Soleus Capital Management, L.P. — 13F Holdings & Portfolio
CIK 1802630 · latest 13F-HR filed 2026-05-14
Soleus Capital Management, L.P. manages $2.47B in 13F-reported U.S. long-equity assets across 93 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are KRYS (12.06%), CELC (5.94%), TGTX (5.42%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 25 new positions, exited 26, added to 25, and trimmed 37.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$2.47B
Long-equity book
93
Distinct positions
2026-03-31
Filed 2026-05-14
+25 / −26 / ↑25 / ↓37
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- UNITED THERAPEUTICS CORP DEL$81.8M +279.7%
- INSULET CORP$75.4M +176.8%
- KRYSTAL BIOTECH INC$65.9M +28.4%
- VERICEL CORP$54.5M +198.1%
- TG THERAPEUTICS INC$40.3M +43.0%
Top Trims
- DEXCOM INC-$77.3M -89.8%
- BIOMARIN PHARMACEUTICAL INC-$41.7M -53.2%
- CELCUITY INC-$33.8M -18.7%
- BETA BIONICS INC-$33.6M -43.5%
- ORGANOGENESIS HLDGS INC-$27.8M -53.8%
New Positions
- INDIVIOR PHARMACEUTICALS INC$38.8M
- PROGYNY INC$35.1M
- MERCK & CO INC$24.4M
- ICON PLC$21.2M
- CONTEXT THERAPEUTICS INC$18.2M
Exited Positions
- AMICUS THERAPEUTICS INC$74.2M
- GSK PLC$31.3M
- RAPT THERAPEUTICS INC$25.9M
- NEUROCRINE BIOSCIENCES INC$25.0M
- TELEFLEX INCORPORATED$23.2M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | KRYSTAL BIOTECH INC | KRYS | 501147102 | $297.9M | 12.06% | 1,153,087 | SH |
| 2 | CELCUITY INC | CELC | 15102K100 | $146.6M | 5.94% | 1,284,378 | SH |
| 3 | TG THERAPEUTICS INC | TGTX | 88322Q108 | $133.9M | 5.42% | 4,029,319 | SH |
| 4 | INSULET CORP | PODD | 45784P101 | $118.0M | 4.78% | 562,500 | SH |
| 5 | NOVOCURE LTD | NVCR | G6674U108 | $114.4M | 4.63% | 10,492,391 | SH |
| 6 | UNITED THERAPEUTICS CORP DEL | UTHR | 91307C102 | $111.0M | 4.50% | 187,187 | SH |
| 7 | PRAXIS PRECISION MEDICINES I | PRAX | 74006W207 | $106.5M | 4.31% | 330,517 | SH |
| 8 | VERICEL CORP | VCEL | 92346J108 | $82.0M | 3.32% | 2,549,079 | SH |
| 9 | ALKERMES PLC | ALKS | G01767105 | $69.7M | 2.82% | 1,970,864 | SH |
| 10 | ANI PHARMACEUTICALS INC | ANIP | 00182C103 | $63.1M | 2.55% | 820,243 | SH |
| 11 | GLOBUS MED INC | GMED | 379577208 | $62.9M | 2.55% | 729,467 | SH |
| 12 | GERON CORP | GERN | 374163103 | $61.8M | 2.50% | 41,508,659 | SH |
| 13 | TWIST BIOSCIENCE CORP | TWST | 90184D100 | $58.3M | 2.36% | 1,226,629 | SH |
| 14 | EDGEWISE THERAPEUTICS INC | EWTX | 28036F105 | $45.7M | 1.85% | 1,449,915 | SH |
| 15 | BETA BIONICS INC | BBNX | 08659B102 | $43.6M | 1.77% | 4,354,501 | SH |
| 16 | ALNYLAM PHARMACEUTICALS INC | ALNY | 02043Q107 | $43.6M | 1.76% | 131,650 | SH |
| 17 | SYNDAX PHARMACEUTICALS INC | SNDX | 87164F105 | $40.3M | 1.63% | 1,726,908 | SH |
| 18 | INDIVIOR PHARMACEUTICALS INC | INDV | 45579U109 | $38.8M | 1.57% | 1,274,000 | SH |
