Opaleye Management Inc.
CIK 1595855 · last filed 2026-07-24
Opaleye Management Inc. is a corporate insider who has filed 207 SEC Form 4 insider transactions across 13 companies since 2015. The most recent filing shows the insider bought $1.6M of ACOG on Jul 24, 2026. Across all open-market trades the lifetime net is +$26.7M, making them a net buyer over the disclosed history. Current disclosed insider exposure totals $314.8M across reported positions.
"Disclosed insider exposure" sums this person's most-recently-reported share counts across each company they're an insider in, multiplied by the current underlying price. It is not net worth — it misses retail holdings, private investments, real estate, index funds, and any company where the person isn't an SEC-reporting insider. For informational purposes only.
$314.80M
13
207
$26.72M
Holdings By Company
| Symbol | Role | Shares | Price | Disclosed Exposure | Lifetime OM Net | Filings | Latest Filed |
|---|---|---|---|---|---|---|---|
| ACOG | 10%+ Owner | 100,000 | $8.57 | $857.0K | $5.67M | 17 | 2026-07-24 |
| ETON | 10%+ Owner | 2,665,000 | $46.65 | $124.32M | -$13.95M | 17 | 2026-07-17 |
| SLGL | 10%+ Owner | 493,936 | $83.80 | $41.39M | $7.36M | 20 | 2026-07-15 |
| SNWV | 10%+ Owner | 5,000 | $6.34 | $31.7K | -$669.0K | 4 | 2026-05-04 |
| HROW | 10%+ Owner | 3,756,000 | $38.84 | $145.88M | -$6.77M | 9 | 2026-03-05 |
| CDXS | 10%+ Owner | 179,989 | $1.50 | $270.9K | $11.11M | 28 | 2025-12-15 |
| HARROW, INC. (HROWM) Delisted | 10%+ Owner | 90,000 | $26.03 | $2.34M | -$571.8K | 16 | 2025-06-11 |
| TARA | 10%+ Owner | 51,500 | $3.92 | $202.1K | $5.07M | 24 | 2024-09-12 |
| Tracon Pharmaceuticals, Inc. (TCON) Delisted | 10%+ Owner | 0 | $0.03 | $0 | $7.74M | 36 | 2023-11-14 |
| TELA | 10%+ Owner | 124,813 | $0.67 | $83.7K | $3.99M | 19 | 2023-04-20 |
| HARROW, INC. (HROWL) Delisted | 10%+ Owner | 3,600,000 | $25.61 | $92.20M | $6.80M | 8 | 2022-12-14 |
| OCUL | 10%+ Owner | 207,500 | $8.50 | $1.76M | $137.9K | 3 | 2020-04-03 |
| HARROW, INC. (IMMY) Delisted | 10%+ Owner | 1,250,000 | — | — | $789.4K | 5 | 2016-03-14 |
Recent Filings
207 filings| Filed | Symbol | Action | Net Shares | Net $ | Link |
|---|---|---|---|---|---|
| 2026-07-24 | ACOG | Buy (P) | +200,086 | $1.57M | EDGAR |
| 2026-07-17 | ETON | Sell (S) | −28,315 | -$1.06M | EDGAR |
| 2026-07-16 | ETON | Sell (S) | −28,315 | -$1.06M | EDGAR |
| 2026-07-15 | SLGL | Buy (P) | +1,695 | $124.8K | EDGAR |
| 2026-07-10 | SLGL | Buy (P) | +529 | $39.0K | EDGAR |
| 2026-07-07 | ETON | Sell (S) | −126,685 | -$4.77M | EDGAR |
| 2026-07-02 | SLGL | Buy (P) | +1,712 | $123.2K | EDGAR |
| 2026-06-29 | ACOG | Buy (P) | +152,533 | $976.5K | EDGAR |
| 2026-06-15 | ACOG | Buy (P) | +7,685 | $45.8K | EDGAR |
| 2026-06-11 | ACOG | Buy (P) | +30,728 | $183.7K | EDGAR |
Notice (144 / 144/A): Form 144 is a notice of intent to sell restricted/control stock under Rule 144, filed before the sale; 144/A is an amendment. Many notices are pre-scheduled under Rule 10b5-1 plans. A Form 4 with code S typically follows within a few days when the planned sale executes; missing follow-up Form 4s suggest the notice was cancelled or modified.