Prothena Corporation plc Ordinary Shares(PRTA)

Stock quote, options chain, IV rank, technicals, AI analysis, and institutional ownership.

Market data may be delayed, incomplete, or inaccurate. Not a recommendation to buy, sell, or hold any security. Verify quotes with your broker before trading. See Terms §17.

PRTA $8.29 —
Snapshot
$8.29
52-Week Range
$7.73 – $11.80
YTD
-9.89%
IV Rank (30D)
72.81
Straddle Price
$0.98
P/C Vol Ratio
0.00
Market Cap
$0.4B
Fair Value
MODEL: LONG

A blended fair-value estimate combining up to six valuation methods. Each method is weighted by how well it fits the company — DCF down-weights for unprofitable names; DDM only fires for steady dividend payers; comparables down-weight when peer multiples disagree.

  • DCF (quality-aware) — projects free cash flow with a horizon that scales to business quality. True compounders (quality 6/6) get 10 years explicit + 10 years fade before terminal; cyclical/struggling names (quality 0-1) get a 5-year terminal cliff. Quality is scored from ROE, gross margin, growth, FCF margin, debt load, and FCF consistency — the same factors that drive market premium for compounders.
  • Market-Implied Growth (in Model Inputs) — reverse-DCF that answers "what growth rate is the market pricing in?". Lets you sanity-check the deviation: if implied growth is plausible for the business, the model's bearish flag may be wrong; if implausible, the market may be over-extrapolating.
  • DDM (Gordon Growth Dividend Model) — values the stream of future dividends. Only used when trailing yield ≥ 2% and dividend payments are stable — below that the dividend is a token payout and Gordon (which values only the dividend stream) systematically underprices growth names, so those route to DCF + comparables + market anchor instead.
  • P/E, EV/EBITDA, P/B, P/S — applies the peer-group median multiple to this company's per-share metric. Peers come from the same set as the "Related symbols" card. Earnings/sales metrics are forward-tilted by the company's recent revenue growth (capped at 25%) so they're comparable to peers' growth-embedded multiples — mimics how analysts use NTM rather than TTM. Per-multiple weights are biased by company quality (e.g. P/B down-weighted for asset-light tech).
  • Market Anchor (SMA50) — the 50-day moving average, weighted by recent trading-range stability (tighter Bollinger bands → higher weight). Captures information fundamentals miss (forward consensus, sentiment, supply/demand) — but only when recent trading is steady enough that the market has converged on a view. During wild breakouts or breakdowns the anchor's weight collapses.
  • Options Expected (B-L 30d) — the risk-neutral expected stock price at 30-day options expiration, derived from the full implied-volatility surface via Breeden-Litzenberger (second derivative of call price wrt strike → implied PDF, then E[S_T]). Forward-looking, captures all options-implied information (smile, skew, term structure) in one number. Weighted by chain liquidity. SP500-only at present (pre-computed daily). Backtest evidence: adds modest alpha across most bucket × holding combos.
  • Blended value — weighted average. Confidence reflects how many methods fired and how tight peer dispersion is.
  • Deviation pill — green when blended FV ≥ 10% above current price (undervalued); red when ≥ 10% below; grey otherwise.
10-yr Treasury (rf)4.96%
Beta vs SPY0.87
Cost of Equity (CAPM)9.32% (VRP-adj)
WACC9.38%
Volatility Risk Premium+144.5pp (IV − HV30)
Effective Tax Rate21.0%
Rev. Growth (YoY, DCF input)-10.0%
DCF Horizon10 years explicit + fade
Free Cash Flow (TTM)$-0.1B
Return on Equity (TTM)-15.3%
Book / Price64.5% — banking bias active (P/B is primary)
Gross Margin (TTM)100.0%
FCF Margin (TTM)-111.3%
Debt / Equity0.00
Quality Score2/6 — normal (10y DCF)
SMA 50$8.89 (Market Anchor value)
SMA 20 / Bollinger Mid$9.01
Bollinger Width / SMA20241.7% (drives anchor stability)
Net Debt$-0.3B
Market Cap$0B
Peers used for multiples: ACAD, ALKS, BIIB, DNTH, XENE (filtered from 8 ETF-co-members; sector bias active)
Model Conviction
96%
20-Day Fair Value
≈ by Oct 26, 2026
$8.73
α +5.3% rank 86%
40-Day Fair Value
≈ by Nov 24, 2026
$9.46
α +14.1% rank 91%
60-Day Fair Value
≈ by Dec 23, 2026
$10.37
α +25.1% rank 94%
MethodImplied PriceWeightDetail
DCF n/a 0%
DDM (Gordon) n/a 0%
Peer P/E n/a 0% median 40.3× · 3 peers
Peer EV/EBITDA n/a 0% median 39.3× · 3 peers
Peer P/B $17.97 50% median 3.4× · 5 peers
Peer P/S $4.12 50% median 4.0× · 4 peers
Market Anchor (SMA50) $8.89 0% stability 0% (BB-width)
Options Expected (B-L 30d) $9.30 0% 8 strikes · skew -0.79
As of 2026-09-25 · updated
Info
Industry (SIC)
PHARMACEUTICAL PREPARATIONS (2834)
Exchange
XNAS
Market Cap
$0.4B

