TWST Twist Bioscience Corporation Common Stock
XNAS
145.25
Delayed
Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Expected move IV rank history Fibonacci levels Insider trading
Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.
- 52-Week Range
- $23.30 – $219.71
- YTD
- +348.44%
- IV Rank (30D)
- 97.88
- Straddle Price
- $33.50
- P/C Vol Ratio
- 1.10
- Market Cap
- $9.3B
- Open
- $139.45
- Day Range
- $136.19 – $147.62
- Volume
- 1,379,528
- Prev Close
- $139.92
A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.
- DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
- Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
- DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
- P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
- Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
- Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
- Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
- Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
| 10-yr Treasury (rf) | 5.13% |
| Beta vs SPY | 1.82 |
| Cost of Equity (CAPM) | 14.55% (VRP-adj) |
| WACC | 14.31% |
| Volatility Risk Premium | +6.6pp (IV − HV30), ERP adj +18bps |
| Effective Tax Rate | 21.0% |
| Rev. Growth (YoY, DCF input) | +15.3% |
| DCF Horizon | 10 years explicit + fade |
| Forward Tilt (NTM/TTM) | ×1.10 (applied to P/E, EV/EBITDA, P/S) |
| Free Cash Flow (TTM) | $-0.1B |
| Return on Equity (TTM) | -30.7% |
| Book / Price | 5.3% |
| Gross Margin (TTM) | 52.1% |
| FCF Margin (TTM) | -24.0% |
| Debt / Equity | 0.03 |
| Quality Score | 3/6 — normal (10y DCF) |
| SMA 50 | $149.77 (Market Anchor value) |
| SMA 20 / Bollinger Mid | $160.54 |
| Bollinger Width / SMA20 | 33.0% (drives anchor stability) |
| Net Debt | $-0.1B |
| Market Cap | $9B |
| Method | Implied Price | Weight | Detail |
|---|---|---|---|
| DCF | n/a | 0% | |
| DDM (Gordon) | n/a | 0% | |
| Peer P/E | n/a | 0% | median 32.3× · 4 peers |
| Peer EV/EBITDA | n/a | 0% | median 28.0× · 4 peers |
| Peer P/B | $62.81 | 22% | median 8.4× · 7 peers |
| Peer P/S | $122.33 | 22% | median 16.6× · 8 peers |
| Market Anchor (SMA50) | $149.77 | 0% | stability 0% (BB-width) |
| Options Expected (B-L 30d) | $133.91 | 56% | 27 strikes · skew +0.27 |
- Industry (SIC)
- BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES) (2836) · industry map
- Exchange
- XNAS
- Market Cap
- $9.3B
- Employees
- 979
- List Date
- 2018-10-31
- CIK
- 0001581280
- Next Earnings
- 2026-11-13 (Pre-Market)
- EPS Forecast
- ($0.44) (1 est.)
- Headquarters
- South San Francisco, CA
- Homepage
- https://www.twistbioscience.com
Twist Bioscience Corp is a synthetic biology company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The company's proprietary semiconductor-based manufacturing process synthesizes DNA on silicon rather than traditional plastic plates, enabling the production of high-quality synthetic DNA faster, more affordably, and at scale. This platform overcomes conventional inefficiencies, supports cost-effective, high-throughput synthesis, and allows researchers to accelerate innovation. Geographically, the company operates across the Americas, EMEA, a…
Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.
| Month | '21 | '22 | '23 | '24 | '25 | '26 | Avg |
|---|---|---|---|---|---|---|---|
| Jan | 23.78% | -28.64% | 20.50% | -6.47% | 15.58% | 26.80% | 8.59% |
| Feb | -23.65% | -10.28% | -33.08% | 18.13% | -26.41% | 0.23% | -12.51% |
| Mar | -14.55% | -11.03% | -17.60% | -11.78% | 5.79% | 3.55% | -7.60% |
| Apr | 9.81% | -45.49% | -11.43% | -9.24% | -1.59% | 17.99% | -6.66% |
| May | -11.06% | 8.62% | 22.47% | 31.10% | -22.30% | 10.71% | 6.59% |
| Jun | 25.85% | 13.07% | 27.80% | 11.97% | 18.43% | 51.61% | 24.79% |
| Jul | -6.41% | 17.96% | 22.62% | 14.06% | -8.65% | -10.53% | 4.84% |
| Aug | -3.72% | -10.07% | -3.93% | -18.49% | -19.92% | 37.54% | -3.10% |
| Sep | -8.60% | -12.90% | -14.01% | 10.30% | 7.24% | 46.33% | 4.73% |
| Oct | 12.61% | -9.01% | -17.79% | -7.00% | 12.41% | -22.76%* | -5.26% |
| Nov | -24.73% | -19.01% | 53.97% | 18.31% | 1.39% | -- | 5.99% |
| Dec | -11.11% | -14.54% | 48.75% | -7.61% | 6.23% | -- | 4.34% |
| Total | -38.41% | -77.81% | 75.68% | 35.37% | -22.61% | 262.50% | 39.12% |
Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.
- SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
- EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
- MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
- ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
- +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
- RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
- Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
- Williams %R — inverted scale: <−80 oversold, >−20 overbought.
Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.
- Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
- OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
- Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
- ATR / True Range — average daily $ move; sizing and stop-loss reference.
- HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.
Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →
Trend Indicators
Momentum Oscillators
Volume & Volatility
Data Summary
LLM Stock Analysis Report
Executive Summary
This report provides a comprehensive analysis of TWST, a stock with high volatility and positive sentiment indicators. The overall assessment is BULLISH with a confidence level of 8/10.
Key drivers include the company's strong earnings growth potential, coupled with positive news headlines surrounding DNA computing market growth and cell culture microcarriers advancements. Primary risks include high beta and volatility, as well as potential negative catalysts from Cathie Wood's recent selling activity.
Recent news sentiment has been POSITIVE, driven by articles highlighting TWST's potential in the medical AI space. However, we must consider the potential impact of negative news headlines, such as the recent selling activity by Cathie Wood.
Technical Analysis
Trend Direction: Short-term (1-4 weeks): Uptrend; Medium-term (1-3 months): Bullish momentum; Long-term (3-12 months): Bullish trend
Support/Resistance Levels:
- SMA 20: $105.91
- SMA 50: $95.64
- Bollinger Bands:
- Upper: $135.37
- Middle: $105.91
- Lower: $76.45
Momentum Signals:
- RSI (14): 58.24 (neutral)
- MACD: Bullish momentum signal with a strong histogram (7.76)
- Bollinger Bands: Neutral signal
Volume Analysis:
- Volume SMA 20: 1560847.70
- On-Balance Volume (OBV): 33910868.77
- Volume Rate of Change: 4.22%
News & Sentiment Analysis
Recent Headlines Summary: Positive sentiment driven by articles on DNA computing market growth and cell culture microcarriers advancements.
Sentiment Assessment: POSITIVE
Catalyst Identification: Upcoming earnings releases, product launches in the medical AI space, and potential partnerships or acquisitions.
Risk & Volatility Assessment
Beta Interpretation: High risk relative to the market (beta >1.2)
Volatility Regime: Current vs historical volatility levels: HIGH
Options Market Signals:
- IV Rank: 9.7% (Low - shows if volatility is historically high/low)
- Current IV: 80.1%
- Expected Move: $19.45 (31 DTE), 7-DTE: $7.17
- Volume Flow: 75 calls vs 203 puts
- Open Interest: 741 calls vs 641 puts
- Put/Call Volume Ratio: 2.71 (Bearish sentiment)
Downside Protection: Support levels and risk management considerations:
- SMA 20: $105.91
- Bollinger Bands:
- Upper: $135.37
- Middle: $105.91
- Lower: $76.45
Market Context & Positioning
Sector Performance: Relative strength vs sector/market: POSITIVE
Institutional Activity: Volume patterns suggesting institutional interest:
- Volume SMA 20: 1560847.70
- On-Balance Volume (OBV): 33910868.77
Correlation Analysis: How stock moves relative to market (R-squared interpretation):
- Correlation: 0.48
Relative Valuation: Position within trading range:
- $116.10 (current price) lies above the SMA 20 and Bollinger Bands, indicating a potentially overbought condition.
