Cytokinetics Inc.(CYTK)
Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership.
Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.
Snapshot
$81.20
After hours
$81.20
+0.00%
- 52-Week Range
- $32.22 – $82.83
- YTD
- +31.54%
- IV Rank (30D)
- 16.79
- Straddle Price
- $6.55
- P/C Vol Ratio
- 0.04
- Market Cap
- $10.9B
Fair Value
-26.7% vs price
A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.
- DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
- Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
- DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 0.5% and dividend payments are stable.
- P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
- Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
- Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
- Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
- Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
| 10-yr Treasury (rf) | 4.46% |
| Beta vs SPY | 1.00 |
| Cost of Equity (CAPM) | 9.96% (VRP-adj) |
| WACC | 9.32% |
| Volatility Risk Premium | +41.4pp (IV − HV30), ERP adj +50bps |
| Effective Tax Rate | 21.0% |
| Rev. Growth (YoY, DCF input) | -10.0% |
| DCF Horizon | 10 years explicit + fade |
| Free Cash Flow (TTM) | $-0.5B |
| Return on Equity (TTM) | 100.4% |
| Book / Price | -8.6% |
| Gross Margin (TTM) | 97.6% |
| FCF Margin (TTM) | -518.8% |
| Quality Score | 2/6 — normal (10y DCF) |
| SMA 50 | $71.52 (Market Anchor value) |
| SMA 20 / Bollinger Mid | $73.58 |
| Bollinger Width / SMA20 | 29.6% (drives anchor stability) |
| Net Debt | $1.0B |
| Market Cap | $10B |
Peers used for multiples: AMGN, GILD, REGN, RVMD, TGTX, TVTX, TWST, VRTX
Blended Fair Value
$59.54
Current Price
$81.20
Deviation
-26.7%
Forward-Return Rank
SHORT
gates ✓
?
| Horizon | Expected α | z Pred | Blended z | Rank % | Active? |
|---|---|---|---|---|---|
| 21d | -3.7% | -0.08 | -0.74 | 42.7% | — |
| 42d | -5.7% | -0.10 | -0.74 | 42.7% | — |
| 63d | -6.7% | -0.20 | -0.74 | 42.7% | — |
Expected α = forward-return point estimate vs SPY (e.g., +7.5% means the predictor expects this stock to outperform SPY by 7.5% over that horizon).
For SHORT direction the model uses a different ranking metric (conviction-weighted deviation, not the LGBM prediction); Expected α is shown for reference.
⚠ flags rows where Expected α disagrees with the FV direction — two independent signals are in conflict; conviction is low even if rank looks extreme.
Forward-Return Rank. A proprietary ensemble of a machine-learning forward-return model and a conviction-weighted fundamental score, ranked cross-sectionally each day across the S&P 500 (and broader universes on the screener). Each stock is scored at three horizons (21/42/63 trading days). "Active" = top/bottom 5% AND all risk filters pass. Backtested mean alpha vs SPY on active picks: 21d LONG +13.4%, 63d +34.9% (S&P 500, walk-forward). Past performance is not indicative of future results.
Value vs momentum conflict ⚠. The "FV direction" (long/short) comes from the fundamentals-based engine — price vs intrinsic value. The "Expected α" comes from a separate machine-learning predictor trained on ~12 features (sector, options-implied move, beta, institutional flow, etc.). Sometimes the two disagree: a stock is overvalued by fundamentals but the predictor expects it to keep outperforming (sector or momentum tailwinds). When all 3 horizons disagree, treat the direction signal as low-conviction — neither model is strongly recommending a position.
