DSGN Design Therapeutics, Inc. Common Stock

XNAS 10.63 Delayed
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DSGN $10.63 —
Key stats
$10.63
52-Week Range
$5.73 – $17.25
YTD
+16.81%
IV Rank (30D)
31.55
Straddle Price
$3.80
P/C Vol Ratio
6.00
Market Cap
$0.6B
Open
$10.29
Day Range
$10.13 – $10.79
Volume
388,875
Prev Close
$10.34
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)4.96%
Beta vs SPY1.45
Cost of Equity (CAPM)12.96% (VRP-adj)
WACC13.15%
Volatility Risk Premium+88.0pp (IV − HV30), ERP adj +50bps
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)+3.0%
DCF Horizon5 years explicit + fade
Forward Tilt (NTM/TTM)×1.03 (applied to P/E, EV/EBITDA, P/S)
Free Cash Flow (TTM)$-0.1B
Return on Equity (TTM)-35.1%
Book / Price32.8% — banking bias active (P/B is primary)
Debt / Equity0.00
Quality Score1/6 — cyclical/struggling (5y DCF)
SMA 50$13.02 (Market Anchor value)
SMA 20 / Bollinger Mid$11.19
Bollinger Width / SMA20296.1% (drives anchor stability)
Net Debt$-0.0B
Market Cap$1B
Peers used for multiples: ACAD, ALKS, BIIB, DNTH, XENE (filtered from 8 ETF-co-members; sector bias active)
60-Day Conviction
80%
20-Day Fair Value
≈ by Nov 25, 2026
$10.73
α +0.9% rank 56%
conviction
55%
40-Day Fair Value
≈ by Dec 24, 2026
$10.97
α +3.2% rank 64%
conviction
90%
60-Day Fair Value
≈ by Jan 22, 2027
$10.95
α +3.0% rank 55%
conviction
80%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0% median 44.4× · 3 peers
Peer EV/EBITDA n/a 0% median 32.4× · 3 peers
Peer P/B $9.32 31% median 2.8× · 5 peers
Peer P/S n/a 0% median 4.0× · 4 peers
Market Anchor (SMA50) $13.02 0% stability 0% (BB-width)
Options Expected (B-L 30d) $10.04 69% 17 strikes · skew +0.14
As of 2026-10-27 · updated
About
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834) · industry map
Exchange
XNAS
Market Cap
$0.6B
Employees
55
List Date
2021-03-26
CIK
0001807120
Next Earnings
2026-11-04 (After-Close)
EPS Forecast
($0.38) (2 est.)
Headquarters
Carlsbad, CA
Homepage
https://www.designtx.com

Design Therapeutics Inc is a clinical-stage biopharmaceutical company pioneering the research and development of GeneTAC molecules, which are a novel class of small-molecule gene targeted chimera therapeutic candidates designed to be disease-modifying by addressing the underlying cause of diseases caused by inherited nucleotide repeat expansion mutations. Its pipeline includes Friedreich Ataxia, FECD, DM1, and Huntington's Disease. The company operates in one operating and reportable segment focused on utilizing the company's proprietary GeneTAC platform to design and develop therapeutic candi…

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
Month'21'22'23'24'25'26Avg
Jan---39.49%-19.65%-6.69%-21.39%12.20%-15.00%
Feb--6.26%-11.29%15.35%2.97%0.29%2.72%
Mar-27.93%15.36%-18.27%40.91%-14.60%4.01%-0.09%
Apr-11.83%-30.30%7.32%-12.44%34.81%23.52%1.85%
May-4.62%0.32%-20.25%11.88%-20.81%-21.20%-9.11%
Jun-23.85%11.64%16.02%-17.69%-16.17%38.60%1.42%
Jul-22.72%39.25%26.01%56.92%9.94%-15.06%15.72%
Aug-0.95%9.04%-67.79%-5.94%44.76%18.26%-0.44%
Sep-7.38%-21.94%-4.84%13.74%31.41%-16.97%-1.00%
Oct4.60%-4.46%-10.53%1.75%-1.33%-13.15%*-3.85%
Nov5.48%-7.71%18.81%15.38%43.36%--15.06%
Dec32.73%-26.50%5.58%-1.75%4.80%--2.97%
Total-52.08%-55.52%-74.92%136.81%91.80%14.37%10.07%
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $11.09
SMA 50: $12.93
SMA 200: $12.14
Current: $10.63
EMA 12: $10.71
EMA 26: $11.38
MACD: -0.6652 | Signal: 0.0619
BEARISH
ADX (14): 27.28
TREND
+DI: 20.14
−DI: 25.83

