Biotech & Health Innovation ETFs
26 US-listed ETFs in the Biotech & Health Innovation category, from 18 issuers, with $31.6B in assets. The largest is iShares Biotechnology ETF (IBB) at $10.8B. The cheapest with at least $50M in assets is IBBQ at 0.19%. The median fund charges 0.50%.
Funds
26
18 issuers
Assets
$31.6B
Median fee
0.50%
0.19% to 0.75%
Median 1-year return
+35.7%
price return
Net flows, May 2026
−$487M
from SEC filings
Best 1-year return
+69.9%
IDNA, $50M+ in assets
Net flows by month
through Jul 2026SEC filingsNet creations across these funds as reported in SEC filings. The most recent months only include funds that have filed for them; funds whose filing covers other share classes are left out.
View as a table
| Month | Creations | Redemptions | Net flow | Funds reporting |
|---|---|---|---|---|
| Jul 2026 | $246M | $254M | −$7.5M | 7 partial |
| Jun 2026 | $5.2B | $3.9B | +$1.3B | 19 partial |
| May 2026 | $3.4B | $3.9B | −$487M | 24 |
| Apr 2026 | $4.7B | $4.0B | +$704M | 22 |
| Mar 2026 | $4.1B | $5.2B | −$1.1B | 22 |
| Feb 2026 | $4.4B | $4.8B | −$362M | 22 |
| Jan 2026 | $5.1B | $3.8B | +$1.3B | 22 |
| Dec 2025 | $3.8B | $4.4B | −$650M | 22 |
| Nov 2025 | $6.6B | $4.3B | +$2.3B | 22 |
| Oct 2025 | $4.2B | $3.8B | +$413M | 22 |
| Sep 2025 | $2.5B | $2.3B | +$168M | 22 |
| Aug 2025 | $2.3B | $2.5B | −$178M | 22 |
| Jul 2025 | $1.9B | $2.5B | −$547M | 22 |
| Jun 2025 | $2.4B | $2.6B | −$202M | 22 |
| May 2025 | $2.4B | $2.9B | −$462M | 22 |
| Apr 2025 | $2.3B | $2.9B | −$534M | 22 |
| Mar 2025 | $1.8B | $2.4B | −$571M | 22 |
| Feb 2025 | $1.4B | $1.6B | −$194M | 22 |
| Jan 2025 | $2.0B | $2.4B | −$326M | 22 |
| Dec 2024 | $2.1B | $2.7B | −$544M | 22 |
| Nov 2024 | $3.0B | $3.6B | −$605M | 22 |
| Oct 2024 | $2.2B | $2.8B | −$682M | 22 |
| Sep 2024 | $2.1B | $2.5B | −$456M | 21 |
| Aug 2024 | $1.7B | $1.9B | −$250M | 21 |
| Jul 2024 | $2.2B | $2.2B | +$46M | 21 |
| Jun 2024 | $2.5B | $2.4B | +$113M | 21 |
| May 2024 | $2.3B | $2.7B | −$384M | 21 |
| Apr 2024 | $2.3B | $2.9B | −$607M | 20 |
| Mar 2024 | $3.2B | $3.4B | −$180M | 20 |
| Feb 2024 | $2.6B | $2.0B | +$575M | 20 |
| Jan 2024 | $2.4B | $3.1B | −$702M | 20 |
| Dec 2023 | $2.2B | $2.3B | −$52M | 20 |
| Nov 2023 | $2.2B | $2.2B | −$36M | 20 |
| Oct 2023 | $1.9B | $2.1B | −$183M | 20 |
| Sep 2023 | $1.3B | $1.8B | −$512M | 20 |
| Aug 2023 | $1.3B | $1.6B | −$341M | 20 |
All Biotech & Health Innovation ETFs
| # | Fund | Issuer | Fee | Assets | YTD | 1Y | Yield | 3M flow | Score | Holdings as of |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | IBBiShares Biotechnology ETF | iShares | 0.44% | $10.8B | +22.4% | +35.9% | 0.17% | −$43M | 83 | Oct 8, 2026 issuer |
| 2 | XBIState Street SPDR S&P Biotech ETF | State Street SPDR | 0.35% | $9.9B | +26.1% | +45.8% | 0.35% | +$1.3B | 96 | Oct 8, 2026 issuer |
| 3 | IHIiShares U.S. Medical Devices ETF | iShares | 0.37% | $3.6B | −16.8% | −14.4% | 0.51% | +$96M | 79 | Oct 8, 2026 issuer |
| 4 | FBTFirst Trust NYSE Arca Biotechnology Index Fund | First Trust | 0.55% | $2.9B | +28.5% | +41.3% | — | +$2.5M | 67 | Jun 30, 2026 SEC |
| 5 | ARKGARK Genomic Revolution ETFActive | ARK | 0.75% | $2.1B | +77.1% | +59.7% | — | −$3.3M | 57 | Oct 9, 2026 issuer |
| 6 | BBHVanEck Biotech ETF | VanEck | 0.35% | $485M | +27.1% | +36.9% | 0.40% | −$5.5M | 63 | Oct 8, 2026 issuer |
