LXRX Lexicon Pharmaceuticals, Inc.

XNAS 1.85 Delayed
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Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership. Iron condor setups Fibonacci levels Insider trading

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

LXRX $1.85 —

What changed

Recent filings, trades and moves
Key stats
$1.85
52-Week Range
$1.10 – $2.68
YTD
+62.25%
Straddle Price
$0.53
P/C Vol Ratio
0.55
Market Cap
$0.8B
Open
$1.88
Day Range
$1.83 – $1.92
Volume
1,567,175
Prev Close
$1.78
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)4.90%
Beta vs SPY1.51
Cost of Equity (CAPM)13.19% (VRP-adj)
WACC12.77%
Volatility Risk Premium+135.4pp (IV − HV30), ERP adj +50bps
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)-10.0%
DCF Horizon10 years explicit + fade
Free Cash Flow (TTM)$-0.1B
Return on Equity (TTM)-35.0%
Book / Price20.7%
Gross Margin (TTM)98.9%
FCF Margin (TTM)-169.3%
Debt / Equity0.32
Quality Score2/6 — normal (10y DCF)
SMA 50$1.81 (Market Anchor value)
SMA 20 / Bollinger Mid$1.54
Bollinger Width / SMA2023.8% (drives anchor stability)
Net Debt$0.0B
Market Cap$1B
Peers used for multiples: LLY, MANE, MAZE, PCRX, SEPN, SUPN, VTRS, XERS
60-Day Conviction
88%
20-Day Fair Value
≈ by Dec 8, 2026
$1.85
α -0.5% rank 28%
conviction
39%
40-Day Fair Value
≈ by Jan 6, 2027
$1.95
α +4.4% rank 38%
conviction
93%
60-Day Fair Value
≈ by Feb 4, 2027
$1.96
α +4.8% rank 40%
conviction
88%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0%
Peer EV/EBITDA n/a 0% median 15.2× · 5 peers
Peer P/B $1.13 16% median 3.1× · 6 peers
Peer P/S $0.61 16% median 7.1× · 7 peers
Market Anchor (SMA50) $1.81 68% stability 82% (BB-width)
Options Expected (B-L 30d) n/a 0%
As of 2026-11-09 · updated
About
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834) · industry map
Exchange
XNAS
Market Cap
$0.8B
Employees
81
List Date
2000-04-07
CIK
0001062822
Last Earnings
Nov 5 before open · +8.8% vs ±49.0% expected
Next Earnings
~Jan 28, 2027 (estimated)
Headquarters
The Woodlands, TX
Homepage
https://www.lexpharma.com

Lexicon Pharmaceuticals Inc is a biopharmaceutical company. It is engaged in the discovery, development, and commercialization of pharmaceutical products for the treatment of human diseases. Some of its drug candidates are LX9211, an orally-delivered small molecule drug candidate, and LX9851, an orally-delivered small molecule drug candidate, as a treatment for obesity and associated cardiometabolic.

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Month'21'22'23'24'25'26Avg
Jan124.72%-18.51%12.56%17.61%-2.69%1.75%22.57%
Feb-13.06%-36.89%-0.88%25.76%-3.84%17.60%-1.88%
Mar-22.76%-0.95%10.45%-3.23%57.48%0.00%6.83%
Apr-17.21%-19.56%-2.85%-32.46%57.47%-1.83%-2.74%
May-9.30%-8.29%35.25%3.03%-13.51%33.74%6.82%
Jun2.68%6.29%-15.50%-4.00%52.14%15.94%9.59%
Jul-18.81%22.68%-13.36%34.33%21.03%-2.74%7.19%
Aug29.32%16.03%-11.34%-14.36%2.80%-3.43%3.17%
Sep1.91%-13.04%-35.50%-2.48%20.54%-14.38%-7.16%
Oct9.75%-12.24%21.57%23.42%-2.13%-21.98%3.06%
Nov-19.37%-3.60%-20.90%-34.12%5.15%28.82%*-7.34%
Dec-13.97%-10.75%33.04%-7.79%-15.44%---2.98%
Total-5.22%-62.67%-13.28%-19.58%298.50%47.22%40.83%
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $1.55
SMA 50: $1.80
SMA 200: $1.89
Current: $1.86
EMA 12: $1.60
EMA 26: $1.64
MACD: -0.0356 | Signal: 0.0576
BEARISH
ADX (14): 36.87
TREND
+DI: 33.96
−DI: 17.47

