Frazier Life Sciences Management, L.P. — 13F Holdings & Portfolio
CIK 1892134 · latest 13F-HR filed 2026-08-14
Frazier Life Sciences Management, L.P. manages $4.59B in 13F-reported U.S. long-equity assets across 41 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are MIRM (19.58%), NAMS (13.35%), ERAS (9.96%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 6 new positions, exited 3, added to 27, and trimmed 5.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$4.59B
Long-equity book
41
Distinct positions
2026-06-30
Filed 2026-08-14
+6 / −3 / ↑27 / ↓5
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Share-count changes vs the prior 13F.
Top Adds (vs prior quarter)
- MIRUM PHARMACEUTICALS INC$189.6M +26.7%
- MBX BIOSCIENCES INC$168.6M +84.9%
- NEWAMSTERDAM PHARMA COMPANY$70.7M +13.0%
- TREVI THERAPEUTICS INC$66.8M +56.3%
- ERASCA INC$58.3M +14.6%
Top Trims
- BRIDGEBIO PHARMA INC-$140.8M -55.0%
- TARSUS PHARMACEUTICALS INC-$5.3M -10.3%
- LEXEO THERAPEUTICS INC-$2.9M -11.6%
- VALNEVA SE-$2.3M -16.3%
- IBIO INC-$293.0K -7.9%
New Positions
- PARABILIS MEDICINES INC$52.6M
- ACHIEVE LIFE SCIENCE INC$49.7M
- DESIGN THERAPEUTICS INC$26.2M
- SHATTUCK LABS INC$26.0M
- KAILERA THERAPEUTICS INC$24.2M
Exited Positions
- KALVISTA PHARMACEUTICALS INC$99.9M
- REVOLUTION MEDICINES INC$65.7M
- AGIOS PHARMACEUTICALS INC$42.5M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | MIRUM PHARMACEUTICALS INC | MIRM | 604749101 | $899.1M | 19.58% | 7,679,684 | SH |
| 2 | NEWAMSTERDAM PHARMA COMPANY | NAMS | N62509109 | $613.0M | 13.35% | 18,088,902 | SH |
| 3 | ERASCA INC | ERAS | 29479A108 | $457.5M | 9.96% | 24,975,188 | SH |
| 4 | MBX BIOSCIENCES INC | MBX | 55287L101 | $367.2M | 8.00% | 6,652,013 | SH |
| 5 | ARCUTIS BIOTHERAPEUTICS INC | ARQT | 03969K108 | $258.9M | 5.64% | 9,874,511 | SH |
| 6 | TREVI THERAPEUTICS INC | TRVI | 89532M101 | $185.4M | 4.04% | 9,939,447 | SH |
| 7 | KRYSTAL BIOTECH INC | KRYS | 501147102 | $178.9M | 3.90% | 481,307 | SH |
| 8 | MAZE THERAPEUTICS INC | MAZE | 578784100 | $150.2M | 3.27% | 5,032,915 | SH |
| 9 | PHATHOM PHARMACEUTICALS INC | PHAT | 71722W107 | $135.3M | 2.95% | 12,466,489 | SH |
| 10 | PALVELLA THERAPEUTICS INC NE | PVLA | 697947109 | $134.8M | 2.94% | 882,400 | SH |
| 11 | BRIDGEBIO PHARMA INC | BBIO | 10806X102 | $115.3M | 2.51% | 1,548,139 | SH |
| 12 | DISC MEDICINE INC | IRON | 254604101 | $99.1M | 2.16% | 1,354,852 | SH |
| 13 | CYTOKINETICS INC | CYTK | 23282W605 | $98.8M | 2.15% | 1,159,879 | SH |
| 14 | DYNE THERAPEUTICS INC | DYN | 26818M108 | $70.0M | 1.53% | 3,153,082 | SH |
