RTW INVESTMENTS, LP — 13F Holdings & Portfolio
CIK 1493215 · latest 13F-HR filed 2026-05-15
RTW INVESTMENTS, LP manages $10.05B in 13F-reported U.S. long-equity assets across 88 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are MDGL (10.38%), INSM (7.88%), PTGX (5.31%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 9 new positions, exited 12, added to 28, and trimmed 42.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$10.05B
Long-equity book
88
Distinct positions
2026-03-31
Filed 2026-05-15
+9 / −12 / ↑28 / ↓42
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- CG ONCOLOGY INC$389.2M +465.9%
- CELCUITY INC$292.1M +532.3%
- TANGO THERAPEUTICS INC$265.0M +2006.0%
- ERASCA INC$260.9M +47819.9%
- PROTAGONIST THERAPEUTICS INC$91.4M +20.7%
Top Trims
- MADRIGAL PHARMACEUTICALS INC-$117.4M -10.1%
- NATERA INC-$93.6M -27.3%
- PTC THERAPEUTICS INC-$60.7M -10.3%
- COGENT BIOSCIENCES INC-$59.6M -22.1%
- BETA BIONICS INC-$56.1M -73.7%
New Positions
- WAYSTAR HLDG CORP$39.3M
- CANDEL THERAPEUTICS INC$31.5M
- AKTIS ONCOLOGY INC$28.5M
- DIANTHUS THERAPEUTICS INC$20.8M
- CENTURY THERAPEUTICS INC$19.7M
Exited Positions
- PENUMBRA INC$269.4M
- AXSOME THERAPEUTICS INC$162.2M
- INSULET CORP$92.3M
- MASIMO CORP$88.9M
- RAPT THERAPEUTICS INC$55.5M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | MADRIGAL PHARMACEUTICALS INC | MDGL | 558868105 | $1.04B | 10.38% | 1,993,687 | SH |
| 2 | INSMED INC | INSM | 457669307 | $791.9M | 7.88% | 4,842,880 | SH |
| 3 | PROTAGONIST THERAPEUTICS INC | PTGX | 74366E102 | $533.2M | 5.31% | 5,059,053 | SH |
| 4 | PTC THERAPEUTICS INC | PTCT | 69366J200 | $527.8M | 5.25% | 7,746,415 | SH |
| 5 | ARGENX SE | ARGX | 04016X101 | $518.1M | 5.16% | 709,446 | SH |
| 6 | CG ONCOLOGY INC | CGON | 156944100 | $472.7M | 4.70% | 6,984,808 | SH |
| 7 | CELCUITY INC | CELC | 15102K100 | $346.9M | 3.45% | 3,039,621 | SH |
| 8 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $278.2M | 2.77% | 13,300,620 | SH |
| 9 | ERASCA INC | ERAS | 29479A108 | $261.4M | 2.60% | 16,157,175 | SH |
| 10 | NATERA INC | NTRA | 632307104 | $250.0M | 2.49% | 1,250,000 | SH |
| 11 | RADNET INC | RDNT | 750491102 | $239.5M | 2.38% | 4,285,000 | SH |
| 12 | TARSUS PHARMACEUTICALS INC | TARS | 87650L103 | $234.7M | 2.34% | 3,346,025 | SH |
| 13 | APOGEE THERAPEUTICS INC | APGE | 03770N101 | $234.2M | 2.33% | 2,782,097 | SH |
| 14 | SPYRE THERAPEUTICS INC | SYRE | 00773J202 | $210.4M | 2.09% | 4,171,996 | SH |
| 15 | COGENT BIOSCIENCES INC | COGT | 19240Q201 | $210.1M | 2.09% | 5,458,675 | SH |
| 16 | IRHYTHM HOLDINGS INC | IRTC | 450056106 | $196.9M | 1.96% | 1,668,500 | SH |
| 17 | STOKE THERAPEUTICS INC | STOK | 86150R107 | $183.1M | 1.82% | 5,623,525 | SH |
| 18 | CYTOKINETICS INC | CYTK | 23282W605 | $179.4M | 1.78% | 2,721,158 | SH |
| 19 | ACADIA PHARMACEUTICALS INC | ACAD | 004225108 | $159.0M | 1.58% | 7,144,524 | SH |
