PFM Health Sciences, LP — 13F Holdings & Portfolio
CIK 1442756 · latest 13F-HR filed 2026-08-14
PFM Health Sciences, LP manages $1.17B in 13F-reported U.S. long-equity assets across 98 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are ASND (5.34%), AXSM (4.61%), LLY (4.04%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 33 new positions, exited 14, added to 40, and trimmed 20.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$1.17B
Long-equity book
98
Distinct positions
2026-06-30
Filed 2026-08-14
+33 / −14 / ↑40 / ↓20
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Share-count changes vs the prior 13F.
Top Adds (vs prior quarter)
- UNITEDHEALTH GROUP INC$21.0M +133.6%
- ICON PUB LTD CO$17.3M +272.6%
- REVOLUTION MEDICINES INC$13.1M +95.9%
- STRYKER CORPORATION$10.6M +147.2%
- WATERS CORP$10.6M +89.5%
Top Trims
- TENET HEALTHCARE CORP-$51.5M -68.5%
- PENUMBRA INC-$26.9M -58.6%
- ELI LILLY & CO-$13.4M -22.2%
- ABBOTT LABORATORIES-$7.0M -48.2%
- NATERA INC-$6.0M -50.1%
New Positions
- ASCENDIS PHARMA A/S$62.2M
- HUMANA INC$37.5M
- METTLER TOLEDO INTERNATIONAL$17.0M
- MERCK & CO INC$16.3M
- CYTOKINETICS INC$16.3M
Exited Positions
- ASCENDIS PHARMA A/S$34.8M
- GLAUKOS CORP$23.2M
- CENTESSA PHARMACEUTICALS PLC$21.0M
- ASCENDIS PHARMA A/S$16.9M
- NEOGENOMICS INC$13.2M
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | ASCENDIS PHARMA A/S | ASND | K08588103 | $62.2M | 5.34% | 233,171 | SH |
| 2 | AXSOME THERAPEUTICS INC. | AXSM | 05464T104 | $53.8M | 4.61% | 219,596 | SH |
| 3 | ELI LILLY & CO | LLY | 532457108 | $47.1M | 4.04% | 39,258 | SH |
| 4 | JAZZ PHARMACEUTICALS PLC | JAZZ | G50871105 | $38.7M | 3.32% | 160,768 | SH |
| 5 | HUMANA INC | HUM | 444859102 | $37.5M | 3.22% | 94,375 | SH |
| 6 | UNITEDHEALTH GROUP INC | UNH | 91324P102 | $36.7M | 3.15% | 88,276 | SH |
| 7 | NEUROCRINE BIOSCIENCES INC | NBIX | 64125C109 | $36.0M | 3.09% | 213,407 | SH |
| 8 | INHIBRX BIOSCIENCES INC | INBX | 45720N103 | $29.2M | 2.51% | 308,385 | SH |
| 9 | UNITED THERAPEUTICS CORP DEL | UTHR | 91307C102 | $27.1M | 2.32% | 49,991 | SH |
| 10 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $26.8M | 2.30% | 143,222 | SH |
| 11 | ICON PUB LTD CO | ICLR | G4705A100 | $23.7M | 2.03% | 136,482 | SH |
| 12 | TENET HEALTHCARE CORP | THC | 88033G407 | $23.7M | 2.03% | 126,572 | SH |
| 13 | EDWARDS LIFESCIENCES CORP | EW | 28176E108 | $22.7M | 1.94% | 250,453 | SH |
| 14 | WATERS CORP | WAT | 941848103 | $22.4M | 1.93% | 59,825 | SH |
| 15 | PENUMBRA INC | PEN | 70975L107 | $19.0M | 1.63% | 60,221 | SH |
| 16 | BRIDGEBIO PHARMA INC | BBIO | 10806X102 | $18.9M | 1.62% | 253,358 | SH |
| 17 | STRYKER CORPORATION | SYK | 863667101 | $17.8M | 1.53% | 56,637 | SH |
| 18 | METTLER TOLEDO INTERNATIONAL | MTD | 592688105 | $17.0M | 1.46% | 13,344 | SH |
| 19 | INDIVIOR PHARMACEUTICALS INC | INDV | 45579U109 | $16.5M | 1.41% | 401,208 | SH |
