TWST Twist Bioscience Corporation Common Stock

XNAS 145.25 Delayed
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Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Expected move IV rank history Fibonacci levels Insider trading

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

TWST $145.25 —
Key stats
$145.25
Pre-market $144.94 -0.21%
52-Week Range
$23.30 – $219.71
YTD
+348.44%
IV Rank (30D)
97.88
Straddle Price
$33.50
P/C Vol Ratio
1.10
Market Cap
$9.3B
Open
$139.45
Day Range
$136.19 – $147.62
Volume
1,379,528
Prev Close
$139.92
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)5.13%
Beta vs SPY1.82
Cost of Equity (CAPM)14.55% (VRP-adj)
WACC14.31%
Volatility Risk Premium+6.6pp (IV − HV30), ERP adj +18bps
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)+15.3%
DCF Horizon10 years explicit + fade
Forward Tilt (NTM/TTM)×1.10 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$-0.1B
Return on Equity (TTM)-30.7%
Book / Price5.3%
Gross Margin (TTM)52.1%
FCF Margin (TTM)-24.0%
Debt / Equity0.03
Quality Score3/6 — normal (10y DCF)
SMA 50$149.77 (Market Anchor value)
SMA 20 / Bollinger Mid$160.54
Bollinger Width / SMA2033.0% (drives anchor stability)
Net Debt$-0.1B
Market Cap$9B
Peers used for multiples: CDNA, CRSP, GH, LLY, MRNA, NTRA, VCYT, VRTX
60-Day Conviction
60%
20-Day Fair Value
≈ by Nov 24, 2026
$148.04
α +1.9% rank 68%
conviction
88%
40-Day Fair Value
≈ by Dec 23, 2026
$147.14
α +1.3% rank 58%
conviction
44%
60-Day Fair Value
≈ by Jan 21, 2027
$147.97
α +1.9% rank 60%
conviction
60%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0% median 32.3× · 4 peers
Peer EV/EBITDA n/a 0% median 28.0× · 4 peers
Peer P/B $62.81 22% median 8.4× · 7 peers
Peer P/S $122.33 22% median 16.6× · 8 peers
Market Anchor (SMA50) $149.77 0% stability 0% (BB-width)
Options Expected (B-L 30d) $133.91 56% 27 strikes · skew +0.27
As of 2026-10-26 · updated
About
Industry (SIC)
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES) (2836) · industry map
Exchange
XNAS
Market Cap
$9.3B
Employees
979
List Date
2018-10-31
CIK
0001581280
Next Earnings
2026-11-13 (Pre-Market)
EPS Forecast
($0.44) (1 est.)
Headquarters
South San Francisco, CA
Homepage
https://www.twistbioscience.com

Twist Bioscience Corp is a synthetic biology company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The company's proprietary semiconductor-based manufacturing process synthesizes DNA on silicon rather than traditional plastic plates, enabling the production of high-quality synthetic DNA faster, more affordably, and at scale. This platform overcomes conventional inefficiencies, supports cost-effective, high-throughput synthesis, and allows researchers to accelerate innovation. Geographically, the company operates across the Americas, EMEA, a…

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Month'21'22'23'24'25'26Avg
Jan23.78%-28.64%20.50%-6.47%15.58%26.80%8.59%
Feb-23.65%-10.28%-33.08%18.13%-26.41%0.23%-12.51%
Mar-14.55%-11.03%-17.60%-11.78%5.79%3.55%-7.60%
Apr9.81%-45.49%-11.43%-9.24%-1.59%17.99%-6.66%
May-11.06%8.62%22.47%31.10%-22.30%10.71%6.59%
Jun25.85%13.07%27.80%11.97%18.43%51.61%24.79%
Jul-6.41%17.96%22.62%14.06%-8.65%-10.53%4.84%
Aug-3.72%-10.07%-3.93%-18.49%-19.92%37.54%-3.10%
Sep-8.60%-12.90%-14.01%10.30%7.24%46.33%4.73%
Oct12.61%-9.01%-17.79%-7.00%12.41%-22.76%*-5.26%
Nov-24.73%-19.01%53.97%18.31%1.39%--5.99%
Dec-11.11%-14.54%48.75%-7.61%6.23%--4.34%
Total-38.41%-77.81%75.68%35.37%-22.61%262.50%39.12%
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $158.82
SMA 50: $150.30
SMA 200: $86.49
Current: $145.25
EMA 12: $146.89
EMA 26: $150.99
MACD: -4.1031 | Signal: -2.7837
BEARISH
ADX (14): 18.37
RANGE
+DI: 21.72
−DI: 20.04