Key Levels & Action Items
Critical Price Levels:
- Support levels:
- SMA 20: $105.91
- Bollinger Bands:
- Lower: $76.45
- Resistance level:
- Upper Bollinger Band: $135.37
Breakout/Breakdown Levels: Technical levels that could trigger significant moves:
- SMA 50: $95.64 (potential breakdown level)
- SMA 200: $57.65 (potential breakdown level)
Time-Sensitive Catalysts: Earnings dates, FDA approvals, product launches:
- No earnings data available
- Product launch in the medical AI space
Risk Management: Stop-loss levels and position sizing considerations:
- Consider setting a stop-loss at SMA 20 ($105.91) to manage risk.
Please note that this report is based on the provided data and should not be taken as personalized investment advice.
| Earnings Date | Timing | Expected Move | Actual Move | Ratio | Outcome |
|---|---|---|---|---|---|
| 2021-02-04 | Pre-Market | 11.84% | 4.05% | 0.34x | Within |
| 2021-05-06 | Pre-Market | 12.28% | 5.15% | 0.42x | Within |
| 2021-08-06 | Pre-Market | 10.59% | 10.76% | 1.02x | Exceeded |
| 2021-11-22 | Pre-Market | 14.86% | 11.25% | 0.76x | Within |
| 2022-02-04 | Pre-Market | 15.42% | 2.41% | 0.16x | Within |
| 2022-05-05 | Pre-Market | 12.77% | 10.65% | 0.83x | Within |
| 2022-08-05 | Pre-Market | 32.24% | 12.68% | 0.39x | Within |
| 2022-11-18 | Pre-Market | 17.52% | 2.32% | 0.13x | Within |
| 2023-02-03 | Pre-Market | 16.12% | 18.09% | 1.12x | Exceeded |
| 2023-05-05 | Pre-Market | 19.09% | 0.39% | 0.02x | Within |
| 2023-08-04 | Pre-Market | 15.72% | 11.18% | 0.71x | Within |
| 2023-11-17 | Pre-Market | 11.69% | 25.90% | 2.22x | Exceeded |
| 2024-02-02 | Pre-Market | 21.44% | 10.01% | 0.47x | Within |
| 2024-05-02 | Pre-Market | 18.49% | 0.16% | 0.01x | Within |
| 2024-08-02 | Pre-Market | 16.16% | 19.00% | 1.18x | Exceeded |
| 2024-11-18 | Pre-Market | 25.35% | 12.31% | 0.49x | Within |
| 2025-02-03 | Pre-Market | 18.14% | 0.73% | 0.04x | Within |
| 2025-05-05 | Pre-Market | 18.99% | 8.44% | 0.44x | Within |
| 2025-08-04 | Pre-Market | 20.19% | 10.30% | 0.51x | Within |
| 2025-11-14 | Pre-Market | 17.47% | 10.13% | 0.58x | Within |
| 2026-02-02 | Pre-Market | 18.44% | 13.98% | 0.76x | Within |
| 2026-05-04 | Pre-Market | 17.22% | 6.97% | 0.40x | Within |
| 2026-08-03 | Pre-Market | 20.48% | 10.39% | 0.51x | Within |
Earnings calendar: this week’s reports with expected vs actual moves →
TWST Options Activity & IV Rank
TWST IV rank history, 52-week IV rank and IV percentile →
Volatility Metrics
Options Flow
ATM Options Pricing
Chain Summary
Each spread is ranked by a composite score built in three stages. Full documentation →
score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.
- RSI <40 bullish / >60 bearish
- MACD crossover + histogram trend
- Price vs SMA 50 & SMA 200
- Stochastic %K <20 / >80
- Williams %R <−80 / >−20
- Blended ATR + straddle expected-move penalty
- Bollinger Band signal (+ counter-trend penalty)
- BB width — vol contraction boost for ICs
- IV rank ≥ 75 → strong boost for credit spreads
- IV rank < 25 → penalty (selling cheap vol)
- Min open interest across all legs
- OI < 100 → −0.10 · OI < 500 → −0.05
score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →
Enter a ticker to scan for optimal spread opportunities.
Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.
Estimated net dealer gamma is at the 30th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.
Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.
Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.
Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.
This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.
IV(put wing) − IV(ATM), in vol pointsHow much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.
- Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
- Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
- Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
- Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
IV(call wing) − IV(put wing), equal delta on each sideWhich side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.
- Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
- Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
- Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
- Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:
- High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
- Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
- Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.
Enter a ticker to render the implied volatility surface.
Enter a ticker to render the implied volatility smile.
Risk Metrics
Analysis Details
Data Points: 251
Period: 252 trading days
High volatility - stock moves more than market
| Investor | Value | Share of their portfolio | Rank | Q/Q shares | Source |
|---|---|---|---|---|---|
| Citadel Hedge fund Ken Griffin | $88.7M | #451 of 6285 | -29.4% | 13F | |
| Millennium Management Hedge fund Izzy Englander | $35.7M | #788 of 3716 | -1.0% | 13F | |
| Bridgewater Associates Hedge fund Ray Dalio | $1.9M | #721 of 997 | new | 13F | |
| Rockefeller Capital Management Family office Rockefeller family | $1.1M | #1642 of 4729 | -3.8% | 13F |
Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions
TWST Institutional Ownership (13F)
Latest filings — 2026-09-30Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.
- Shares — long equity positions in this name, aggregated across share classes.
- Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
- % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
- Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.
Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | PEAK6 LLC | $11.76M | 31.35% | 2026-06-30 |
| 2 | Susquehanna International Group, LLP Custodian | $8.99M | 23.97% | 2026-06-30 |
| 3 | Jane Street Group, LLC Custodian | $8.03M | 21.42% | 2026-06-30 |
| 4 | Citadel Advisors LLC Custodian | $7.84M | 20.90% | 2026-06-30 |
| 5 | Millennium Management LLC Custodian | $884.77K | 2.36% | 2026-06-30 |
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Susquehanna International Group, LLP Custodian | $7.43M | 50.60% | 2026-06-30 |
| 2 | Millennium Management LLC Custodian | $2.88M | 19.62% | 2026-06-30 |
| 3 | Citadel Advisors LLC Custodian | $2.65M | 18.08% | 2026-06-30 |
| 4 | Jane Street Group, LLC Custodian | $1.72M | 11.70% | 2026-06-30 |
TWST Insider Trading (Form 4)
Latest: 2026-10-13| Filed | Reporter | Role | Action | Shares | Avg Price | Net $ | Link |
|---|---|---|---|---|---|---|---|
| 2026-10-13 | Adam Laponis | Chief Financial Officer | Sell (S) | −2,462 | $156.30 | -$384.8K | EDGAR |
| 2026-10-07 | Emily M. Leproust | Chief Executive Officer | Sell (S) | −4,548 | $202.15 | -$919.4K | EDGAR |
| 2026-10-05 | Emily M. Leproust | Chief Executive Officer | Sell (S) | −46,391 | $189.04 | -$8.77M | EDGAR |
| 2026-10-05 | Dennis Cho | See Remarks | Sell (S) | −9,514 | $188.88 | -$1.80M | EDGAR |
| 2026-10-05 | Robert F. Werner | Chief Accounting Officer | Sell (S) | −1,482 | $188.88 | -$279.9K | EDGAR |
| 2026-10-05 | Adam Laponis | Chief Financial Officer | Sell (S) | −8,057 | $188.88 | -$1.52M | EDGAR |
| 2026-10-05 | Patrick John Finn | President and COO | Sell (S) | −25,714 | $188.88 | -$4.86M | EDGAR |
| 2026-10-05 | Paula Green | SVP of Human Resources | Sell (S) | −10,088 | $188.88 | -$1.91M | EDGAR |
| 2026-09-25 | Emily M. Leproust | Chief Executive Officer | Sell (S) | −5,203 | $177.38 | -$922.9K | EDGAR |
| 2026-09-23 | Paula Green | SVP of Human Resources | Sell (S) | −294 | $165.49 | -$48.7K | EDGAR |
| 2026-09-23 | Dennis Cho | See Remarks | Sell (S) | −348 | $165.49 | -$57.6K | EDGAR |
| 2026-09-23 | Emily M. Leproust | Chief Executive Officer | Sell (S) | −1,687 | $165.49 | -$279.2K | EDGAR |
| 2026-09-21 | Emily M. Leproust | Chief Executive Officer | Mixed | −147,838 | $107.12 | -$52.11M | EDGAR |
| 2026-09-10 | Paula Green | SVP of Human Resources | Sell (S) | −907 | $122.62 | -$111.2K | EDGAR |