Momentum Oscillators

RSI (14): 65.41
NEUTRAL
Stoch %K: 88.98
Stoch %D: 70.64
Williams %R: -9.55

Volume & Volatility

BB Upper: $1.77
BB Lower: $1.32
OVERBOUGHT
OBV: 400,020,726
Vol SMA 20: 1,990,983
Vol ROC: -29.09%
ATR: $0.11
True Range: $0.14
HV 20: 68.5%
HV 30: 60.2%
HV 60: 60.5%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-11-08T00:00:00 – 2026-11-06T00:00:00
AI Analysis

Click Frenzy-Pro™ for an AI analysis of this ticker.

Analysis includes technical indicators, news sentiment, risk assessment, and specific price levels to watch.

Earnings History
18 of 21 under expected move
Avg Expected Move
22.58%
Avg Actual Move
9.37%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2021-03-10 After-Close 18.08% 4.79% 0.26x Within
2021-05-06 After-Close 8.97% 2.69% 0.30x Within
2021-07-30 After-Close 18.36% 3.11% 0.17x Within
2021-11-03 After-Close 11.09% 13.86% 1.25x Exceeded
2022-02-28 After-Close 21.26% 1.93% 0.09x Within
2022-08-02 After-Close 30.77% 3.46% 0.11x Within
2022-11-09 After-Close 16.33% 14.29% 0.88x Within
2023-03-02 After-Close 14.22% 22.94% 1.61x Exceeded
2023-05-02 After-Close 25.63% 15.13% 0.59x Within
2023-08-03 After-Close 16.15% 2.60% 0.16x Within
2024-03-11 After-Close 15.30% 10.32% 0.67x Within
2024-05-02 After-Close 15.88% 2.35% 0.15x Within
2024-08-01 Pre-Market 18.89% 10.22% 0.54x Within
2024-11-12 Pre-Market 39.37% 6.30% 0.16x Within
2025-05-13 After-Close 31.75% 15.57% 0.49x Within
2025-08-06 After-Close 17.39% 2.61% 0.15x Within
2025-11-06 After-Close 33.22% 12.59% 0.38x Within
2026-01-29 After-Close 34.72% 19.44% 0.56x Within
2026-05-07 After-Close 13.39% 19.05% 1.42x Exceeded
2026-08-06 After-Close 24.36% 4.66% 0.19x Within
2026-11-05 Pre-Market 48.99% 8.78% 0.18x Within

Earnings calendar: this week’s reports with expected vs actual moves →

LXRX Options Activity & IV Rank

Volatility Metrics

Current IV: —
7-DTE IV: —
Expected Move: $0.53
7-DTE Move: $0.48
Days to Exp: 39 (2026-12-18)

Options Flow · All expiries

Call Volume: 1,180
Put Volume: 644
P/C Volume: 0.546
BULLISH
Call OI: 25,655
Put OI: 1,666
P/C OI: 0.065
Total OI: 27,321

ATM Options Pricing

ATM Call: $0.20
ATM Put: $0.33
Call %: 10.8%
Put %: 17.6%

Chain Summary

Chain Volume: 1,824
Chain OI: 27,321
Last Updated: 11/9/2026
Spread Scanner

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
Calendars: the long leg is valued at the short leg’s expiration (Black-Scholes at its current IV) across the range of prices the short leg’s IV implies, giving the best-case profit (R/R = that over the debit) and P(profit).

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Scanning bull put, bear call, iron condor and calendar spreads…

Dealer Positioning
TYPICAL γ

Estimated net dealer gamma is at the 34th percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.

Gamma percentile
34%
vs own history
GEX tilt
+0.33
OI-weighted, today
Vanna tilt
+0.39
δ-sensitivity to IV
Charm tilt
-0.15
δ-decay vs time
Vanna tilt +0.39: the estimated dealer exposure leans positive, so the modeled hedge would shift noticeably if implied volatility changed.

Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.

Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.

Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.

This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.

