Rock Springs Capital Management LP — 13F Holdings & Portfolio
CIK 1595725 · latest 13F-HR filed 2026-08-14
Rock Springs Capital Management LP manages $2.05B in 13F-reported U.S. long-equity assets across 104 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are RVMD (10.10%), TVTX (6.04%), LLY (5.78%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 17 new positions and exited 13; 54 existing positions rose in reported value and 24 fell.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
Long-equity book
Distinct positions
Filed 2026-08-14
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.
Top Adds (vs prior quarter)
- REVOLUTION MEDICINES INC$89.4M +76.0%
- TRAVERE THERAPEUTICS INC$79.9M +181.9%
- ELI LILLY & CO$27.6M +30.4%
- AGILON HEALTH INC$26.1M +1268.5%
- MIRUM PHARMACEUTICALS INC$18.5M +24.7%
Top Trims
- ARGENX SE-$23.0M -32.0%
- INSMED INC-$12.8M -24.9%
- BOSTON SCIENTIFIC CORP-$9.8M -30.2%
- COMPASS THERAPEUTICS INC-$9.8M -55.9%
- ENLIVEN THERAPEUTICS INC-$8.8M -27.2%
New Positions
- ASCENDIS PHARMA A/S$45.0M
- AVALYN PHARMACEUTICALS INC$21.8M
- HEMAB THERAPEUTICS HLDGS INC$21.1M
- PARABILIS MEDICINES INC$15.8M
- OMEROS CORP$6.8M
Exited Positions
- ASCENDIS PHARMA A/S$44.4M
- ARCELLX INC$19.5M
- CENTESSA PHARMACEUTICALS PLC$14.0M
- SOLENO THERAPEUTICS INC$8.6M
- REGENERON PHARMACEUTICALS$7.8M
Rock Springs Capital Management LP Holdings (2026-06-30)
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $207.0M | 10.10% | 1,105,210 | SH |
| 2 | TRAVERE THERAPEUTICS INC | TVTX | 89422G107 | $123.8M | 6.04% | 2,179,069 | SH |
| 3 | ELI LILLY & CO | LLY | 532457108 | $118.4M | 5.78% | 98,700 | SH |
| 4 | MADRIGAL PHARMACEUTICALS INC | MDGL | 558868105 | $94.0M | 4.59% | 174,999 | SH |
| 5 | MIRUM PHARMACEUTICALS INC | MIRM | 604749101 | $93.4M | 4.56% | 798,145 | SH |
| 6 | RHYTHM PHARMACEUTICALS INC | RYTM | 76243J105 | $76.9M | 3.75% | 692,598 | SH |
| 7 | KYMERA THERAPEUTICS INC | KYMR | 501575104 | $52.0M | 2.54% | 453,156 | SH |
| 8 | ARGENX SE | ARGX | 04016X101 | $48.9M | 2.39% | 52,750 | SH |
| 9 | ASCENDIS PHARMA A/S | ASND | K08588103 | $45.0M | 2.20% | 168,750 | SH |
| 10 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $41.3M | 2.01% | 683,907 | SH |
| 11 | SCHOLAR ROCK HLDG CORP | SRRK | 80706P103 | $39.3M | 1.92% | 715,452 | SH |
| 12 | INSMED INC | INSM | 457669307 | $38.6M | 1.88% | 362,150 | SH |
| 13 | PENUMBRA INC | PEN | 70975L107 | $36.5M | 1.78% | 115,750 | SH |
| 14 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $34.4M | 1.68% | 640,317 | SH |
| 15 | ULTRAGENYX PHARMACEUTICAL IN | RARE | 90400D108 | $32.3M | 1.58% | 967,855 | SH |
| 16 | IRHYTHM HOLDINGS INC | IRTC | 450056106 | $32.1M | 1.57% | 269,650 | SH |
| 17 | INTUITIVE SURGICAL INC | ISRG | 46120E602 | $30.4M | 1.48% | 76,460 | SH |
| 18 | AGILON HEALTH INC | AGL | 00857U206 | $28.1M | 1.37% | 262,600 | SH |
| 19 | UNITEDHEALTH GROUP INC | UNH | 91324P102 | $26.5M | 1.29% | 63,750 | SH |