Momentum Oscillators

RSI (14): 46.97
NEUTRAL
Stoch %K: 17.95
Stoch %D: 14.44
Williams %R: -61.91

Volume & Volatility

BB Upper: $200.86
BB Lower: $116.78
NEUTRAL
OBV: 23,778,204
Vol SMA 20: 3,129,118
Vol ROC: -48.00%
ATR: $13.90
True Range: $11.43
HV 20: 106.6%
HV 30: 104.6%
HV 60: 102.6%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-10-28T00:00:00 – 2026-10-26T00:00:00
AI Analysis

LLM Stock Analysis Report

Executive Summary

This report provides a comprehensive analysis of TWST, a stock with high volatility and positive sentiment indicators. The overall assessment is BULLISH with a confidence level of 8/10.

Key drivers include the company's strong earnings growth potential, coupled with positive news headlines surrounding DNA computing market growth and cell culture microcarriers advancements. Primary risks include high beta and volatility, as well as potential negative catalysts from Cathie Wood's recent selling activity.

Recent news sentiment has been POSITIVE, driven by articles highlighting TWST's potential in the medical AI space. However, we must consider the potential impact of negative news headlines, such as the recent selling activity by Cathie Wood.

Technical Analysis

Trend Direction: Short-term (1-4 weeks): Uptrend; Medium-term (1-3 months): Bullish momentum; Long-term (3-12 months): Bullish trend

Support/Resistance Levels:

  • SMA 20: $105.91
  • SMA 50: $95.64
  • Bollinger Bands:
    • Upper: $135.37
    • Middle: $105.91
    • Lower: $76.45

Momentum Signals:

  • RSI (14): 58.24 (neutral)
  • MACD: Bullish momentum signal with a strong histogram (7.76)
  • Bollinger Bands: Neutral signal

Volume Analysis:

  • Volume SMA 20: 1560847.70
  • On-Balance Volume (OBV): 33910868.77
  • Volume Rate of Change: 4.22%

News & Sentiment Analysis

Recent Headlines Summary: Positive sentiment driven by articles on DNA computing market growth and cell culture microcarriers advancements.

Sentiment Assessment: POSITIVE

Catalyst Identification: Upcoming earnings releases, product launches in the medical AI space, and potential partnerships or acquisitions.

Risk & Volatility Assessment

Beta Interpretation: High risk relative to the market (beta >1.2)

Volatility Regime: Current vs historical volatility levels: HIGH

Options Market Signals:

  • IV Rank: 9.7% (Low - shows if volatility is historically high/low)
  • Current IV: 80.1%
  • Expected Move: $19.45 (31 DTE), 7-DTE: $7.17
  • Volume Flow: 75 calls vs 203 puts
  • Open Interest: 741 calls vs 641 puts
  • Put/Call Volume Ratio: 2.71 (Bearish sentiment)

Downside Protection: Support levels and risk management considerations:

  • SMA 20: $105.91
  • Bollinger Bands:
    • Upper: $135.37
    • Middle: $105.91
    • Lower: $76.45

Market Context & Positioning

Sector Performance: Relative strength vs sector/market: POSITIVE

Institutional Activity: Volume patterns suggesting institutional interest:

  • Volume SMA 20: 1560847.70
  • On-Balance Volume (OBV): 33910868.77

Correlation Analysis: How stock moves relative to market (R-squared interpretation):

  • Correlation: 0.48

Relative Valuation: Position within trading range:

  • $116.10 (current price) lies above the SMA 20 and Bollinger Bands, indicating a potentially overbought condition.