Momentum Oscillators

RSI (14): 40.97
NEUTRAL
Stoch %K: 35.29
Stoch %D: 32.13
Williams %R: -52.76

Volume & Volatility

BB Upper: $12.83
BB Lower: $9.34
NEUTRAL
OBV: -1,644,249
Vol SMA 20: 504,688
Vol ROC: -46.54%
ATR: $0.65
True Range: $0.66
HV 20: 62.8%
HV 30: 60.1%
HV 60: 55.0%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-10-29T00:00:00 – 2026-10-27T00:00:00
AI Analysis

Here is a comprehensive stock analysis report for DSGN:

Executive Summary

Overall Assessment: BULLISH (Confidence Level: 8/10)

Key Drivers:

  • Strong technical momentum, with MACD indicating bullish signals
  • Positive news sentiment from recent clinical trial data and investor events
  • Low risk profile due to relatively low volatility

Primary Risks:

  • High implied volatility, potentially indicative of market uncertainty
  • Beta above 1.2, suggesting high correlation with the broader market

Investment Thesis:

DSGN is a strong candidate for further upside potential, driven by its recent clinical trial data and investor events. The company's geneTAC platform shows promising results, and investors are increasingly optimistic about its prospects.

Recent News Sentiment Impact:

The positive news sentiment from recent headlines has contributed to the stock's upward momentum. Design Therapeutics' announcement of four-week IV data from the RESTORE-FA trial demonstrated clinical improvements and comprehensive biomarker activity in Friedreich Ataxia, which has boosted investor confidence.

Technical Analysis

Trend Direction: Short-term (1-4 weeks) - Uptrend, Medium-term (1-3 months) - Uptrend, Long-term (3-12 months) - Uptrend

Support/Resistance Levels:

  • Upper Bollinger Band: $16.59
  • Middle Line: $13.66
  • Lower Bollinger Band: $10.73

Momentum Signals:

  • RSI: 52.44 (neutral)
  • MACD: Bullish signal with a significant gap above the signal line
  • Bollinger Bands: Neutral signal, with price hovering near the middle band

Volume Analysis:

  • Volume SMA 20: 997066.50
  • On-Balance Volume (OBV): 11358817.44
  • Volume Rate of Change: -90.61%

News & Sentiment Analysis

Recent Headlines Summary:

  • Positive news headlines from clinical trial data and investor events, highlighting the company's progress in Friedreich Ataxia treatment

Sentiment Assessment:

  • Aggregate sentiment is positive, with 4 out of 6 recent news articles having a positive tone

Catalyst Identification:

  • Upcoming investor webcast to review RESTORE-FA trial data on May 18, 2026
  • Participation in upcoming investor conferences and RBC Capital Markets Global Healthcare Conference

Market Narrative:

The positive news sentiment has aligned with the technical signals, suggesting a strong upward momentum.

Risk & Volatility Assessment

Beta Interpretation:

  • Beta: 1.26 (high risk relative to market)

Volatility Regime:

  • Current volatility is high compared to historical levels

Options Market Signals:

  • IV Rank: 43.3% (medium)
  • Current IV: 171.2%
  • Expected Move: $5.25 (39 DTE), 7-DTE: $3.02
  • Volume Flow: 4 calls vs 3 puts
  • Open Interest: 4 calls vs 3 puts
  • Put/Call Volume Ratio: 0.75 (neutral sentiment)
  • Put/Call OI Ratio: 0.75

Downside Protection:

  • Support levels: $13.66 (SMA 20) and $12.76 (SMA 50)

Market Context & Positioning

Sector Performance:

  • Biotech sector is strong, with DSGN outperforming the broader market

Institutional Activity:

  • Volume patterns suggest institutional interest and potential accumulation

Correlation Analysis:

  • Correlation: 0.19 (low correlation with the broader market)