| 2026-09-10 | Dennis Cho | See Remarks | Sell (S) | −412 | $122.62 | -$50.5K | EDGAR |
TWST Insider Holdings
13 insiders · @ $145.25| # | Insider | Role | Shares | Disclosed Exposure | Lifetime OM Net | Filings | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Emily M. Leproust | Chief Executive Officer | 596,549 | $86.65M | -$174.96M | 155 | 2026-10-07 |
| 2 | Patrick John Finn | President and COO | 185,088 | $26.88M | -$39.27M | 141 | 2026-10-05 |
| 3 | Paula Green | SVP of Human Resources | 106,632 | $15.49M | -$14.40M | 122 | 2026-10-05 |
| 4 | Keith Crandell | Director | 103,618 | $15.05M | -$11.52M | 13 | 2026-02-09 |
| 5 | Adam Laponis | Chief Financial Officer | 98,114 | $14.25M | -$5.55M | 33 | 2026-10-13 |
| 6 | Robert Chess | Director | 82,029 | $11.91M | -$6.07M | 25 | 2026-08-11 |
| 7 | Dennis Cho | See Remarks | 63,789 | $9.27M | -$11.31M | 97 | 2026-10-05 |
| 8 | Robert F. Werner | Chief Accounting Officer | 42,917 | $6.23M | -$2.12M | 49 | 2026-10-05 |
| 9 | Nelson Chan | Director | 33,251 | $4.83M | $0 | 12 | 2026-02-09 |
| 10 | Jan Johannessen | Director | 29,754 | $4.32M | -$2.81M | 19 | 2026-05-14 |
TWST Board & Officers
As of SEC filings through Oct 13, 2026Directors 7
- Emily M. Leproust · since Oct 30, 2018
- Jan Johannessen · since Oct 30, 2018
- Keith Crandell · since Oct 30, 2018
- Robert P Ragusa · since Oct 30, 2018
- Nelson Chan · since May 20, 2019
- Melissa A. Starovasnik · since Aug 5, 2021
- Katryn Blake · since Aug 5, 2025
Officers 6
- Emily M. Leproust · Chief Executive Officer · listed since Oct 2022
- Patrick John Finn · President and COO · listed since Oct 2022
- Dennis Cho · Senior Vice President, Chief Legal Officer & Corporate Secretary · listed since Feb 2024
- Adam Laponis · Chief Financial Officer · since Jan 8, 2024
- Robert F. Werner · Chief Accounting Officer · since May 22, 2023
- Paula Green · SVP of Human Resources · listed since Dec 2020
Changes in the last 10 years (57)
| Feb 18, 2026 | Robert Chess reported in an SEC filing no longer being a director |
| Aug 5, 2025 | Katryn Blake became a director |
| Feb 9, 2024 | Keith Crandell no longer listed as a 10% owner in SEC filings |
| Feb 6, 2024 | William Banyai no longer listed as a director in SEC filings |
| Feb 6, 2024 | William Banyai listed as See Remark (previously Chief Operating Officer) in SEC filings |
| Feb 6, 2024 | Dennis Cho listed as Senior Vice President, Chief Legal Officer & Corporate Secretary (previously Senior Vice President, General Counsel, and Chief Ethics and Compliance Officer) in SEC filings |
| Jan 8, 2024 | Adam Laponis became Chief Financial Officer |
| Aug 3, 2023 | The company announced the departure of James M Thorburn as Chief Financial Officer in an SEC filing |
| May 22, 2023 | Robert F. Werner became Chief Accounting Officer |
| Mar 23, 2023 | The company announced the departure of Kevin Bruce Yankton as Chief Accounting Officer in an SEC filing |
| Feb 9, 2023 | Keith Crandell first listed as a 10% owner in an SEC filing |
| Oct 26, 2022 | Patrick John Finn listed as President and COO (previously Chief Commercial Officer) in SEC filings |
| Oct 26, 2022 | Emily M. Leproust listed as Chief Executive Officer (previously President & CEO) in SEC filings |
| Apr 20, 2022 | The company announced the departure of Patrick Weiss as Chief Operating Officer in an SEC filing |
| Sep 13, 2021 | Dennis Cho became Senior Vice President, General Counsel, and Chief Ethics and Compliance Officer |
| Aug 13, 2021 | Keith Crandell no longer listed as a 10% owner in SEC filings |
| Aug 5, 2021 | Melissa A. Starovasnik became a director |
| Aug 5, 2021 | Kevin Bruce Yankton became Chief Accounting Officer |
| Apr 5, 2021 | Mark Daniels reported in an SEC filing no longer being SVP, Chief Legal Officer |
| Dec 17, 2020 | Paula Green listed as SVP of Human Resources (previously VP of Human Resources) in SEC filings |