· 6 ATM contracts, 2k total OI
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
No data
30 DTE / 10d —
— pts EXTREME
No data

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Loading the implied volatility surface…

Volatility Smile

Loading the implied volatility smile…

IV Rank (7 DTE)
IV Rank (30 DTE)
Straddle Price (30 DTE)$0.53Nov 9
Beta Analysis

Risk Metrics

Beta: 1.1344
Alpha: 52.31%
Correlation: 0.2110
R-Squared: 4.5%
Stock Volatility: 74.1%
Market Volatility: 13.8%

Analysis Details

Benchmark: SPY
Data Points: 251
Period: 252 trading days
Interpretation:
Above average volatility - stock moves with market amplification
Beta & Alpha Over Time
Notable investors who own LXRX
5 of 37 tracked investors
InvestorValueShare of their portfolioRankQ/Q sharesSource
Point72 Hedge fund
Steve Cohen
$19.8M
0.03%
#588 of 1945+5.6%13F
Citadel Hedge fund
Ken Griffin
$3.8M
0.00%
#2301 of 6285+46.2%13F
Millennium Management Hedge fund
Izzy Englander
$2.7M
0.00%
#2407 of 3716-77.1%13F
Renaissance Technologies Hedge fund
Jim Simons
$2.7M
0.00%
#1802 of 3138-29.6%13F
Rockefeller Capital Management Family office
Rockefeller family
$1K
0.00%
#4559 of 4729-10.4%13F

Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions

LXRX Institutional Ownership (13F)

Filings for 2026-06-30 · 52 already for 2026-09-30
Diluted shares outstanding: 411,504,750 (as of 2026-09-30)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

155 filers363,505,339 shares$867.76M value88.34% of float
# Filer Shares Value % of Total % of Float Period
1 Artal Group S.A. 175,156,062 $420.37M 48.44% 42.56% 2026-06-30
2 FMR LLC Custodian 51,782,045 $124.28M 14.32% 12.58% 2026-06-30
3 Siren, L.L.C. 44,303,518 $106.33M 12.25% 10.77% 2026-06-30
4 Sessa Capital IM, L.P. 18,960,836 $45.51M 5.24% 4.61% 2026-06-30
5 BlackRock, Inc. Custodian 17,348,741 $41.64M 4.80% 4.22% 2026-06-30
6 Vanguard Capital Management LLC 9,901,208 $23.76M 2.74% 2.41% 2026-06-30
7 Point72 Asset Management, L.P. 8,251,325 $19.80M 2.28% 2.01% 2026-06-30
8 State Street Corp 4,917,769 $11.80M 1.36% 1.20% 2026-06-30
9 Geode Capital Management, LLC Custodian 5,891,974 $11.05M 1.27% 1.43% 2026-09-30
10 Vanguard Portfolio Management LLC 2,357,749 $5.66M 0.65% 0.57% 2026-06-30
11 Northern Trust Corp Custodian 1,968,619 $4.72M 0.54% 0.48% 2026-06-30
12 Charles Schwab Investment Management, Inc. 1,956,775 $4.70M 0.54% 0.48% 2026-06-30
13 Vanguard Fiduciary Trust Co 1,634,571 $3.92M 0.45% 0.40% 2026-06-30
14 Citadel Advisors LLC Custodian 1,601,182 $3.84M 0.44% 0.39% 2026-06-30
15 Ishara Investments LP 1,271,000 $3.05M 0.35% 0.31% 2026-06-30
16 Millennium Management LLC Custodian 1,134,229 $2.72M 0.31% 0.28% 2026-06-30
17 RENAISSANCE TECHNOLOGIES LLC 1,127,000 $2.70M 0.31% 0.27% 2026-06-30
18 ADAR1 Capital Management, LLC 750,000 $1.80M 0.21% 0.18% 2026-06-30
19 Susquehanna International Group, LLP Custodian 696,776 $1.67M 0.19% 0.17% 2026-06-30
20 ACADIAN ASSET MANAGEMENT LLC 696,617 $1.67M 0.19% 0.17% 2026-06-30
21 UBS Group AG Custodian 684,713 $1.64M 0.19% 0.17% 2026-06-30
22 Two Sigma Investments, LP Custodian 643,444 $1.54M 0.18% 0.16% 2026-06-30
23 Nuveen, LLC Custodian 586,664 $1.41M 0.16% 0.14% 2026-06-30
24 Invesco Ltd. Custodian 508,071 $1.22M 0.14% 0.12% 2026-06-30
25 Goldman Sachs Group Inc Custodian 485,546 $1.17M 0.13% 0.12% 2026-06-30
5 filers$5.09M notional
# Filer Notional Value % of Total Period
1 Susquehanna International Group, LLP Custodian $1.60M 31.52% 2026-06-30
2 Jane Street Group, LLC Custodian $1.40M 27.48% 2026-06-30
3 GROUP ONE TRADING LLC Custodian $1.11M 21.75% 2026-06-30
4 Citadel Advisors LLC Custodian $886.32K 17.41% 2026-06-30
5 Simplex Trading, LLC Custodian $93.56K 1.84% 2026-09-30
4 filers$162.16K notional
# Filer Notional Value % of Total Period
1 GROUP ONE TRADING LLC Custodian $51.12K 31.52% 2026-06-30
2 Citadel Advisors LLC Custodian $42.96K 26.49% 2026-06-30
3 Susquehanna International Group, LLP Custodian $42.96K 26.49% 2026-06-30
4 Simplex Trading, LLC Custodian $25.12K 15.49% 2026-09-30

