Sio Capital Management, LLC — 13F Holdings & Portfolio
CIK 1482416 · latest 13F-HR filed 2026-08-14
Sio Capital Management, LLC manages $604.3M in 13F-reported U.S. long-equity assets across 59 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are AVR (9.04%), COR (8.13%), MMS (6.36%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 15 new positions and exited 31; 14 existing positions rose in reported value and 23 fell.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
Long-equity book
Distinct positions
Filed 2026-08-14
vs 2026-03-31
Portfolio charts
Latest quarter's book, what changed, and how the portfolio has evolved across filings.
| Name | Title / Status | Ownership | Type |
|---|
Quarter-over-quarter changes
Changes in reported position value vs the prior 13F, so price moves count too, not just shares bought or sold.
Top Adds (vs prior quarter)
- ANTERIS TECHNOLOGIES GLOBAL$24.8M +82.9%
- CENCORA INC$17.4M +55.0%
- ORUKA THERAPEUTICS INC$10.4M +159.4%
- SENSEONICS HLDGS INC$8.3M +1073.2%
- ZIMMER BIOMET HOLDINGS INC$5.7M +99.9%
Top Trims
- DIANTHUS THERAPEUTICS INC-$25.3M -81.4%
- WAYSTAR HLDG CORP-$20.6M -52.0%
- ICON PUB LTD CO-$18.6M -54.8%
- ANI PHARMACEUTICALS INC-$12.4M -60.6%
- MAXIMUS INC-$10.8M -22.0%
New Positions
- ALLOGENE THERAPEUTICS INC$27.7M
- GLOBUS MED INC$23.8M
- IDEAYA BIOSCIENCES INC$17.9M
- THE CIGNA GROUP$15.9M
- VIATRIS INC$15.2M
Exited Positions
- CORCEPT THERAPEUTICS INC$27.2M
- LIVANOVA PLC$26.8M
- EMBECTA CORP$16.3M
- ABIVAX SA$15.1M
- HAEMONETICS CORP MASS$12.4M
Sio Capital Management, LLC Holdings (2026-06-30)
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | ANTERIS TECHNOLOGIES GLOBAL | AVR | 03675P102 | $54.6M | 9.04% | 5,545,984 | SH |
| 2 | CENCORA INC | COR | 03073E105 | $49.1M | 8.13% | 173,588 | SH |
| 3 | MAXIMUS INC | MMS | 577933104 | $38.5M | 6.36% | 715,267 | SH |
| 4 | ALLOGENE THERAPEUTICS INC | ALLO | 019770106 | $27.7M | 4.59% | 13,323,431 | SH |
| 5 | GLOBUS MED INC | GMED | 379577208 | $23.8M | 3.95% | 301,816 | SH |
| 6 | GSK PLC | GSK | 37733W204 | $22.9M | 3.79% | 436,700 | SH |
| 7 | TYRA BIOSCIENCES INC | TYRA | 90240B106 | $22.2M | 3.68% | 695,315 | SH |
| 8 | WAYSTAR HLDG CORP | WAY | 946784105 | $19.0M | 3.15% | 925,834 | SH |
| 9 | SELLAS LIFE SCIENCES GROUP I Put | SLS | 81642T209 | $18.2M | 3.01% | 1,230,700 | SH |
| 10 | IDEAYA BIOSCIENCES INC | IDYA | 45166A102 | $17.9M | 2.96% | 480,383 | SH |
| 11 | ORUKA THERAPEUTICS INC | ORKA | 687604108 | $16.9M | 2.79% | 177,118 | SH |
| 12 | THE CIGNA GROUP | CI | 125523100 | $15.9M | 2.63% | 57,750 | SH |
| 13 | SANOFI SA | SNY | 80105N105 | $15.5M | 2.57% | 364,200 | SH |
| 14 | ICON PUB LTD CO | ICLR | G4705A100 | $15.3M | 2.53% | 88,186 | SH |
| 15 | VIATRIS INC | VTRS | 92556V106 | $15.2M | 2.51% | 954,299 | SH |
| 16 | CROSS CTRY HEALTHCARE INC | CCRN | 227483104 | $14.5M | 2.40% | 1,098,393 | SH |
| 17 | RAPPORT THERAPEUTICS INC | RAPP | 75383L102 | $12.8M | 2.12% | 307,657 | SH |
