Sofinnova Investments, Inc. — 13F Holdings & Portfolio
CIK 1631134 · latest 13F-HR filed 2026-05-15
Sofinnova Investments, Inc. manages $2.63B in 13F-reported U.S. long-equity assets across 75 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are NTRA (11.78%), IWM (5.66%), XBI (5.10%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 17 new positions, exited 16, added to 21, and trimmed 18.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$2.63B
Long-equity book
75
Distinct positions
2026-03-31
Filed 2026-05-15
+17 / −16 / ↑21 / ↓18
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- Ultragenyx Pharmaceutical Inc$64.0M +3340.0%
- Bristol-Myers Squibb Co$39.0M +47.8%
- Axsome Therapeutics Inc.$33.7M +1505.1%
- Insmed Inc$29.3M +107.4%
- Alcon AG$28.8M +109.9%
Top Trims
- Jazz Pharmaceuticals PLC-$50.1M -30.7%
- Natera Inc-$45.1M -12.7%
- Vera Therapeutics Inc-$29.1M -20.6%
- BridgeBio Pharma Inc-$24.7M -44.9%
- Praxis Precision Medicines Inc-$16.5M -44.6%
New Positions
- AstraZeneca PLC$89.9M
- Biogen Inc$42.1M
- Genmab A/S$20.2M
- Stryker Corporation$14.6M
- Oric Pharmaceuticals Inc$8.6M
Exited Positions
- ASTRAZENECA PLC$150.1M
- VERTEX PHARMACEUTICALS INC$74.6M
- ABBVIE INC$72.6M
- INTUITIVE SURGICAL INC$71.9M
- ELI LILLY & CO$66.3M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | Natera Inc | NTRA | 632307104 | $310.0M | 11.78% | 1,550,280 | SH |
| 2 | iShares TR Put | IWM | 464287655 | $148.8M | 5.66% | 600,000 | SH |
| 3 | SPDR Series Trust Put | XBI | 78464A870 | $134.1M | 5.10% | 1,050,000 | SH |
| 4 | Bristol-Myers Squibb Co | BMY | 110122108 | $120.6M | 4.58% | 1,988,721 | SH |
| 5 | Jazz Pharmaceuticals PLC | JAZZ | G50871105 | $113.1M | 4.30% | 598,327 | SH |
| 6 | Vera Therapeutics Inc | VERA | 92337R101 | $112.4M | 4.27% | 2,793,987 | SH |
| 7 | United Therapeutics Corp | UTHR | 91307C102 | $94.9M | 3.61% | 160,070 | SH |
| 8 | AstraZeneca PLC | AZN | G0593M107 | $89.9M | 3.42% | 456,031 | SH |
| 9 | Invesco QQQ TR Put | QQQ | 46090E103 | $86.6M | 3.29% | 150,000 | SH |
| 10 | Cogent Biosciences Inc | COGT | 19240Q201 | $81.4M | 3.09% | 2,113,551 | SH |
| 11 | iShares TR Put | IBB | 464287556 | $80.2M | 3.05% | 475,000 | SH |
| 12 | Ultragenyx Pharmaceutical Inc | RARE | 90400D108 | $65.9M | 2.50% | 3,145,888 | SH |
| 13 | Rapport Therapeutics Inc | RAPP | 75383L102 | $59.6M | 2.26% | 1,904,408 | SH |
| 14 | Insmed Inc | INSM | 457669307 | $56.6M | 2.15% | 346,075 | SH |
| 15 | Alcon AG | ALC | H01301128 | $55.0M | 2.09% | 729,972 | SH |
| 16 | Supernus Pharmaceuticals | SUPN | 868459108 | $49.3M | 1.87% | 954,309 | SH |
| 17 | United Therapeutics Corp Put | UTHR | 91307C102 | $47.6M | 1.81% | 80,300 | SH |
| 18 | BioMarin Pharmaceutical Inc | BMRN | 09061G101 | $44.2M | 1.68% | 781,982 | SH |