LXRX Insider Trading (Form 4)

Latest: 2026-06-04
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-06-04 Christopher J Sobecki Director Exer (M) +89,312 — EDGAR
2026-06-04 Ivan Cheung Director Exer (M) +89,312 — EDGAR
2026-06-04 Raymond Debbane Director Exer (M) +89,312 — EDGAR
2026-06-04 Philippe Amouyal Director Exer (M) +89,312 — EDGAR
2026-06-04 Judith L Swain Director Exer (M) +89,312 — EDGAR
2026-06-04 Diane E. Sullivan Director Exer (M) +89,312 — EDGAR
2026-06-04 Sam L Barker Director Exer (M) +89,312 — EDGAR
2026-05-08 International S.C.A. Artal Director Exer (M) +20,421,735 — EDGAR
2026-05-04 Ivan Cheung Director Grant (A) +79,192 RSU — EDGAR
2026-05-04 Sam L Barker Director Grant (A) +79,192 opt — EDGAR
2026-05-04 Philippe Amouyal Director Grant (A) +79,192 RSU — EDGAR
2026-05-04 Raymond Debbane Director Grant (A) +79,192 RSU — EDGAR
2026-05-04 Christopher J Sobecki Director Grant (A) +79,192 RSU — EDGAR
2026-05-04 Judith L Swain Director Grant (A) +79,192 opt — EDGAR
2026-05-04 Diane E. Sullivan Director Grant (A) +79,192 RSU — EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.

LXRX Insider Holdings

19 insiders · @ $1.86
Officers, directors, and 10%+ owners who have filed a Form 4 in the past two years, ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 International S.C.A. Artal Director 175,156,062 $326.67M $6.75M 2 2026-05-08
2 Raymond Debbane Director 3,533,960 $6.59M $5.17M 35 2026-06-04
3 Michael Exton Chief Executive Officer 503,263 $938.6K $0 4 2026-03-03
4 Brian T Crum SVP, General Counsel & Secr. 428,802 $799.7K $0 15 2026-03-03
5 Artal Group S.A. Director 408,434 $761.7K $42.43M 3 2026-02-19
6 Philippe Amouyal Director 374,486 $698.4K $201.5K 26 2026-06-04
7 Christopher J Sobecki Director 293,177 $546.8K $302.5K 27 2026-06-04
8 Alan J Main EVP, Innov & Chem Sciences 281,391 $524.8K $0 36 2025-03-03
9 Sam L Barker Director 218,771 $408.0K $148.9K 30 2026-06-04
10 Wendy McDermott SVP, Human Resources 201,659 $376.1K $35.3K 12 2026-03-03
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.