| 20 | MERCK & CO INC | MRK | 58933Y105 | $16.3M | 1.40% | 127,118 | SH |
| 21 | CYTOKINETICS INC | CYTK | 23282W605 | $16.3M | 1.40% | 191,686 | SH |
| 22 | LANTHEUS HLDGS INC | LNTH | 516544103 | $16.2M | 1.39% | 146,403 | SH |
| 23 | CENTENE CORP DEL | CNC | 15135B101 | $16.0M | 1.37% | 248,867 | SH |
| 24 | COOPER COS INC | COO | 216648501 | $15.8M | 1.36% | 220,890 | SH |
| 25 | MADRIGAL PHARMACEUTICALS INC | MDGL | 558868105 | $15.7M | 1.35% | 29,313 | SH |
| 26 | ACADIA HEALTHCARE COMPANY IN | ACHC | 00404A109 | $15.5M | 1.33% | 524,934 | SH |
| 27 | ORUKA THERAPEUTICS INC | ORKA | 687604108 | $15.1M | 1.30% | 158,825 | SH |
| 28 | OSCAR HEALTH INC | OSCR | 687793109 | $14.8M | 1.27% | 519,016 | SH |
| 29 | THERMO FISHER SCIENTIFIC INC | TMO | 883556102 | $14.3M | 1.23% | 28,496 | SH |
| 30 | CVS HEALTH CORP | CVS | 126650100 | $14.2M | 1.22% | 137,457 | SH |
| 31 | MERIT MED SYS INC | MMSI | 589889104 | $13.7M | 1.17% | 197,038 | SH |
| 32 | PRAXIS PRECISION MEDICINES I | PRAX | 74006W207 | $12.9M | 1.11% | 38,575 | SH |
| 33 | CELLDEX THERAPEUTICS INC NEW | CLDX | 15117B202 | $12.8M | 1.09% | 342,751 | SH |
| 34 | NOVO-NORDISK A S | NVO | 670100205 | $12.7M | 1.09% | 265,016 | SH |
| 35 | INTEGER HLDGS CORP | ITGR | 45826H109 | $11.8M | 1.02% | 126,669 | SH |
| 36 | DIANTHUS THERAPEUTICS INC | DNTH | 252828108 | $11.8M | 1.01% | 121,222 | SH |
| 37 | DEFINIUM THERAPEUTICS INC | DFTX | 24477V105 | $11.7M | 1.01% | 249,020 | SH |
| 38 | GILEAD SCIENCES INC | GILD | 375558103 | $11.5M | 0.98% | 90,858 | SH |
| 39 | RHYTHM PHARMACEUTICALS INC | RYTM | 76243J105 | $11.3M | 0.97% | 101,550 | SH |
| 40 | SCHEIN HENRY INC | HSIC | 806407102 | $11.2M | 0.96% | 134,423 | SH |
| 41 | ARROWHEAD PHARMACEUTICALS IN | ARWR | 04280A100 | $10.7M | 0.92% | 131,667 | SH |
| 42 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $10.2M | 0.87% | 326,047 | SH |
| 43 | TELEFLEX INCORPORATED | TFX | 879369106 | $10.1M | 0.87% | 79,708 | SH |
| 44 | VIKING THERAPEUTICS INC | VKTX | 92686J106 | $10.0M | 0.85% | 255,330 | SH |
| 45 | BRIGHTSPRING HEALTH SVCS INC | BTSG | 10950A106 | $9.9M | 0.85% | 141,914 | SH |
| 46 | VERA THERAPEUTICS INC | VERA | 92337R101 | $9.6M | 0.83% | 224,289 | SH |
| 47 | ROIVANT SCIENCES LTD | ROIV | G76279101 | $9.5M | 0.81% | 268,008 | SH |
| 48 | CG ONCOLOGY INC | CGON | 156944100 | $9.1M | 0.78% | 128,286 | SH |
| 49 | AMNEAL PHARMACEUTICALS INC | AMRX | 03168L105 | $8.3M | 0.71% | 480,715 | SH |
| 50 | EUPRAXIA PHARMACEUTICALS INC | EPRX | 29842P105 | $8.0M | 0.69% | 1,210,661 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $1.17B | 98 | 0001442756-26-000006 |
| 2026-03-31 | 2026-05-15 | $1.10B | 83 | 0001442756-26-000002 |
| 2025-12-31 | 2026-02-17 | $1.00B | 78 | 0001442756-26-000001 |
| 2025-09-30 | 2025-11-14 | $1.30B | 72 | 0001442756-25-000007 |
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