Prothena Corp PLC is a late-stage clinical biotechnology company that focuses on protein dysregulation and a pipeline of investigational therapeutics with the potential to change the course of devastating neurodegenerative and rare and peripheral amyloid diseases. Prothena is developing and applying its proprietary CYTOPE technology to target a broad spectrum of intracellular disease pathways in the brain and periphery. The company's pipeline includes both wholly-owned and partnered programs like Prasinezumab, Coramitug (PRX004), BMS-986446 (PRX005), PRX019, TDP-43 CYTOPE, and PRX012-TfR, bein…

Summary
—
composite
—
No summary data available for this symbol yet.

Each spoke is this symbol's rank within its sector (0–100; the dotted ring marks the sector median at 50). Higher is more constructive for a long. One spoke — News sentiment — is an absolute reading, not a sector rank. Grayed spokes have no data. A fuller shape is a summary, not a recommendation.

Chart
Seasonality
MonthAvg ReturnYears of Data
Jan -7.80% 6
Feb +10.30% 6
Mar -5.19% 6
Apr -5.64% 6
May -0.69% 6
Jun +17.81% 6
Jul +4.89% 6
Aug +2.25% 6
Sep +18.41% 6
Oct -6.64% 5
Nov -7.67% 5
Dec +1.59% 5
Technical Indicators

Quick-reference for reading the values below. Indicators combine to confirm a view — no single one is a trade signal on its own.

Trend Indicators
  • SMA 20 / 50 / 200 — price above = uptrend, below = downtrend. SMA 50 crossing SMA 200 is the golden/death cross.
  • EMA 12 / 26 — faster-reacting averages; 12 above 26 is short-term bullish.
  • MACD — bullish when MACD > signal (green badge), bearish when below. Divergence from price often precedes reversals.
  • ADX (14) — trend strength regardless of direction. <20 range, 20–25 weak trend, 25–50 trend, >50 strong trend.
  • +DI / −DI — +DI > −DI favors bulls; the reverse favors bears. Read alongside ADX.
Momentum Oscillators
  • RSI (14) — <30 oversold, >70 overbought. 40–60 is neutral; trending names can stay extreme.
  • Stochastic %K / %D — <20 oversold, >80 overbought. %K crossing %D is an early momentum signal.
  • Williams %R — inverted scale: <−80 oversold, >−20 overbought.

Oscillators work best in range-bound markets; in strong trends they give premature reversal signals.

Volume & Volatility
  • Bollinger Bands — price at upper band = overbought, lower = oversold. Narrow bands (squeeze) often precede expansion.
  • OBV — cumulative volume; rising OBV confirms uptrend, falling OBV confirms downtrend. Divergence from price is a warning.
  • Vol SMA 20 / Vol ROC — today's volume vs. 20-day average. Positive ROC with price move = conviction.
  • ATR / True Range — average daily $ move; sizing and stop-loss reference.
  • HV 20 / 30 / 60 — realized (historical) volatility. Compare to IV on the options cards: IV > HV = rich premium.

