LABU vs SBIO
Direxion Daily S&P Biotech Bull 3X ETF against ALPS Medical Breakthroughs ETF: cost, size, returns, what they hold and how much of it is the same.
Overlap by weight
17%
44 shared positions
Fee gap
—
same fee
1-year return gap
88.3 pts
LABU is ahead
Larger fund
LABU
$553M
Side by side
| LABU | SBIO | |
|---|---|---|
| Fund | Direxion Daily S&P Biotech Bull 3X ETF | ALPS Medical Breakthroughs ETF |
| Issuer | Direxion | ALPS |
| Category | Leveraged Equity | Biotech & Health Innovation |
| Expense ratio | — | 0.50% |
| Assets | $553M | $200M |
| Average daily dollar volume | $105M | $2.6M |
| Listed | May 28, 2015 | Dec 30, 2014 |
| FrenzyCap score | 84 | 57 |
| 1-month return | −8.6% | −13.7% |
| 3-month return | −10.9% | −15.8% |
| Year to date | +52.5% | +7.5% |
| 1-year return | +123.0% | +34.6% |
| 30-day volatility | 81.8% | 28.1% |
| Worst drawdown, 1 year | −34.7% | −23.8% |
| Trailing 12-month yield | 0.37% | — |
| Holdings | 173 | 89 |
| Top 10 weight | 248.9% | 34.8% |
| Look-through P/E | — | — |
| Holdings vs fair value | +5.8% | +12.5% |
| Holdings above 200-day average | 62% | 43% |
| Net flow, latest 3 reported months | −$198M thru Jul 2026 | +$17M thru May 2026 |
| 30-day implied volatility | 94.0% | 37.3% |
| Holdings as of | as of Oct 9, 2026issuer data | as of May 31, 2026SEC filing |
Returns are price returns and exclude distributions. Flows are each fund's own latest reported months and may not cover the same period.
Largest shared holdings
17% of LABU · 65% of SBIO| Holding | LABU | SBIO |
|---|---|---|
| SYRE | 1.09% | 3.68% |
| ALKS | 1.04% | 4.48% |
| ORKA | 1.00% | 1.80% |
| KYMR | 0.94% | 4.24% |
| TVTX | 0.93% | 2.77% |
| DNTH | 0.91% | 2.63% |
| MIRM | 0.80% | 3.90% |
| CGON | 0.78% | 3.35% |
| VKTX | 0.76% | 2.41% |
| RLAY | 0.68% | 1.60% |
| CELC | 0.65% | 3.92% |
| IDYA | 0.46% | 1.65% |
| DNLI | 0.46% | 2.13% |
| VERA | 0.44% | 1.61% |
| AGIO | 0.44% | 1.10% |
| SRPT | 0.43% | 1.20% |
| NVAX | 0.41% | 1.14% |
| ACAD | 0.39% | 2.35% |
| PVLA | 0.38% | 1.03% |
| CLDX | 0.38% | 1.33% |
| VCEL | 0.35% | 1.08% |
| IRON | 0.35% | 1.69% |
| MLYS | 0.26% | 1.59% |
| XNCR | 0.26% | 0.56% |
| STOK | 0.25% | 1.13% |
Sector mix of the stock holdings
| Sector | LABU | SBIO | Gap |
|---|---|---|---|
| Health Care | 77.2% | 100.0% | −22.8% |
| Financials | 0.5% | 0.0% | +0.5% |
More: full overlap table · LABU holdings · SBIO holdings
Fund data comes from each fund's SEC filings and issuer disclosures and is shown with the date it is as of. SEC portfolio and flow filings become public about 60 days after the period they cover. Nothing here is investment advice; see Terms.