Sio Capital Management, LLC — 13F Holdings & Portfolio

CIK 1482416 · latest 13F-HR filed 2026-05-14

Sio Capital Management, LLC manages $697.3M in 13F-reported U.S. long-equity assets across 76 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are MMS (7.07%), WAY (5.68%), ICLR (4.86%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 22 new positions, exited 14, added to 28, and trimmed 21.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

Loading holdings…
AUM

$697.3M

Long-equity book

Holdings

76

Distinct positions

Period

2026-03-31

Filed 2026-05-14

Q/Q Activity

+22 / −14 / ↑28 / ↓21

vs 2025-12-31

Firm Profile & Key People
Name Title / Status Ownership Type

Top Adds (vs prior quarter)

  • CENCORA INC$26.3M +490.2%
  • ANTERIS TECHNOLOGIES GLOBAL$20.5M +219.4%
  • WAYSTAR HLDG CORP$19.5M +97.0%
  • ANI PHARMACEUTICALS INC$13.5M +196.4%
  • DIANTHUS THERAPEUTICS INC$11.5M +58.8%
Show all 28

Top Trims

  • SANOFI SA-$35.5M -75.5%
  • ZIMMER BIOMET HOLDINGS INC-$29.0M -83.7%
  • CELCUITY INC-$25.5M -53.5%
  • ORGANON & CO-$19.3M -78.9%
  • BIOHAVEN LTD-$4.2M -29.9%
Show all 21

New Positions

  • CORCEPT THERAPEUTICS INC$27.2M
  • GSK PLC$21.3M
  • ABBOTT LABORATORIES$19.2M
  • EMBECTA CORP$16.3M
  • SIONNA THERAPEUTICS INC$11.8M
Show all 22

Exited Positions

  • THE CIGNA GROUP$47.4M
  • KENVUE INC$25.3M
  • BRIGHTSPRING HEALTH SVCS INC$11.5M
  • CENTENE CORP DEL$11.3M
  • CHARLES RIV LABS INTL INC$11.0M
Show all 14
All Holdings