Relative Valuation:

  • Position within trading range: relatively undervalued compared to historical norms

Key Levels & Action Items

Critical Price Levels:

  • Upper Bollinger Band: $16.59
  • Middle Line: $13.66
  • Lower Bollinger Band: $10.73

Breakout/Breakdown Levels:

  • Breakout above $16.59 could trigger further upside momentum
  • Breakdown below $12.76 could indicate a reversal in trend

Time-Sensitive Catalysts:

  • Upcoming investor webcast on May 18, 2026
  • Participation in upcoming investor conferences and RBC Capital Markets Global Healthcare Conference

Risk Management:

  • Stop-loss levels: $13.66 (SMA 20) and $12.76 (SMA 50)
  • Position sizing considerations: consider reducing exposure during times of high volatility
Generated
Earnings History
14 of 14 under expected move
Avg Expected Move
35.22%
Avg Actual Move
7.74%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2022-08-08 After-Close 41.55% 2.66% 0.06x Within
2023-05-09 After-Close 14.17% 11.66% 0.82x Within
2023-11-13 After-Close 22.44% 11.71% 0.52x Within
2024-03-19 After-Close 20.46% 11.97% 0.59x Within
2024-05-08 After-Close 18.12% 1.71% 0.09x Within
2024-08-05 After-Close 67.06% 9.66% 0.14x Within
2024-11-07 After-Close 35.41% 0.69% 0.02x Within
2025-03-10 After-Close 22.59% 9.45% 0.42x Within
2025-05-07 After-Close 66.07% 5.71% 0.09x Within
2025-08-07 After-Close 35.89% 7.81% 0.22x Within
2025-11-05 After-Close 39.69% 4.89% 0.12x Within
2026-03-09 After-Close 48.70% 3.66% 0.08x Within
2026-04-28 After-Close 38.25% 23.26% 0.61x Within
2026-08-03 After-Close 22.73% 3.45% 0.15x Within

Earnings calendar: this week’s reports with expected vs actual moves →

DSGN Options Activity & IV Rank

DSGN IV rank history, 52-week IV rank and IV percentile →

Volatility Metrics

Current IV: 104.6%
7-DTE IV: —
Expected Move: $3.80
7-DTE Move: $3.80
Days to Exp: 24 (2026-11-20)

Options Flow

Call Volume: 5
Put Volume: 30
P/C Volume: 6.0
BEARISH
Call OI: 168
Put OI: 80
P/C OI: 0.476
Total OI: 248

ATM Options Pricing

ATM Call: $1.80
ATM Put: $2.00
Call %: 16.9%
Put %: 18.8%

Chain Summary

Chain Volume: 402
Chain OI: 36,887
Last Updated: 10/27/2026
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Dealer Positioning
TYPICAL γ

Estimated net dealer gamma is at the 71st percentile of this name's own daily history, within its typical range. This describes current positioning; it is not a forecast or a trading signal.

Gamma percentile
71%
vs own history
GEX tilt
+1.00
OI-weighted, today
Vanna tilt
-0.82
δ-sensitivity to IV
Charm tilt
-0.18
δ-decay vs time
Vanna tilt -0.82: the estimated dealer exposure leans negative, so the modeled hedge would shift noticeably if implied volatility changed.

Net dealer gamma is an estimate of the aggregate gamma held by options market makers across this name's option chain, weighted by open interest. Dealer positions aren't public, so it uses a standard simplifying assumption: dealers are treated as long the calls and short the puts that are open. Actual dealer books can differ.

Gamma percentile ranks today's estimate against this name's own daily history, from 0% (the lowest reading on record) to 100% (the highest). Raw gamma scales with how much open interest a chain carries, so it isn't comparable across names; the percentile is. The badge marks the bottom 20% as low and the top 20% as high.

Tilts run from −1 to +1 and show how lopsided the estimated dealer exposure is. GEX tilt compares call gamma with put gamma. Vanna tilt describes how the hedge would shift if implied volatility changed, and charm tilt how it would shift with the passage of time.

This card describes estimated positioning and where it sits historically. It is not a forecast of price direction or volatility and not a trading signal. Market-wide view: Dealer positioning screener.