Key Levels & Action Items

Critical Price Levels:

  • Support levels:
    • SMA 20: $105.91
    • Bollinger Bands:
      • Lower: $76.45
  • Resistance level:
    • Upper Bollinger Band: $135.37

Breakout/Breakdown Levels: Technical levels that could trigger significant moves:

  • SMA 50: $95.64 (potential breakdown level)
  • SMA 200: $57.65 (potential breakdown level)

Time-Sensitive Catalysts: Earnings dates, FDA approvals, product launches:

  • No earnings data available
  • Product launch in the medical AI space

Risk Management: Stop-loss levels and position sizing considerations:

  • Consider setting a stop-loss at SMA 20 ($105.91) to manage risk.

Please note that this report is based on the provided data and should not be taken as personalized investment advice.

Generated
Earnings History
19 of 23 under expected move
Avg Expected Move
17.50%
Avg Actual Move
9.45%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2021-02-04 Pre-Market 11.84% 4.05% 0.34x Within
2021-05-06 Pre-Market 12.28% 5.15% 0.42x Within
2021-08-06 Pre-Market 10.59% 10.76% 1.02x Exceeded
2021-11-22 Pre-Market 14.86% 11.25% 0.76x Within
2022-02-04 Pre-Market 15.42% 2.41% 0.16x Within
2022-05-05 Pre-Market 12.77% 10.65% 0.83x Within
2022-08-05 Pre-Market 32.24% 12.68% 0.39x Within
2022-11-18 Pre-Market 17.52% 2.32% 0.13x Within
2023-02-03 Pre-Market 16.12% 18.09% 1.12x Exceeded
2023-05-05 Pre-Market 19.09% 0.39% 0.02x Within
2023-08-04 Pre-Market 15.72% 11.18% 0.71x Within
2023-11-17 Pre-Market 11.69% 25.90% 2.22x Exceeded
2024-02-02 Pre-Market 21.44% 10.01% 0.47x Within
2024-05-02 Pre-Market 18.49% 0.16% 0.01x Within
2024-08-02 Pre-Market 16.16% 19.00% 1.18x Exceeded
2024-11-18 Pre-Market 25.35% 12.31% 0.49x Within
2025-02-03 Pre-Market 18.14% 0.73% 0.04x Within
2025-05-05 Pre-Market 18.99% 8.44% 0.44x Within
2025-08-04 Pre-Market 20.19% 10.30% 0.51x Within
2025-11-14 Pre-Market 17.47% 10.13% 0.58x Within
2026-02-02 Pre-Market 18.44% 13.98% 0.76x Within
2026-05-04 Pre-Market 17.22% 6.97% 0.40x Within
2026-08-03 Pre-Market 20.48% 10.39% 0.51x Within

Earnings calendar: this week’s reports with expected vs actual moves →

TWST Options Activity & IV Rank

TWST IV rank history, 52-week IV rank and IV percentile →

Volatility Metrics

Current IV: 106.6%
7-DTE IV: —
Expected Move: $33.50
7-DTE Move: $33.50
Days to Exp: 25 (2026-11-20)

Options Flow

Call Volume: 467
Put Volume: 514
P/C Volume: 1.101
NEUTRAL
Call OI: 5,245
Put OI: 4,544
P/C OI: 0.866
Total OI: 9,789

ATM Options Pricing

ATM Call: $16.80
ATM Put: $16.70
Call %: 11.6%
Put %: 11.5%

Chain Summary

Chain Volume: 3,817
Chain OI: 19,195
Last Updated: 10/26/2026
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Dealer Positioning
TYPICAL γ

Estimated net dealer gamma is at the 30th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.