Confluence matters: trend + momentum + volume agreeing carries far more weight than any single indicator. For how these feed the spread scanner score, see the algorithm docs →

Trend Indicators

SMA 20: $8.97
SMA 50: $8.89
SMA 200: $9.36
Current: $8.29
EMA 12: $8.66
EMA 26: $8.84
MACD: -0.1848 | Signal: -0.0723
BEARISH
ADX (14): 14.66
RANGE
+DI: 17.60
−DI: 26.66

Momentum Oscillators

RSI (14): 39.63
NEUTRAL
Stoch %K: 14.33
Stoch %D: 24.54
Williams %R: -92.93

Volume & Volatility

BB Upper: $10.00
BB Lower: $7.94
NEUTRAL
OBV: -8,666,821
Vol SMA 20: 439,461
Vol ROC: 27.84%
ATR: $0.39
True Range: $0.33
HV 20: 44.9%
HV 30: 45.7%
HV 60: 40.7%

Data Summary

Data Points: 500
Last Updated:
Date Range: 2024-09-27T00:00:00 – 2026-09-25T00:00:00
AI Analysis

LLM Stock Analysis Report

Executive Summary

Overall Assessment: NEUTRAL (Confidence Level: 6/10)

Key Drivers:

  • Positive news sentiment from recent headlines, particularly Novo Nordisk's Coramitug study and Alpha-Synuclein Inhibitors clinical trial pipeline
  • Bullish momentum signals from technical indicators, including MACD and Stochastic %K

Primary Risks:

  • Negative news impact from FDA guidelines on Leqembi therapy and Prothena Corporation PLC's mid-stage Parkinson's trial missing primary endpoint
  • Volatility regime indicating moderate risk relative to market

Investment Thesis: PRTA's neutral sentiment and moderate volatility suggest a potential range-bound trading environment. The stock's recent uptrend may continue, driven by positive news flows and bullish momentum signals.

Recent News Sentiment Impact: The overall sentiment is NEUTRAL, with two positive headlines and three negative/neutral headlines. This mix of sentiment does not significantly impact the analysis, as the technical indicators are more prominent in determining the current trading environment.

Technical Analysis

Trend Direction: Short-term (1-4 weeks) - UPTREND; Medium-term (1-3 months) - UPTREND; Long-term (3-12 months) - NEUTRAL

Support/Resistance Levels: Key price levels include: + Lower band: $8.71 + Middle band: $9.27 + Upper band: $9.83 + Trend line: $9.44 (EMA 26)

Momentum Signals:

  • RSI interpretation: Neutral (63.37) - not overbought or oversold
  • MACD signal: Bullish (0.21 / Signal: 0.06 / Histogram: 0.15)
  • Bollinger Bands position: Squeeze ( price touching upper band)

Volume Analysis: Volume trends and institutional interest signals: + Volume SMA 20: 359105.03 + On-Balance Volume (OBV): -8151475.14 + Volume Rate of Change: 2.10%

News & Sentiment Analysis

Recent Headlines Summary: Positive news flows from Novo Nordisk's Coramitug study and Alpha-Synuclein Inhibitors clinical trial pipeline, while negative/neutral headlines from FDA guidelines and Prothena Corporation PLC's mid-stage Parkinson's trial missing primary endpoint.

Sentiment Assessment: Aggregate news sentiment is NEUTRAL, with a mix of positive and negative headlines.

Catalyst Identification: Upcoming events include earnings releases from Novo Nordisk and Prothena Corporation PLC. Regulatory changes and product launches may also impact the stock price.

Market Narrative: The recent uptrend in PRTA's stock price is driven by positive news flows and bullish momentum signals, which align with the technical indicators' trend direction.

Risk & Volatility Assessment

Beta Interpretation: Beta of 0.99 indicates moderate volatility relative to market (SPY).

Volatility Regime: The current regime suggests a moderate risk environment, with historical volatility levels indicating a higher-than-average level of uncertainty.

Options Market Signals: IV rank is low at 13.2%, suggesting historically low volatility. Put/call ratios indicate bullish sentiment, while unusual activity signals institutional interest in the options market.

Downside Protection: Support levels include lower band ($8.71), middle band ($9.27), and trend line ($9.44).