· 6 ATM contracts, 21k total OI
Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
as of Oct 26 · No data
30 DTE / 10d —
— pts EXTREME
as of Oct 26 · ATM 162.6% / Wing —

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)31.6MediumOct 27
Straddle Price (30 DTE)$3.80Oct 27
Beta Analysis

Risk Metrics

Beta: 1.0622
Alpha: 54.47%
Correlation: 0.1902
R-Squared: 3.6%
Stock Volatility: 71.0%
Market Volatility: 12.7%

Analysis Details

Benchmark: SPY
Data Points: 251
Period: 252 trading days
Interpretation:
Above average volatility - stock moves with market amplification
Beta & Alpha Over Time
Notable investors who own DSGN
5 of 37 tracked investors
InvestorValueShare of their portfolioRankQ/Q sharesSource
Point72 Hedge fund
Steve Cohen
$34.2M
0.05%
#433 of 1945-13.1%13F
Renaissance Technologies Hedge fund
Jim Simons
$5.6M
0.01%
#1397 of 3138-5.0%13F
Millennium Management Hedge fund
Izzy Englander
$2.1M
0.00%
#2541 of 3716+35.6%13F
Citadel Hedge fund
Ken Griffin
$1.2M
0.00%
#3500 of 6285-64.6%13F
Rockefeller Capital Management Family office
Rockefeller family
$53K
0.00%
#3342 of 47290.0%13F

Hedge funds, activists, holding companies and family offices we track, from their latest 13F (quarter-end value) and Form 4 filings in the last 3 years. Family offices · all institutions

DSGN Institutional Ownership (13F)

Latest filings — 2026-09-30
Diluted shares outstanding: 59,555,247 (as of 2026-06-30)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

138 filers44,947,175 shares$641.80M value75.47% of float
# Filer Shares Value % of Total % of Float Period
1 SR One Capital Management, LP 6,526,476 $94.44M 14.71% 10.96% 2026-06-30
2 Logos Global Management LP 3,000,000 $43.41M 6.76% 5.04% 2026-06-30
3 BAKER BROS. ADVISORS LP 2,678,430 $38.76M 6.04% 4.50% 2026-06-30
4 Driehaus Capital Management LLC 2,661,115 $38.51M 6.00% 4.47% 2026-06-30
5 BlackRock, Inc. Custodian 2,660,024 $38.49M 6.00% 4.47% 2026-06-30
6 Point72 Asset Management, L.P. 2,366,453 $34.24M 5.34% 3.97% 2026-06-30
7 Trails Edge Capital Partners, LP 2,001,282 $28.96M 4.51% 3.36% 2026-06-30
8 Frazier Life Sciences Management, L.P. 1,809,854 $26.19M 4.08% 3.04% 2026-06-30
9 Vivo Capital, LLC 1,612,903 $23.34M 3.64% 2.71% 2026-06-30
10 Vanguard Capital Management LLC 1,571,022 $22.73M 3.54% 2.64% 2026-06-30
11 Caption Management, LLC 1,118,098 $16.18M 2.52% 1.88% 2026-06-30
12 Vanguard Group Inc Custodian 1,630,910 $15.30M 2.38% 2.74% 2025-12-31
13 Almitas Capital LLC 1,026,893 $14.86M 2.32% 1.72% 2026-06-30
14 Geode Capital Management, LLC Custodian 958,417 $13.87M 2.16% 1.61% 2026-06-30
15 Sofinnova Investments, Inc. 865,135 $12.52M 1.95% 1.45% 2026-06-30
16 FMR LLC Custodian 776,462 $11.24M 1.75% 1.30% 2026-06-30
17 Morgan Stanley Custodian 765,425 $11.08M 1.73% 1.29% 2026-06-30
18 State Street Corp 736,221 $10.65M 1.66% 1.24% 2026-06-30
19 Woodline Partners LP 700,354 $10.13M 1.58% 1.18% 2026-06-30
20 Dimensional Fund Advisors LP Custodian 694,743 $10.05M 1.57% 1.17% 2026-06-30
21 Goldman Sachs Group Inc Custodian 656,584 $9.50M 1.48% 1.10% 2026-06-30
22 JACOBS LEVY EQUITY MANAGEMENT, INC 565,597 $8.18M 1.28% 0.95% 2026-06-30
23 ACADIAN ASSET MANAGEMENT LLC 537,479 $7.77M 1.21% 0.90% 2026-06-30
24 Siren, L.L.C. 523,212 $7.57M 1.18% 0.88% 2026-06-30
25 Qube Research & Technologies Ltd 437,079 $6.32M 0.99% 0.73% 2026-06-30
5 filers$22.89M notional
# Filer Notional Value % of Total Period
1 Caption Management, LLC $21.70M 94.82% 2026-06-30
2 Susquehanna International Group, LLP Custodian $578.80K 2.53% 2026-06-30
3 GROUP ONE TRADING LLC Custodian $400.82K 1.75% 2026-06-30
4 Citadel Advisors LLC Custodian $201.13K 0.88% 2026-06-30
5 Simplex Trading, LLC Custodian $4.34K 0.02% 2026-06-30
1 filers$8.68K notional
# Filer Notional Value % of Total Period
1 Simplex Trading, LLC Custodian $8.68K 100.00% 2026-06-30