Gamma percentile
30%
vs own history
GEX tilt
-0.02
OI-weighted, today
Vanna tilt
+0.40
δ-sensitivity to IV
Charm tilt
-0.34
δ-decay vs time
Vanna tilt +0.40: the estimated dealer exposure leans positive, so the modeled hedge would shift noticeably if implied volatility changed.
Charm tilt -0.34: the estimated dealer exposure leans negative, so the modeled hedge would shift noticeably as time passes and options approach expiry.

Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.

Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.

Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.

This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.

· 40 ATM contracts, 7k total OI
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
as of Oct 26 · No data
30 DTE / 10d 78%
+10.7 pts EXTREME
as of Oct 26 · ATM 111.3% / Wing 122.0%

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)97.9HighOct 26
Straddle Price (30 DTE)$33.50Oct 26
Beta Analysis

Risk Metrics

Beta: 2.6637
Alpha: 140.99%
Correlation: 0.4339
R-Squared: 18.8%
Stock Volatility: 78.2%
Market Volatility: 12.7%

Analysis Details

Benchmark: SPY
Data Points: 251
Period: 252 trading days
Interpretation:
High volatility - stock moves more than market
Beta & Alpha Over Time
Notable investors who own TWST
4 of 37 tracked investors
InvestorValueShare of their portfolioRankQ/Q sharesSource
Citadel Hedge fund
Ken Griffin
$88.7M
0.05%
#451 of 6285-29.4%13F
Millennium Management Hedge fund
Izzy Englander
$35.7M
0.02%
#788 of 3716-1.0%13F
Bridgewater Associates Hedge fund
Ray Dalio
$1.9M
0.01%
#721 of 997new13F
Rockefeller Capital Management Family office
Rockefeller family
$1.1M
0.00%
#1642 of 4729-3.8%13F

Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions

TWST Institutional Ownership (13F)

Latest filings — 2026-09-30
Diluted shares outstanding: 60,938,500 (as of 2026-03-31)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

370 filers82,470,051 shares$8.08B value135.33% of float
# Filer Shares Value % of Total % of Float Period
1 BlackRock, Inc. Custodian 5,833,891 $600.19M 7.43% 9.57% 2026-06-30
2 Artisan Partners Limited Partnership 4,802,017 $494.03M 6.11% 7.88% 2026-06-30
3 FMR LLC Custodian 4,703,044 $483.85M 5.99% 7.72% 2026-06-30
4 ARK Investment Management LLC 4,549,803 $468.08M 5.79% 7.47% 2026-06-30
5 T. Rowe Price Associates, Inc. 3,634,652 $373.93M 4.63% 5.96% 2026-06-30
6 State Street Corp 3,232,532 $332.56M 4.11% 5.30% 2026-06-30
7 Vanguard Portfolio Management LLC 2,824,989 $290.63M 3.60% 4.64% 2026-06-30
8 Vanguard Capital Management LLC 2,699,280 $277.70M 3.44% 4.43% 2026-06-30
9 EdgePoint Investment Group Inc. 2,521,635 $259.43M 3.21% 4.14% 2026-06-30
10 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 2,174,594 $223.72M 2.77% 3.57% 2026-06-30
11 FARALLON CAPITAL MANAGEMENT, L.L.C. 2,136,400 $219.79M 2.72% 3.51% 2026-06-30
12 Invesco Ltd. Custodian 1,928,229 $198.38M 2.45% 3.16% 2026-06-30
13 Vanguard Group Inc Custodian 5,776,198 $183.22M 2.27% 9.48% 2025-12-31
14 Geode Capital Management, LLC Custodian 1,619,361 $166.63M 2.06% 2.66% 2026-06-30
15 Thrivent Financial for Lutherans 1,433,503 $147.48M 1.82% 2.35% 2026-06-30
16 Goldman Sachs Group Inc Custodian 1,408,418 $144.90M 1.79% 2.31% 2026-06-30
17 Morgan Stanley Custodian 1,189,861 $122.41M 1.51% 1.95% 2026-06-30
18 D. E. Shaw & Co., Inc. Custodian 1,185,605 $121.98M 1.51% 1.95% 2026-06-30
19 BAILLIE GIFFORD & CO 1,086,779 $111.81M 1.38% 1.78% 2026-06-30
20 Driehaus Capital Management LLC 1,022,526 $105.20M 1.30% 1.68% 2026-06-30
21 Sumitomo Mitsui Trust Group, Inc. 1,000,344 $102.92M 1.27% 1.64% 2026-06-30
22 Amova Asset Management Americas, Inc. 999,734 $102.84M 1.27% 1.64% 2026-06-30
23 Bank of America Corp Custodian 922,647 $94.92M 1.17% 1.51% 2026-06-30
24 Citadel Advisors LLC Custodian 862,042 $88.69M 1.10% 1.41% 2026-06-30
25 LOOMIS SAYLES & CO L P 861,309 $88.61M 1.10% 1.41% 2026-06-30
5 filers$37.51M notional
# Filer Notional Value % of Total Period
1 PEAK6 LLC $11.76M 31.35% 2026-06-30
2 Susquehanna International Group, LLP Custodian $8.99M 23.97% 2026-06-30
3 Jane Street Group, LLC Custodian $8.03M 21.42% 2026-06-30
4 Citadel Advisors LLC Custodian $7.84M 20.90% 2026-06-30
5 Millennium Management LLC Custodian $884.77K 2.36% 2026-06-30
4 filers$14.68M notional
# Filer Notional Value % of Total Period
1 Susquehanna International Group, LLP Custodian $7.43M 50.60% 2026-06-30
2 Millennium Management LLC Custodian $2.88M 19.62% 2026-06-30
3 Citadel Advisors LLC Custodian $2.65M 18.08% 2026-06-30
4 Jane Street Group, LLC Custodian $1.72M 11.70% 2026-06-30