Market Context & Positioning

Sector Performance: PRTA's sector (Biotech) has been relatively strong, with a positive correlation to the broader market (SPY).

Institutional Activity: Institutional interest is moderate, with a volume flow of 6 calls vs 0 puts and open interest of 83 calls vs 0 puts.

Correlation Analysis: PRTA's correlation to SPY is 0.27, indicating a relatively low level of correlation.

Relative Valuation: PRTA's relative valuation suggests it is trading within its historical range, with no clear value or overvaluation signals.

Key Levels & Action Items

Critical Price Levels:

  • Lower band: $8.71
  • Middle band: $9.27
  • Upper band: $9.83

Breakout/Breakdown Levels: Trend line ($9.44) and middle band ($9.27)

Time-Sensitive Catalysts: Upcoming earnings releases from Novo Nordisk and Prothena Corporation PLC.

Risk Management: Stop-loss levels can be set at the lower band ($8.71) or trend line ($9.44), with position sizing considerations based on risk tolerance and market conditions.

Generated
News
Earnings History
7 of 7 under expected move
Avg Expected Move
24.12%
Avg Actual Move
2.38%
Each row pairs the pre-earnings straddle-implied expected move with the realized close-to-close move. Sorted oldest first.
Earnings Date Timing Expected Move Actual Move Ratio Outcome
2024-11-12 Pre-Market 15.49% 3.98% 0.26x Within
2025-05-08 Pre-Market 18.86% 2.81% 0.15x Within
2025-08-04 Pre-Market 30.84% 1.91% 0.06x Within
2025-11-06 Pre-Market 17.04% 2.34% 0.14x Within
2026-02-19 Pre-Market 21.42% 0.53% 0.02x Within
2026-05-07 After-Close 9.27% 2.00% 0.22x Within
2026-08-06 Pre-Market 55.95% 3.06% 0.05x Within
Options Activity
IV Rank (30D)
72.81
IV Rank (7D)
72.81
Avg IV
240.6%
Straddle (30D)
$0.98
Straddle (7D)
$0.98
P/C Volume
0.00
Spread Scanner GPU

Each spread is ranked by a composite score built in three stages. Full documentation →

Stage 1 — Base Score (GPU scanner)

score = P(profit) × (credit / spread_width)
P(profit) from short leg delta (1 − |delta|), penalised above 85%. Credit uses mid-price to handle illiquid chains fairly.

Stage 2 — Skew Adjustment (±25% cap)

RR and BF (30-delta) from the persisted per-symbol skew snapshot — wing strikes picked by real greeks.delta, not a moneyness proxy. Put skew boosts bull puts, penalises bear calls. High butterfly boosts iron condors. Calendars are skew-neutral.

Stage 3 — Technical Overlay (±50% cap, 5 groups)
Group 1 · Directional Bias (±0.25)
  • RSI <40 bullish / >60 bearish
  • MACD crossover + histogram trend
  • Price vs SMA 50 & SMA 200
Group 2 · Momentum (±0.10)
  • Stochastic %K <20 / >80
  • Williams %R <−80 / >−20
Group 3 · Volatility (up to −0.25 / +0.15)
  • Blended ATR + straddle expected-move penalty
  • Bollinger Band signal (+ counter-trend penalty)
  • BB width — vol contraction boost for ICs
Group 4 · IV Regime (±0.15)
  • IV rank ≥ 75 → strong boost for credit spreads
  • IV rank < 25 → penalty (selling cheap vol)
Group 5 · Liquidity (penalty up to −0.10)
  • Min open interest across all legs
  • OI < 100 → −0.10 · OI < 500 → −0.05

score = base_score × skew_multiplier × tech_multiplier
Both multipliers are shown per spread. Beta is informational only — ATR already captures realized vol. Full algorithm documentation →

Enter a ticker to scan for optimal spread opportunities.

Evaluates all bull put, bear call, iron condor, and calendar spread combinations using GPU-accelerated analysis.

Skew (Wing IV − ATM IV)
DTE:
Wing Δ:
Metric:
Wing vs ATM
IV(put wing) − IV(ATM), in vol points

How much the OTM put trades above (or below) the at-the-money strike. Measures the height of the put-side tail relative to ATM — i.e. how expensive crash insurance is on this name.