| 19 | NEUROPACE INC | NPCE | 641288105 | $38.6M | 1.56% | 2,932,207 | SH |
| 20 | LIVANOVA PLC | LIVN | G5509L101 | $37.0M | 1.50% | 582,500 | SH |
| 21 | MIRUM PHARMACEUTICALS INC | MIRM | 604749101 | $37.0M | 1.50% | 400,306 | SH |
| 22 | BIOMARIN PHARMACEUTICAL INC | BMRN | 09061G101 | $36.8M | 1.49% | 650,572 | SH |
| 23 | PROGYNY INC | PGNY | 74340E103 | $35.1M | 1.42% | 2,067,000 | SH |
| 24 | INSPIRE MED SYS INC | INSP | 457730109 | $29.7M | 1.20% | 576,299 | SH |
| 25 | EDAP TMS S A | EDAP | 268311107 | $27.2M | 1.10% | 7,309,254 | SH |
| 26 | KINIKSA PHARMACEUTICALS INTL | KNSA | G52694109 | $25.1M | 1.02% | 521,353 | SH |
| 27 | MERCK & CO INC | MRK | 58933Y105 | $24.4M | 0.99% | 203,000 | SH |
| 28 | ORGANOGENESIS HLDGS INC | ORGO | 68621F102 | $23.9M | 0.97% | 10,085,951 | SH |
| 29 | NATERA INC | NTRA | 632307104 | $23.8M | 0.96% | 119,000 | SH |
| 30 | AXOGEN INC | AXGN | 05463X106 | $22.5M | 0.91% | 679,170 | SH |
| 31 | VAXCYTE INC | PCVX | 92243G108 | $22.4M | 0.91% | 385,472 | SH |
| 32 | ICON PLC | ICLR | G4705A100 | $21.2M | 0.86% | 192,000 | SH |
| 33 | PHARVARIS N V | PHVS | N69605108 | $19.8M | 0.80% | 702,052 | SH |
| 34 | CERUS CORP | CERS | 157085101 | $19.6M | 0.79% | 10,753,700 | SH |
| 35 | TREVI THERAPEUTICS INC | TRVI | 89532M101 | $19.3M | 0.78% | 1,620,000 | SH |
| 36 | INHIBIKASE THERAPEUTICS INC | IKT | 45719W205 | $18.3M | 0.74% | 10,875,000 | SH |
| 37 | CONTEXT THERAPEUTICS INC | CNTX | 21077P108 | $18.2M | 0.74% | 6,963,141 | SH |
| 38 | VIR BIOTECHNOLOGY INC | VIR | 92764N102 | $17.9M | 0.73% | 2,002,000 | SH |
| 39 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $17.0M | 0.69% | 292,000 | SH |
| 40 | TRAVERE THERAPEUTICS INC | TVTX | 89422G107 | $16.2M | 0.66% | 546,000 | SH |
| 41 | TANDEM DIABETES CARE INC | TNDM | 875372203 | $15.0M | 0.61% | 783,000 | SH |
| 42 | NURIX THERAPEUTICS INC | NRIX | 67080M103 | $14.5M | 0.59% | 938,163 | SH |
| 43 | UROGEN PHARMA LTD | URGN | M96088105 | $13.1M | 0.53% | 727,000 | SH |
| 44 | SIONNA THERAPEUTICS INC | SION | 829401108 | $11.8M | 0.48% | 293,500 | SH |
| 45 | CORCEPT THERAPEUTICS INC | CORT | 218352102 | $11.5M | 0.47% | 285,531 | SH |
| 46 | JADE BIOSCIENCES INC | JBIO | 008064206 | $11.2M | 0.45% | 796,744 | SH |
| 47 | VERACYTE INC | VCYT | 92337F107 | $10.3M | 0.42% | 319,912 | SH |
| 48 | INVIVYD INC | IVVD | 00534A102 | $10.0M | 0.41% | 7,708,727 | SH |
| 49 | C4 THERAPEUTICS INC | CCCC | 12529R107 | $10.0M | 0.41% | 3,803,942 | SH |
| 50 | ORTHOPEDIATRICS CORP | KIDS | 68752L100 | $9.8M | 0.40% | 615,447 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-14 | $2.47B | 93 | 0001802630-26-000003 |
| 2025-12-31 | 2026-02-12 | $2.71B | 95 | 0001802630-26-000002 |
| 2025-09-30 | 2025-11-14 | $1.99B | 88 | 0001802630-25-000018 |