TWST Insider Trading (Form 4)

Latest: 2026-10-13
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-10-13 Adam Laponis Chief Financial Officer Sell (S) −2,462 $156.30 -$384.8K EDGAR
2026-10-07 Emily M. Leproust Chief Executive Officer Sell (S) −4,548 $202.15 -$919.4K EDGAR
2026-10-05 Emily M. Leproust Chief Executive Officer Sell (S) −46,391 $189.04 -$8.77M EDGAR
2026-10-05 Dennis Cho See Remarks Sell (S) −9,514 $188.88 -$1.80M EDGAR
2026-10-05 Robert F. Werner Chief Accounting Officer Sell (S) −1,482 $188.88 -$279.9K EDGAR
2026-10-05 Adam Laponis Chief Financial Officer Sell (S) −8,057 $188.88 -$1.52M EDGAR
2026-10-05 Patrick John Finn President and COO Sell (S) −25,714 $188.88 -$4.86M EDGAR
2026-10-05 Paula Green SVP of Human Resources Sell (S) −10,088 $188.88 -$1.91M EDGAR
2026-09-25 Emily M. Leproust Chief Executive Officer Sell (S) −5,203 $177.38 -$922.9K EDGAR
2026-09-23 Paula Green SVP of Human Resources Sell (S) −294 $165.49 -$48.7K EDGAR
2026-09-23 Dennis Cho See Remarks Sell (S) −348 $165.49 -$57.6K EDGAR
2026-09-23 Emily M. Leproust Chief Executive Officer Sell (S) −1,687 $165.49 -$279.2K EDGAR
2026-09-21 Emily M. Leproust Chief Executive Officer Mixed −147,838 $107.12 -$52.11M EDGAR
2026-09-10 Paula Green SVP of Human Resources Sell (S) −907 $122.62 -$111.2K EDGAR
2026-09-10 Dennis Cho See Remarks Sell (S) −412 $122.62 -$50.5K EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.