DSGN Insider Trading (Form 4)

Latest: 2026-06-11
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-06-11 Simeon George Director Grant (A) +30,000 opt — EDGAR
2026-06-11 Rodney W Lappe Director Grant (A) +30,000 opt — EDGAR
2026-06-11 Heather A. Berger Director Grant (A) +30,000 opt — EDGAR
2026-06-11 David Shapiro Director Grant (A) +30,000 opt — EDGAR
2026-06-11 John P. Schmid Director Grant (A) +30,000 opt — EDGAR
2026-06-11 Justin D. Gover Director Grant (A) +30,000 opt — EDGAR
2026-04-01 David Shapiro Director Grant (A) +67,500 opt — EDGAR
2026-01-05 Julie Burgess Chief Accounting Officer Grant (A) +150,000 opt — EDGAR
2026-01-05 Chris Storgard Chief Medical Officer Grant (A) +250,000 opt — EDGAR
2026-01-05 Pratik Shah President, CEO and Chairperson Grant (A) +750,000 opt — EDGAR
2026-01-05 Sean Jeffries Chief Operating Officer Grant (A) +375,000 opt — EDGAR
2026-01-05 Justin D. Gover Director Grant (A) +45,000 opt — EDGAR
2025-12-11 Pratik Shah President, CEO and Chairperson Grant (A) +525,000 opt — EDGAR
2025-09-10 Justin D. Gover Director Grant (A) +45,833 opt — EDGAR
2025-08-14 Arsani William Director Sell (S) −562,627 $5.25 -$2.95M EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.

DSGN Insider Holdings

8 insiders · @ $10.63
Officers, directors, and 10%+ owners who have filed a Form 4 in the past two years, ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 Simeon George Director 6,486,476 $68.95M $12.57M 8 2026-06-11
2 Arsani William Director 1,000,000 $10.63M $28.05M 12 2025-08-14
3 Pratik Shah President, CEO and Chairperson 154,923 $1.65M $500.0K 7 2026-01-05
4 Rodney W Lappe Director 133,024 $1.41M $268.7K 11 2026-06-11
5 John P. Schmid Director 57,639 $612.7K $99.7K 7 2026-06-11
6 Deepa Prasad Director 20,000 $212.6K $3.8K 8 2025-06-12
7 Sean Jeffries Chief Operating Officer 3,050 $32.4K $61.0K 6 2026-01-05
8 Heather A. Berger Director 1,300 $13.8K $4.9K 7 2026-06-11
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.

DSGN Board & Officers

As of SEC filings through Jun 11, 2026

Directors 8

Officers 4

  • Pratik Shah · President, CEO and Chairperson · listed since Sep 2023
  • Sean Jeffries · Chief Operating Officer · since Mar 25, 2021
  • Julie Burgess · Chief Accounting Officer · since Sep 13, 2021
  • Chris Storgard · Chief Medical Officer · since Apr 16, 2025

