BBC vs SBIO
Virtus Biotech Clinical Trials ETF against ALPS Medical Breakthroughs ETF: cost, size, returns, what they hold and how much of it is the same.
Overlap by weight
30%
43 shared positions
Fee gap
15 bp
SBIO is cheaper
1-year return gap
17.7 pts
BBC is ahead
Larger fund
SBIO
$200M
Side by side
| BBC | SBIO | |
|---|---|---|
| Fund | Virtus Biotech Clinical Trials ETF | ALPS Medical Breakthroughs ETF |
| Issuer | Virtus | ALPS |
| Category | Biotech & Health Innovation | Biotech & Health Innovation |
| Expense ratio | 0.65% | 0.50% |
| Assets | $42M | $200M |
| Average daily dollar volume | $866K | $2.6M |
| Listed | Dec 16, 2014 | Dec 30, 2014 |
| FrenzyCap score | 44 | 57 |
| 1-month return | −11.6% | −13.7% |
| 3-month return | −14.0% | −15.8% |
| Year to date | +14.5% | +7.5% |
| 1-year return | +52.3% | +34.6% |
| 30-day volatility | 32.2% | 28.1% |
| Worst drawdown, 1 year | −22.8% | −23.8% |
| Trailing 12-month yield | 1.49% | — |
| Holdings | 125 | 89 |
| Top 10 weight | 16.2% | 34.8% |
| Look-through P/E | — | — |
| Holdings vs fair value | +16.7% | +12.5% |
| Holdings above 200-day average | 46% | 43% |
| Net flow, latest 3 reported months | +$5.1M thru Jul 2026 | +$17M thru May 2026 |
| 30-day implied volatility | 43.3% | 37.3% |
| Holdings as of | as of Apr 30, 2026SEC filing | as of May 31, 2026SEC filing |
Returns are price returns and exclude distributions. Flows are each fund's own latest reported months and may not cover the same period.
Largest shared holdings
35% of BBC · 61% of SBIO| Holding | BBC | SBIO |
|---|---|---|
| ORKA | 1.68% | 1.80% |
| SYRE | 1.64% | 3.68% |
| DNTH | 1.54% | 2.63% |
| CGON | 1.21% | 3.35% |
| RLAY | 1.19% | 1.60% |
| TYRA | 1.14% | 1.15% |
| EWTX | 0.97% | 2.33% |
| PVLA | 0.96% | 1.03% |
| XENE | 0.94% | 2.90% |
| AMLX | 0.90% | 1.01% |
| CLDX | 0.88% | 1.33% |
| BCAX | 0.86% | 0.88% |
| AVBP | 0.94% | 0.85% |
| CELC | 0.85% | 3.92% |
| MLTX | 0.82% | 0.88% |
| TSHA | 0.82% | 1.02% |
| RAPP | 0.81% | 1.20% |
| APGE | 0.80% | 2.93% |
| DNLI | 0.77% | 2.13% |
| MBX | 0.75% | 0.90% |
| STOK | 0.75% | 1.13% |
| SION | 0.67% | 1.23% |
| KYMR | 0.67% | 4.24% |
| CRVS | 1.34% | 0.66% |
| IDYA | 0.63% | 1.65% |
Sector mix of the stock holdings
| Sector | BBC | SBIO | Gap |
|---|---|---|---|
| Health Care | 92.6% | 100.0% | −7.5% |
| Technology | 0.6% | 0.0% | +0.6% |
More: full overlap table · BBC holdings · SBIO holdings
Fund data comes from each fund's SEC filings and issuer disclosures and is shown with the date it is as of. SEC portfolio and flow filings become public about 60 days after the period they cover. Nothing here is investment advice; see Terms.