  • Positive (typical) — wing IV > ATM IV. Standard equity put skew: portfolios bid up crash protection, so OTM puts trade richer than ATM.
  • Near zero or negative (unusual) — wing IV ≤ ATM IV. Flat or inverted put side. Common when there's no fear demand, in tightly mean-reverting names, or right after an earnings catalyst clears.
  • Percentile vs own 3-yr history: high = wings rich (good time to sell wing premium); low = wings cheap (good time to buy protection).
  • Not directional — high or low wings don't predict up or down moves. It's a price tag on tail insurance, not a forecast.
Risk Reversal
IV(call wing) − IV(put wing), equal delta on each side

Which side of the smile is the market paying up for? Measures the tilt of the surface — call skew vs put skew at matched deltas.

  • Negative (typical) — puts richer than calls. Standard equity behavior: hedging demand makes puts carry a premium. Most large-caps sit in the −1 to −5 vol-point range.
  • Strongly negative (< −5 pts) — heavy downside hedging, elevated fear, or an upcoming catalyst (earnings, FDA, macro event). Worth flagging.
  • Positive — calls richer than puts. Unusual for equities; signals bullish momentum, short-squeeze positioning, or takeover/M&A speculation.
  • Near zero — symmetric surface. Market sees roughly equal up/down risk. Rare for large-caps; more common in commodities and FX.
Reading them together

Wing-vs-ATM tells you how expensive the tails are. Risk Reversal tells you which side is favored. Combined:

  • High wing percentile + deeply negative RR → strong put bid; stress or major event priced in. Owning protection costs a premium; selling put premium is dangerous.
  • Low wing percentile + near-zero RR → complacency; insurance cheap and balanced. Good environment to add cheap downside hedges.
  • Positive RR + elevated wings → call-side fear-of-missing-out; common in squeeze setups. Upside calls expensive, downside puts not bid.
14 DTE / 10d —
— pts EXTREME
ATM — / Wing —
30 DTE / 10d —
— pts EXTREME
ATM — / Wing —

Percentile is the rank of today's reading within ~3 years of this symbol's own history. High percentile = wings are rich relative to history; not a directional signal. Skew is read off the chain in real time, not from CBOE SKEW.

Volatility Surface

Enter a ticker to render the implied volatility surface.

Volatility Smile

Enter a ticker to render the implied volatility smile.

IV Rank (7 DTE)
IV Rank (30 DTE)
Straddle Price (30 DTE)
Beta Analysis
Beta (1Y vs SPY)
1.06
Correlation (SPY)
29.2%
R²
0.08
Ann. Volatility
47.1%
SPY Volatility
13.0%

Above average volatility - stock moves with market amplification

Beta & Alpha Over Time
Institutional Ownership (13F)
Latest filings — 2026-06-30
Diluted shares outstanding: 53,478,250 (as of 2026-06-30)

Institutional managers with $100M+ AUM file Form 13F-HR quarterly, due 45 days after quarter end. Holdings are reported gross at quarter-end market value — they are a snapshot, not a real-time position.

  • Shares — long equity positions in this name, aggregated across share classes.
  • Calls / Puts — notional value of long call / put exposure where this ticker is the underlying.
  • % of Float — holder's reported shares divided by the latest diluted shares outstanding. Sums above 100% indicate large custodian / prime broker positions where the same shares are reported by multiple filers.
  • Custodian badge — filers with more than 5,000 holdings are typically broker-dealers / custodians reporting customer-held shares, not active managers.

Each filer is counted once at its latest 13F-HR filing. New filings are ingested on a weekly cadence.