| Method | Implied Price | Weight | Detail |
|---|---|---|---|
| DCF | n/a | 0% | |
| DDM (Gordon) | n/a | 0% | |
| Peer P/E | n/a | 0% | median 18.0× · 5 peers |
| Peer EV/EBITDA | n/a | 0% | median 19.0× · 6 peers |
| Peer P/B | n/a | 0% | median 13.0× · 8 peers |
| Peer P/S | $8.38 | 19% | median 9.6× · 7 peers |
| Market Anchor (SMA50) | $71.52 | 81% | stability 64% (BB-width) |
| Options Expected (B-L 30d) | n/a | 0% |
As of 2026-06-24 · updated 2026-06-24 20:59:31.125000
Info
- Industry (SIC)
- PHARMACEUTICAL PREPARATIONS (2834)
- Exchange
- XNAS
- Market Cap
- $10.9B
Cytokinetics Inc is a late-stage biopharmaceutical company focused on discovering, developing, and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised and/or declining. The company develops treatments for diseases such as amyotrophic lateral sclerosis, heart failure, spinal muscular atrophy, and chronic obstructive pulmonary disease. The company's product, named as MYQORZO, is an allosteric and reversible inhibitor of cardiac myosin motor activity. The company is develo…
Chart
Seasonality
| Month | Avg Return | Years of Data |
|---|---|---|
| Jan | -1.36% | 22 |
| Feb | -3.21% | 22 |
| Mar | -0.16% | 22 |
| Apr | +1.69% | 23 |
| May | +2.73% | 23 |
| Jun | +0.26% | 23 |
| Jul | +5.29% | 22 |
| Aug | +4.11% | 22 |
| Sep | +2.25% | 22 |
| Oct | -7.21% | 22 |
| Nov | +1.72% | 22 |
| Dec | +9.05% | 22 |
Technical Indicators
Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.
Trend Indicators
- SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
- EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
- MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
- ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
- +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
- RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
- Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
- Williams %R — inverted scale: <−80 oversold, >−20 overbought.
Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.
Volume & Volatility
- Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
- OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
- Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
- ATR / True Range — average daily $ move; sizing and stop-loss reference.
- HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.
Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →
Trend Indicators
SMA 20: $73.82
SMA 50: $71.81
SMA 200: $64.16
Current: $81.20
EMA 12: $76.19
EMA 26: $74.31
MACD: 1.8797 | Signal: 1.0054
BULLISH
ADX (14): 24.66
WEAK TREND
+DI: 31.07
−DI: 12.37
Momentum Oscillators
RSI (14): 67.79
NEUTRAL
Stoch %K: 90.95
Stoch %D: 90.51
Williams %R: -10.06
Volume & Volatility
BB Upper: $82.43
BB Lower: $65.22
NEUTRAL
OBV: 45,618,907
Vol SMA 20: 2,069,538
Vol ROC: -2.69%
ATR: $3.17
True Range: $3.71
HV 20: 41.4%
HV 30: 38.6%
HV 60: 50.3%
Data Summary
Data Points: 500
Last Updated: 2026-06-24T21:15:26.243000
Date Range: 2024-06-26T00:00:00 – 2026-06-24T00:00:00
AI Analysis
Choose Frenzy-Fast™ for quick analysis or Frenzy-Pro™ for comprehensive analysis.
Analysis includes technical indicators, news sentiment, risk assessment, and specific price levels to watch.
News
Earnings History
7 of 7 under expected move
| Earnings Date | Timing | Expected Move | Actual Move | Ratio | Outcome |
|---|---|---|---|---|---|
| 2024-08-08 | After-Close | 17.04% | 2.59% | 0.15x | Within |
| 2025-02-27 | After-Close | 16.94% | 3.46% | 0.20x | Within |
| 2025-05-06 | After-Close | 11.73% | 2.84% | 0.24x | Within |
| 2025-08-07 | After-Close | 7.09% | 3.23% | 0.46x | Within |
| 2025-11-05 | After-Close | 10.82% | 3.95% | 0.37x | Within |
| 2026-02-24 | After-Close | 11.49% | 11.43% | 0.99x | Within |
| 2026-05-05 | After-Close | 11.66% | 0.60% | 0.05x | Within |
Options Activity
- IV Rank (30D)
- 16.79
- IV Rank (7D)
- 16.79
- Avg IV
- 91.1%
- Straddle (30D)
- $6.55
- Straddle (7D)
- $6.55
- P/C Volume
- 0.04
Spread Scanner GPU
Each spread is ranked by a composite score built in three stages. Full documentation →
Stage 1 — Base Score (GPU scanner)
score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.
