James N Topper
CIK 1341382 · last filed 2026-05-21
"Disclosed insider exposure" sums this person's most-recently-reported share counts across each company they're an insider in, multiplied by the current underlying price. It is not net worth — it misses retail holdings, private investments, real estate, index funds, and any company where the person isn't an SEC-reporting insider. For informational purposes only.
Loading insider history…
Disclosed Exposure
$1.07B
Companies
17
Total Filings
114
Lifetime Open-Market Net
$281.48M
Filer Profile
Reported Address
550 HAMILTON AVENUE, SUITE 100PALO ALTO, CA 94301
Related Filers
Patrick J Heron — 23 joint filings, latest 2025-09-30
ANAPTYSBIO, INC — 11 joint filings, latest 2023-01-10
FHMLS X, L.L.C. — 11 joint filings, latest 2025-09-30
Frazier Life Sciences X, L.P. — 11 joint filings, latest 2025-09-30
FHMLS IX, L.L.C. — 9 joint filings, latest 2020-10-20
Frazier Life Sciences IX, L.P. — 9 joint filings, latest 2020-10-20
FHM LIFE SCIENCES VIII, L.L.C. — 8 joint filings, latest 2023-10-26
Frazier Life Sciences VIII, L.P. — 8 joint filings, latest 2023-10-26
Profile details as reported on the filer's SEC submissions — for individual insiders the address is often in care of the issuer. Related filers are identified from jointly filed SEC submissions and shared reported addresses.
View filings on SEC EDGAR.
Holdings By Company
Latest on-record share count from this person's most recent non-derivative Form 4 transaction in each company. Disclosed exposure = shares × current underlying price.
| Symbol | Role | Shares | Price | Disclosed Exposure | Lifetime OM Net | Filings | Latest Filed |
|---|---|---|---|---|---|---|---|
| PHAT | Director | 126,121 | $8.36 | $1.05M | $100.19M | 10 | 2026-05-21 |
| NAMSW | Director | 3,801,000 | $11.78 | $44.78M | $586.2K | 8 | 2025-09-17 |
| MBX | 10%+ Owner | 4,552,774 | $59.02 | $268.70M | $40.00M | 1 | 2024-09-17 |
| ALPINE IMMUNE SCIENCES, INC. (ALPN) Delisted | Director | 1,371,450 | $64.97 | $89.10M | $2.00M | 13 | 2024-05-20 |
| HilleVax, Inc. (HLVX) Delisted | 10%+ Owner | 8,544,187 | $2.09 | $17.86M | $641.6K | 1 | 2024-04-08 |
| ANAB | Director | 280,341 | $53.87 | $15.10M | $6.00M | 10 | 2023-01-10 |
| Allena Pharmaceuticals, Inc. (ALNA) Delisted | Director | 1,466,805 | $0.07 | $110.0K | $7.00M | 4 | 2020-11-18 |
| Aptinyx Inc. (APTX) Delisted | Director | 3,195,055 | $0.06 | $194.9K | $2.40M | 7 | 2020-04-02 |
| PASG | 10%+ Owner | 148,862 | $5.00 | $744.3K | $39.60M | 1 | 2020-03-03 |
| MIRM | 10%+ Owner | 3,116,912 | $98.22 | $306.14M | $27.00M | 1 | 2019-07-24 |
| Entasis Therapeutics Holdings Inc. (ETTX) Delisted | Director | 337,707 | $2.19 | $739.6K | $5.64M | 2 | 2019-01-22 |
| Sierra Oncology, Inc. (SRRA) Delisted | Director | 148,148 | $54.99 | $8.15M | $8.00M | 1 | 2017-02-16 |
| Sierra Oncology, Inc. (DNAI) Delisted | Director | 1,966,195 | — | — | $3.74M | 2 | 2016-06-20 |
| GKOS | 10%+ Owner | 2,603,362 | $167.25 | $435.41M | $0 | 1 | 2015-06-30 |
| AMICUS THERAPEUTICS, INC. (FOLD) Delisted | Director | 907,464 | $14.49 | $13.15M | $34.05M | 46 | 2013-06-17 |
| PORTOLA PHARMACEUTICALS INC (PTLA) Delisted | Director | 7,252 | — | — | $0 | 2 | 2013-06-07 |
| LA JOLLA PHARMACEUTICAL CO (LJPC) Delisted | Director | 84,214 | $6.22 | $523.8K | $4.63M | 4 | 2009-02-26 |
Recent Filings · Page 3 of 12
114 filingsInsider activity across all companies, newest first. Form 4 rows are post-trade confirmations (buys, sells, grants, exercises). Notice (144) rows are pre-trade notices of intent to sell restricted or control stock under Rule 144 — they may not all execute. Compare adjacent dates to see which notices became actual sales.
| Filed | Symbol | Action | Net Shares | Net $ | Link |
|---|---|---|---|---|---|
| 2023-05-30 | PHAT | Grant (A) | +9,000 | $0 | EDGAR |
| 2023-01-10 | ANAB | Grant (A) | — | $0 | EDGAR |
| 2023-01-05 | ALPINE IMMUNE SCIENCES, INC. (ALPN) Delisted | Grant (A) | — | $0 | EDGAR |
| 2022-09-26 | PHAT | Grant (A) | — | $0 | EDGAR |
| 2022-02-14 | ANAB | Grant (A) | — | $0 | EDGAR |
| 2022-01-04 | ALPINE IMMUNE SCIENCES, INC. (ALPN) Delisted | Grant (A) | — | $0 | EDGAR |
| 2021-09-21 | ALPINE IMMUNE SCIENCES, INC. (ALPN) Delisted | Mixed | −6,000,000 | $0 | EDGAR |
| 2021-02-12 | ANAB | Grant (A) | — | $0 | EDGAR |
| 2021-01-05 | ALPINE IMMUNE SCIENCES, INC. (ALPN) Delisted | Grant (A) | — | $0 | EDGAR |
| 2020-11-18 | ANAB | Other (J) | −1,367,789 | $0 | EDGAR |
Form 4 codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (see filing footnote). Only P / S codes carry directional signal.
Notice (144 / 144/A): Form 144 is a notice of intent to sell restricted/control stock under Rule 144, filed before the sale; 144/A is an amendment. Many notices are pre-scheduled under Rule 10b5-1 plans. A Form 4 with code S typically follows within a few days when the planned sale executes; missing follow-up Form 4s suggest the notice was cancelled or modified.
Notice (144 / 144/A): Form 144 is a notice of intent to sell restricted/control stock under Rule 144, filed before the sale; 144/A is an amendment. Many notices are pre-scheduled under Rule 10b5-1 plans. A Form 4 with code S typically follows within a few days when the planned sale executes; missing follow-up Form 4s suggest the notice was cancelled or modified.