TRV GP V, LLC — 13F Holdings & Portfolio

CIK 1990717 · latest 13F-HR filed 2026-08-10

TRV GP V, LLC manages $498.2M in 13F-reported U.S. long-equity assets across 3 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are RAPP (52.53%), SEPN (41.78%), MAZE (5.69%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 0 new positions, exited 0, added to 2, and trimmed 0.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

Filer Information
Address
201 BROOKLINE AVE.
BOSTON, MA 02215
Phone
(617) 585-2000
Filing Manager
TRV GP V, LLC
Boston, MA
Signatory
Kevin Gillis
Chief Operating Officer
Loading holdings…
AUM

$498.2M

Long-equity book

Holdings

3

Distinct positions

Period

2026-06-30

Filed 2026-08-10

Q/Q Activity

+0 / −0 / ↑2 / ↓0

vs 2026-03-31

Firm Profile & Key People
Name Title / Status Ownership Type

Top Adds (vs prior quarter)

  • SEPTERNA, INC.$58.8M +39.4%
  • RAPPORT THERAPEUTICS, INC.$38.4M +17.2%
Show all 2

Top Trims

  • No decreased positions.
Show all 0

New Positions

  • No new positions this quarter.
Show all 0

Exited Positions

  • No exits this quarter.
Show all 0
All Holdings

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 RAPPORT THERAPEUTICS, INC. RAPP 75383L102 $261.7M 52.53% 6,280,525 SH
2 SEPTERNA, INC. SEPN 81734D104 $208.2M 41.78% 6,215,591 SH
3 MAZE THERAPEUTICS, INC. MAZE 578784100 $28.4M 5.69% 950,800 SH
Filing History
Period Filed AUM Holdings Accession
2026-06-30 2026-08-10 $498.2M 3 0001193125-26-340725
2026-03-31 2026-05-07 $401.0M 3 0001193125-26-212010
2025-12-31 2026-02-13 $429.2M 3 0001193125-26-051785