TWST Insider Holdings

13 insiders · @ $145.25
Officers, directors, and 10%+ owners who have filed a Form 4 in the past two years, ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 Emily M. Leproust Chief Executive Officer 596,549 $86.65M -$174.96M 155 2026-10-07
2 Patrick John Finn President and COO 185,088 $26.88M -$39.27M 141 2026-10-05
3 Paula Green SVP of Human Resources 106,632 $15.49M -$14.40M 122 2026-10-05
4 Keith Crandell Director 103,618 $15.05M -$11.52M 13 2026-02-09
5 Adam Laponis Chief Financial Officer 98,114 $14.25M -$5.55M 33 2026-10-13
6 Robert Chess Director 82,029 $11.91M -$6.07M 25 2026-08-11
7 Dennis Cho See Remarks 63,789 $9.27M -$11.31M 97 2026-10-05
8 Robert F. Werner Chief Accounting Officer 42,917 $6.23M -$2.12M 49 2026-10-05
9 Nelson Chan Director 33,251 $4.83M $0 12 2026-02-09
10 Jan Johannessen Director 29,754 $4.32M -$2.81M 19 2026-05-14
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.

TWST Board & Officers

As of SEC filings through Oct 13, 2026

Directors 7

Officers 6

  • Emily M. Leproust · Chief Executive Officer · listed since Oct 2022
  • Patrick John Finn · President and COO · listed since Oct 2022
  • Dennis Cho · Senior Vice President, Chief Legal Officer & Corporate Secretary · listed since Feb 2024
  • Adam Laponis · Chief Financial Officer · since Jan 8, 2024
  • Robert F. Werner · Chief Accounting Officer · since May 22, 2023
  • Paula Green · SVP of Human Resources · listed since Dec 2020
Changes in the last 10 years (57)
Feb 18, 2026Robert Chess reported in an SEC filing no longer being a director
Aug 5, 2025Katryn Blake became a director
Feb 9, 2024Keith Crandell no longer listed as a 10% owner in SEC filings
Feb 6, 2024William Banyai no longer listed as a director in SEC filings
Feb 6, 2024William Banyai listed as See Remark (previously Chief Operating Officer) in SEC filings
Feb 6, 2024Dennis Cho listed as Senior Vice President, Chief Legal Officer & Corporate Secretary (previously Senior Vice President, General Counsel, and Chief Ethics and Compliance Officer) in SEC filings
Jan 8, 2024Adam Laponis became Chief Financial Officer
Aug 3, 2023The company announced the departure of James M Thorburn as Chief Financial Officer in an SEC filing
May 22, 2023Robert F. Werner became Chief Accounting Officer
Mar 23, 2023The company announced the departure of Kevin Bruce Yankton as Chief Accounting Officer in an SEC filing
Feb 9, 2023Keith Crandell first listed as a 10% owner in an SEC filing
Oct 26, 2022Patrick John Finn listed as President and COO (previously Chief Commercial Officer) in SEC filings
Oct 26, 2022Emily M. Leproust listed as Chief Executive Officer (previously President & CEO) in SEC filings
Apr 20, 2022The company announced the departure of Patrick Weiss as Chief Operating Officer in an SEC filing
Sep 13, 2021Dennis Cho became Senior Vice President, General Counsel, and Chief Ethics and Compliance Officer
Aug 13, 2021Keith Crandell no longer listed as a 10% owner in SEC filings
Aug 5, 2021Melissa A. Starovasnik became a director
Aug 5, 2021Kevin Bruce Yankton became Chief Accounting Officer
Apr 5, 2021Mark Daniels reported in an SEC filing no longer being SVP, Chief Legal Officer
Dec 17, 2020Paula Green listed as SVP of Human Resources (previously VP of Human Resources) in SEC filings
Not reported recently (13)
Compiled from SEC filings by the company and its directors and officers. Dates are as stated in those filings. Where no filing says when someone left, we show the last filing that listed them.

