TRV GP VI, LLC — 13F Holdings & Portfolio
CIK 1990716 · latest 13F-HR filed 2026-08-10
TRV GP VI, LLC manages $232.3M in 13F-reported U.S. long-equity assets across 4 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are SEPN (60.72%), SPTX (19.27%), RAPP (17.39%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 1 new position, exited 0, added to 3, and trimmed 0.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
BOSTON, MA 02215
$232.3M
Long-equity book
4
Distinct positions
2026-06-30
Filed 2026-08-10
+1 / −0 / ↑3 / ↓0
vs 2026-03-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- SEPTERNA, INC.$39.8M +39.4%
- RAPPORT THERAPEUTICS, INC.$10.1M +33.2%
- TANGO THERAPEUTICS, INC.$2.0M +49.4%
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | SEPTERNA, INC. | SEPN | 81734D104 | $141.0M | 60.72% | 4,211,659 | SH |
| 2 | SEAPORT THEREAPEUTICS, INC. | SPTX | 81221K108 | $44.8M | 19.27% | 2,061,222 | SH |
| 3 | RAPPORT THERAPEUTICS, INC. | RAPP | 75383L102 | $40.4M | 17.39% | 969,218 | SH |
| 4 | TANGO THERAPEUTICS, INC. | TNGX | 87583X109 | $6.1M | 2.61% | 194,174 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-10 | $232.3M | 4 | 0001193125-26-340715 |
| 2026-03-31 | 2026-05-07 | $135.6M | 3 | 0001193125-26-212009 |
| 2025-12-31 | 2026-02-13 | $148.5M | 3 | 0001193125-26-051801 |