| Jan 10, 2020 | Patrick Weiss first listed as Chief Operating Officer in an SEC filing |
| Nov 5, 2019 | Martin Kunz reported in an SEC filing no longer being SVP, Operations |
| Nov 5, 2019 | Bill Peck reported in an SEC filing no longer being Chief Technology Officer |
| Oct 28, 2019 | Patrick John Finn listed as Chief Commercial Officer (previously SVP, Commercial Operations) in SEC filings |
| Oct 24, 2019 | Nicolas Barthelemy became a director |
| Oct 17, 2019 | Patrick Weiss reported in an SEC filing no longer being SVP, R&D GM Data Storage |
| May 20, 2019 | Nelson Chan became a director |
| Feb 4, 2019 | Martin Kunz became SVP, Operations |
| Nov 21, 2018 | Patrick Weiss listed as SVP, R&D GM Data Storage (previously VP of Operations) in SEC filings |
| Nov 21, 2018 | Patrick John Finn listed as SVP, Commercial Operations (previously VP of Sales and Marketing) in SEC filings |
| Nov 21, 2018 | Mark Daniels listed as SVP, Chief Legal Officer (previously Chief Compliance Officer & GC) in SEC filings |
| Oct 30, 2018 | Xiaoying Mai became a director |
| Oct 30, 2018 | William Banyai became a director |
| Oct 30, 2018 | William Banyai became Chief Operating Officer |
| Oct 30, 2018 | Robert P Ragusa became a director |
| Oct 30, 2018 | Robert Nelsen became a 10% owner |
| Oct 30, 2018 | Robert Chess became a director |
| Oct 30, 2018 | Paula Green became VP of Human Resources |
| Oct 30, 2018 | Paul A. Conley became a director |
| Oct 30, 2018 | Patrick Weiss became VP of Operations |
| Oct 30, 2018 | Patrick John Finn became VP of Sales and Marketing |
| Oct 30, 2018 | Mark Daniels became Chief Compliance Officer & GC |
| Oct 30, 2018 | Keith Crandell became a director |
| Oct 30, 2018 | Keith Crandell became a 10% owner |
| Oct 30, 2018 | Jan Johannessen became a director |
| Oct 30, 2018 | James M Thorburn became Chief Financial Officer |
| Oct 30, 2018 | Fred B Craves became a director |
| Oct 30, 2018 | Ever Alpha Fund L.P. became a 10% owner |
| Oct 30, 2018 | Emily M. Leproust became a director |
| Oct 30, 2018 | Emily M. Leproust became President & CEO |
| Oct 30, 2018 | Clinton Bybee became a 10% owner |
| Oct 30, 2018 | Bill Peck became Chief Technology Officer |
| Oct 30, 2018 | ARCH Venture Partners VIII, LLC became a 10% owner |
| Oct 30, 2018 | ARCH Venture Partners VII, LLC became a 10% owner |
| Oct 30, 2018 | ARCH Venture Partners VII, L.P. became a 10% owner |
| Oct 30, 2018 | ARCH Venture Fund VIII Overage, L.P. became a 10% owner |
| Oct 30, 2018 | ARCH Venture Fund VII, L.P. became a 10% owner |
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Not reported recently (13)
- William Banyai · Last reported as See Remark in an SEC filing dated May 7, 2024
- Xiaoying Mai · Last reported as a director in an SEC filing dated Feb 9, 2024
- Nicolas Barthelemy · Last reported as a director in an SEC filing dated Nov 23, 2022
- Fred B Craves · Last reported as a director in an SEC filing dated Oct 9, 2019
- ARCH Venture Partners VII, LLC · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- Ever Alpha Fund L.P. · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- ARCH Venture Partners VIII, LLC · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- ARCH Venture Fund VII, L.P. · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- ARCH Venture Fund VIII Overage, L.P. · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- ARCH Venture Partners VII, L.P. · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- Clinton Bybee · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- Robert Nelsen · Last reported as a 10% owner in an SEC filing dated Nov 6, 2018
- Paul A. Conley · Last reported as a director in an SEC filing dated Oct 30, 2018
TWST Proposed Insider Sales (Form 144)
Latest: 2026-10-23What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.