Stage 2 — Skew Adjustment (±25% cap)
RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.
Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
- RSI <40 bullish / >60 bearish
- MACD crossover + histogram trend
- Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
- Stochastic %K <20 / >80
- Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
- Blended ATR + straddle expected-move penalty
- Bollinger Band signal (+ counter-trend penalty)
- BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
- IV rank ≥ 75 → strong boost for credit spreads
- IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
- Min open interest across all legs
- OI < 100 → −0.10 · OI < 500 → −0.05
score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →
Enter a ticker to scan for optimal spread opportunities.
Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Wing vs ATM
IV(put wing) − IV(ATM), in vol pointsHow much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.
- Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
- Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
- Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
- Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each sideWhich side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.
- Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
- Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
- Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
- Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together
Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:
- High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
- Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
- Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d
—
—
pts
EXTREME
ATM — / Wing —
30 DTE / 10d
—
—
pts
EXTREME
ATM — / Wing —
Extreme reading.
Historically these have been contrarian — on the small set of observed earnings-day cases, large negative wing-vs-ATM gaps (calls pricing much richer than puts at the same delta) preceded sharp drops in the underlying within 1-12 days. Not financial advice and the dataset is small.
Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.
Volatility Surface
Enter a ticker to render the implied volatility surface.
Volatility Smile
Enter a ticker to render the implied volatility smile.
IV Rank (7 DTE)
IV Rank (30 DTE)
Straddle Price (30 DTE)
Beta Analysis
- Beta (1Y vs SPY)
- 0.76
- Correlation (SPY)
- 15.5%
- R²
- 0.02
- Ann. Volatility
- 61.1%
- SPY Volatility
- 12.5%
Low volatility - stock moves less than market
Beta & Alpha Over Time
Institutional Ownership (13F)
Latest filings — 2026-03-31
? 13F Guide
Diluted shares outstanding: 120,703,750 (as of 2026-03-31)
Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.
- Shares — long equity positions in this name, aggregated across share classes.
- Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
- % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
- Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.
Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.
37 filers$1.04B notional
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | ARMISTICE CAPITAL, LLC | $224.09M | 21.47% | 2026-03-31 |
| 2 | Caption Management, LLC | $162.14M | 15.53% | 2026-03-31 |
| 3 | Integral Health Asset Management, LLC | $131.82M | 12.63% | 2026-03-31 |