| 20 | CELLDEX THERAPEUTICS INC NEW | CLDX | 15117B202 | $26.0M | 1.27% | 699,146 | SH |
| 21 | ERASCA INC | ERAS | 29479A108 | $25.7M | 1.25% | 1,402,150 | SH |
| 22 | NEUROCRINE BIOSCIENCES INC | NBIX | 64125C109 | $24.4M | 1.19% | 144,750 | SH |
| 23 | ENLIVEN THERAPEUTICS INC | ELVN | 29337E102 | $23.6M | 1.15% | 464,625 | SH |
| 24 | TENET HEALTHCARE CORP | THC | 88033G407 | $23.4M | 1.14% | 125,000 | SH |
| 25 | DEXCOM INC | DXCM | 252131107 | $23.1M | 1.13% | 343,000 | SH |
| 26 | ACLARIS THERAPEUTICS INC | ACRS | 00461U105 | $22.9M | 1.12% | 4,330,532 | SH |
| 27 | MINIMED GROUP INC | MMED | 60365F109 | $22.7M | 1.11% | 1,520,000 | SH |
| 28 | BOSTON SCIENTIFIC CORP | BSX | 101137107 | $22.6M | 1.10% | 528,500 | SH |
| 29 | PHARVARIS N V | PHVS | N69605108 | $22.4M | 1.09% | 648,333 | SH |
| 30 | AVALYN PHARMACEUTICALS INC | AVLN | 05348Y105 | $21.8M | 1.07% | 662,918 | SH |
| 31 | HEMAB THERAPEUTICS HLDGS INC | COAG | 423494103 | $21.1M | 1.03% | 575,432 | SH |
| 32 | DYNE THERAPEUTICS INC | DYN | 26818M108 | $20.9M | 1.02% | 942,154 | SH |
| 33 | ALNYLAM PHARMACEUTICALS INC | ALNY | 02043Q107 | $20.1M | 0.98% | 66,750 | SH |
| 34 | COGENT BIOSCIENCES INC | COGT | 19240Q201 | $20.0M | 0.97% | 515,917 | SH |
| 35 | AGIOS PHARMACEUTICALS INC | AGIO | 00847X104 | $19.8M | 0.96% | 532,563 | SH |
| 36 | NEWAMSTERDAM PHARMA COMPANY | NAMS | N62509109 | $19.7M | 0.96% | 582,744 | SH |
| 37 | VERA THERAPEUTICS INC | VERA | 92337R101 | $18.3M | 0.90% | 427,584 | SH |
| 38 | TARSUS PHARMACEUTICALS INC | TARS | 87650L103 | $17.4M | 0.85% | 277,087 | SH |
| 39 | HEARTFLOW INC | HTFL | 42238D107 | $16.8M | 0.82% | 573,500 | SH |
| 40 | MBX BIOSCIENCES INC | MBX | 55287L101 | $16.5M | 0.80% | 298,218 | SH |
| 41 | CYTOKINETICS INC | CYTK | 23282W605 | $16.0M | 0.78% | 187,980 | SH |
| 42 | BICARA THERAPEUTICS INC | BCAX | 055477103 | $15.9M | 0.78% | 535,286 | SH |
| 43 | PARABILIS MEDICINES INC | PBLS | 698955101 | $15.8M | 0.77% | 578,028 | SH |
| 44 | ZAI LAB LTD | ZLAB | 98887Q104 | $15.5M | 0.76% | 814,707 | SH |
| 45 | DANAHER CORP DEL | DHR | 235851102 | $14.5M | 0.71% | 76,300 | SH |
| 46 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $14.3M | 0.70% | 456,551 | SH |
| 47 | EVOLENT HEALTH INC | EVH | 30050B101 | $13.6M | 0.66% | 2,500,000 | SH |
| 48 | PTC THERAPEUTICS INC | PTCT | 69366J200 | $13.2M | 0.65% | 162,298 | SH |
| 49 | MINERALYS THERAPEUTICS INC | MLYS | 603170101 | $13.1M | 0.64% | 484,951 | SH |
| 50 | ZENAS BIOPHARMA INC | ZBIO | 98937L105 | $12.7M | 0.62% | 502,077 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $2.05B | 104 | 0001172661-26-003527 |
| 2026-03-31 | 2026-05-15 | $1.70B | 100 | 0001172661-26-002225 |
| 2025-12-31 | 2026-02-17 | $1.95B | 99 | 0001172661-26-000917 |
| 2025-09-30 | 2025-11-14 | $1.71B | 93 | 0001172661-25-004882 |
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