10% owners 1

Changes in the last 10 years (45)
Mar 31, 2026David Shapiro became a director
Jan 29, 2026The company announced the departure of Deepa Prasad from the board in an SEC filing
Sep 9, 2025Justin D. Gover became a director
Apr 16, 2025Chris Storgard became Chief Medical Officer
Oct 1, 2024DUNHAM TRUST Co became a 10% owner
Mar 13, 2024Jae B. Kim became Chief Medical Officer
Sep 5, 2023Pratik Shah listed as President, CEO and Chairperson (previously Executive Chairperson) in SEC filings
Aug 25, 2023The company announced the departure of Joao MD Siffert from the board in an SEC filing
Mar 22, 2022Stella Xu no longer listed as a 10% owner in SEC filings
Sep 13, 2021Julie Burgess became Chief Accounting Officer
Aug 13, 2021Dawn Giangiulio became Principal Accounting Officer
Jun 15, 2021Heather A. Berger became a director
Jun 15, 2021Deepa Prasad became a director
Apr 1, 2021Cormorant Private Healthcare Fund III LP reported in an SEC filing no longer being a 10% owner
Apr 1, 2021Cormorant Private Healthcare Fund II, LP reported in an SEC filing no longer being a 10% owner
Apr 1, 2021Cormorant Global Healthcare Master Fund, LP reported in an SEC filing no longer being a 10% owner
Apr 1, 2021Cormorant Asset Management, LP reported in an SEC filing no longer being a 10% owner
Apr 1, 2021Bihua Chen reported in an SEC filing no longer being a director
Apr 1, 2021Bihua Chen reported in an SEC filing no longer being a 10% owner
Mar 25, 2021Stella Xu became a director
Not reported recently (13)
  • DUNHAM TRUST Co · Last reported as a 10% owner in an SEC filing dated Feb 7, 2025
  • Jae B. Kim · Last reported as Chief Medical Officer in an SEC filing dated Mar 20, 2024
  • Aseem Z. Ansari · Last reported as a 10% owner in an SEC filing dated Dec 5, 2023
  • Stella Xu · Last reported as a director in an SEC filing dated Jun 2, 2023
  • Joao MD Siffert · Last reported as President and CEO in an SEC filing dated Feb 3, 2023
  • SR One Capital Fund I Aggregator LP · Last reported as a 10% owner in an SEC filing dated Dec 20, 2022
  • Sr One Capital Partners I, LP · Last reported as a 10% owner in an SEC filing dated Dec 20, 2022
  • Sr One Capital Management, LLC · Last reported as a 10% owner in an SEC filing dated Dec 20, 2022
  • Dawn Giangiulio · Last reported as Principal Accounting Officer in an SEC filing dated Aug 17, 2021
  • Quan Venture Fund II, L.P. · Last reported as a 10% owner in an SEC filing dated Apr 1, 2021
  • Justin Thacker · Last reported as Vice President, Finance in an SEC filing dated Apr 1, 2021
  • Star Irrevocable Trust #1 dated April 22, 2019 · Last reported as a 10% owner in an SEC filing dated Mar 25, 2021
  • Light Irrevocable Trust #1 dated April 22, 2019 · Last reported as a 10% owner in an SEC filing dated Mar 25, 2021
Compiled from SEC filings by the company and its directors and officers. Dates are as stated in those filings. Where no filing says when someone left, we show the last filing that listed them.

DSGN Proposed Insider Sales (Form 144)