LXRX Board & Officers

As of SEC filings through Jun 4, 2026

Directors 19

Officers 8

10% owners 11

Changes in the last 10 years (50)
Feb 17, 2026Rachel Yap Martens listed as SVP, Partnerships & Corp Strat (previously VP, Partnerships & Corp Strat) in SEC filings
Feb 2, 2026Avicenna Life Sci Master GP LLC became a director
Feb 2, 2026Avicenna Life Sci Master GP LLC became a 10% owner
Feb 2, 2026Avicenna Life Sci Master Fund LP became a director
Feb 2, 2026Avicenna Life Sci Master Fund LP became a 10% owner
Jun 1, 2025Suma Gopinathan became SVP, Discovery
Jun 1, 2025Rachel Yap Martens became VP, Partnerships & Corp Strat
Mar 3, 2025Lisa DeFrancesco listed as SVP, IR and Corp Comm (previously VP, IR and Corp Strategy) in SEC filings
Feb 18, 2025Wendy McDermott listed as SVP, Human Resources (previously VP, Human Resources) in SEC filings
Jan 2, 2025Scott M Coiante became SVP, Chief Financial Officer
Dec 5, 2024Artal Participations S.a r.l. became a director
Dec 5, 2024Artal Participations S.a r.l. became a 10% owner
Dec 2, 2024Ivan Cheung became a director
Nov 19, 2024The company announced the departure of Robert J Md Lefkowitz from the board in an SEC filing
Oct 2, 2024Lisa DeFrancesco became VP, IR and Corp Strategy
Aug 12, 2024Brian Corrigan became SVP, Regulatory & QA
Jul 25, 2024Siren, L.L.C. became a director
Jul 25, 2024Siren, L.L.C. became a 10% owner
Jul 25, 2024Invus Global Management, LLC became a director
Jul 25, 2024Invus Global Management, LLC became a 10% owner
Not reported recently (19)
  • Alan J Main · Last reported as EVP, Innov & Chem Sciences in an SEC filing dated Mar 3, 2025
  • Kristen Alexander · Last reported as VP, Finance and Accounting in an SEC filing dated Mar 3, 2025
  • Brian Corrigan · Last reported as SVP, Regulatory & QA in an SEC filing dated Feb 18, 2025
  • Jeffrey L Wade · Last reported as President and CFO in an SEC filing dated Jul 8, 2024
  • Invus Public Equities Advisors, LLC · Last reported as a 10% owner in an SEC filing dated May 14, 2024
  • Invus Public Equities, L.P. · Last reported as a 10% owner in an SEC filing dated May 14, 2024
  • Invus Advisors, L.L.C. · Last reported as a 10% owner in an SEC filing dated May 14, 2024
  • Invus, L.P. · Last reported as a 10% owner in an SEC filing dated May 14, 2024
  • Kenneth B. Kassler-Taub · Last reported as SVP, Regulatory & QA in an SEC filing dated Feb 29, 2024
  • Thomas Garner · Last reported as SVP, Chief Commercial Officer in an SEC filing dated Feb 12, 2024
  • Kiernan Seth · Last reported as VP, Chief Commercial Officer in an SEC filing dated Mar 1, 2023
  • Ulys, L.L.C. · Last reported as a 10% owner in an SEC filing dated Aug 9, 2022
  • Invus US Partners LLC · Last reported as a director in an SEC filing dated Aug 9, 2022
  • James F Tessmer · Last reported as VP, Finance & Accounting in an SEC filing dated Mar 16, 2021
  • Praveen Tyle · Last reported as EVP, R&D in an SEC filing dated Mar 2, 2021
  • Pascal Minne · Last reported as a director in an SEC filing dated Dec 17, 2020
  • Artal Treasury Ltd · Last reported as a director in an SEC filing dated Dec 17, 2020
  • Pablo Lapuerta · Last reported as EVP and CMO in an SEC filing dated Apr 24, 2020
  • Alexander A Santini · Last reported as EVP and CCO in an SEC filing dated Apr 24, 2020
Compiled from SEC filings by the company and its directors and officers. Dates are as stated in those filings. Where no filing says when someone left, we show the last filing that listed them.

