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Knott David M Jr — 13F Holdings & Portfolio

CIK 1892770 · latest 13F-HR filed 2026-05-14

Backtest portfolio

Knott David M Jr manages $168.0M in 13F-reported U.S. long-equity assets across 88 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are GOOG (15.57%), APO (14.92%), SNDX (5.87%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 10 new positions, exited 12, added to 22, and trimmed 42.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

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AUM

$168.0M

Long-equity book

Holdings

88

Distinct positions

Period

2026-03-31

Filed 2026-05-14

Q/Q Activity

+10 / −12 / ↑22 / ↓42

vs 2025-12-31

Firm Profile & Key People
Name Title / Status Ownership Type

Top Adds (vs prior quarter)

  • Agios Pharmaceutical, Inc.$2.7M +542.5%
  • TG Therapeutics, Inc.$1.6M +122.9%
  • Alkermes PLC$1.6M +59.6%
  • Centessa Pharmaceuticals PLC$1.4M +1448.5%
  • Syndax Pharmaceutical, Inc.$1.1M +13.1%
Show all 22 →

Top Trims

  • Apollo Global Management, Inc.-$7.5M -23.0%
  • Travere Therapeutics, Inc.-$2.9M -41.2%
  • Alphabet Inc-Cl C-$2.5M -8.6%
  • Xeris Biopharma Holdings, Inc.-$1.5M -19.3%
  • Catalyst Pharmaceuticals, Inc.-$1.4M -32.6%
Show all 42 →

New Positions

  • Iovance Biotherapeutics, Inc.$5.6M
  • LPL Financial Holdings Inc.$5.0M
  • Relmada Therapeutics, Inc.$3.1M
  • Ardelyx, Inc.$1.2M
  • Verastem Inc.$551.2K
Show all 10 →

Exited Positions

  • Calumet, Inc.$44.0M
  • Tectonic Therapeutic, Inc.$1.5M
  • Biohaven LTD$1.3M
  • Nektar Therapeutics$655.3K
  • Scholar Rock Holding Corporation$612.9K
Show all 12 →
All Holdings

