Propel Bio Management, LLC — 13F Holdings & Portfolio
CIK 1969764 · latest 13F-HR filed 2026-08-13
Propel Bio Management, LLC manages $191.1M in 13F-reported U.S. long-equity assets across 29 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are PAGP (16.16%), ACHV (13.79%), CORT (6.21%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 4 new positions and exited 13; 15 existing positions rose in reported value and 5 fell.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
Long-equity book
Distinct positions
Filed 2026-08-13
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.
Top Adds (vs prior quarter)
- ACHIEVE LIFE SCIENCES INC$15.0M +131.7%
- CORCEPT THERAPEUTICS INC$5.8M +97.1%
- ARTIVA BIOTHERAPEUTICS IN$5.8M +611.2%
- MILESTONE PHARMACEUTICALS$4.9M +95.9%
- COMPASS PATHWAYS PLC$4.0M +96.9%
Top Trims
- UPSTREAM BIO INC-$675.4K -21.8%
- CELLDEX THERAPEUTICS INC-$276.6K -6.7%
- 4D MOLECULAR THERAPEUTICS IN-$220.9K -6.2%
- CORVUS PHARMACEUTICALS INC-$199.6K -16.0%
- LEONABIO INC-$123.9K -8.3%
New Positions
- IMMUNIC INC$5.0M
- SCYNEXIS INC$2.2M
- SILENCE THERAPEUTICS PLC$2.1M
- SAGIMET BIOSCIENCES INC-A$973.0K
Exited Positions
- VOR BIOPHARMA INC$5.6M
- VIRIDIAN THERAPEUTICS INC$4.1M
- OCULIS HOLDING AG$3.3M
- TREVI THERAPEUTICS INC$2.6M
- IMMUNIC INC$2.6M
Propel Bio Management, LLC Holdings (2026-06-30)
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | PLAINS GP HOLDINGS LP-CL | PAGP | 72651A207 | $30.9M | 16.16% | 1,272,360 | SH |
| 2 | ACHIEVE LIFE SCIENCES INC | ACHV | 004468500 | $26.3M | 13.79% | 4,034,018 | SH |
| 3 | CORCEPT THERAPEUTICS INC | CORT | 218352102 | $11.9M | 6.21% | 136,499 | SH |
| 4 | PHATHOM PHARMACEUTICALS I | PHAT | 71722W107 | $11.4M | 5.96% | 1,050,358 | SH |
| 5 | DELCATH SYSTEMS INC | DCTH | 24661P807 | $11.0M | 5.74% | 871,460 | SH |
| 6 | MILESTONE PHARMACEUTICALS | MIST | 59935V107 | $10.0M | 5.21% | 7,429,590 | SH |
| 7 | COMPASS PATHWAYS PLC | CMPS | 20451W101 | $8.1M | 4.24% | 573,086 | SH |
| 8 | KYVERNA THERAPEUTICS INC | KYTX | 501976104 | $7.9M | 4.12% | 883,198 | SH |
| 9 | ARTIVA BIOTHERAPEUTICS IN | ARTV | 04317A107 | $6.8M | 3.54% | 696,436 | SH |
| 10 | ABEONA THERAPEUTICS INC | ABEO | 00289Y206 | $6.1M | 3.18% | 983,070 | SH |
| 11 | AQUESTIVE THERAPEUTICS IN | AQST | 03843E104 | $6.0M | 3.14% | 1,442,397 | SH |
| 12 | PALISADE BIO INC | PALI | 696389402 | $5.4M | 2.82% | 2,582,388 | SH |
| 13 | IMMUNIC INC | IMUX | 4525EP200 | $5.0M | 2.61% | 325,022 | SH |
| 14 | INVENTIVA SA - ADR | IVA | 46124U107 | $4.8M | 2.53% | 1,281,212 | SH |
| 15 | SAB BIOTHERAPEUTICS INC | SABS | 78397T202 | $4.2M | 2.20% | 1,076,578 | SH |
| 16 | ORCHESTRA BIOMED HOLDINGS | OBIO | 68572M106 | $3.9M | 2.02% | 896,701 | SH |
| 17 | CELLDEX THERAPEUTICS INC | CLDX | 15117B202 | $3.9M | 2.02% | 103,695 | SH |
| 18 | ZEVRA THERAPEUTICS INC | ZVRA | 488445206 | $3.6M | 1.90% | 253,544 | SH |
| 19 | OCULAR THERAPEUTIX INC | OCUL | 67576A100 | $3.5M | 1.84% | 357,966 | SH |
| 20 | 4D MOLECULAR THERAPEUTICS IN | FDMT | 35104E100 | $3.4M | 1.76% | 252,654 | SH |
| 21 | OVID THERAPEUTICS INC | OVID | 690469101 | $3.0M | 1.57% | 1,115,538 | SH |
| 22 | EYEPOINT INC | EYPT | 30233G209 | $2.7M | 1.43% | 191,745 | SH |
| 23 | UPSTREAM BIO INC | UPB | 91678A107 | $2.4M | 1.27% | 350,389 | SH |
| 24 | SCYNEXIS INC | SCYX | 811292309 | $2.2M | 1.16% | 543,478 | SH |
| 25 | SILENCE THERAPEUTICS PLC | SLN | 82686Q101 | $2.1M | 1.10% | 191,733 | SH |
| 26 | LEONABIO INC | LONA | 04746L203 | $1.4M | 0.72% | 149,279 | SH |
| 27 | MAZE THERAPEUTICS INC | MAZE | 578784100 | $1.3M | 0.68% | 43,798 | SH |
| 28 | CORVUS PHARMACEUTICALS INC | CRVS | 221015100 | $1.1M | 0.55% | 70,380 | SH |
| 29 | SAGIMET BIOSCIENCES INC-A | SGMT | 786700104 | $973.0K | 0.51% | 125,878 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-13 | $191.1M | 29 | 0001829126-26-008753 |
| 2026-03-31 | 2026-05-14 | $158.7M | 38 | 0000898432-26-000369 |
| 2025-12-31 | 2026-02-11 | $117.1M | 20 | 0000898432-26-000087 |
| 2025-09-30 | 2025-11-12 | $99.9M | 16 | 0000898432-25-000886 |
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