TWST Proposed Insider Sales (Form 144)

Latest: 2026-10-23
Last 30d: 10 filings · $20.7M notice value  ·  Last 90d: 40 filings · $118.0M notice value · 8 unique filers · 30% under 10b5-1 plans

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Top 90-day filers: Leproust Emily M. (13, $89.5M) · Finn Patrick John (5, $15.5M) · Cho Dennis (7, $5.6M) · Green Paula (5, $2.4M) · Laponis Adam (3, $2.2M)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-10-23 Finn Patrick John Officer 2,245 $302.2K 2026-10-23 Fidelity Brokerage Services LLC — EDGAR
2026-10-09 Laponis Adam Officer 2,462 $384.8K 2026-10-09 Fidelity Brokerage Services LLC — EDGAR
2026-10-05 Leproust Emily M. Officer, Director 4,548 $919.4K 2026-10-05 Fidelity Brokerage Services LLC 10b5-1 EDGAR
2026-10-02 Green Paula Officer 10,088 $1.91M 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-10-02 WERNER ROBERT F. Officer 1,482 $279.9K 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-10-02 Cho Dennis Officer 9,514 $1.80M 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-10-02 Leproust Emily M. Officer, Director 45,736 $8.64M 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-10-02 Laponis Adam Officer 8,057 $1.52M 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-10-02 Finn Patrick John Officer 25,714 $4.86M 2026-10-02 Fidelity Brokerage Services LLC — EDGAR
2026-10-01 Leproust Emily M. Officer, Director 655 $131.0K 2026-10-01 Fidelity Brokerage Services LLC 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed. Market-wide feed: Planned sales (Form 144).
ETF Holders
95 ETFs hold TWST
25 shown · $1.90B total exposure · 0.31% AUM-weighted avg weight
# ETF Provider Weight $ Exposure ETF AUM As Of
1 VTI Vanguard Morningstar Total Stock Market ETF Vanguard 0.02% $407.4M — 2026-09-30
2 VB Vanguard Morningstar Small-Cap ETF Vanguard 0.16% $288.3M — 2026-09-30
3 IWM iShares Russell 2000 ETF iShares (BlackRock) 0.31% $232.7M $74.6B 2026-10-23
4 XBI State Street® SPDR® S&P® Biotech ETF SPDR (State Street) 1.69% $174.8M $10.4B 2026-10-23
5 VBK Vanguard Morningstar Small-Cap Growth ETF Vanguard 0.37% $160.5M — 2026-09-30
6 VXF Vanguard Extended Market ETF Vanguard 0.15% $144.3M — 2026-09-30
7 IWO iShares Russell 2000 Growth ETF iShares (BlackRock) 0.64% $86.6M $13.7B 2026-10-23
8 VTWO Vanguard Russell 2000 ETF Vanguard 0.42% $74.4M — 2026-09-30
9 IBB iShares Biotechnology ETF iShares (BlackRock) 0.63% $67.9M $10.7B 2026-10-23
10 KOMP State Street® SPDR® S&P Kensho New Economies Composite ETF SPDR (State Street) 1.57% $39.1M $2.5B 2026-10-23
11 VHT Vanguard Health Care ETF Vanguard 0.16% $34.0M — 2026-09-30
12 FESM Fidelity Enhanced Small Cap Core ETF Fidelity 0.36% $24.1M $6.6B 2026-10-23
13 JTEK JPMorgan U.S. Tech Leaders ETF JPMorgan 0.49% $22.2M $4.6B 2026-10-23
14 SCHA Schwab U.S. Small-Cap ETF Nport 0.09% $19.7M — 2026-05-31
15 IDNA iShares Genomics Immunology and Healthcare ETF iShares (BlackRock) 5.82% $18.6M $321.2M 2026-10-23
16 DFAS Dimensional US Small Cap ETF Dimensional 0.05% $17.0M — 2026-10-23
17 TSME Thrivent Small-Mid Cap Equity ETF Nport 1.38% $14.5M — 2026-06-30
18 VTWG Vanguard Russell 2000 Growth ETF Vanguard 0.83% $14.0M — 2026-09-30
19 ITOT iShares Core S&P Total U.S. Stock Market ETF iShares (BlackRock) 0.01% $12.2M $96.5B 2026-10-23
20 VT Vanguard Total World Stock ETF Vanguard 0.01% $10.8M — 2026-09-30
21 SMLF iShares U.S. Small-Cap Equity Factor ETF iShares (BlackRock) 0.24% $9.9M $4.2B 2026-10-23
22 DFAC Dimensional US Core Equity 2 ETF Dimensional 0.01% $8.4M — 2026-10-23
23 FRTY Alger Mid Cap 40 ETF Nport 4.79% $7.4M — 2026-06-30
24 GNOM Global X Genomics & Biotechnology ETF Global X 6.42% $6.8M — 2026-10-26
25 LABU Direxion Daily S&P Biotech Bull 3X ETF Direxion 1.18% $6.8M — 2026-10-26
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

