5AM Venture Management, LLC — 13F Holdings & Portfolio
CIK 1799883 · latest 13F-HR filed 2026-08-14
5AM Venture Management, LLC manages $287.9M in 13F-reported U.S. long-equity assets across 16 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are MPLT (11.83%), TYRA (11.42%), TRDA (10.37%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 0 new positions and exited 4; 10 existing positions rose in reported value and 4 fell.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
Long-equity book
Distinct positions
Filed 2026-08-14
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.
Top Adds (vs prior quarter)
- MAPLIGHT THERAPEUTICS INC$14.7M +76.3%
- ZENTALIS PHARMACEUTICALS INC$9.9M +107.3%
- ARTIVA BIOTHERAPEUTICS INC$7.7M +50.6%
- PHARVARIS N V$5.0M +22.4%
- BIOHAVEN LTD$4.7M +75.9%
Top Trims
- ENTRADA THERAPEUTICS INC-$21.3M -41.7%
- TYRA BIOSCIENCES INC-$6.5M -16.6%
- SURROZEN INC-$4.2M -37.6%
- PROTARA THERAPEUTICS INC-$1.9M -26.7%
Exited Positions
- ERASCA INC$56.4M
- CENTESSA PHARMACEUTICALS PLC$23.1M
- GH RESEARCH PLC$8.1M
- RALLYBIO CORP$2.6M
5AM Venture Management, LLC Holdings (2026-06-30)
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | MAPLIGHT THERAPEUTICS INC | MPLT | 56565P103 | $34.0M | 11.83% | 950,011 | SH |
| 2 | TYRA BIOSCIENCES INC | TYRA | 90240B106 | $32.9M | 11.42% | 1,029,298 | SH |
| 3 | ENTRADA THERAPEUTICS INC | TRDA | 29384C108 | $29.9M | 10.37% | 4,056,379 | SH |
| 4 | PHARVARIS N V | PHVS | N69605108 | $27.6M | 9.58% | 797,600 | SH |
| 5 | CAMP4 THERAPEUTICS CORP | CAMP | 13463J101 | $25.6M | 8.91% | 5,869,091 | SH |
| 6 | ARTIVA BIOTHERAPEUTICS INC | ARTV | 04317A107 | $22.8M | 7.93% | 2,353,304 | SH |
| 7 | TECTONIC THERAPEUTIC INC | TECX | 878972108 | $20.9M | 7.24% | 606,660 | SH |
| 8 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 98943L107 | $19.1M | 6.65% | 3,947,913 | SH |
| 9 | CELLDEX THERAPEUTICS INC NEW | CLDX | 15117B202 | $18.5M | 6.43% | 497,270 | SH |
| 10 | EYEPOINT INC | EYPT | 30233G209 | $15.0M | 5.22% | 1,050,000 | SH |
| 11 | BIOHAVEN LTD | BHVN | G1110E107 | $11.0M | 3.82% | 738,972 | SH |
| 12 | SURROZEN INC | SRZN | 86889P208 | $7.0M | 2.44% | 271,250 | SH |
| 13 | SKYE BIOSCIENCE INC | SKYE | 83086J200 | $6.7M | 2.33% | 9,681,763 | SH |
| 14 | ALX ONCOLOGY HLDGS INC | ALXO | 00166B105 | $6.3M | 2.20% | 3,057,325 | SH |
| 15 | PROTARA THERAPEUTICS INC | TARA | 74365U107 | $5.2M | 1.82% | 1,369,782 | SH |
| 16 | SILENCE THERAPEUTICS PLC | SLN | 82686Q101 | $5.2M | 1.82% | 476,200 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $287.9M | 16 | 0001799883-26-000003 |
| 2026-03-31 | 2026-05-15 | $360.2M | 20 | 0001799883-26-000002 |
| 2025-12-31 | 2026-02-17 | $318.1M | 21 | 0001799883-26-000001 |
| 2025-09-30 | 2025-11-14 | $273.0M | 25 | 0001799883-25-000002 |
SAN FRANCISCO, CA 94111