LXRX Proposed Insider Sales (Form 144)

Latest: 2024-08-15
Last 30d: 0 filings  ·  Last 90d: 0 filings

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2024-08-15 COATS LONNEL Former Affiliate 300,000 $480.0K 2024-08-15 Charles Schwab & Co., Inc. — EDGAR
2023-07-12 Seth Kiernan Former Affiliate 19,000 $43.9K 2023-07-12 Charles Schwab & Co., Inc. — EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed. Market-wide feed: Planned sales (Form 144).
Recent SEC Filings
Latest: 2026-11-05
Current reports — material events the company must disclose within 4 business days (earnings releases, M&A, executive changes, etc.).
Filing Date Event Link
2026-11-05 Earnings results EDGAR
2026-08-06 Earnings results EDGAR
Annual report — audited financial statements, MD&A, risk factors. Filed 60–90 days after fiscal year-end.
Filing Date Accession Link
Quarterly report — unaudited financials and MD&A. Filed 40–45 days after each of the first three fiscal quarters.
Filing Date Accession Link
2026-11-05 0001062822-26-000128 EDGAR
2026-08-06 0001062822-26-000117 EDGAR
ETF Holders
30 ETFs hold LXRX
25 shown · $46.91M total exposure · 0.02% AUM-weighted avg weight
# ETF Provider Weight $ Exposure ETF AUM As Of
1 VTI Vanguard Morningstar Total Stock Market ETF Vanguard 0.00% $13.3M — 2026-09-30
2 IWM iShares Russell 2000 ETF iShares (BlackRock) 0.01% $10.5M $76.6B 2026-11-06
3 VXF Vanguard Extended Market ETF Vanguard 0.00% $4.6M — 2026-09-30
4 IWO iShares Russell 2000 Growth ETF iShares (BlackRock) 0.03% $3.8M $13.7B 2026-11-06
5 XPH State Street® SPDR® S&P® Pharmaceuticals ETF SPDR (State Street) 0.75% $3.5M $466.5M 2026-11-05
6 VTWO Vanguard Russell 2000 ETF Vanguard 0.01% $2.5M — 2026-09-30
7 SCHA Schwab U.S. Small-Cap ETF Nport 0.01% $2.4M — 2026-08-31
8 IWC iShares Micro-Cap ETF iShares (BlackRock) 0.10% $1.2M $1.2B 2026-11-06
9 VHT Vanguard Health Care ETF Vanguard 0.01% $1.2M — 2026-09-30
10 VFMO Vanguard U.S. Momentum Factor ETF Vanguard 0.06% $1.0M — 2026-11-05
11 PRFZ Invesco RAFI US 1500 Small-Mid ETF Nport 0.03% $747,193 — 2026-07-31
12 VTWG Vanguard Russell 2000 Growth ETF Vanguard 0.03% $463,665 — 2026-09-30
13 BBC Virtus Biotech Clinical Trials Etf Nport 0.81% $373,947 — 2026-07-31
14 GSSC Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF Goldman 0.03% $266,622 $1.0B 2026-11-05
15 SCHB Schwab U.S. Broad Market ETF Nport 0.00% $250,682 — 2026-08-31
16 RSSL Global X Russell 2000 ETF Global X 0.01% $192,799 — 2026-11-06
17 FHLC Fidelity MSCI Health Care Index ETF Fidelity 0.00% $176,203 $4.0B 2026-11-05
18 IWV iShares Russell 3000 ETF iShares (BlackRock) 0.00% $154,908 $19.7B 2026-11-06
19 QQQS Invesco NASDAQ Future Gen 200 ETF Invesco 0.43% $84,255 — 2026-11-05
20 PILL Direxion Daily Pharmaceutical & Medical Bull 3X ETF Direxion 0.52% $68,082 — 2026-11-06
21 VTHR Vanguard Russell 3000 ETF Vanguard 0.00% $39,197 — 2026-09-30
22 MSSM Morgan Stanley Pathway Small-Mid Cap Equity ETF Nport 0.00% $33,199 — 2026-08-31
23 WSML iShares MSCI World Small-Cap ETF iShares (BlackRock) 0.01% $32,690 $656.6M 2026-11-06
24 ITWO ProShares Russell 2000 High Income ETF ProShares 0.01% $22,855 — 2026-11-06
25 URTY ProShares UltraPro Russell2000 ProShares 0.01% $17,723 — 2026-11-06
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