| 18 | ABBOTT LABORATORIES | ABT | 002824100 | $11.7M | 1.93% | 128,656 | SH |
| 19 | CELCUITY INC | CELC | 15102K100 | $11.5M | 1.90% | 110,022 | SH |
| 20 | ZIMMER BIOMET HOLDINGS INC | ZBH | 98956P102 | $11.3M | 1.87% | 131,445 | SH |
| 21 | REGENERON PHARMACEUTICALS | REGN | 75886F107 | $11.2M | 1.86% | 18,000 | SH |
| 22 | BRISTOL-MYERS SQUIBB CO | BMY | 110122108 | $11.1M | 1.85% | 193,500 | SH |
| 23 | MEDTRONIC PLC | MDT | G5960L103 | $11.1M | 1.84% | 142,500 | SH |
| 24 | VIR BIOTECHNOLOGY INC | VIR | 92764N102 | $11.0M | 1.81% | 1,075,274 | SH |
| 25 | SENSEONICS HLDGS INC | SENS | 81727U303 | $9.0M | 1.50% | 1,592,692 | SH |
| 26 | EYEPOINT INC | EYPT | 30233G209 | $8.9M | 1.47% | 623,130 | SH |
| 27 | CYBIN INC | HELP | 23256X407 | $8.6M | 1.42% | 1,300,000 | SH |
| 28 | ANI PHARMACEUTICALS INC | ANIP | 00182C103 | $8.1M | 1.33% | 97,305 | SH |
| 29 | PROTARA THERAPEUTICS INC | TARA | 74365U107 | $7.3M | 1.21% | 1,921,872 | SH |
| 30 | RELMADA THERAPEUTICS INC | RLMD | 75955J402 | $6.9M | 1.15% | 1,003,562 | SH |
| 31 | TANGO THERAPEUTICS INC | TNGX | 87583X109 | $6.5M | 1.08% | 208,500 | SH |
| 32 | AQUESTIVE THERAPEUTICS INC | AQST | 03843E104 | $6.2M | 1.02% | 1,486,175 | SH |
| 33 | DIANTHUS THERAPEUTICS INC | DNTH | 252828108 | $5.8M | 0.96% | 59,254 | SH |
| 34 | SIONNA THERAPEUTICS INC | SION | 829401108 | $5.6M | 0.93% | 127,808 | SH |
| 35 | OCULAR THERAPEUTIX INC | OCUL | 67576A100 | $5.3M | 0.88% | 539,493 | SH |
| 36 | ZENAS BIOPHARMA INC | ZBIO | 98937L105 | $5.3M | 0.88% | 208,557 | SH |
| 37 | BRIGHT MINDS BIOSCIENCES INC | DRUG | 10919W405 | $5.2M | 0.86% | 73,952 | SH |
| 38 | ONKURE THERAPEUTICS INC | OKUR | 68277Q105 | $4.9M | 0.81% | 1,078,965 | SH |
| 39 | SAVARA INC | SVRA | 805111101 | $3.8M | 0.63% | 617,675 | SH |
| 40 | PMV PHARMACEUTICALS INC | PMVP | 69353Y103 | $3.5M | 0.58% | 2,634,137 | SH |
| 41 | AVEANNA HEALTHCARE HLDGS INC | AVAH | 05356F105 | $3.2M | 0.52% | 369,036 | SH |
| 42 | OVID THERAPEUTICS INC | OVID | 690469101 | $2.7M | 0.45% | 1,005,334 | SH |
| 43 | IMMUNOME INC | IMNM | 45257U108 | $2.6M | 0.44% | 124,168 | SH |
| 44 | HIMS & HERS HEALTH INC Call | HIMS | 433000106 | $2.6M | 0.43% | 75,000 | SH |
| 45 | AN2 THERAPEUTICS INC | ANTX | 037326105 | $2.6M | 0.42% | 529,933 | SH |
| 46 | SERINA THERAPEUTICS INC | SER | 81751A108 | $1.9M | 0.32% | 1,000,000 | SH |
| 47 | ALIGOS THERAPEUTICS INC | ALGS | 01626L204 | $1.9M | 0.31% | 327,237 | SH |
| 48 | IBIO INC | IBIO | 451033708 | $1.6M | 0.26% | 904,268 | SH |
| 49 | XILIO THERAPEUTICS INC | XLO | 98422T209 | $1.5M | 0.24% | 152,464 | SH |
| 50 | ARTIVION INC | AORT | 228903100 | $1.1M | 0.18% | 48,481 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | $604.3M | 59 | 0001214659-26-010311 |
| 2026-03-31 | 2026-05-14 | $697.3M | 76 | 0001214659-26-006200 |
| 2025-12-31 | 2026-02-17 | $635.7M | 68 | 0001214659-26-001854 |
| 2025-09-30 | 2025-11-13 | $395.2M | 51 | 0001214659-25-016415 |
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