| 19 | Biogen Inc | BIIB | 09062X103 | $42.1M | 1.60% | 229,521 | SH |
| 20 | Celcuity Inc | CELC | 15102K100 | $41.8M | 1.59% | 366,175 | SH |
| 21 | BioAge Labs Inc | BIOA | 09077V100 | $40.1M | 1.52% | 2,293,788 | SH |
| 22 | Rhythm Pharmaceuticals Inc | RYTM | 76243J105 | $39.1M | 1.49% | 450,096 | SH |
| 23 | Arrivent BioPharma Inc | AVBP | 04272N102 | $39.1M | 1.49% | 1,696,752 | SH |
| 24 | IDEAYA Biosciences Inc | IDYA | 45166A102 | $37.7M | 1.43% | 1,131,786 | SH |
| 25 | Immunome Inc | IMNM | 45257U108 | $37.2M | 1.41% | 1,701,904 | SH |
| 26 | Nektar Therapeutics | NKTR | 640268306 | $36.7M | 1.39% | 509,546 | SH |
| 27 | Axsome Therapeutics Inc. | AXSM | 05464T104 | $36.0M | 1.37% | 212,747 | SH |
| 28 | Immatics N.V | IMTX | N44445109 | $35.7M | 1.36% | 3,630,454 | SH |
| 29 | Celcuity Inc Put | CELC | 15102K100 | $34.2M | 1.30% | 300,000 | SH |
| 30 | Axsome Therapeutics Inc. Put | AXSM | 05464T104 | $33.8M | 1.28% | 200,000 | SH |
| 31 | BridgeBio Pharma Inc | BBIO | 10806X102 | $30.4M | 1.15% | 409,183 | SH |
| 32 | Dyne Therapeutics Inc | DYN | 26818M108 | $29.6M | 1.13% | 1,633,897 | SH |
| 33 | Inhibrx Biosciences Inc | INBX | 45720N103 | $27.3M | 1.04% | 406,029 | SH |
| 34 | Dexcom Inc | DXCM | 252131107 | $24.7M | 0.94% | 393,576 | SH |
| 35 | Pharvaris N V | PHVS | N69605108 | $23.1M | 0.88% | 818,328 | SH |
| 36 | Pfizer Inc Call | PFE | 717081103 | $22.5M | 0.85% | 800,000 | SH |
| 37 | Praxis Precision Medicines Inc | PRAX | 74006W207 | $20.5M | 0.78% | 63,680 | SH |
| 38 | Genmab A/S | GMAB | 372303206 | $20.2M | 0.77% | 752,261 | SH |
| 39 | Arcus Biosciences Inc | RCUS | 03969F109 | $19.9M | 0.76% | 923,086 | SH |
| 40 | Liquidia Corporation Put | LQDA | 53635D202 | $18.9M | 0.72% | 500,000 | SH |
| 41 | Xenon Pharmaceuticals Inc | XENE | 98420N105 | $17.7M | 0.67% | 305,216 | SH |
| 42 | Stryker Corporation | SYK | 863667101 | $14.6M | 0.56% | 44,480 | SH |
| 43 | AnaptysBio Inc | ANAB | 032724106 | $13.8M | 0.52% | 248,253 | SH |
| 44 | Roivant Sciences Ltd | ROIV | G76279101 | $13.2M | 0.50% | 477,995 | SH |
| 45 | Edgewise Therapeutics Inc | EWTX | 28036F105 | $12.2M | 0.46% | 386,498 | SH |
| 46 | Compass Therapeutics Inc | CMPX | 20454B104 | $10.9M | 0.41% | 2,056,161 | SH |
| 47 | Exelixis Inc Put | EXEL | 30161Q104 | $10.8M | 0.41% | 251,500 | SH |
| 48 | Oric Pharmaceuticals Inc | ORIC | 68622P109 | $8.6M | 0.33% | 679,578 | SH |
| 49 | Tango Therapeutics Inc | TNGX | 87583X109 | $8.3M | 0.31% | 395,081 | SH |
| 50 | Tyra Biosciences Inc | TYRA | 90240B106 | $7.8M | 0.30% | 204,015 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-15 | $2.63B | 75 | 0001104659-26-062256 |
| 2025-12-31 | 2026-02-13 | $2.32B | 60 | 0001104659-26-015127 |
| 2025-09-30 | 2025-11-14 | $1.83B | 62 | 0001104659-25-111551 |