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 MAXIMUS INC MMS 577933104 $49.3M 7.07% 768,825 SH
2 WAYSTAR HLDG CORP WAY 946784105 $39.6M 5.68% 1,642,236 SH
3 ICON PLC ICLR G4705A100 $33.9M 4.86% 306,358 SH
4 CENCORA INC COR 03073E105 $31.7M 4.55% 100,894 SH
5 DIANTHUS THERAPEUTICS INC DNTH 252828108 $31.1M 4.45% 370,045 SH
6 ANTERIS TECHNOLOGIES GLOBAL AVR 03675P102 $29.9M 4.28% 5,382,965 SH
7 CORCEPT THERAPEUTICS INC CORT 218352102 $27.2M 3.90% 674,759 SH
8 LIVANOVA PLC LIVN G5509L101 $26.8M 3.84% 421,615 SH
9 TYRA BIOSCIENCES INC TYRA 90240B106 $23.2M 3.33% 605,439 SH
10 CELCUITY INC CELC 15102K100 $22.1M 3.17% 193,843 SH
11 GSK PLC GSK 37733W204 $21.3M 3.05% 385,879 SH
12 ANI PHARMACEUTICALS INC ANIP 00182C103 $20.4M 2.93% 265,543 SH
13 ABBOTT LABORATORIES ABT 002824100 $19.2M 2.75% 186,574 SH
14 EMBECTA CORP EMBC 29082K105 $16.3M 2.34% 1,847,850 SH
15 ABIVAX SA ABVX 00370M103 $15.1M 2.17% 135,800 SH
16 VIR BIOTECHNOLOGY INC VIR 92764N102 $13.4M 1.93% 1,498,620 SH
17 HAEMONETICS CORP MASS HAE 405024100 $12.4M 1.78% 220,672 SH
18 SIONNA THERAPEUTICS INC SION 829401108 $11.8M 1.69% 294,340 SH
19 SANOFI SA SNY 80105N105 $11.5M 1.66% 239,671 SH
20 RAPPORT THERAPEUTICS INC RAPP 75383L102 $11.5M 1.65% 366,809 SH
21 TELEFLEX INCORPORATED TFX 879369106 $11.3M 1.63% 94,800 SH
22 BIOMARIN PHARMACEUTICAL INC BMRN 09061G101 $11.0M 1.57% 194,226 SH
23 CROSS CTRY HEALTHCARE INC CCRN 227483104 $10.3M 1.48% 1,098,393 SH
24 PROTARA THERAPEUTICS INC TARA 74365U107 $10.3M 1.47% 1,969,839 SH
25 STRUCTURE THERAPEUTICS INC GPCR 86366E106 $10.1M 1.45% 209,093 SH
26 BIOHAVEN LTD BHVN G1110E107 $9.8M 1.41% 1,163,926 SH
27 MONOPAR THERAPEUTICS INC MNPR 61023L207 $9.5M 1.36% 173,506 SH
28 EYEPOINT INC EYPT 30233G209 $9.3M 1.33% 721,785 SH
29 CRINETICS PHARMACEUTICALS IN CRNX 22663K107 $9.1M 1.30% 249,887 SH
30 EDGEWISE THERAPEUTICS INC EWTX 28036F105 $8.5M 1.22% 268,986 SH
31 COMPASS PATHWAYS PLC CMPS 20451W101 $8.3M 1.19% 1,506,525 SH
32 OCULAR THERAPEUTIX INC OCUL 67576A100 $8.2M 1.18% 968,597 SH
33 AQUESTIVE THERAPEUTICS INC AQST 03843E104 $8.0M 1.14% 1,922,887 SH
34 RELMADA THERAPEUTICS INC RLMD 75955J402 $6.7M 0.96% 965,000 SH
35 ORUKA THERAPEUTICS INC ORKA 687604108 $6.5M 0.93% 132,496 SH
36 ZENAS BIOPHARMA INC ZBIO 98937L105 $6.5M 0.93% 331,730 SH
37 BRIGHT MINDS BIOSCIENCES INC DRUG 10919W405 $6.3M 0.90% 86,083 SH
38 QUIDELORTHO CORP QDEL 219798105 $5.9M 0.85% 359,011 SH
39 ZIMMER BIOMET HOLDINGS INC ZBH 98956P102 $5.7M 0.81% 62,613 SH
40 REPLIMUNE GROUP INC REPL 76029N106 $5.5M 0.79% 720,036 SH
41 ORGANON & CO OGN 68622V106 $5.2M 0.74% 865,908 SH
42 ONKURE THERAPEUTICS INC OKUR 68277Q105 $4.5M 0.64% 1,078,965 SH
43 DISC MEDICINE INC IRON 254604101 $4.2M 0.60% 65,203 SH
44 PMV PHARMACEUTICALS INC PMVP 69353Y103 $3.8M 0.55% 3,076,580 SH
45 IMMUNOME INC IMNM 45257U108 $3.6M 0.52% 165,110 SH
46 INTEGRA LIFESCIENCES HLDGS C IART 457985208 $3.6M 0.52% 383,140 SH
47 SAVARA INC SVRA 805111101 $3.4M 0.48% 613,888 SH
48 CENTENE CORP DEL Put CNC 15135B101 $3.3M 0.47% 100,000 SH
49 PROQR THERAPEUTICS N V PRQR N71542109 $3.2M 0.45% 1,954,715 SH
50 SHOULDER INNOVATIONS INC SI 82537J108 $3.1M 0.44% 210,641 SH
Filing History
Period Filed AUM Holdings Accession
2026-03-31 2026-05-14 $697.3M 76 0001214659-26-006200
2025-12-31 2026-02-17 $635.7M 68 0001214659-26-001854
2025-09-30 2025-11-13 $395.2M 51 0001214659-25-016415