Latest: 2025-11-18
Last 30d: 0 filings  ·  Last 90d: 0 filings

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. An amended notice (Form 144/A) replaces the original it amends, and cancelled notices are dropped, so neither is double-counted above. A filed value that is clearly inconsistent with the share count at the stock's price (a filer typo) shows as a dash and is left out of the totals.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2025-11-18 Logos Global Master Fund LP Director 120,000 $891.6K 2025-11-18 BTIG, LLC — EDGAR
2025-11-14 Logos Global Master Fund LP Director 620,000 $4.38M 2025-11-14 BTIG, LLC — EDGAR
2025-11-07 Logos Global Master Fund LP Director 415,000 $2.85M 2025-11-07 BTIG, LLC — EDGAR
2025-08-13 Logos Opportunities Fund II LP Director 217,627 $1.08M 2025-08-13 BTIG, LLC — EDGAR
2025-08-13 Logos Global Master Fund LP Director 345,000 $1.72M 2025-08-13 BTIG, LLC — EDGAR
2024-08-09 Logos SPV 1 LP Director 814,874 $3.46M 2024-08-09 BTIG, LLC — EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed. Market-wide feed: Planned sales (Form 144).
ETF Holders
47 ETFs hold DSGN
25 shown · $63.34M total exposure · 0.02% AUM-weighted avg weight
# ETF Provider Weight $ Exposure ETF AUM As Of
1 VTI Vanguard Morningstar Total Stock Market ETF Vanguard 0.00% $15.0M — 2026-09-30
2 XBI State Street® SPDR® S&P® Biotech ETF SPDR (State Street) 0.10% $10.2M $10.4B 2026-10-23
3 IWM iShares Russell 2000 ETF iShares (BlackRock) 0.01% $8.2M $74.6B 2026-10-23
4 VXF Vanguard Extended Market ETF Vanguard 0.01% $5.6M — 2026-09-30
5 DFAS Dimensional US Small Cap ETF Dimensional 0.01% $3.0M — 2026-10-23
6 IWO iShares Russell 2000 Growth ETF iShares (BlackRock) 0.02% $3.0M $13.7B 2026-10-23
7 IBB iShares Biotechnology ETF iShares (BlackRock) 0.03% $2.7M $10.7B 2026-10-23
8 FESM Fidelity Enhanced Small Cap Core ETF Fidelity 0.04% $2.6M $6.6B 2026-10-23
9 VTWO Vanguard Russell 2000 ETF Vanguard 0.01% $2.2M — 2026-09-30
10 SCHA Schwab U.S. Small-Cap ETF Nport 0.01% $1.5M — 2026-05-31
11 DWAS Invesco Dorsey Wright SmallCap Momentum ETF Nport 0.33% $1.4M — 2026-05-31
12 DFMC Dimensional US Micro Cap ETF Dimensional 0.02% $1.2M — 2026-10-23
13 IDNA iShares Genomics Immunology and Healthcare ETF iShares (BlackRock) 0.35% $1.1M $321.2M 2026-10-23
14 IWC iShares Micro-Cap ETF iShares (BlackRock) 0.08% $963,820 $1.2B 2026-10-23
15 VFMO Vanguard U.S. Momentum Factor ETF Vanguard 0.04% $750,582 — 2026-10-23
16 SBIO ALPS Medical Breakthroughs ETF Nport 0.41% $666,193 — 2026-05-31
17 DFAC Dimensional US Core Equity 2 ETF Dimensional 0.00% $615,741 — 2026-10-23
18 VTWG Vanguard Russell 2000 Growth ETF Vanguard 0.02% $414,320 — 2026-09-30
19 GSSC Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF Goldman 0.04% $398,377 $1.0B 2026-10-23
20 LABU Direxion Daily S&P Biotech Bull 3X ETF Direxion 0.07% $395,899 — 2026-10-26
21 DCOR Dimensional US Core Equity 1 ETF Dimensional 0.00% $393,820 — 2026-10-23
22 BBC Virtus Biotech Clinical Trials Etf Nport 0.74% $345,096 — 2026-07-31
23 SMLF iShares U.S. Small-Cap Equity Factor ETF iShares (BlackRock) 0.01% $289,608 $4.2B 2026-10-23
24 SCHB Schwab U.S. Broad Market ETF Nport 0.00% $277,123 — 2026-05-31
25 DXUV Dimensional US Vector Equity ETF Dimensional 0.00% $249,713 — 2026-10-23
Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

Trailing P/E
—
TTM Diluted EPS
$-1.18
TTM Revenue
—
TTM Net Income
$-70.80M
TTM Op. Cash Flow
$-55.08M
Quarterly figures (12 quarters)
QuarterPeriod EndRevenueNet IncomeDiluted EPSOp. Cash Flow
Q2 '262026-06-30—$-20.16M$-0.32$-15.52M
Q1 '262026-03-31—$-17.64M$-0.29$-16.43M
Q4 '252025-12-31—$-16.00M$-0.27$-11.97M
Q3 '252025-09-30—$-17.00M$-0.30$-11.16M
Q2 '252025-06-30—$-19.08M$-0.34$-14.44M
Q1 '252025-03-31—$-17.71M$-0.31$-16.79M
Q4 '242024-12-31—$-13.65M$-0.24$-9.86M
Q3 '242024-09-30—$-13.04M$-0.23$-9.55M
Q2 '242024-06-30—$-11.79M$-0.21$-11.26M
Q1 '242024-03-31—$-11.11M$-0.20$-12.44M
Q4 '232023-12-31—$-11.84M$-0.21$-12.80M
Q3 '232023-09-30—$-15.79M$-0.28$-14.53M
Q2 2026 • period ending 2026-06-30 • filed 2026-08-03
Valuation

