Karen L. Smith
CIK 1639637 · Chief Medical Officer · last filed 2026-04-02
Karen L. Smith is a Chief Medical Officer who has filed 54 SEC Form 4 insider transactions across 12 companies since 2015. The most recent filing, for SKYE, was dated Apr 2, 2026. Across all open-market trades the lifetime net is −$2.7M, making them a net seller over the disclosed history. Current disclosed insider exposure totals $7.1M across reported positions.
"Disclosed insider exposure" sums this person's most-recently-reported share counts across each company they're an insider in, multiplied by the current underlying price. It is not net worth — it misses retail holdings, private investments, real estate, index funds, and any company where the person isn't an SEC-reporting insider. For informational purposes only.
$7.06M
12
54
-$2.68M
Holdings By Company
| Symbol | Role | Shares | Price | Disclosed Exposure | Lifetime OM Net | Filings | Latest Filed |
|---|---|---|---|---|---|---|---|
| SKYE | Director | — | $0.79 | — | $0 | 5 | 2026-04-02 |
| SANGAMO THERAPEUTICS, INC (SGMO) Delisted | Director | 102,100 | $0.18 | $18.1K | $0 | 9 | 2025-06-16 |
| CNTX | Director | — | $1.39 | — | $0 | 2 | 2025-06-12 |
| AUPH | Director | 24,807 | $15.82 | $392.4K | -$44.2K | 3 | 2024-11-25 |
| Tourmaline Bio, Inc. (TALS) Delisted | Director | — | $27.20 | — | $0 | 3 | 2023-06-14 |
| QNCX | Chief Medical Officer | — | $0.93 | — | $0 | 1 | 2023-02-02 |
| Quince Therapeutics, Inc. (CRTX) Delisted | Chief Medical Officer | 194,690 | $1.95 | $379.6K | $0 | 2 | 2022-05-27 |
| ACCELERON PHARMA INC (XLRN) Delisted | Director | 0 | $178.75 | $0 | -$2.88M | 8 | 2021-11-22 |
| ANTARES PHARMA, INC. (ATRS) Delisted | Director | 79,645 | $5.59 | $445.2K | $0 | 4 | 2021-06-14 |
| EBS | EVP, Chief Medical Officer | 11,888 | $8.32 | $98.9K | $0 | 2 | 2021-05-11 |
| JAZZ | EVP, R&D and CMO | 28,474 | $230.56 | $6.56M | $250.0K | 13 | 2018-03-07 |
| Sucampo Pharmaceuticals, Inc. (SCMP) Delisted | Director | — | — | — | $0 | 1 | 2018-02-13 |
Recent Filings
54 filings| Filed | Symbol | Action | Net Shares | Net $ | Link |
|---|---|---|---|---|---|
| 2026-04-02 | SKYE | Grant (A) | — | $0 | EDGAR |
| 2026-02-09 | SKYE | Grant (A) | — | $0 | EDGAR |
| 2025-06-16 | SANGAMO THERAPEUTICS, INC (SGMO) Delisted | Grant (A) | +25,000 | $0 | EDGAR |
| 2025-06-12 | CNTX | Grant (A) | — | $0 | EDGAR |
| 2025-02-26 | SKYE | Grant (A) | — | $0 | EDGAR |
| 2024-11-25 | AUPH | Grant (A) | +12,135 | $0 | EDGAR |
| 2024-11-12 | AUPH | Mixed | +12,672 | -$44.2K | EDGAR |
| 2024-10-30 | SKYE | Grant (A) | — | $0 | EDGAR |
| 2024-09-05 | CNTX | Grant (A) | — | $0 | EDGAR |
| 2024-07-05 | SKYE | Grant (A) | — | $0 | EDGAR |