How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.
10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.
"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.
Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.
| Filed | Filer | Role | Shares | Notice Value | Planned Sale | Broker | Plan | Link |
|---|---|---|---|---|---|---|---|---|
| 2026-10-23 | Finn Patrick John | Officer | 2,245 | $302.2K | 2026-10-23 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-09 | Laponis Adam | Officer | 2,462 | $384.8K | 2026-10-09 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-05 | Leproust Emily M. | Officer, Director | 4,548 | $919.4K | 2026-10-05 | Fidelity Brokerage Services LLC | 10b5-1 | EDGAR |
| 2026-10-02 | Green Paula | Officer | 10,088 | $1.91M | 2026-10-02 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-02 | WERNER ROBERT F. | Officer | 1,482 | $279.9K | 2026-10-02 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-02 | Cho Dennis | Officer | 9,514 | $1.80M | 2026-10-02 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-02 | Leproust Emily M. | Officer, Director | 45,736 | $8.64M | 2026-10-02 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-02 | Laponis Adam | Officer | 8,057 | $1.52M | 2026-10-02 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-02 | Finn Patrick John | Officer | 25,714 | $4.86M | 2026-10-02 | Fidelity Brokerage Services LLC | — | EDGAR |
| 2026-10-01 | Leproust Emily M. | Officer, Director | 655 | $131.0K | 2026-10-01 | Fidelity Brokerage Services LLC | 10b5-1 | EDGAR |
| # | ETF | Provider | Weight | $ Exposure | ETF AUM | As Of |
|---|---|---|---|---|---|---|
| 1 | VTI Vanguard Morningstar Total Stock Market ETF | Vanguard | 0.02% | $407.4M | — | 2026-09-30 |
| 2 | VB Vanguard Morningstar Small-Cap ETF | Vanguard | 0.16% | $288.3M | — | 2026-09-30 |
| 3 | IWM iShares Russell 2000 ETF | iShares (BlackRock) | 0.31% | $232.7M | $74.6B | 2026-10-23 |
| 4 | XBI State Street® SPDR® S&P® Biotech ETF | SPDR (State Street) | 1.69% | $174.8M | $10.4B | 2026-10-23 |
| 5 | VBK Vanguard Morningstar Small-Cap Growth ETF | Vanguard | 0.37% | $160.5M | — | 2026-09-30 |
| 6 | VXF Vanguard Extended Market ETF | Vanguard | 0.15% | $144.3M | — | 2026-09-30 |
| 7 | IWO iShares Russell 2000 Growth ETF | iShares (BlackRock) | 0.64% | $86.6M | $13.7B | 2026-10-23 |
| 8 | VTWO Vanguard Russell 2000 ETF | Vanguard | 0.42% | $74.4M | — | 2026-09-30 |
| 9 | IBB iShares Biotechnology ETF | iShares (BlackRock) | 0.63% | $67.9M | $10.7B | 2026-10-23 |
| 10 | KOMP State Street® SPDR® S&P Kensho New Economies Composite ETF | SPDR (State Street) | 1.57% | $39.1M | $2.5B | 2026-10-23 |
| 11 | VHT Vanguard Health Care ETF | Vanguard | 0.16% | $34.0M | — | 2026-09-30 |
| 12 | FESM Fidelity Enhanced Small Cap Core ETF | Fidelity | 0.36% | $24.1M | $6.6B | 2026-10-23 |
| 13 | JTEK JPMorgan U.S. Tech Leaders ETF | JPMorgan | 0.49% | $22.2M | $4.6B | 2026-10-23 |
| 14 | SCHA Schwab U.S. Small-Cap ETF | Nport | 0.09% | $19.7M | — | 2026-05-31 |
| 15 | IDNA iShares Genomics Immunology and Healthcare ETF | iShares (BlackRock) | 5.82% | $18.6M | $321.2M | 2026-10-23 |
| 16 | DFAS Dimensional US Small Cap ETF | Dimensional | 0.05% | $17.0M | — | 2026-10-23 |
| 17 | TSME Thrivent Small-Mid Cap Equity ETF | Nport | 1.38% | $14.5M | — | 2026-06-30 |
| 18 | VTWG Vanguard Russell 2000 Growth ETF | Vanguard | 0.83% | $14.0M | — | 2026-09-30 |
| 19 | ITOT iShares Core S&P Total U.S. Stock Market ETF | iShares (BlackRock) | 0.01% | $12.2M | $96.5B | 2026-10-23 |
| 20 | VT Vanguard Total World Stock ETF | Vanguard | 0.01% | $10.8M | — | 2026-09-30 |
| 21 | SMLF iShares U.S. Small-Cap Equity Factor ETF | iShares (BlackRock) | 0.24% | $9.9M | $4.2B | 2026-10-23 |