Trailing P/E
—
TTM Diluted EPS
$-0.14
TTM Revenue
$38.38M
TTM Net Income
$-62.35M
TTM Op. Cash Flow
$-49.23M
Quarterly figures (12 quarters)
QuarterPeriod EndRevenueNet IncomeDiluted EPSOp. Cash Flow
Q3 '262026-09-30$11.25M$-14.01M$-0.03$-8.08M
Q1 '262026-03-31$21.10M$-1.04M—$-14.73M
Q4 '252025-12-31$5.34M$-15.53M$-0.04$-17.23M
Q3 '252025-09-30$14.18M$-12.77M$-0.04$-23.83M
Q2 '252025-06-30$28.87M$3.25M$0.01$16.99M
Q1 '252025-03-31$1.26M$-25.30M$-0.07$-43.78M
Q4 '242024-12-31$26.47M$-33.77M$-0.09$-21.49M
Q3 '242024-09-30$1.75M$-64.81M$-0.18$-53.62M
Q2 '242024-06-30$1.65M$-53.43M$-0.17$-48.54M
Q1 '242024-03-31$1.13M$-48.40M$-0.20$-55.13M
Q4 '232023-12-31$672.00K$-49.76M$-0.20$-50.55M
Q3 '232023-09-30$148.00K$-50.52M$-0.21$-41.62M
Q3 2026 • period ending 2026-09-30 • filed 2026-11-05
Valuation

Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.

Price Multiples
  • P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
  • P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
  • P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
  • EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
  • EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
Profitability & Yields
  • ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
  • ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
  • Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
  • FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
Balance Sheet
  • Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
  • Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
Reading the history chart
  • Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
  • Multiples expanding while earnings are flat = sentiment-driven rally.
  • Multiples compressing while earnings grow = value coming from fundamentals.
P/E
—
P/B
3.41
P/S
9.95
EV/EBITDA
—
EV/Sales
10.11
ROE
-12.9%
ROA
-9.7%
Div Yield
0.00%
FCF Yield
-5.61%
Debt/Equity
0.24
Current Ratio
—
Market Cap
$691.11M
as of 2026-11-09

LXRX vs Peers

Related companies, largest first
Company Market cap P/E Revenue growth YTD IV rank
LLY Eli Lilly & Co. $1.21T 46.0 +45.5% +31.3% 27
VTRS Viatris Inc. Common Stock $22.8B — +4.3% +64.5% 43
MANE Veradermics, Incorporated $5.8B — — +283.1% 1
XERS Xeris Biopharma Holdings, Inc. Common St $2.8B — +38.4% +114.7% 15
SEPN Septerna, Inc. Common Stock $2.3B — +13520.1% +76.9% 36
MAZE Maze Therapeutics, Inc. Common Stock $1.9B — +700.0% −12.0% 43
SUPN Supernus, Inc. Common Stock $1.5B — +26.9% −44.0% 11
PCRX Pacira BioSciences, Inc. Common Stock $1.5B 104.2 +5.7% +49.1% 67
LXRX Lexicon Pharmaceuticals, Inc. $815M — −45.8% +63.6% 55
Peer median $2.5B 75.1 +38.4% +56.8% 32

P/E uses the latest reported trailing-12-month diluted EPS; "—" means no positive earnings or no data.

Short Interest & Float

Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.

Metric definitions
  • Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
  • SI % of Float — short interest / free float. The key crowding metric.
  • Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
  • Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
  • Free Float — shares available for public trading (total shares minus insider / restricted).
  • Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
How to read the signals
  • SI % of Float < 5% — typical, no particular signal.
  • 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
  • 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
  • >30% — extreme; borrow is likely expensive and squeeze risk is material.
  • Days to Cover > 5 combined with high SI% amplifies squeeze potential.
History chart
  • Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
  • A sudden drop in SI after a rally may indicate a squeeze in progress.

Short interest is reported mid-month and end-of-month; short volume is daily.

Short Interest
26.70M
SI % of Float
11.79%
Days to Cover
12.97
Short Vol Ratio
56.4%
Free Float
226.44M
Float %
50.9%
Short interest 2026-10-15 • Short volume 2026-11-06 • Float 2026-08-14