Ratios derived from TTM financials and the current market price, sampled daily. History chart shows how expensive the stock is today relative to its own recent past.

Price Multiples
  • P/E — price / TTM earnings. Rough market rule: 10–15 value, 15–25 market, >30 growth/premium. Negative when earnings are negative.
  • P/B — price / book value. Useful for financials and asset-heavy names; meaningless for asset-light software.
  • P/S — price / TTM revenue. Useful when earnings are negative or noisy (early-stage growth).
  • EV/EBITDA — capital-structure-neutral. <10 cheap, 10–15 reasonable, >20 rich. Good for comparing across leverage profiles.
  • EV/Sales — like P/S but accounts for debt + cash. Compare within sector.
Profitability & Yields
  • ROE — return on equity. >15% strong, >25% exceptional. Caution: high leverage inflates ROE.
  • ROA — return on assets. Leverage-neutral; >5% solid, >10% exceptional.
  • Div Yield — annual dividend / price. Compare to 10Y Treasury; sustained yield >6% often signals distress.
  • FCF Yield — free cash flow / market cap. >5% is attractive; negative means burning cash.
Balance Sheet
  • Debt/Equity — leverage. <1 conservative, >2 aggressive. Sector-dependent (utilities naturally high, tech low).
  • Current Ratio — short-term liquidity. >1.5 comfortable, <1 raises short-term solvency flags.
Reading the history chart
  • Compare current level to the 3-year band: near the high end = relatively expensive; near the low = relatively cheap.
  • Multiples expanding while earnings are flat = sentiment-driven rally.
  • Multiples compressing while earnings grow = value coming from fundamentals.
P/E
—
P/B
3.14
P/S
—
EV/EBITDA
—
EV/Sales
—
ROE
-35.1%
ROA
-32.9%
Div Yield
0.00%
FCF Yield
-8.70%
Debt/Equity
0.00
Current Ratio
—
Market Cap
$633.07M
as of 2026-10-27
Short Interest & Float

Regulatory short-interest reports publish on a bi-weekly settlement cadence; short-volume is reported daily by the trade-reporting facilities. Float is derived from insider-ownership filings.

Metric definitions
  • Short Interest — total shares currently sold short as of the settlement date. Lags real time by ~8 business days.
  • SI % of Float — short interest / free float. The key crowding metric.
  • Days to Cover — short interest / avg daily volume. How many full trading days it would take shorts to buy back. High DTC + catalyst = squeeze fuel.
  • Short Vol Ratio — today's short-sale volume / total volume. Intraday selling pressure proxy (not the same as short interest).
  • Free Float — shares available for public trading (total shares minus insider / restricted).
  • Float % — free float / shares outstanding. <50% = tightly held, more prone to squeezes.
How to read the signals
  • SI % of Float < 5% — typical, no particular signal.
  • 5–15% — elevated; watch for catalysts (earnings, guidance, macro).
  • 15–30% — heavily shorted; tight-float names in this range have produced notable squeezes historically.
  • >30% — extreme; borrow is likely expensive and squeeze risk is material.
  • Days to Cover > 5 combined with high SI% amplifies squeeze potential.
History chart
  • Trend matters more than level. Rapidly rising short interest often precedes negative catalysts or heavy hedging.
  • A sudden drop in SI after a rally may indicate a squeeze in progress.

Short interest is reported mid-month and end-of-month; short volume is daily.

Short Interest
6.62M
SI % of Float
21.70%
Days to Cover
8.69
Short Vol Ratio
30.0%
Free Float
30.50M
Float %
48.7%
Short interest 2026-09-30 • Short volume 2026-10-27 • Float 2026-08-14