Omega Fund Management, LLC — 13F Holdings & Portfolio

CIK 1637359 · latest 13F-HR filed 2026-08-14

Omega Fund Management, LLC manages $185.7M in 13F-reported U.S. long-equity assets across 10 reported positions as of its 2026-06-30 13F-HR filing. Its largest disclosed positions are BCAX (29.14%), NUVB (24.72%), KMTS (14.00%). Quarter over quarter (versus its 2026-03-31 filing) the fund opened 1 new position, exited 1, added to 7, and trimmed 2.

AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.

Filer Information
Address
888 BOYLSTON ST., SUITE 1111
BOSTON, MA 02199
Phone
(617) 502-6538
Filing Manager
Omega Fund Management, LLC
Boston, MA
Signatory
Eric Cooper
Chief Financial Officer, Omega Fund Management, LLC
Loading holdings…
AUM

$185.7M

Long-equity book

Holdings

10

Distinct positions

Period

2026-06-30

Filed 2026-08-14

Q/Q Activity

+1 / −1 / ↑7 / ↓2

vs 2026-03-31

Firm Profile & Key People
Name Title / Status Ownership Type

Top Adds (vs prior quarter)

  • Nuvation Bio Inc.$11.2M +32.4%
  • Beta Bionics Inc.$7.4M +56.4%
  • Bicara Therapeutics Inc.$6.5M +13.7%
  • Kestra Med Technologies Ltd$5.6M +27.6%
  • Alumis Inc.$1.5M +27.7%
Show all 7

Top Trims

  • enGene Holdings Inc.-$4.5M -74.6%
  • BridgeBio Oncology Therapeutics Inc.-$4.4M -14.9%
Show all 2

New Positions

  • Odyssey Therapeutics Inc.$54.1K
Show all 1

Exited Positions

  • Replimune Group$1.9M
Show all 1
All Holdings

Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).

# Issuer Symbol CUSIP Value Weight Shares Type
1 Bicara Therapeutics Inc. BCAX 055477103 $54.1M 29.14% 1,822,150 SH
2 Nuvation Bio Inc. NUVB 67080N101 $45.9M 24.72% 8,081,089 SH
3 Kestra Med Technologies Ltd KMTS G52441105 $26.0M 14.00% 1,022,149 SH
4 BridgeBio Oncology Therapeutics Inc. BBOT 107924102 $25.1M 13.50% 3,289,661 SH
5 Beta Bionics Inc. BBNX 08659B102 $20.6M 11.11% 1,316,183 SH
6 Alumis Inc. ALMS 022307102 $6.8M 3.66% 241,255 SH
7 Sana Biotechnology, Inc. SANA 799566104 $2.9M 1.59% 843,750 SH
8 ImageneBio, Inc. IMA 45175G207 $2.7M 1.45% 455,361 SH
9 enGene Holdings Inc. ENGNW 29286M105 $1.5M 0.82% 876,357 SH
10 Odyssey Therapeutics Inc. ODTX 67613T104 $54.1K 0.03% 2,893 SH
Filing History
Period Filed AUM Holdings Accession
2026-06-30 2026-08-14 $185.7M 10 0001193125-26-350681
2026-03-31 2026-05-15 $163.1M 10 0001193125-26-225480
2025-12-31 2026-02-17 $286.5M 11 0001193125-26-053268
2025-09-30 2025-11-14 $222.4M 12 0001193125-25-281790