197 filers49,757,320 shares$467.85M value93.04% of float
# Filer Shares Value % of Total % of Float Period
1 FMR LLC Custodian 7,199,218 $70.48M 15.06% 13.46% 2026-06-30
2 Rubric Capital Management LP 5,000,000 $48.95M 10.46% 9.35% 2026-06-30
3 BlackRock, Inc. Custodian 4,867,955 $47.66M 10.19% 9.10% 2026-06-30
4 STATE STREET CORP 2,393,424 $23.43M 5.01% 4.48% 2026-06-30
5 VANGUARD GROUP INC Custodian 2,140,909 $20.45M 4.37% 4.00% 2025-12-31
6 VANGUARD PORTFOLIO MANAGEMENT LLC 1,651,293 $16.17M 3.46% 3.09% 2026-06-30
7 D. E. Shaw & Co., Inc. Custodian 1,611,457 $15.78M 3.37% 3.01% 2026-06-30
8 ADAR1 Capital Management, LLC 1,554,535 $15.22M 3.25% 2.91% 2026-06-30
9 TWO SIGMA INVESTMENTS, LP Custodian 1,264,987 $12.38M 2.65% 2.37% 2026-06-30
10 Palo Alto Investors LP 1,143,155 $11.19M 2.39% 2.14% 2026-06-30
11 GEODE CAPITAL MANAGEMENT, LLC Custodian 1,125,877 $11.02M 2.36% 2.11% 2026-06-30
12 FEDERATED HERMES, INC. 1,084,401 $10.62M 2.27% 2.03% 2026-06-30
13 MORGAN STANLEY Custodian 995,348 $9.74M 2.08% 1.86% 2026-06-30
14 GOLDMAN SACHS GROUP INC Custodian 979,730 $9.59M 2.05% 1.83% 2026-06-30
15 JACOBS LEVY EQUITY MANAGEMENT, INC 965,988 $9.46M 2.02% 1.81% 2026-06-30
16 DIMENSIONAL FUND ADVISORS LP Custodian 905,651 $8.87M 1.90% 1.69% 2026-06-30
17 Qube Research & Technologies Ltd 791,169 $7.75M 1.66% 1.48% 2026-06-30
18 RENAISSANCE TECHNOLOGIES LLC 697,615 $6.83M 1.46% 1.30% 2026-06-30
19 Man Group plc 678,116 $6.64M 1.42% 1.27% 2026-06-30
20 Mariner, LLC 625,095 $6.12M 1.31% 1.17% 2026-06-30
21 Nuveen, LLC Custodian 557,157 $5.45M 1.17% 1.04% 2026-06-30
22 VANGUARD CAPITAL MANAGEMENT LLC 479,945 $4.70M 1.00% 0.90% 2026-06-30
23 NORTHERN TRUST CORP Custodian 457,124 $4.48M 0.96% 0.85% 2026-06-30
24 Birchview Capital, LP 449,019 $4.40M 0.94% 0.84% 2026-06-30
25 Rangeley Capital, LLC 417,270 $4.09M 0.87% 0.78% 2026-06-30
5 filers$7.87M notional
# Filer Notional Value % of Total Period
1 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $4.12M 52.38% 2026-06-30
2 MILLENNIUM MANAGEMENT LLC Custodian $1.47M 18.65% 2026-06-30
3 CITADEL ADVISORS LLC Custodian $1.14M 14.55% 2026-06-30
4 JANE STREET GROUP, LLC Custodian $1.01M 12.89% 2026-06-30
5 WOLVERINE TRADING, LLC Custodian $120.05K 1.53% 2025-09-30
4 filers$2.61M notional
# Filer Notional Value % of Total Period
1 CITADEL ADVISORS LLC Custodian $1.39M 53.46% 2026-06-30
2 SUSQUEHANNA INTERNATIONAL GROUP, LLP Custodian $646.14K 24.80% 2026-06-30
3 JANE STREET GROUP, LLC Custodian $465.02K 17.85% 2026-06-30
4 WOLVERINE TRADING, LLC Custodian $101.50K 3.90% 2025-09-30
Insider Activity
Latest: 2026-09-21
Form 4 filings — insider beneficial-ownership changes by officers, directors, and 10%+ holders. Filed within 2 business days of transaction.
Filed Reporter Role Action Shares Avg Price Net $ Link
2026-09-21 WILLIAM P SCULLY 10%+ Owner Buy (P) +100,000 $8.43 $843.5K EDGAR
2026-09-03 WILLIAM P SCULLY 10%+ Owner Buy (P) +27,000 $9.47 $255.7K EDGAR
