Paradigm Biocapital Advisors LP — 13F Holdings & Portfolio
CIK 1855655 · latest 13F-HR filed 2026-05-15
Paradigm Biocapital Advisors LP manages $4.89B in 13F-reported U.S. long-equity assets across 35 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are ACLX (13.55%), RVMD (13.23%), NUVL (11.15%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 10 new positions, exited 4, added to 13, and trimmed 10.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$4.89B
Long-equity book
35
Distinct positions
2026-03-31
Filed 2026-05-15
+10 / −4 / ↑13 / ↓10
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- ARCELLX INC$289.8M +77.6%
- REVOLUTION MEDICINES INC$118.0M +22.3%
- ERASCA INC$115.5M +219.2%
- VAXCYTE INC$90.8M +48.4%
- TERNS PHARMACEUTICALS INC$84.1M +257.0%
Top Trims
- ABIVAX SA-$105.1M -55.0%
- SCHOLAR ROCK HLDG CORP-$74.6M -55.3%
- UROGEN PHARMA LTD-$74.1M -70.8%
- OLEMA PHARMACEUTICALS INC-$69.0M -36.6%
- TARSUS PHARMACEUTICALS INC-$30.1M -14.3%
New Positions
- INSMED INC$205.1M
- BELITE BIO INC$177.7M
- CENTESSA PHARMACEUTICALS PLC$142.0M
- CYTOKINETICS INC$97.6M
- TANGO THERAPEUTICS INC$83.9M
Exited Positions
- CIDARA THERAPEUTICS INC$167.8M
- CRINETICS PHARMACEUTICALS IN$102.9M
- BRIDGEBIO PHARMA INC$52.3M
- OCULAR THERAPEUTIX INC$35.6M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | ARCELLX INC | ACLX | 03940C100 | $663.0M | 13.55% | 5,774,016 | SH |
| 2 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $647.3M | 13.23% | 6,655,703 | SH |
| 3 | NUVALENT INC | NUVL | 670703107 | $545.5M | 11.15% | 5,324,433 | SH |
| 4 | VAXCYTE INC | PCVX | 92243G108 | $278.5M | 5.69% | 4,793,020 | SH |
| 5 | EDGEWISE THERAPEUTICS INC | EWTX | 28036F105 | $232.0M | 4.74% | 7,365,038 | SH |
| 6 | GENMAB A/S | GMAB | 372303206 | $213.8M | 4.37% | 7,967,836 | SH |
| 7 | INSMED INC | INSM | 457669307 | $205.1M | 4.19% | 1,254,488 | SH |
| 8 | TARSUS PHARMACEUTICALS INC | TARS | 87650L103 | $179.7M | 3.67% | 2,562,154 | SH |
| 9 | BELITE BIO INC | BLTE | 07782B104 | $177.7M | 3.63% | 1,114,784 | SH |
| 10 | ERASCA INC | ERAS | 29479A108 | $168.2M | 3.44% | 10,392,702 | SH |
| 11 | CENTESSA PHARMACEUTICALS PLC | CNTA | 152309100 | $142.0M | 2.90% | 3,574,048 | SH |
| 12 | OLEMA PHARMACEUTICALS INC | OLMA | 68062P106 | $119.6M | 2.44% | 8,020,576 | SH |
| 13 | TERNS PHARMACEUTICALS INC | TERN | 880881107 | $116.9M | 2.39% | 2,216,499 | SH |
| 14 | ORUKA THERAPEUTICS INC | ORKA | 687604108 | $113.8M | 2.33% | 2,320,316 | SH |
| 15 | APOGEE THERAPEUTICS INC | APGE | 03770N101 | $113.5M | 2.32% | 1,348,243 | SH |
| 16 | SPYRE THERAPEUTICS INC | SYRE | 00773J202 | $98.7M | 2.02% | 1,957,266 | SH |
| 17 | CYTOKINETICS INC | CYTK | 23282W605 | $97.6M | 1.99% | 1,480,857 | SH |
| 18 | ABIVAX SA | ABVX | 00370M103 | $86.0M | 1.76% | 772,473 | SH |
| 19 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $83.9M | 1.71% | 4,009,679 | SH |
| 20 | MAZE THERAPEUTICS INC | MAZE | 578784100 | $81.9M | 1.67% | 2,744,399 | SH |
| 21 | TYRA BIOSCIENCES INC | TYRA | 90240B106 | $78.7M | 1.61% | 2,054,991 | SH |
| 22 | VIRIDIAN THERAPEUTICS INC | VRDN | 92790C104 | $61.6M | 1.26% | 3,148,893 | SH |
| 23 | SCHOLAR ROCK HLDG CORP | SRRK | 80706P103 | $60.3M | 1.23% | 1,226,080 | SH |
| 24 | MIRUM PHARMACEUTICALS INC | MIRM | 604749101 | $57.7M | 1.18% | 625,000 | SH |
| 25 | EYEPOINT INC | EYPT | 30233G209 | $40.5M | 0.83% | 3,142,437 | SH |
| 26 | LEXEO THERAPEUTICS INC | LXEO | 52886X107 | $35.5M | 0.73% | 6,184,134 | SH |
| 27 | VERADERMICS INC | MANE | 922967104 | $33.2M | 0.68% | 525,000 | SH |
| 28 | VOR BIOPHARMA INC | VOR | 929033207 | $31.2M | 0.64% | 1,750,000 | SH |
| 29 | UROGEN PHARMA LTD | URGN | M96088105 | $30.6M | 0.63% | 1,703,949 | SH |
| 30 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $26.3M | 0.54% | 545,287 | SH |
| 31 | INVENTIVA SA | IVA | 46124U107 | $22.2M | 0.45% | 4,000,000 | SH |
| 32 | ORIC PHARMACEUTICALS INC | ORIC | 68622P109 | $21.6M | 0.44% | 1,701,217 | SH |
| 33 | ASSEMBLY BIOSCIENCES INC | ASMB | 045396207 | $18.5M | 0.38% | 665,251 | SH |
| 34 | BRIDGEBIO ONCOLOGY THERAPEUT | BBOT | 107924102 | $7.8M | 0.16% | 868,213 | SH |
| 35 | KALARIS THERAPEUTICS INC | KLRS | 482929106 | $4.0M | 0.08% | 700,000 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-15 | $4.89B | 35 | 0001855655-26-000011 |
| 2025-12-31 | 2026-02-17 | $3.92B | 30 | 0001855655-26-000003 |
| 2025-09-30 | 2025-11-14 | $3.52B | 36 | 0001855655-25-000014 |