RTW INVESTMENTS, LP — 13F Holdings & Portfolio
CIK 1493215 · latest 13F-HR filed 2026-08-14
RTW INVESTMENTS, LP manages $11.71B in 13F-reported U.S. long-equity assets across 84 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are MDGL (9.14%), ARGX (5.62%), PTCT (5.39%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 9 new positions, exited 13, added to 48, and trimmed 15.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$11.71B
Long-equity book
84
Distinct positions
2026-06-30
Filed 2026-08-14
+9 / −13 / ↑48 / ↓15
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Share-count changes vs the prior 13F.
Top Adds (vs prior quarter)
- ORUKA THERAPEUTICS INC$197.8M +195.9%
- ULTRAGENYX PHARMACEUTICAL IN$183.9M +240.6%
- SPYRE THERAPEUTICS INC$167.1M +79.4%
- TANGO THERAPEUTICS INC$156.3M +56.2%
- ARGENX SE$140.1M +27.0%
Top Trims
- INSMED INC-$275.6M -34.8%
- COGENT BIOSCIENCES INC-$120.7M -57.5%
- HINGE HEALTH INC-$32.9M -44.2%
- TARSUS PHARMACEUTICALS INC-$23.4M -10.0%
- EVOMMUNE INC-$14.6M -42.2%
New Positions
- KAILERA THERAPEUTICS INC$237.4M
- STRUCTURE THERAPEUTICS INC$86.3M
- AXOGEN INC$46.7M
- DANAHER CORP DEL$43.8M
- SOLID BIOSCIENCES INC$38.9M
Exited Positions
- APOGEE THERAPEUTICS INC$234.2M
- APELLIS PHARMACEUTICALS INC$148.2M
- INTUITIVE SURGICAL INC$101.4M
- CENTESSA PHARMACEUTICALS PLC$81.6M
- CRINETICS PHARMACEUTICALS IN$52.7M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | MADRIGAL PHARMACEUTICALS INC | MDGL | 558868105 | $1.07B | 9.14% | 1,993,687 | SH |
| 2 | ARGENX SE | ARGX | 04016X101 | $658.2M | 5.62% | 709,446 | SH |
| 3 | PTC THERAPEUTICS INC | PTCT | 69366J200 | $631.9M | 5.39% | 7,746,415 | SH |
| 4 | PROTAGONIST THERAPEUTICS INC | PTGX | 74366E102 | $620.4M | 5.30% | 5,061,175 | SH |
| 5 | CG ONCOLOGY INC | CGON | 156944100 | $605.0M | 5.16% | 8,514,590 | SH |
| 6 | INSMED INC | INSM | 457669307 | $516.3M | 4.41% | 4,842,880 | SH |
| 7 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $434.5M | 3.71% | 13,900,620 | SH |
| 8 | SPYRE THERAPEUTICS INC | SYRE | 00773J202 | $377.5M | 3.22% | 4,251,996 | SH |
| 9 | CELCUITY INC | CELC | 15102K100 | $345.8M | 2.95% | 3,304,903 | SH |
| 10 | ERASCA INC | ERAS | 29479A108 | $328.8M | 2.81% | 17,946,754 | SH |
| 11 | RADNET INC | RDNT | 750491102 | $298.9M | 2.55% | 4,846,958 | SH |
| 12 | ORUKA THERAPEUTICS INC | ORKA | 687604108 | $298.7M | 2.55% | 3,139,030 | SH |
| 13 | NATERA INC | NTRA | 632307104 | $271.4M | 2.32% | 1,000,000 | SH |
| 14 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 90400D108 | $260.3M | 2.22% | 7,796,895 | SH |
| 15 | IRHYTHM HOLDINGS INC | IRTC | 450056106 | $259.6M | 2.22% | 2,182,631 | SH |
| 16 | CYTOKINETICS INC | CYTK | 23282W605 | $243.8M | 2.08% | 2,862,003 | SH |
| 17 | KAILERA THERAPEUTICS INC | KLRA | 482931102 | $237.4M | 2.03% | 10,776,820 | SH |
| 18 | ESTABLISHMENT LABS HLDGS INC | ESTA | G31249108 | $227.9M | 1.95% | 2,655,695 | SH |
