Opaleye Management Inc. — 13F Holdings & Portfolio
CIK 1595855 · latest 13F-HR filed 2026-04-13
Opaleye Management Inc. manages $757.9M in 13F-reported U.S. long-equity assets across 54 reported positions as of its 2025-12-31 13F-HR filing. Its largest disclosed positions are HROW (25.25%), LQDA (11.21%), ETON (6.38%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 0 new positions, exited 0, added to 0, and trimmed 1.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$757.9M
Long-equity book
54
Distinct positions
2025-12-31
Filed 2026-04-13
+0 / −0 / ↑0 / ↓1
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | HARROW HEALTH INC | HROW | 415858109 | $191.3M | 25.25% | 3,905,000 | SH |
| 2 | LIQUIDIA CORPORATION | LQDA | 53635D202 | $85.0M | 11.21% | 2,435,000 | SH |
| 3 | ETON PHARMACEUTICALS INC | ETON | 29772L108 | $48.4M | 6.38% | 2,860,000 | SH |
| 4 | RHYTHM PHARMACEUTICALS INC | RYTM | 76243J105 | $35.3M | 4.66% | 330,000 | SH |
| 5 | APOGEE THERAPEUTICS INC | APGE | 03770N101 | $29.3M | 3.87% | 388,257 | SH |
| 6 | SANUWAVE HEALTH INC | SNWV | 80303D305 | $29.3M | 3.86% | 981,267 | SH |
| 7 | STOKE THERAPEUTICS INC | STOK | 86150R107 | $22.1M | 2.91% | 695,000 | SH |
| 8 | OCULAR THERAPEUTIX INC | OCUL | 67576A100 | $19.4M | 2.55% | 1,595,000 | SH |
| 9 | SOL GEL TECHNOLOGIES | SLGL | M8694L137 | $19.1M | 2.52% | 453,739 | SH |
| 10 | CG ONCOLOGY INC | CGON | 156944100 | $17.0M | 2.25% | 410,000 | SH |
| 11 | TG THERAPEUTICS INC | TGTX | 88322Q108 | $15.9M | 2.10% | 535,000 | SH |
| 12 | DISC MEDICINE INC | IRON | 254604101 | $15.9M | 2.10% | 200,000 | SH |
| 13 | REZOLUTE INC | RZLT | 76200L309 | $14.8M | 1.96% | 6,287,156 | SH |
| 14 | CRESCENT BIOPHARMA INC | CBIO | G2545C104 | $14.0M | 1.84% | 1,178,300 | SH |
| 15 | ALKERMES PLC | ALKS | G01767105 | $13.7M | 1.81% | 490,000 | SH |
| 16 | ALPHA COGNITION INC | ACOG | 02074J501 | $13.5M | 1.78% | 2,070,784 | SH |
| 17 | ANNEXON INC | ANNX | 03589W102 | $13.1M | 1.72% | 2,600,000 | SH |
| 18 | EDGEWISE THERAPEUTICS INC | EWTX | 28036F105 | $12.4M | 1.64% | 500,000 | SH |
| 19 | CODEXIS INC | CDXS | 192005106 | $11.1M | 1.46% | 6,789,738 | SH |
| 20 | PROTAGONIST THERAPEUTICS INC | PTGX | 74366E102 | $9.2M | 1.21% | 105,000 | SH |
| 21 | GOSSAMER BIO INC | GOSS | 38341P102 | $8.4M | 1.11% | 2,720,000 | SH |
| 22 | MBX BIOSCIENCES INC | MBX | 55287L101 | $8.2M | 1.08% | 260,000 | SH |
| 23 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $8.0M | 1.05% | 100,000 | SH |
| 24 | XOMA CORP DEL | XOMA | 98419J206 | $7.8M | 1.03% | 292,590 | SH |
| 25 | JOURNEY MEDICAL CORP | DERM | 48115J109 | $7.5M | 0.99% | 975,000 | SH |
| 26 | KARYOPHARM THERAPEUTICS INC | KPTI | 48576U205 | $6.8M | 0.90% | 930,000 | SH |
| 27 | JADE BIOSCIENCES INC | JBIO | 008064206 | $6.6M | 0.87% | 427,608 | SH |
| 28 | UROGEN PHARMA LTD | URGN | M96088105 | $6.3M | 0.83% | 268,423 | SH |
| 29 | ALUMIS INC | ALMS | 022307102 | $5.2M | 0.69% | 535,000 | SH |
| 30 | PERSPECTIVE THERAPEUTICS INC | CATX | 46489V302 | $5.0M | 0.66% | 1,184,500 | SH |
| 31 | VOYAGER THERAPEUTICS INC | VYGR | 92915B106 | $4.7M | 0.62% | 1,196,904 | SH |
| 32 | RELMADA THERAPEUTICS INC | RLMD | 75955J402 | $4.5M | 0.60% | 935,000 | SH |
| 33 | TECTONIC THERAPEUTICS INC | TECX | 878972108 | $4.5M | 0.59% | 214,747 | SH |
| 34 | PROTALIX BIOTHERAPEUTICS INC | PLX | 74365A309 | $4.5M | 0.59% | 2,478,176 | SH |
| 35 | TREVI THERAPEUTICS INC | TRVI | 89532M101 | $4.3M | 0.57% | 345,100 | SH |
| 36 | FORTRESS BIOTECH INC | FBIO | 34960Q307 | $4.0M | 0.53% | 1,090,000 | SH |
| 37 | ROCKET PHARMACEUTICALS INC | RCKT | 77313F106 | $3.4M | 0.44% | 955,000 | SH |
| 38 | MEIRAGTX HOLDINGS PLC | MGTX | G59665102 | $3.1M | 0.41% | 390,844 | SH |
| 39 | RIGEL PHARMACEUTICALS INC | RIGL | 766559702 | $3.0M | 0.40% | 70,000 | SH |
| 40 | ZYMEWORKS INC | ZYME | 98985Y108 | $2.9M | 0.38% | 108,929 | SH |
| 41 | ASSERTIO HOLDINGS INC | ASRT | 04546C205 | $2.6M | 0.34% | 285,000 | SH |
| 42 | VENTYX BIOSCIENCES INC | VTYX | 92332V107 | $2.3M | 0.30% | 251,932 | SH |
| 43 | OPUS GENETICS INC | IRD | 67577R102 | $2.3M | 0.30% | 1,120,000 | SH |
| 44 | SUTRO BIOPHARMA INC | STRO | 869367201 | $2.2M | 0.29% | 190,671 | SH |
| 45 | CABALETTA BIO INC | CABA | 12674W109 | $2.0M | 0.26% | 900,000 | SH |
| 46 | ZENTALIS PHARMACEUTICALS INC | ZNTL | 98943L107 | $1.9M | 0.25% | 1,400,906 | SH |
| 47 | GENERATION BIO CO | GBIO | 37148K209 | $1.8M | 0.23% | 310,000 | SH |
| 48 | BRIDGEBIO PHARMA INC | BBIO | 10806X102 | $1.4M | 0.18% | 18,319 | SH |
| 49 | ENANTA PHARMACEUTICALS INC | ENTA | 29251M106 | $1.2M | 0.16% | 75,000 | SH |
| 50 | Q32 BIO INC | QTTB | 746964105 | $708.4K | 0.09% | 213,363 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2025-12-31 | 2026-04-13 | $757.9M | 54 | 0001493152-26-016299 |
| 2025-12-31 | 2026-02-17 | $758.0M | 54 | 0001493152-26-007085 |