Avoro Capital Advisors LLC — 13F Holdings & Portfolio
CIK 1633313 · latest 13F-HR filed 2026-05-15
Avoro Capital Advisors LLC manages $10.16B in 13F-reported U.S. long-equity assets across 33 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are UTHR (15.34%), ASND (11.39%), MDGL (9.36%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 4 new positions, exited 7, added to 12, and trimmed 12.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$10.16B
Long-equity book
33
Distinct positions
2026-03-31
Filed 2026-05-15
+4 / −7 / ↑12 / ↓12
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- UNITED THERAPEUTICS CORP$289.7M +22.8%
- APELLIS PHARMACEUTICALS INC$184.7M +60.2%
- TERNS PHARMACEUTICALS INC$124.5M +70.8%
- XENON PHARMACEUTICALS INC$92.9M +38.2%
- CENTESSA PHARMACEUTICALS PLC$90.0M +24.7%
Top Trims
- STRUCTURE THERAPEUTICS INC-$140.0M -30.7%
- ARGENX SE-$102.3M -12.3%
- MADRIGAL PHARMACEUTICALS INC-$100.8M -9.6%
- VERA THERAPEUTICS INC-$61.3M -20.6%
- SOLENO THERAPEUTICS INC-$57.3M -42.6%
New Positions
- CYTOKINETICS INC$219.7M
- DAMORA THERAPEUTICS INC$98.0M
- DEFINIUM THERAPEUTICS INC$94.5M
- AVALO THERAPEUTICS$21.1M
Exited Positions
- AVIDITY BIOSCIENCES INC$393.5M
- SPDR SERIES TRUST - S&P BIOTECH$256.1M
- MIND MEDICINE (MINDMED) INC$67.0M
- PTC THERAPEUTICS INC$52.0M
- ORUKA THERAPEUTICS INC$40.4M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | UNITED THERAPEUTICS CORP | UTHR | 91307C102 | $1.56B | 15.34% | 2,630,000 | SH |
| 2 | ASCENDIS PHARMA | ASND | 04351P101 | $1.16B | 11.39% | 5,062,500 | SH |
| 3 | MADRIGAL PHARMACEUTICALS INC | MDGL | 558868105 | $951.8M | 9.36% | 1,818,181 | SH |
| 4 | KRYSTAL BIOTECH INC | KRYS | 501147102 | $746.3M | 7.34% | 2,888,888 | SH |
| 5 | ARGENX SE | ARGX | 04016X101 | $730.2M | 7.18% | 1,000,000 | SH |
| 6 | ARROWHEAD PHARMACEUTICALS INC | ARWR | 04280A100 | $670.9M | 6.60% | 10,699,999 | SH |
| 7 | KYMERA THERAPEUTICS INC | KYMR | 501575104 | $622.6M | 6.12% | 7,474,747 | SH |
| 8 | APELLIS PHARMACEUTICALS INC | APLS | 03753U106 | $491.7M | 4.84% | 12,222,222 | SH |
| 9 | CENTESSA PHARMACEUTICALS PLC | CNTA | 152309100 | $454.0M | 4.47% | 11,430,455 | SH |
| 10 | CELCUITY INC | CELC | 15102K100 | $385.2M | 3.79% | 3,375,000 | SH |
| 11 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $336.0M | 3.31% | 5,777,777 | SH |
| 12 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $316.0M | 3.11% | 6,555,555 | SH |
| 13 | TERNS PHARMACEUTICALS INC | TERN | 880881107 | $300.2M | 2.95% | 5,695,000 | SH |
| 14 | VERA THERAPEUTICS INC | VERA | 92337R101 | $236.9M | 2.33% | 5,888,888 | SH |
| 15 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $228.0M | 2.24% | 2,344,444 | SH |
| 16 | CYTOKINETICS INC | CYTK | 23282W605 | $219.7M | 2.16% | 3,333,333 | SH |
| 17 | OCULAR THERAPEUTIX INC | OCUL | 67576A100 | $104.3M | 1.03% | 12,315,000 | SH |
| 18 | DAMORA THERAPEUTICS INC | DMRA | 36322Q206 | $98.0M | 0.96% | 3,783,000 | SH |
| 19 | UNIQURE NV | QURE | N90064101 | $97.4M | 0.96% | 5,959,595 | SH |
| 20 | TAYSHA GENE THERAPIES INC | TSHA | 877619106 | $97.0M | 0.95% | 21,700,000 | SH |
| 21 | DEFINIUM THERAPEUTICS INC | DFTX | 24477V105 | $94.5M | 0.93% | 5,000,000 | SH |
| 22 | SOLENO THERAPEUTICS INC | SLNO | 834203309 | $77.0M | 0.76% | 2,300,000 | SH |
| 23 | ALKERMES PLC | ALKS | G01767105 | $42.4M | 0.42% | 1,200,000 | SH |
| 24 | SEPTERNA INC | SEPN | 81734D104 | $32.1M | 0.32% | 1,337,500 | SH |
| 25 | VIRIDIAN THERAPEUTICS INC | VRDN | 92790C104 | $29.3M | 0.29% | 1,500,000 | SH |
| 26 | GH RESEARCH PLC | GHRS | G3855L106 | $25.3M | 0.25% | 1,800,000 | SH |
| 27 | AVALO THERAPEUTICS | AVTX | 05338F306 | $21.1M | 0.21% | 1,410,000 | SH |
| 28 | LEXEO THERAPEUTICS INC | LXEO | 52886X107 | $10.8M | 0.11% | 1,875,000 | SH |
| 29 | WHITEHAWK THERAPEUTICS INC | WHWK | 00032Q104 | $9.8M | 0.10% | 2,849,402 | SH |
| 30 | UNITED THERAPEUTICS CORP Call | UTHR | 91307C102 | $5.7M | 0.06% | 200,000 | SH |
| 31 | MANNKIND CORP | MNKD | 56400P706 | $5.4M | 0.05% | 2,200,000 | SH |
| 32 | UNITED THERAPEUTICS CORP Call | UTHR | 91307C102 | $4.6M | 0.05% | 180,000 | SH |
| 33 | CELCUITY INC Call | CELC | 15102K100 | $3.0M | 0.03% | 200,000 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-15 | $10.16B | 33 | 0001104659-26-061754 |
| 2025-12-31 | 2026-03-16 | $10.17B | 34 | 0001104659-26-027799 |
| 2025-12-31 | 2026-02-17 | $10.17B | 34 | 0001104659-26-015748 |