| 20 | ESTABLISHMENT LABS HLDGS INC | ESTA | G31249108 | $150.8M | 1.50% | 2,655,695 | SH |
| 21 | APELLIS PHARMACEUTICALS INC | APLS | 03753U106 | $148.2M | 1.48% | 3,685,045 | SH |
| 22 | IMMUNOCORE HLDGS PLC | IMCR | 45258D105 | $146.8M | 1.46% | 4,869,798 | SH |
| 23 | REPLIGEN CORP | RGEN | 759916109 | $142.1M | 1.41% | 1,206,000 | SH |
| 24 | NEUROCRINE BIOSCIENCES INC | NBIX | 64125C109 | $139.9M | 1.39% | 1,062,072 | SH |
| 25 | GUARDANT HEALTH INC | GH | 40131M109 | $136.8M | 1.36% | 1,481,033 | SH |
| 26 | IMMATICS N.V | IMTX | N44445109 | $126.6M | 1.26% | 12,869,340 | SH |
| 27 | ZAI LAB LTD | ZLAB | 98887Q104 | $123.7M | 1.23% | 6,574,032 | SH |
| 28 | BELITE BIO INC | BLTE | 07782B104 | $114.1M | 1.13% | 715,332 | SH |
| 29 | INTUITIVE SURGICAL INC | ISRG | 46120E602 | $101.4M | 1.01% | 220,000 | SH |
| 30 | ORUKA THERAPEUTICS INC | ORKA | 687604108 | $101.0M | 1.00% | 2,058,148 | SH |
| 31 | GH RESEARCH PLC | GHRS | G3855L106 | $83.4M | 0.83% | 5,933,815 | SH |
| 32 | XENCOR INC | XNCR | 98401F105 | $81.7M | 0.81% | 6,777,461 | SH |
| 33 | UROGEN PHARMA LTD | URGN | M96088105 | $81.7M | 0.81% | 4,543,895 | SH |
| 34 | CENTESSA PHARMACEUTICALS PLC | CNTA | 152309100 | $81.6M | 0.81% | 2,054,175 | SH |
| 35 | IMMUNOVANT INC | IMVT | 45258J102 | $78.9M | 0.79% | 3,177,849 | SH |
| 36 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 90400D108 | $76.4M | 0.76% | 3,648,795 | SH |
| 37 | HINGE HEALTH INC | HNGE | 433313103 | $74.4M | 0.74% | 1,930,000 | SH |
| 38 | CASTLE BIOSCIENCES INC | CSTL | 14843C105 | $67.7M | 0.67% | 2,758,335 | SH |
| 39 | ROCKET PHARMACEUTICALS INC | RCKT | 77313F106 | $63.3M | 0.63% | 17,687,772 | SH |
| 40 | TAYSHA GENE THERAPIES INC | TSHA | 877619106 | $61.2M | 0.61% | 13,680,248 | SH |
| 41 | ALKERMES PLC | ALKS | G01767105 | $59.1M | 0.59% | 1,672,356 | SH |
| 42 | COMPASS PATHWAYS PLC | CMPS | 20451W101 | $58.8M | 0.59% | 10,632,390 | SH |
| 43 | KODIAK SCIENCES INC | KOD | 50015M109 | $56.7M | 0.56% | 1,487,934 | SH |
| 44 | REPLIMUNE GROUP INC | REPL | 76029N106 | $56.3M | 0.56% | 7,356,916 | SH |
| 45 | CRINETICS PHARMACEUTICALS IN | CRNX | 22663K107 | $52.7M | 0.52% | 1,451,326 | SH |
| 46 | UNIQURE NV | QURE | N90064101 | $42.3M | 0.42% | 2,586,356 | SH |
| 47 | WAYSTAR HLDG CORP | WAY | 946784105 | $39.3M | 0.39% | 1,630,000 | SH |
| 48 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 04280A100 | $36.7M | 0.37% | 585,682 | SH |
| 49 | ORCHESTRA BIOMED HLDGS INC | OBIO | 68572M106 | $35.3M | 0.35% | 8,306,063 | SH |
| 50 | VERASTEM INC | VSTM | 92337C203 | $34.9M | 0.35% | 6,576,306 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-15 | $10.05B | 88 | 0001493215-26-000130 |
| 2025-12-31 | 2026-02-17 | $9.98B | 91 | 0001493215-26-000060 |
| 2025-09-30 | 2025-11-14 | $8.12B | 74 | 0001493215-25-000054 |