DAFNA Capital Management LLC — 13F Holdings & Portfolio
CIK 1389933 · latest 13F-HR filed 2026-05-15
DAFNA Capital Management LLC manages $439.6M in 13F-reported U.S. long-equity assets across 83 reported positions as of its 2026-03-31 13F-HR filing. Its largest disclosed positions are RVMD (12.85%), XBI (9.25%), STXS (5.73%). Quarter over quarter (versus its 2025-12-31 filing) the fund opened 10 new positions, exited 4, added to 23, and trimmed 42.
AUM is the long-equity portion reported on Form 13F-HR. Excludes short positions, cash, foreign holdings, and non-13F assets. For informational purposes only — not investment advice.
$439.6M
Long-equity book
83
Distinct positions
2026-03-31
Filed 2026-05-15
+10 / −4 / ↑23 / ↓42
vs 2025-12-31
| Name | Title / Status | Ownership | Type |
|---|
Top Adds (vs prior quarter)
- DAY ONE BIOPHARMACEUTICALS I$11.7M +125.3%
- NEKTAR THERAPEUTICS$8.7M +274.8%
- REVOLUTION MEDICINES INC$8.3M +17.3%
- COMPASS PATHWAYS PLC$7.8M +139.0%
- LARIMAR THERAPEUTICS INC$5.6M +155.2%
Top Trims
- CYTOKINETICS INC-$9.2M -39.2%
- AXOGEN INC-$7.3M -46.9%
- ATRICURE INC-$6.6M -27.9%
- STEREOTAXIS INC-$6.3M -20.0%
- BIOHAVEN LTD-$3.6M -33.7%
New Positions
- FULCRUM THERAPEUTICS INC$1.6M
- ORTHOPEDIATRICS CORP$1.5M
- CYTOMX THERAPEUTICS INC$1.1M
- MAZE THERAPEUTICS INC$1.0M
- SCYNEXIS INC$996.6K
Exited Positions
- ASTRIA THERAPEUTICS INC$4.0M
- ERASCA INC$946.5K
- BRAINSWAY LTD$246.6K
- PERSPECTIVE THERAPEUTICS INC$137.5K
Rows tagged Call or Put are options positions, not stock. Per SEC Form 13F-HR, Value shows the notional value of the underlying (shares covered × underlying price), not the option premium. Shares is the number of underlying shares covered (divide by 100 for contract count).
| # | Issuer | Symbol | CUSIP | Value | Weight | Shares | Type |
|---|---|---|---|---|---|---|---|
| 1 | REVOLUTION MEDICINES INC | RVMD | 76155X100 | $56.5M | 12.85% | 580,678 | SH |
| 2 | SPDR S&P BIOTECH ETF | XBI | 78464A870 | $40.7M | 9.25% | 318,505 | SH |
| 3 | STEREOTAXIS INC | STXS | 85916J409 | $25.2M | 5.73% | 13,680,554 | SH |
| 4 | DAY ONE BIOPHARMACEUTICALS I | DAWN | 23954D109 | $21.0M | 4.77% | 978,463 | SH |
| 5 | ATRICURE INC | ATRC | 04963C209 | $17.0M | 3.88% | 597,431 | SH |
| 6 | IDEAYA BIOSCIENCES INC | IDYA | 45166A102 | $15.9M | 3.61% | 476,740 | SH |
| 7 | XENON PHARMACEUTICALS INC | XENE | 98420N105 | $14.6M | 3.32% | 250,772 | SH |
| 8 | CYTOKINETICS INC | CYTK | 23282W605 | $14.3M | 3.26% | 217,497 | SH |
| 9 | COMPASS PATHWAYS PLC | CMPS | 20451W101 | $13.4M | 3.04% | 2,418,882 | SH |
| 10 | NEKTAR THERAPEUTICS | NKTR | 640268306 | $11.9M | 2.70% | 165,178 | SH |
| 11 | ISHARES NASDAQ BIOTECH INDX | IBB | 464287556 | $10.5M | 2.39% | 62,095 | SH |
| 12 | ARCUS BIOSCIENCES INC | RCUS | 03969F109 | $9.6M | 2.18% | 443,829 | SH |
| 13 | NEUROCRINE BIOSCIENCES INC | NBIX | 64125C109 | $9.3M | 2.12% | 70,615 | SH |
| 14 | LARIMAR THERAPEUTICS INC | LRMR | 517125100 | $9.1M | 2.08% | 2,029,164 | SH |
| 15 | BICARA THERAPEUTICS INC | BCAX | 055477103 | $8.4M | 1.91% | 421,733 | SH |