2026-08-21 WILLIAM P SCULLY 10%+ Owner Buy (P) +50,000 $8.79 $439.4K EDGAR
2026-08-18 WILLIAM P SCULLY 10%+ Owner Gift (G) −291,553 — EDGAR
2026-08-11 WILLIAM P SCULLY 10%+ Owner Gift (G) +251,553 — EDGAR
2026-08-10 WILLIAM P SCULLY 10%+ Owner Buy (P) +37,500 $8.62 $323.2K EDGAR
2026-07-30 Anne Evans Kingston Chief Strategy Officer Mixed −11,160 $8.50 -$94.9K EDGAR
2026-07-30 Karin L Walker Chief Accounting Officer Mixed — $8.56 -$128.4K EDGAR
2026-07-30 Tran Nguyen Chief Strategy Officer and CFO Mixed — $8.56 -$487.9K EDGAR
2026-07-30 Brandon S. Smith Chief Operating Officer Mixed — $8.56 -$667.7K EDGAR
2026-07-30 Michael John Isaacs General Counsel & Company Sec. Mixed −13,080 $8.50 -$111.2K EDGAR
2026-07-30 Chad J. Swanson Chief Development Officer Mixed +6,733 $8.56 -$378.9K EDGAR
2026-07-30 Wagner M. Zago Chief Scientific Officer Mixed — $8.56 -$436.6K EDGAR
2026-07-30 Gene G. Kinney President and CEO Mixed — $8.56 -$719.0K EDGAR
2026-06-18 WILLIAM P SCULLY 10%+ Owner Buy (P) +20,000 $7.90 $158.0K EDGAR
Codes: P = open-market purchase · S = open-market sale · A = grant/award · M = option exercise · F = tax withholding at vest · G = bona-fide gift · D = disposition to issuer · J = other (described in filing footnote — typically 401(k), trust, inheritance) · W = will/inheritance. Only P / S codes carry directional signal.
Insider Holdings
19 insiders · @ $8.29
Officers, directors, and 10%+ owners ranked by current disclosed exposure (shares × today's price). Shares are direct + indirect (via trusts / LLCs / spouse). Excludes unvested RSU and option grants — those aren't beneficially owned until vest.
# Insider Role Shares Disclosed Exposure Lifetime OM Net Filings Last Filed
1 EcoR1 Capital, LLC 10%+ Owner 8,266,342 $68.53M -$5.40M 10 2025-05-06
2 WILLIAM P SCULLY 10%+ Owner 1,010,500 $8.38M $7.71M 13 2026-09-21
3 Tran Nguyen Chief Strategy Officer and CFO 97,205 $805.8K -$15.19M 31 2026-07-30
4 Wagner M. Zago Chief Scientific Officer 85,000 $704.6K -$7.97M 20 2026-07-30
5 Michael J Malecek Chief Legal Officer 80,000 $663.2K -$9.34M 21 2026-03-05
6 Gene G. Kinney President and CEO 68,793 $570.3K -$12.41M 34 2026-07-30
7 Anne Evans Kingston Chief Strategy Officer 55,782 $462.4K -$64.9K 2 2026-07-30
8 Brandon S. Smith Chief Operating Officer 52,000 $431.1K -$1.31M 15 2026-07-30
9 Dale B. Schenk President and CEO 42,910 $355.7K -$3.72M 8 2016-02-26
10 Chad J. Swanson Chief Development Officer 40,733 $337.7K $0 5 2026-07-30
Lifetime OM Net = signed sum of open-market buys (P) and sells (S) over their career; excludes grants, tax withholdings, and dispositions to issuer. A large negative number is normal for long-tenured executives — they've sold compensation grants over many years.
Notice of Proposed Sale (Form 144)
Latest: 2026-07-29
Last 30d: 0 filings  ·  Last 90d: 2 filings · $136K notice value · 2 unique filers · 100% under 10b5-1 plans

