SAMUEL D ISALY

CIK 1055949 · last filed 2018-01-04

"Disclosed insider exposure" sums this person's most-recently-reported share counts across each company they're an insider in, multiplied by the current underlying price. It is not net worth — it misses retail holdings, private investments, real estate, index funds, and any company where the person isn't an SEC-reporting insider. For informational purposes only.

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Disclosed Exposure

$2.03B

Companies

23

Total Filings

36

Lifetime Open-Market Net

-$250.26M

Holdings By Company

Latest on-record share count from this person's most recent non-derivative Form 4 transaction in each company. Disclosed exposure = shares × current underlying price.
Symbol Role Shares Price Disclosed Exposure Lifetime OM Net Filings Latest Filed
PALVELLA THERAPEUTICS, INC. (PIRS) Delisted 10%+ Owner 68,759 $13.60 $935.1K -$40.22M 2 2018-01-04
Loxo Oncology, Inc. (LOXO) Delisted Director 1,191,000 -$109.49M 3 2017-11-27
X4 Pharmaceuticals, Inc (ASNS) Delisted 10%+ Owner 33 $0.08 $3 $0 1 2017-11-20
Roka BioScience, Inc. (ROKA) Delisted 10%+ Owner 0 -$1.44M 2 2017-10-05
BOLD 10%+ Owner 4,806,638 $2.46 $11.82M -$335.2K 1 2017-09-11
GKOS Director 1,628,111 $162.06 $263.85M -$89.00M 2 2017-08-17
KALA 10%+ Owner 951 $0.70 $664 $14.37M 1 2017-07-27
ALPINE IMMUNE SCIENCES, INC. (ALPN) Delisted Director 3,298,516 $64.97 $214.30M $0 1 2017-07-26
ASND Director 6,149,377 $253.03 $1.56B $15.00M 1 2017-03-28
CRVS Director 5,379,349 $13.03 $70.09M $464.3K 3 2016-06-27
OTONOMY, INC. (OTIC) Delisted Director 1,953,300 $0.08 $150.4K -$17.21M 1 2015-11-24
Sientra, Inc. (SIEN) Delisted 10%+ Owner 1,988 $0.17 $346 -$14.36M 1 2015-10-09
Sierra Oncology, Inc. (DNAI) Delisted Director 1,725,790 $8.93M 1 2015-07-21
INTERCEPT PHARMACEUTICALS, INC. (ICPT) Delisted Director 1,656,582 $19.00 $31.48M $0 2 2014-08-11
Anthera Pharmaceuticals Inc (ANTH) Delisted Director 27,531 $2.30M 2 2013-01-29
SUPN 10%+ Owner 0 $46.24 $0 -$6.19M 1 2012-12-19
GNOM 10%+ Owner 730,535 $53.79 $39.30M -$9.91M 1 2012-07-13
PCRX 10%+ Owner 2,546,100 $26.48 $67.42M -$1.40M 1 2012-02-29
CCXI 10%+ Owner 908,509 $13.20 $11.99M $0 1 2012-02-15
AMRN Director 345,455 $14.07 $4.86M -$1.72M 1 2011-03-07
NxStage Medical, Inc. (NXTM) Delisted Director 4,152,700 -$1.67M 2 2010-09-09
ALBIREO PHARMA, INC. (BIOD) Delisted Director 50,430 -$282.8K 1 2009-06-11
ATHERSYS, INC / NEW (ATHX) Delisted Director 137,920 $0.01 $1.9K $1.91M 2 2008-05-23

Recent Filings · Page 3 of 4

36 filings
Insider activity across all companies, newest first. Form 4 rows are post-trade confirmations (buys, sells, grants, exercises). Notice (144) rows are pre-trade notices of intent to sell restricted or control stock under Rule 144 — they may not all execute. Compare adjacent dates to see which notices became actual sales.
Filed Symbol Action Net Shares Net $ Link
2014-08-11 INTERCEPT PHARMACEUTICALS, INC. (ICPT) Delisted Exer (M) +972 $0 EDGAR
2014-08-06 Loxo Oncology, Inc. (LOXO) Delisted Mixed +6,527,571 $10.74M EDGAR
2014-02-11 INTERCEPT PHARMACEUTICALS, INC. (ICPT) Delisted Exer (M) +972 $0 EDGAR
2013-11-12 Buy (P) +4,081,625 $10.00M
2013-01-29 Anthera Pharmaceuticals Inc (ANTH) Delisted Buy (P) +5,286,000 $3.43M EDGAR
2012-12-19 SUPN Sell (S) −893,445 -$6.19M EDGAR
2012-07-13 GNOM Sell (S) −3,623,808 -$9.91M EDGAR
2012-02-29 PCRX Sell (S) −126,300 -$1.40M EDGAR
2012-02-15 CCXI Conv (C) +12,618,856 $0 EDGAR
2011-12-13 Anthera Pharmaceuticals Inc (ANTH) Delisted Sell (S) −168,600 -$1.13M EDGAR
Showing 2130 of 36
Page 3 of 4
Form 4 codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (see filing footnote). Only P / S codes carry directional signal.
Notice (144 / 144/A): Form 144 is a notice of intent to sell restricted/control stock under Rule 144, filed before the sale; 144/A is an amendment. Many notices are pre-scheduled under Rule 10b5-1 plans. A Form 4 with code S typically follows within a few days when the planned sale executes; missing follow-up Form 4s suggest the notice was cancelled or modified.