| 16 | AXOGEN INC | AXGN | 05463X106 | $8.3M | 1.88% | 249,960 | SH |
| 17 | BIOHAVEN LTD | BHVN | G1110E107 | $7.2M | 1.63% | 845,735 | SH |
| 18 | TANDEM DIABETES CARE INC | TNDM | 875372203 | $6.8M | 1.55% | 355,208 | SH |
| 19 | DENALI THERAPEUTICS INC | DNLI | 24823R105 | $6.1M | 1.39% | 318,500 | SH |
| 20 | ASCENDIS PHARMA A/S | ASND | 04351PAD3 | $5.9M | 1.35% | 4,000,000 | PRN |
| 21 | CENTURY THERAPEUTICS INC | IPSC | 15673T100 | $5.5M | 1.25% | 2,434,353 | SH |
| 22 | DEXCOM INC | DXCM | 252131107 | $5.4M | 1.23% | 86,279 | SH |
| 23 | KALVISTA PHARMACEUTICALS INC | KALV | 483497103 | $5.4M | 1.22% | 267,402 | SH |
| 24 | ASCENDIS PHARMA A/S | ASND | 04351P101 | $5.3M | 1.21% | 23,177 | SH |
| 25 | MBX BIOSCIENCES INC | MBX | 55287L101 | $5.2M | 1.19% | 175,465 | SH |
| 26 | INOGEN INC | INGN | 45780L104 | $5.2M | 1.19% | 845,179 | SH |
| 27 | SYNDAX PHARMACEUTICALS INC | SNDX | 87164F105 | $5.1M | 1.16% | 217,355 | SH |
| 28 | ALKERMES PLC | ALKS | G01767105 | $4.9M | 1.12% | 139,482 | SH |
| 29 | STOKE THERAPEUTICS INC | STOK | 86150R107 | $4.3M | 0.97% | 130,875 | SH |
| 30 | BIOCRYST PHARMACEUTICALS INC | BCRX | 09058V103 | $4.1M | 0.93% | 430,248 | SH |
| 31 | GALAPAGOS NV | GLPG | 36315X101 | $3.9M | 0.89% | 130,175 | SH |
| 32 | IMMUNOVANT INC | IMVT | 45258J102 | $3.7M | 0.85% | 150,524 | SH |
| 33 | EDGEWISE THERAPEUTICS INC | EWTX | 28036F105 | $3.5M | 0.80% | 112,236 | SH |
| 34 | MAPLIGHT THERAPEUTICS INC | MPLT | 56565P103 | $3.5M | 0.79% | 171,006 | SH |
| 35 | ALLOGENE THERAPEUTICS INC | ALLO | 019770106 | $3.3M | 0.76% | 1,370,118 | SH |
| 36 | PROCEPT BIOROBOTICS CORP | PRCT | 74276L105 | $3.0M | 0.68% | 120,000 | SH |
| 37 | ALIGN TECHNOLOGY INC | ALGN | 016255101 | $2.6M | 0.58% | 15,000 | SH |
| 38 | PROQR THERAPEUTICS N V | PRQR | N71542109 | $2.5M | 0.58% | 1,567,561 | SH |
| 39 | CYBIN INC | HELP | 23256X407 | $2.4M | 0.54% | 498,361 | SH |
| 40 | RAPPORT THERAPEUTICS INC | RAPP | 75383L102 | $2.3M | 0.53% | 75,000 | SH |
| 41 | INSULET CORP | PODD | 45784P101 | $2.3M | 0.52% | 10,870 | SH |
| 42 | STRUCTURE THERAPEUTICS INC | GPCR | 86366E106 | $2.2M | 0.51% | 46,500 | SH |
| 43 | IMMATICS NV | IMTX | N44445109 | $2.2M | 0.51% | 225,860 | SH |
| 44 | CELLDEX THERAPEUTICS INC | CLDX | 15117B202 | $2.2M | 0.49% | 68,518 | SH |
| 45 | LEXEO THERAPEUTICS INC | LXEO | 52886X107 | $2.2M | 0.49% | 377,059 | SH |
| 46 | ALECTOR INC | ALEC | 014442107 | $2.0M | 0.44% | 908,351 | SH |
| 47 | VIKING THERAPEUTICS INC | VKTX | 92686J106 | $1.9M | 0.44% | 59,516 | SH |
| 48 | KURA ONCOLOGY INC | KURA | 50127T109 | $1.9M | 0.44% | 235,868 | SH |
| 49 | PROFOUND MEDICAL CORP | PROF | 74319B502 | $1.7M | 0.39% | 263,005 | SH |
| 50 | FULCRUM THERAPEUTICS INC | FULC | 359616109 | $1.6M | 0.36% | 205,000 | SH |
| Period | Filed | AUM | Holdings | Accession |
|---|---|---|---|---|
| 2026-03-31 | 2026-05-15 | $439.6M | 83 | 0001389933-26-000004 |
| 2025-12-31 | 2026-02-17 | $430.5M | 77 | 0001389933-26-000002 |
| 2025-09-30 | 2025-11-14 | $404.8M | 75 | 0001389933-25-000008 |