reported as a director in an SEC filing dated Sep 24, 2020
| # | ETF | Provider | Weight | $ Exposure | ETF AUM | As Of |
|---|---|---|---|---|---|---|
| 1 | VTI Vanguard Morningstar Total Stock Market ETF | Vanguard | 0.00% | $5.9M | — | 2026-09-30 |
| 2 | IWM iShares Russell 2000 ETF | iShares (BlackRock) | 0.00% | $2.5M | $74.6B | 2026-10-23 |
| 3 | VXF Vanguard Extended Market ETF | Vanguard | 0.00% | $1.4M | — | 2026-09-30 |
| 4 | IWO iShares Russell 2000 Growth ETF | iShares (BlackRock) | 0.01% | $953,721 | $13.7B | 2026-10-23 |
| 5 | VTWO Vanguard Russell 2000 ETF | Vanguard | 0.00% | $628,224 | — | 2026-09-30 |
| 6 | IWC iShares Micro-Cap ETF | iShares (BlackRock) | 0.03% | $308,996 | $1.2B | 2026-10-23 |
| 7 | VTWG Vanguard Russell 2000 Growth ETF | Vanguard | 0.01% | $117,871 | — | 2026-09-30 |
| 8 | AVSC Avantis U.S. Small Cap Equity ETF | Avantis | 0.00% | $104,464 | $3.2B | 2026-10-23 |
| 9 | DFAS Dimensional US Small Cap ETF | Dimensional | 0.00% | $72,222 | — | 2026-10-23 |
| 10 | OMFS Invesco Russell 2000 Dynamic Multifactor ETF | Invesco | 0.03% | $71,086 | — | 2026-10-24 |
| 11 | DFMC Dimensional US Micro Cap ETF | Dimensional | 0.00% | $65,173 | — | 2026-10-23 |
| 12 | RSSL Global X Russell 2000 ETF | Global X | 0.00% | $50,150 | — | 2026-10-26 |
| 13 | DCOR Dimensional US Core Equity 1 ETF | Dimensional | 0.00% | $22,978 | — | 2026-10-23 |
| 14 | DFSU Dimensional US Sustainability Core 1 ETF | Dimensional | 0.00% | $12,062 | $2.4B | 2026-10-23 |
| 15 | VTHR Vanguard Russell 3000 ETF | Vanguard | 0.00% | $6,721 | — | 2026-09-30 |
| 16 | ITWO ProShares Russell 2000 High Income ETF | ProShares | 0.00% | $5,872 | — | 2026-10-26 |
| 17 | URTY ProShares UltraPro Russell2000 | ProShares | 0.00% | $4,507 | — | 2026-10-26 |
| 18 | FSEG Fidelity Enhanced Small Cap Growth ETF | Fidelity | 0.04% | $3,191 | $7.6M | 2026-10-23 |
| 19 | UWM ProShares Ultra Russell2000 | ProShares | 0.00% | $3,164 | — | 2026-10-26 |
| 20 | HDG ProShares Hedge Replication ETF | ProShares | 0.00% | $126 | — | 2026-10-26 |
| 21 | RB ProShares Russell 2000 Dynamic Buffer ETF | ProShares | 0.00% | $37 | — | 2026-10-26 |
Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.
- Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
- Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
- Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
- Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
- Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
- YoY growth — compare to the same quarter a year earlier to remove seasonality.
- Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
- Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.
TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.
Quarterly figures (12 quarters)
| Quarter | Period End | Revenue | Net Income | Diluted EPS | Op. Cash Flow |
|---|---|---|---|---|---|
| Q2 '26 | 2026-06-30 | $5.70M | $-13.92M | $-0.14 | $-15.57M |
| Q1 '26 | 2026-03-31 | $4.58M | $-10.38M | $-0.13 | $-21.68M |
| Q4 '25 | 2025-12-31 | $5.64M | $-16.46M | $-0.20 | $23.12M |
| Q3 '25 | 2025-09-30 | $6.50M | $-19.73M | $-0.26 | $-19.11M |
| Q2 '25 | 2025-06-30 | — | $-31.23M | $-0.41 | $-26.07M |
| Q1 '25 | 2025-03-31 | — | $-32.09M | $-0.42 | $-34.23M |
| Q4 '24 | 2024-12-31 | $4.00M | $-28.73M | $-0.38 | $-20.74M |
| Q3 '24 | 2024-09-30 | $3.00M | $-32.27M | $-0.43 | $-27.30M |
| Q2 '24 | 2024-06-30 | — | $-34.74M | $-0.46 | $-23.06M |
| Q1 '24 | 2024-03-31 | — | $-31.43M | $-0.42 | $-31.79M |
| Q4 '23 | 2023-12-31 | — | $-33.08M | $-0.47 | $-23.58M |
| Q3 '23 | 2023-09-30 | — | $-30.61M | $-0.45 | $-25.68M |
Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.
- P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
- P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
- P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
- EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
- EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
- ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
- ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
- Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
- FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
- Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
- Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
- Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
- Multiples expanding while earnings are flat = sentiment-driven rally.
- Multiples compressing while earnings grow = value coming from fundamentals.
Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.
- Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
- SI % of Float — short interest / free float. The key crowding metric.
- Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
- Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
- Free Float — shares available for public trading (total shares minus insider / restricted).
- Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
- SI % of Float < 5% — typical, no particular signal.
- 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
- 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
- >30% — extreme; borrow is likely expensive and squeeze risk is material.
- Days to Cover > 5 combined with high SI% amplifies squeeze potential.
- Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
- A sudden drop in SI after a rally may indicate a squeeze in progress.
Short interest is reported mid-month and end-of-month; short volume is daily.