| 7 | PBEInvesco Biotechnology & Genome ETF | Invesco | 0.58% | $422M | +17.9% | +34.5% | 1.38% | +$5.9M | 49 | Oct 8, 2026 issuer |
| 8 | IDNAiShares Genomics Immunology and Healthcare ETF | iShares | 0.47% | $320M | +61.0% | +69.9% | 0.67% | +$15M | 61 | Oct 8, 2026 issuer |
| 9 | CANCTema Oncology ETFActive | Tema | 0.75% | $203M | +17.5% | +36.2% | 0.05% | +$14M | 36 | May 31, 2026 SEC |
| 10 | SBIOALPS Medical Breakthroughs ETF | ALPS | 0.50% | $200M | +7.5% | +34.6% | — | +$17M | 57 | May 31, 2026 SEC |
| 11 | BBPVirtus Biotech ETF | Virtus | 0.34% | $131M | +31.1% | +45.2% | — | +$32M | 66 | Apr 30, 2026 SEC |
| 12 | LFSCF/m Emerald Life Sciences Innovation ETF | F/m Investments | 0.54% | $118M | +16.4% | +41.1% | — | +$1.2M | 36 | May 31, 2026 SEC |
| 13 | IBBQInvesco Nasdaq Biotechnology ETF | Invesco | 0.19% | $106M | +21.9% | +35.5% | 1.13% | −$7.6M | 62 | Oct 8, 2026 issuer |
| 14 | GNOMGlobal X Genomics & Biotechnology ETF | Global X | 0.50% | $101M | +51.2% | +63.4% | 0.94% | +$1.4M | 50 | Oct 9, 2026 issuer |
| 15 | HTECROBO Global Healthcare Technology and Innovation ETF | ROBO | 0.68% | $74M | +21.8% | +33.4% | 0.81% | +$7.6M | 43 | Apr 30, 2026 SEC |
| 16 | OZEMRoundhill GLP-1 & Weight Loss ETFActive | Roundhill | 0.59% | $55M | −13.3% | +1.4% | 1.39% | +$286K | 33 | Jun 30, 2026 SEC |
| 17 | BBCVirtus Biotech Clinical Trials ETF | Virtus | 0.65% | $42M | +14.5% | +52.3% | 1.49% | +$5.1M | 44 | Apr 30, 2026 SEC |
| 18 | HELXFranklin Genomic Advancements ETFActive | Franklin Templeton | 0.50% | $32M | +17.4% | +29.2% | 0.34% | +$2.0M | 42 | Jun 30, 2026 SEC |
| 19 | IBRNiShares Neuroscience and Healthcare ETF | iShares | 0.47% | $6.4M | −1.8% | +13.3% | 1.01% | $0 | 37 | Oct 8, 2026 issuer |
| 20 | WDNAWisdomTree BioRevolution Fund | WisdomTree | 0.45% | $4.7M | +39.3% | +34.4% | 3.28% | $0 | 41 | Jun 30, 2026 SEC |
| 21 | EKGFirst Trust Nasdaq Lux Digital Health Solutions ETF | First Trust | 0.65% | $4.7M | +23.3% | +29.9% | — | $0 | 24 | Jun 30, 2026 SEC |
| 22 | MDEVFirst Trust Indxx Medical Devices ETF | First Trust | 0.70% | $3.1M | −0.5% | +1.3% | 0.10% | $0 | 22 | Jun 30, 2026 SEC |
| 23 | GNMXCorgi Genomics & Precision Medicine ETF | Corgi | 0.35% | — | — | — | — | +$1.3M | 51 | — |
| 24 | PBPHPortfolio Building Block World Pharma and Biotech Index ETF | Portfolio | — | — | +12.3% | — | 0.08% | — | — | — |
| 25 | TDNAT. Rowe Price Biotech ETFActive | T. Rowe Price | — | — | — | — | — | — | — | — |
| 26 | YUNGCorgi Longevity Consumer ETF | Corgi | — | — | — | — | — | +$1.3M | — | — |
Sorted by assets; click a column to re-sort. 3M flow is each fund's latest three reported months. Returns are price returns and exclude distributions.
Other Thematic categories
Semiconductors34Metals & Mining32AI & Robotics69Infrastructure35Aerospace & Defense38Internet & Innovation75Clean Energy & Climate51Cybersecurity8MLPs & Midstream14Software & Cloud12Natural Resources & Agriculture25Nuclear & Uranium10Quantum Computing6EVs & Batteries19Homebuilders & Housing3Fintech & Blockchain22Travel & Leisure4Cannabis6Gaming & Betting9IPOs & Special Situations3Consumer Trends6Thematic (Other)2
Fund data comes from each fund's SEC filings and issuer disclosures and is shown with the date it is as of. SEC portfolio and flow filings become public about 60 days after the period they cover. Nothing here is investment advice; see Terms.