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 Alphabet Inc-Cl C GOOG 02079K107 $26.2M 15.57% 91,200 SH
2 Apollo Global Management, Inc. APO 03769M106 $25.1M 14.92% 225,000 SH
3 Syndax Pharmaceutical, Inc. SNDX 87164F105 $9.9M 5.87% 422,000 SH
4 Bridgebio Pharma, Inc. BBIO 10806X102 $6.7M 3.98% 90,000 SH
5 Protagonist Therapeutics, Inc PTGX 74366E102 $6.6M 3.95% 63,000 SH
6 Xeris Biopharma Holdings, Inc. XERS 98422E103 $6.1M 3.66% 1,060,000 SH
7 JPMorgan Chase & Co. JPM 46625H100 $5.7M 3.41% 19,477 SH
8 Iovance Biotherapeutics, Inc. IOVA 462260100 $5.6M 3.34% 1,600,000 SH
9 LPL Financial Holdings Inc. LPLA 52012V100 $5.0M 2.95% 16,500 SH
10 Janus Henderson AAA CLO ETF JAAA 47103U845 $4.7M 2.80% 93,528 SH
11 Alkermes PLC ALKS G01767105 $4.2M 2.53% 120,000 SH
12 Travere Therapeutics, Inc. TVTX 89422G107 $4.2M 2.49% 140,633 SH
13 Cogent Biosciences Inc. COGT 19240Q201 $4.0M 2.38% 104,000 SH
14 Viridian Therapeutics, Inc. VRDN 92790C104 $3.5M 2.11% 181,000 SH
15 Agios Pharmaceutical, Inc. AGIO 00847X104 $3.1M 1.87% 93,058 SH
16 Relmada Therapeutics, Inc. RLMD 75955J402 $3.1M 1.82% 439,300 SH
17 TG Therapeutics, Inc. TGTX 88322Q108 $3.0M 1.78% 90,001 SH
18 Catalyst Pharmaceuticals, Inc. CPRX 14888U101 $3.0M 1.77% 120,000 SH
19 Arcellx Inc ACLX 03940C100 $2.2M 1.33% 19,433 SH
20 SPDR S&P Biotech ETF XBI 78464A870 $1.9M 1.14% 15,000 SH
21 AllianceBernstein Holding L.P. AB 01881G106 $1.8M 1.07% 48,000 SH
22 Arcus Biosciences, Inc. RCUS 03969F109 $1.8M 1.04% 81,241 SH
23 DocGo, Inc. DCGO 256086109 $1.7M 1.00% 2,670,850 SH
24 Cybin Inc HELP 23256X407 $1.7M 1.00% 350,000 SH
25 Cytokinetics, Incorporated CYTK 23282W605 $1.6M 0.93% 23,644 SH
26 Centessa Pharmaceuticals PLC CNTA 152309100 $1.5M 0.92% 39,000 SH
27 AtriCure, Inc. ATRC 04963C209 $1.5M 0.87% 51,400 SH
28 Ardelyx, Inc. ARDX 039697107 $1.2M 0.74% 207,000 SH
29 The Panagram BBB-B CLO ETF CLOZ 81752T528 $1.2M 0.73% 47,807 SH
30 Rezolute, Inc. RZLT 76200L309 $1.1M 0.67% 370,000 SH
31 Orchestra Biomed Holdings, Inc. OBIO 68572M106 $1.1M 0.64% 253,651 SH
32 Madrigal Pharmaaceuticals, Inc. MDGL 558868105 $1.0M 0.62% 2,000 SH
33 Vera Therapeutics, Inc. VERA 92337R101 $1.0M 0.62% 26,000 SH
34 Connect Biopharma Holdings Limited CNTB G23549101 $1.0M 0.60% 387,835 SH
35 Johnson & Johnson JNJ 478160104 $977.8K 0.58% 4,000 SH
36 iShares Biotechnology ETF IBB 464287556 $928.7K 0.55% 5,500 SH
37 Pfizer Inc. PFE 717081103 $908.0K 0.54% 32,337 SH
38 Bristol-Myers Squibb Company BMY 110122108 $826.2K 0.49% 13,622 SH
39 Canadian Natural Resources Limited CNQ 136385101 $818.7K 0.49% 16,800 SH
40 Biogen Inc. BIIB 09062X103 $733.3K 0.44% 4,000 SH
41 Ultragenyx Pharmaceutical Inc. RARE 90400D108 $692.8K 0.41% 33,069 SH
42 Apple Inc. AAPL 037833100 $633.0K 0.38% 2,494 SH
43 Microsoft Corporation MSFT 594918104 $592.3K 0.35% 1,600 SH
44 Verastem Inc. VSTM 92337C203 $551.2K 0.33% 104,000 SH
45 ADMA Biologics, Inc. ADMA 000899104 $542.4K 0.32% 60,200 SH
46 International Business Machines IBM 459200101 $519.3K 0.31% 2,142 SH
47 Biohaven Pharmaceutical Holding Co. Ltd — G111OE107 $513.7K 0.31% 60,720 SH
48 Pelthos Therapeutics, Inc. PTHS 171126204 $442.7K 0.26% 21,073 SH
49 Kura Oncology, Inc. KURA 50127T109 $429.0K 0.26% 52,767 SH
50 Evolus, Inc. EOLS 30052C107 $408.3K 0.24% 99,338 SH
Filing History
Period Filed AUM Holdings Accession
2026-03-31 2026-05-14 $168.0M 88 0001104659-26-060750
2025-12-31 2026-02-12 $215.9M 91 0001104659-26-014058
2025-09-30 2025-11-12 $248.0M 92 0001104659-25-110124