What is Form 144? A notice of intent to sell restricted or control stock under Rule 144. Affiliates (officers, directors, 10%+ owners) and holders of restricted shares must file Form 144 when planning to sell more than 5,000 shares or $50,000 in any 3-month rolling window.

How it relates to Form 4: Form 144 is filed before the trade (up to 90 days in advance); Form 4 is filed within 2 business days after the trade executes. Not every Form 144 results in a sale — the filer may cancel or delay. Look for the corresponding Form 4 on the Insider Activity card to confirm a sale actually happened.

10b5-1 plans: Trades made under a pre-scheduled Rule 10b5-1 plan are not discretionary — they execute automatically on dates set months earlier, regardless of news. High 10b5-1 percentages mean less per-filing signal value, though cumulative selling volume still matters.

"Notice value": Aggregate market value the filer wrote into the Form 144 — i.e. the size of the planned sale, not necessarily the executed dollars. Amendments (Form 144/A) and post-cancellation refilings can inflate this if you sum naively; the rollup above excludes filings with zero stated value.

Source & freshness: Sourced from public Form 144 filings. Refreshed daily; new filings typically appear here the morning after they are filed.

Top 90-day filers: MICHAEL JOHN ISAACS (1, $71K) · ANNE KINGSTON (1, $65K)
Filed Filer Role Shares Notice Value Planned Sale Broker Plan Link
2026-07-29 ANNE KINGSTON Officer 7,662 $64.9K 2026-07-29 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-07-29 MICHAEL JOHN ISAACS Officer 8,386 $71.1K 2026-07-29 Morgan Stanley Smith Barney LLC … 10b5-1 EDGAR
2026-06-09 MALECEK MICHAEL J Previous Officer 80,000 $740.0K 2026-06-09 ETRADE FINANCIAL CORPORATION — EDGAR
2024-01-24 Walker Karin L Officer 5,000 $170.0K 2024-01-24 UBS Financial Services, Inc. 10b5-1 EDGAR
2023-12-20 Walker Karin L Officer 5,000 $186.4K 2023-12-20 UBS Financial Services, Inc 10b5-1 EDGAR
2023-11-30 Walker Karin L Officer 5,000 $170.0K 2023-11-30 UBS Financial Services, Inc. 10b5-1 EDGAR
2023-10-25 Walker Karin L Officer 5,000 $206.3K 2023-10-25 UBS Financial Services, Inc. 10b5-1 EDGAR
2023-10-11 Smith Brandon S. Officer 4,000 $189.2K 2023-10-11 UBS Financial Services, Inc. 10b5-1 EDGAR
2023-10-04 Karp Carol D. Officer 5,000 $237.0K 2023-10-04 UBS Financial Services, Inc 10b5-1 EDGAR
2023-09-27 Malecek Michael J Officer 5,000 $241.1K 2023-09-27 UBS Financial Services Inc. 10b5-1 EDGAR
Notice value is the aggregate market value the filer states they intend to sell — not a confirmed transaction. Compare to Insider Activity (Form 4) to see which planned sales actually executed.
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Fundamentals

Quarterly filings sourced from SEC 10-Q / 10-K reports. TTM tiles aggregate the most recent four quarters; bars show the last ~12 quarters oldest → newest.

Metrics
  • Revenue — top-line sales. Look for consistent YoY growth; seasonal businesses need same-quarter comparisons (Q4 '24 vs Q4 '23).
  • Net Income — bottom-line profit after all expenses. Can be volatile from one-time items; red bars = net loss.
  • Diluted EPS — net income per share assuming options/converts are exercised. Direct input to the P/E ratio.
  • Operating Cash Flow — cash generated from core operations, before capex and financing. Harder to manipulate than net income; growing OCF is a quality signal.
How to read the bars
  • Sequential growth — quarter-over-quarter trend. Accelerating bars are a momentum signal.
  • YoY growth — compare to the same quarter a year earlier to remove seasonality.
  • Quality — OCF should roughly track Net Income over time. Large divergence (net income ≫ OCF) flags accruals risk.
  • Margins — scan the bar ratios: Net Income / Revenue tells you margin trend without needing a separate chart.

TTM (trailing-twelve-month) smooths seasonality and is used for the P/E calculation. Filings appear 30–90 days after the period closes.

P/B Ratio1.5
P/S Ratio7.8
EV/EBITDA-2.4
TTM Revenue$0.1B
TTM Net Income$-0.0B
TTM EPS$-0.84
ROE-15.3%