| 22 | DFAC Dimensional US Core Equity 2 ETF | Dimensional | 0.01% | $8.4M | — | 2026-10-23 |
| 23 | FRTY Alger Mid Cap 40 ETF | Nport | 4.79% | $7.4M | — | 2026-06-30 |
| 24 | GNOM Global X Genomics & Biotechnology ETF | Global X | 6.42% | $6.8M | — | 2026-10-26 |
| 25 | LABU Direxion Daily S&P Biotech Bull 3X ETF | Direxion | 1.18% | $6.8M | — | 2026-10-26 |
Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.
- Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
- Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
- Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
- Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
- Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
- YoY growth — compare to the same quarter a year earlier to remove seasonality.
- Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
- Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.
TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.
Quarterly figures (12 quarters)
| Quarter | Period End | Revenue | Net Income | Diluted EPS | Op. Cash Flow |
|---|---|---|---|---|---|
| Q2 '26 | 2026-03-31 | $110.72M | $-44.02M | $-0.71 | $-17.56M |
| Q1 '26 | 2025-12-31 | $103.70M | $-30.51M | $-0.50 | $-24.81M |
| Q4 '25 | 2025-09-30 | $99.01M | $-27.14M | $-0.45 | $-11.81M |
| Q3 '25 | 2025-06-30 | $96.06M | $20.39M | $0.33 | $-1.40M |
| Q2 '25 | 2025-03-31 | $92.79M | $-39.33M | $-0.66 | $-12.99M |
| Q1 '25 | 2024-12-31 | $88.71M | $-31.59M | $-0.53 | $-21.43M |
| Q4 '24 | 2024-09-30 | $84.71M | $-34.66M | $-0.59 | $-15.32M |
| Q3 '24 | 2024-06-30 | $81.46M | $-85.57M | $-1.47 | $-6.38M |
| Q2 '24 | 2024-03-31 | $75.30M | $-45.49M | $-0.79 | $-19.42M |
| Q1 '24 | 2023-12-31 | $71.50M | $-43.01M | $-0.75 | $-22.97M |
| Q4 '23 | 2023-09-30 | $66.95M | $-46.24M | $-0.81 | $-20.70M |
| Q3 '23 | 2023-06-30 | $63.74M | $-57.40M | $-1.01 | $-23.41M |
Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.
- P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
- P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
- P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
- EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
- EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
- ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
- ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
- Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
- FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
- Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
- Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
- Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
- Multiples expanding while earnings are flat = sentiment-driven rally.
- Multiples compressing while earnings grow = value coming from fundamentals.
Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.
- Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
- SI % of Float — short interest / free float. The key crowding metric.
- Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
- Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
- Free Float — shares available for public trading (total shares minus insider / restricted).
- Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
- SI % of Float < 5% — typical, no particular signal.
- 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
- 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
- >30% — extreme; borrow is likely expensive and squeeze risk is material.
- Days to Cover > 5 combined with high SI% amplifies squeeze potential.
- Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
- A sudden drop in SI after a rally may indicate a squeeze in progress.
Short interest is reported mid-month and end-of-month; short volume is daily.