Trailing P/E
—
TTM Diluted EPS
$-1.33
TTM Revenue
$409.48M
TTM Net Income
$-81.28M
TTM Op. Cash Flow
$-55.59M
Quarterly figures (12 quarters)
QuarterPeriod EndRevenueNet IncomeDiluted EPSOp. Cash Flow
Q2 '262026-03-31$110.72M$-44.02M$-0.71$-17.56M
Q1 '262025-12-31$103.70M$-30.51M$-0.50$-24.81M
Q4 '252025-09-30$99.01M$-27.14M$-0.45$-11.81M
Q3 '252025-06-30$96.06M$20.39M$0.33$-1.40M
Q2 '252025-03-31$92.79M$-39.33M$-0.66$-12.99M
Q1 '252024-12-31$88.71M$-31.59M$-0.53$-21.43M
Q4 '242024-09-30$84.71M$-34.66M$-0.59$-15.32M
Q3 '242024-06-30$81.46M$-85.57M$-1.47$-6.38M
Q2 '242024-03-31$75.30M$-45.49M$-0.79$-19.42M
Q1 '242023-12-31$71.50M$-43.01M$-0.75$-22.97M
Q4 '232023-09-30$66.95M$-46.24M$-0.81$-20.70M
Q3 '232023-06-30$63.74M$-57.40M$-1.01$-23.41M
Q2 2026 • period ending 2026-03-31 • filed 2026-05-04
Valuation

Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.

Price Multiples
  • P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
  • P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
  • P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
  • EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
  • EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
Profitability & Yields
  • ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
  • ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
  • Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
  • FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
Balance Sheet
  • Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
  • Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
Reading the history chart
  • Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
  • Multiples expanding while earnings are flat = sentiment-driven rally.
  • Multiples compressing while earnings grow = value coming from fundamentals.
P/E
—
P/B
19.45
P/S
21.62
EV/EBITDA
—
EV/Sales
21.35
ROE
-17.9%
ROA
-12.0%
Div Yield
0.00%
FCF Yield
-0.63%
Debt/Equity
0.03
Current Ratio
—
Market Cap
$8.85B
as of 2026-10-26
Short Interest & Float

Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.

Metric definitions
  • Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
  • SI % of Float — short interest / free float. The key crowding metric.
  • Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
  • Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
  • Free Float — shares available for public trading (total shares minus insider / restricted).
  • Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
How to read the signals
  • SI % of Float < 5% — typical, no particular signal.
  • 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
  • 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
  • >30% — extreme; borrow is likely expensive and squeeze risk is material.
  • Days to Cover > 5 combined with high SI% amplifies squeeze potential.
History chart
  • Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
  • A sudden drop in SI after a rally may indicate a squeeze in progress.

Short interest is reported mid-month and end-of-month; short volume is daily.

Short Interest
10.57M
SI % of Float
17.15%
Days to Cover
3.83
Short Vol Ratio
58.2%
Free Float
61.62M
Float %
98.3%
Short interest 2026-09-30 • Short volume 2026-10-26 • Float 2026-09-22