| 4 | SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian | $131.13M | 12.56% | 2026-03-31 |
| 5 | Ikarian Capital, LLC | $53.84M | 5.16% | 2026-03-31 |
| 6 | JANE STREET GROUP, LLC Custodian | $36.51M | 3.50% | 2026-03-31 |
| 7 | SPHERA FUNDS MANAGEMENT LTD. | $34.18M | 3.27% | 2026-03-31 |
| 8 | NOMURA HOLDINGS INC | $34.14M | 3.27% | 2026-03-31 |
| 9 | GROUP ONE TRADING LLC Custodian | $31.02M | 2.97% | 2026-03-31 |
| 10 | AMERIPRISE FINANCIAL INC Custodian | $23.95M | 2.29% | 2026-03-31 |
| 11 | BOOTHBAY FUND MANAGEMENT, LLC | $19.98M | 1.91% | 2026-03-31 |
| 12 | CITADEL ADVISORS LLC Custodian | $19.21M | 1.84% | 2026-03-31 |
| 13 | MILLENNIUM MANAGEMENT LLC Custodian | $15.95M | 1.53% | 2026-03-31 |
| 14 | BALYASNY ASSET MANAGEMENT L.P. | $13.92M | 1.33% | 2026-03-31 |
| 15 | BARCLAYS PLC Custodian | $13.80M | 1.32% | 2026-03-31 |
| 16 | WOLVERINE TRADING, LLC Custodian | $9.68M | 0.93% | 2025-09-30 |
| 17 | J. Goldman & Co LP | $8.90M | 0.85% | 2026-03-31 |
| 18 | SIMPLEX TRADING, LLC Custodian | $8.79M | 0.84% | 2026-03-31 |
| 19 | CITIGROUP INC Custodian | $7.38M | 0.71% | 2026-03-31 |
| 20 | Centiva Capital, LP | $7.25M | 0.69% | 2026-03-31 |
| 21 | Jefferies Financial Group Inc. | $6.59M | 0.63% | 2026-03-31 |
| 22 | DIADEMA PARTNERS LP | $6.59M | 0.63% | 2026-03-31 |
| 23 | Troluce Capital Advisors LLC | $6.59M | 0.63% | 2026-03-31 |
| 24 | IMC-Chicago, LLC Custodian | $5.42M | 0.52% | 2026-03-31 |
| 25 | D. E. Shaw & Co., Inc. Custodian | $5.37M | 0.51% | 2026-03-31 |
25 filers$410.74M notional
| # | Filer | Notional Value | % of Total | Period |
|---|---|---|---|---|
| 1 | Ikarian Capital, LLC | $72.57M | 17.67% | 2026-03-31 |
| 2 | Caption Management, LLC | $50.30M | 12.25% | 2026-03-31 |
| 3 | SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian | $43.37M | 10.56% | 2026-03-31 |
| 4 | CITADEL ADVISORS LLC Custodian | $40.71M | 9.91% | 2026-03-31 |
| 5 | GOLDMAN SACHS GROUP INC Custodian | $32.95M | 8.02% | 2026-03-31 |
| 6 | ARMISTICE CAPITAL, LLC | $26.36M | 6.42% | 2026-03-31 |
| 7 | DIADEMA PARTNERS LP | $26.36M | 6.42% | 2026-03-31 |
| 8 | Hudson Bay Capital Management LP | $21.22M | 5.17% | 2026-03-31 |
| 9 | BOOTHBAY FUND MANAGEMENT, LLC | $21.13M | 5.14% | 2026-03-31 |
| 10 | MILLENNIUM MANAGEMENT LLC Custodian | $14.22M | 3.46% | 2026-03-31 |
| 11 | LMR Partners LLP | $13.31M | 3.24% | 2026-03-31 |
| 12 | BARCLAYS PLC Custodian | $11.05M | 2.69% | 2026-03-31 |
| 13 | GROUP ONE TRADING LLC Custodian | $7.48M | 1.82% | 2026-03-31 |
| 14 | Walleye Trading LLC | $5.81M | 1.42% | 2026-03-31 |
| 15 | JANE STREET GROUP, LLC Custodian | $5.10M | 1.24% | 2026-03-31 |
| 16 | NOMURA HOLDINGS INC | $3.95M | 0.96% | 2026-03-31 |
| 17 | Exome Asset Management LLC | $3.95M | 0.96% | 2026-03-31 |
| 18 | Alphadyne Asset Management LP | $2.41M | 0.59% | 2026-03-31 |
| 19 | WOLVERINE TRADING, LLC Custodian | $2.10M | 0.51% | 2025-09-30 |
| 20 | SIMPLEX TRADING, LLC Custodian | $1.67M | 0.41% | 2026-03-31 |
| 21 | TUDOR INVESTMENT CORP ET AL | $1.63M | 0.40% | 2026-03-31 |
| 22 | Walleye Capital LLC | $1.34M | 0.33% | 2026-03-31 |
| 23 | Point72 Asset Management, L.P. | $909.56K | 0.22% | 2026-03-31 |
| 24 | IMC-Chicago, LLC Custodian | $626.14K | 0.15% | 2026-03-31 |
| 25 | Persistent Asset Partners Ltd | $169.51K | 0.04% | 2026-03-31 |
Insider Activity
Latest: 2026-06-15
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
