OPK · Insider Trading
Opko Health Inc.
Every open-market purchase and sale reported by OPK officers, directors and 10%+ beneficial owners on SEC Form 4, which must be filed within two business days of the transaction. Sales often reflect scheduled 10b5-1 plans or tax withholding rather than a directional view, so read counts alongside the size and the filer.
| Filed | Insider | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| 2026-11-05 | John A Paganelli | Director | Sell | −13,601 | −$24.58K |
| 2026-07-28 | Steven D Rubin | Executive VP-Administration | F | −53,266 | −$64.98K |
| 2026-07-28 | Adam Logal | Sr. Vice President, CFO | F | −53,266 | −$64.98K |
| 2026-06-22 | John A Paganelli | Director | A | +30,000 deriv. | — |
| 2026-06-22 | Roger Md Medel | Director | A | +30,000 deriv. | — |
| 2026-06-22 | Alice Lin-Tsing Yu | Director | A | +30,000 deriv. | — |
| 2026-06-22 | Subbarao V Uppaluri | Director | A | +80,000 deriv. | — |
| 2026-06-22 | Prem A Lachman | Director | A | +30,000 deriv. | — |
| 2026-06-22 | Richard C Pfenniger Jr | Director | A | +60,000 deriv. | — |
| 2026-03-20 | Subbarao V Uppaluri | Director | A | +50,000 deriv. | — |
| 2026-03-20 | John A Paganelli | Director | Buy | +10,000 | +$11.35K |
| 2025-11-21 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +580,000 | +$768.81K |
| 2025-11-20 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +580,000 | +$771.33K |
| 2025-11-19 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +580,000 | +$759.12K |
| 2025-11-18 | Phillip Md Et Al Frost | CEO & Chairman | MIXED | +580,000 | +$737.75K |
| 2025-10-31 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +150,000 | +$213.44K |
| 2025-08-19 | Frost Gamma Investments Trust | 10%+ Owner | G | −440,000 | — |
| 2025-08-08 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +675,000 | +$891.00K |
| 2025-05-29 | Adam Logal | Sr. Vice President, CFO | A | +437,500 deriv. | — |
| 2025-05-29 | Phillip Md Et Al Frost | CEO & Chairman | A | +500,000 deriv. | — |
| 2025-05-29 | Jane Ph D Hsiao | Vice Chairman & CTO | A | +500,000 deriv. | — |
| 2025-05-29 | Gary J. Nabel | Chief Innovation Officer | A | +437,500 deriv. | — |
| 2025-05-29 | Elias A. Zerhouni | Vice Chairman and President | A | +500,000 deriv. | — |
| 2025-05-29 | Steven D Rubin | Executive VP-Administration | A | +437,500 deriv. | — |
| 2025-04-23 | Roger Md Medel | Director | A | +30,000 deriv. | — |
| 2025-04-23 | Richard M Krasno | Director | A | +30,000 deriv. | — |
| 2025-04-23 | Alice Lin-Tsing Yu | Director | A | +30,000 deriv. | — |
| 2025-04-23 | John A Paganelli | Director | A | +30,000 deriv. | — |
| 2025-04-23 | Richard C Pfenniger Jr | Director | A | +60,000 deriv. | — |
| 2025-04-23 | Prem A Lachman | Director | A | +30,000 deriv. | — |
| 2025-04-10 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +125,000 | +$169.71K |
| 2025-04-08 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +125,000 | +$184.65K |
| 2025-04-01 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +100,000 | +$164.85K |
| 2025-03-28 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +150,000 | +$254.38K |
| 2025-03-17 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +200,000 | +$347.82K |
| 2025-03-04 | Frost Gamma Investments Trust | 10%+ Owner | Buy | — | — |
| 2025-03-03 | Phillip Md Et Al Frost | CEO & Chairman | Buy | — | — |
| 2025-02-28 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +67,434 | +$115.31K |
| 2025-01-28 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +47,537 | +$70.06K |
| 2025-01-17 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +150,000 | +$220.43K |
| 2025-01-15 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +500,000 | +$740.85K |
| 2024-12-13 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +125,000 | +$199.38K |
| 2024-12-11 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +500,000 | +$781.05K |
| 2024-11-29 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +199,072 | +$305.38K |
| 2024-11-22 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +100,000 | +$159.00K |
| 2024-11-20 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +280,183 | +$421.54K |
| 2024-11-14 | Frost Gamma Investments Trust | 10%+ Owner | Buy | +100,000 | +$161.98K |
| 2024-11-08 | Phillip Md Et Al Frost | CEO & Chairman | Buy | +280,183 | +$421.54K |
| 2024-09-27 | Frost Gamma Investments Trust | 10%+ Owner | Buy | — | — |
| 2024-09-27 | Phillip Md Et Al Frost | CEO & Chairman | Buy | — | — |
| Insider | Role | Shares Held | Value |
|---|---|---|---|
| Frost Gamma Investments Trust | 10%+ Owner | 219,801,664 | $386.85M |
| Phillip Md Et Al Frost | CEO & Chairman | 33,696,128 | $59.31M |
| Jane Ph D Hsiao | Vice Chairman & CTO | 33,627,284 | $59.18M |
| Steven D Rubin | Executive VP-Administration | 26,663,028 | $46.93M |
| Elias A. Zerhouni | Vice Chairman and President | 20,367,114 | $35.85M |
| Subbarao V Uppaluri | Sr Vice President - CFO | 3,984,869 | $7.01M |
| Gary J. Nabel | Chief Innovation Officer | 1,052,021 | $1.85M |
| Adam Logal | Sr. Vice President, CFO | 563,396 | $991.58K |
| John A Paganelli | Director | 389,914 | $686.25K |
| Richard C Pfenniger Jr | Director | 325,000 | $572.00K |
| Richard M Krasno | Director | 103,333 | $181.87K |
| Alice Lin-Tsing Yu | Director | 100,000 | $176.00K |
Form 4 reports a change in beneficial ownership by an officer, director or 10%+ holder, and must be filed within two business days of the transaction — so this is close to real time, unlike the 45-day-lagged 13F institutional data.
Transaction codes matter more than the raw buy/sell count. Code P is an open-market purchase — an insider choosing to buy with their own money, which is the signal most research treats as informative. Code S is a sale, but sales are frequently pre-scheduled under a 10b5-1 plan or cover tax withholding on vesting equity, so a run of sales often says nothing directional. Codes A and M are grants and option exercises rather than open-market decisions.
Full filing history and per-insider positions are on the OPK quote page; the site-wide leaderboard is on the insider transactions hub.
Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.