| 15 | ASCENDIS PHARMA A/S | ASND | 04351P101 | $60.1M | 1.31% | 225,155 | SH |
| 16 | SAVARA INC | SVRA | 805111101 | $59.9M | 1.30% | 9,720,852 | SH |
| 17 | PARABILIS MEDICINES INC | PBLS | 698955101 | $52.6M | 1.14% | 1,920,805 | SH |
| 18 | AURA BIOSCIENCES INC | AURA | 05153U107 | $50.4M | 1.10% | 7,100,000 | SH |
| 19 | ACHIEVE LIFE SCIENCE INC | ACHV | 004468500 | $49.7M | 1.08% | 7,614,836 | SH |
| 20 | VOR BIOPHARMA INC | VOR | 929033207 | $46.8M | 1.02% | 2,543,939 | SH |
| 21 | ALLOGENE THERAPEUTICS INC | ALLO | 019770106 | $46.7M | 1.02% | 22,446,668 | SH |
| 22 | TARSUS PHARMACEUTICALS INC | TARS | 87650L103 | $45.9M | 1.00% | 728,644 | SH |
| 23 | BIOCRYST PHARMACEUTICALS INC | BCRX | 09058V103 | $40.1M | 0.87% | 4,009,240 | SH |
| 24 | ALKERMES PLC | ALKS | G01767105 | $36.7M | 0.80% | 700,647 | SH |
| 25 | ACADIA PHARMACEUTICALS INC | ACAD | 004225108 | $36.4M | 0.79% | 1,438,198 | SH |
| 26 | ZAI LAB LTD | ZLAB | 98887Q104 | $36.1M | 0.79% | 1,902,320 | SH |
| 27 | MANNKIND CORP | MNKD | 56400P706 | $28.1M | 0.61% | 6,600,000 | SH |
| 28 | DESIGN THERAPEUTICS INC | DSGN | 25056L103 | $26.2M | 0.57% | 1,809,854 | SH |
| 29 | ACLARIS THERAPEUTICS INC | ACRS | 00461U105 | $26.1M | 0.57% | 4,925,374 | SH |
| 30 | SHATTUCK LABS INC | STTK | 82024L103 | $26.0M | 0.57% | 3,750,000 | SH |
| 31 | KAILERA THERAPEUTICS INC | KLRA | 482931102 | $24.2M | 0.53% | 1,100,000 | SH |
| 32 | MONTE ROSA THERAPEUTICS INC | GLUE | 61225M102 | $24.2M | 0.53% | 1,000,000 | SH |
| 33 | LEXEO THERAPEUTICS INC | LXEO | 52886X107 | $22.5M | 0.49% | 4,824,725 | SH |
| 34 | RELAY THERAPEUTICS INC | RLAY | 75943R102 | $19.0M | 0.41% | 1,015,693 | SH |
| 35 | EVOLUS INC | EOLS | 30052C107 | $18.3M | 0.40% | 2,630,665 | SH |
| 36 | IMMUNOCORE HLDGS PLC | IMCR | 45258D105 | $15.4M | 0.34% | 484,782 | SH |
| 37 | VALNEVA SE | VALN | 92025Y103 | $12.0M | 0.26% | 2,291,666 | SH |
| 38 | NEWAMSTERDAM PHARMA COMPANY | NAMSW | N62509117 | $10.7M | 0.23% | 500,333 | SH |
| 39 | AUTOLUS THERAPEUTICS LTD | AUTL | 05280R100 | $7.1M | 0.15% | 4,447,910 | SH |
| 40 | XILIO THERAPEUTICS INC | XLO | 98422T209 | $4.0M | 0.09% | 422,505 | SH |
| 41 | IBIO INC | IBIO | 451033708 | $3.4M | 0.07% | 1,953,467 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $4.59B | 41 | 0001892134-26-000003 |
| 2026-03-31 | 2026-05-15 | $3.89B | 38 | 0001892134-26-000002 |
| 2025-12-31 | 2026-02-13 | $3.72B | 40 | 0001892134-26-000001 |
| 2025-09-30 | 2025-11-14 | $3.34B | 47 | 0001892134-25-000012 |
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