| Filed | Reporter | Role | Action | Shares | Avg Price | Net $ | Link |
|---|---|---|---|---|---|---|---|
| 2026-06-15 | Robert I Blum | President & CEO | Sell (S) | −7,500 | $70.46 | -$528.5K | EDGAR |
| 2026-06-09 | Fady Ibraham Malik | EVP Research & Development | Mixed | — | $37.89 | -$210.6K | EDGAR |
| 2026-06-01 | B LYNNE PARSHALL | Director | Sell (S) | −5,000 | $74.08 | -$370.4K | EDGAR |
| 2026-06-01 | Andrew Callos | EVP, Chief Commercial Officer | Mixed | — | $48.67 | -$762.3K | EDGAR |
| 2026-06-01 | Edward M. MD Kaye | Director | Sell (S) | −2,933 | $76.09 | -$223.2K | EDGAR |
| 2026-05-28 | Robert I Blum | President & CEO | Sell (S) | −7,500 | $77.21 | -$579.1K | EDGAR |
| 2026-05-27 | Nancy Wysenski | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | WENDELL WIERENGA | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | Robert E Landry | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | B LYNNE PARSHALL | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | Edward M. MD Kaye | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | JOHN T HENDERSON | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | Robert Arthur Harrington | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | James M Daly | Director | Award (A) | +2,851 | — | EDGAR | |
| 2026-05-27 | Muna Bhanji | Director | Award (A) | +2,851 | — | EDGAR |
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.
Insider Holdings
43 insiders · @ $81.20
Officers, directors, and 10%+ owners ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
| # | Insider | Role | Shares | Disclosed Exposure | Lifetime OM Net | Filings | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | MICHAEL SCHMERTZLER | Director | 4,340,923 | $352.48M | -$162.9K | 16 | 2010-06-04 |
| 2 | Portfolio Services Ltd. | 10%+ Owner | 2,883,845 | $234.17M | $12.00M | 1 | 2014-02-27 |
| 3 | BIOTECHNOLOGY VALUE FUND L P | 2,811,818 | $228.32M | $22.60M | 1 | 2019-12-12 | |
| 4 | Biotechnology Value Trading Fund OS LP | 2,777,320 | $225.52M | $0 | 1 | 2020-11-20 | |
| 5 | BVF INC/IL | 2,760,185 | $224.13M | -$77.57M | 1 | 2020-12-11 | |
| 6 | BVF Partners OS Ltd. | 2,350,829 | $190.89M | -$118.47M | 1 | 2020-02-18 | |
| 7 | Robert I Blum | President & CEO | 387,413 | $31.46M | -$50.12M | 243 | 2026-06-15 |
| 8 | JAMES A SPUDICH | Director | 180,600 | $14.66M | -$188.0K | 24 | 2011-05-19 |
| 9 | Fady Ibraham Malik | EVP Research & Development | 157,402 | $12.78M | -$31.40M | 150 | 2026-06-09 |
| 10 | David Cragg | Chief HR & Admin Officer | 153,233 | $12.44M | -$3.80M | 36 | 2022-03-08 |
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.
Notice of Proposed Sale (Form 144)
Latest: 2026-06-01
? Form 144 Guide
Last 30d:
1 filing
· $225K notice value
· Last 90d:
8 filings
· $13.3M notice value
· 7 unique filers
· 100% under 10b5-1 plans
What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.
How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.
10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.
"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. Amendments (Form 144/A) and post-cancellation refilings can inflate this if you sum naively; the rollup above excludes filings with zero stated value.
Source & freshness: Parsed directly from EDGAR primary-doc XML. Daily refresh; new filings typically appear here the morning after they hit EDGAR.