| 19 | GUARDANT HEALTH INC | GH | 40131M109 | $222.2M | 1.90% | 1,481,033 | SH |
| 20 | NEUROCRINE BIOSCIENCES INC | NBIX | 64125C109 | $213.7M | 1.82% | 1,267,925 | SH |
| 21 | TARSUS PHARMACEUTICALS INC | TARS | 87650L103 | $211.3M | 1.80% | 3,357,059 | SH |
| 22 | STOKE THERAPEUTICS INC | STOK | 86150R107 | $184.0M | 1.57% | 5,623,525 | SH |
| 23 | UNIQURE NV | QURE | N90064101 | $181.5M | 1.55% | 3,941,572 | SH |
| 24 | ACADIA PHARMACEUTICALS INC | ACAD | 004225108 | $180.8M | 1.54% | 7,144,524 | SH |
| 25 | REPLIGEN CORP | RGEN | 759916109 | $169.3M | 1.45% | 1,240,637 | SH |
| 26 | UROGEN PHARMA LTD | URGN | M96088105 | $167.2M | 1.43% | 4,543,895 | SH |
| 27 | GH RESEARCH PLC | GHRS | G3855L106 | $159.5M | 1.36% | 5,933,815 | SH |
| 28 | IMMUNOCORE HLDGS PLC | IMCR | 45258D105 | $154.6M | 1.32% | 4,869,798 | SH |
| 29 | COMPASS PATHWAYS PLC | CMPS | 20451W101 | $151.4M | 1.29% | 10,700,974 | SH |
| 30 | IMMATICS N.V | IMTX | N44445109 | $131.1M | 1.12% | 12,946,176 | SH |
| 31 | ZAI LAB LTD | ZLAB | 98887Q104 | $124.9M | 1.07% | 6,574,032 | SH |
| 32 | IMMUNOVANT INC | IMVT | 45258J102 | $122.4M | 1.05% | 3,177,849 | SH |
| 33 | BELITE BIO INC | BLTE | 07782B104 | $110.2M | 0.94% | 715,332 | SH |
| 34 | XENCOR INC | XNCR | 98401F105 | $109.1M | 0.93% | 6,777,461 | SH |
| 35 | TAYSHA GENE THERAPIES INC | TSHA | 877619106 | $92.3M | 0.79% | 13,560,258 | SH |
| 36 | COGENT BIOSCIENCES INC | COGT | 19240Q201 | $89.4M | 0.76% | 2,309,021 | SH |
| 37 | ALKERMES PLC | ALKS | G01767105 | $87.6M | 0.75% | 1,672,356 | SH |
| 38 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $86.3M | 0.74% | 1,607,507 | SH |
| 39 | REPLIMUNE GROUP INC | REPL | 76029N106 | $82.0M | 0.70% | 7,411,581 | SH |
| 40 | CASTLE BIOSCIENCES INC | CSTL | 14843C105 | $66.3M | 0.57% | 2,778,335 | SH |
| 41 | CANDEL THERAPEUTICS INC | CADL | 137404109 | $66.1M | 0.56% | 6,422,018 | SH |
| 42 | ROCKET PHARMACEUTICALS INC | RCKT | 77313F106 | $60.5M | 0.52% | 17,687,772 | SH |
| 43 | KODIAK SCIENCES INC | KOD | 50015M109 | $58.0M | 0.49% | 1,487,934 | SH |
| 44 | AKTIS ONCOLOGY INC | AKTS | 01021M104 | $51.3M | 0.44% | 1,592,043 | SH |
| 45 | AXOGEN INC | AXGN | 05463X106 | $46.7M | 0.40% | 1,011,576 | SH |
| 46 | DANAHER CORP DEL | DHR | 235851102 | $43.8M | 0.37% | 230,000 | SH |
| 47 | CULLINAN THERAPEUTICS INC | CGEM | 230031106 | $43.1M | 0.37% | 2,364,347 | SH |
| 48 | NEUROGENE INC | NGNE | 64135M105 | $42.8M | 0.37% | 1,362,456 | SH |
| 49 | HINGE HEALTH INC | HNGE | 433313103 | $41.5M | 0.35% | 500,000 | SH |
| 50 | ORCHESTRA BIOMED HLDGS INC | OBIO | 68572M106 | $41.2M | 0.35% | 9,556,063 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $11.71B | 84 | 0001493215-26-000164 |
| 2026-03-31 | 2026-05-15 | $10.05B | 88 | 0001493215-26-000130 |
| 2025-12-31 | 2026-02-17 | $9.98B | 91 | 0001493215-26-000060 |
| 2025-09-30 | 2025-11-14 | $8.12B | 74 | 0001493215-25-000054 |
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