ETFs most similar to XBI
The funds whose holdings overlap State Street SPDR S&P Biotech ETF the most, by weight. as of Oct 8, 2026issuer data
By holdings overlap
| Fund | Category | Overlap with XBI | Fee | Assets | 1Y | Yield | Compare |
|---|---|---|---|---|---|---|---|
| XBIState Street SPDR S&P Biotech ETF | Biotech & Health Innovation | — | 0.35% | $9.9B | +45.8% | 0.35% | |
| LABUDirexion Daily S&P Biotech Bull 3X ETF | Leveraged Equity | 78% | — | $553M | +123.0% | 0.37% | side by side |
| IBBiShares Biotechnology ETF | Biotech & Health Innovation | 44% | 0.44% | $10.8B | +35.9% | 0.17% | side by side |
| IBBQInvesco Nasdaq Biotechnology ETF | Biotech & Health Innovation | 43% | 0.19% | $106M | +35.5% | 1.13% | side by side |
| BBPVirtus Biotech ETF | Biotech & Health Innovation | 42% | 0.34% | $131M | +45.2% | — | side by side |
| BBCVirtus Biotech Clinical Trials ETF | Biotech & Health Innovation | 35% | 0.65% | $42M | +52.3% | 1.49% | side by side |
Overlap is the sum of the smaller of the two weights across every shared holding. Try any combination in the overlap tool.
Fund data comes from each fund's SEC filings and issuer disclosures and is shown with the date it is as of. SEC portfolio and flow filings become public about 60 days after the period they cover. Nothing here is investment advice; see Terms.