Top 90-day filers:
ANDREW CALLOS (2, $5.5M) · ROBERT BLUM (1, $3.0M) · SUNG LEE (1, $1.6M) · FADY MALIK (1, $1.4M) · JOHN HENDERSON (1, $1.3M)
| Filed | Filer | Role | Shares | Notice Value | Planned Sale | Broker | Plan | Link |
|---|---|---|---|---|---|---|---|---|
| 2026-06-01 | EDWARD KAYE | Director | 2,933 | $225.1K | 2026-06-01 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-05-05 | WENDELL WIERENGA | Director | 4,032 | $266.3K | 2026-05-05 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-05-05 | JOHN HENDERSON | Director | 20,000 | $1.32M | 2026-05-05 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-05-05 | SUNG LEE | Officer | 23,906 | $1.58M | 2026-05-05 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-04-15 | ANDREW CALLOS | Officer | 79,639 | $5.28M | 2026-04-15 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-04-07 | FADY MALIK | Officer | 22,000 | $1.43M | 2026-04-07 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-04-01 | ROBERT BLUM | Director, Officer | 45,000 | $2.97M | 2026-04-01 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-03-31 | ANDREW CALLOS | Officer | 3,639 | $229.1K | 2026-03-31 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-03-18 | ANDREW CALLOS | Officer | 1,930 | $119.9K | 2026-03-18 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
| 2026-03-16 | ANDREW CALLOS | Officer | 1,709 | $102.6K | 2026-03-16 | Morgan Stanley Smith Barney LLC … | 10b5-1 | EDGAR |
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed.
Recent SEC Filings
Latest: 2026-05-27
Current reports — material events the company must disclose within 4 business days (earnings releases, M&A, executive changes, etc.).
| Filing Date | Accession | Link |
|---|---|---|
| 2026-05-27 | 0001193125-26-241840 | EDGAR |
| 2026-05-08 | 0001193125-26-214606 | EDGAR |
| 2026-05-05 | 0001193125-26-206360 | EDGAR |
| 2026-05-05 | 0001193125-26-206420 | EDGAR |
| 2026-02-24 | 0001193125-26-067012 | EDGAR |
| 2026-02-17 | 0001193125-26-053049 | EDGAR |
| 2025-12-19 | 0001193125-25-326778 | EDGAR |
| 2025-12-12 | 0001193125-25-316904 | EDGAR |
| 2025-11-14 | 0001193125-25-282889 | EDGAR |
| 2025-11-05 | 0001193125-25-266842 | EDGAR |
Annual report — audited financial statements, MD&A, risk factors. Filed 60–90 days after fiscal year-end.
Quarterly report — unaudited financials and MD&A. Filed 40–45 days after each of the first three fiscal quarters.
| Filing Date | Accession | Link |
|---|---|---|
| 2026-05-05 | 0001193125-26-206364 | EDGAR |
| 2025-11-05 | 0001193125-25-267059 | EDGAR |
| 2025-08-07 | 0000950170-25-105108 | EDGAR |
| 2025-05-06 | 0000950170-25-064529 | EDGAR |
| 2024-11-07 | 0000950170-24-123283 | EDGAR |
| 2024-08-09 | 0000950170-24-094743 | EDGAR |
| 2024-05-10 | 0000950170-24-057805 | EDGAR |
| 2023-11-03 | 0000950170-23-058914 | EDGAR |
| 2023-08-03 | 0000950170-23-037995 | EDGAR |
| 2023-05-05 | 0000950170-23-018305 | EDGAR |
ETF Holders
| # | ETF | Provider | Weight | $ Exposure | ETF AUM | As Of |
|---|
Fundamentals
Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.
Metrics
- Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
- Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
- Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
- Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
- Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
- YoY growth — compare to the same quarter a year earlier to remove seasonality.
- Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
- Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.
TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.
| P/B Ratio | -13.1 |
| P/S Ratio | 102.7 |
| EV/EBITDA | -18.9 |
| TTM Revenue | $0.1B |
| TTM Net Income | $-0.8B |
| TTM EPS | $-6.84 |
| ROE | 100.4% |
| Debt/Equity | -1.41 |